The Implicit Relational Assessment Procedure (IRAP) as a measure of spider fear, avoidance and approach

The current study examined the use of the Implicit Relational Assessment Procedure (IRAP) as a measure of spider fear, approach, and avoidance. Participants were drawn from a normative sample of university undergraduates. Experiment 1employed two IRAPs, one targeting spider fear, the other targeting spider approach/avoidance. The Fear of Spiders Questionnaire (FSQ) and a Behavioral Approach Task (BAT) using a spider moult were also employed. Negative response biases for spider fear and avoidance, but not for approach, were recorded. The bias for fear was significantly stronger than for avoidance and approach. Both IRAP's failed to provide evidence for the predicative validity of the IRAP in terms of the BAT. Experiment 2 was a partial replication of Experiment 1 but using a live house spider instead of a moult for the BAT. A similar pattern of results was obtained across the two IRAPs, but one specific trial-type (SpiderApproach) predicted approach responses on the BAT. The research, thus, replicated a previously published study by Nicholson and Barnes-Holmes (2012), thus supporting the predictive validity of the IRAP but at a level of precision not provided in the earlier study. Implications for applied research are considered

Kondo effect in a double quantum-dot molecule under the effect of an electric and magnetic field

Electron tunneling through a double quantum dot molecule, in the Kondo regime, under the effect of a magnetic field and an applied voltage, is studied. This system possesses a complex response to the applied fields characterized by a tristable solution for the conductance. The different nature of the solutions are studied in and out thermodynamical equilibrium. It is shown that the interdot coupling and the fields can be used to control the region of multistability. The mean-field slave-boson formalism is used to obtain the solution of the problem.Comment: 5 pages, 4 figures. To appear in Sol. State Com

Tristability in a non-equilibrium double-quantum-dot in Kondo regime

Electron tunneling through a non-equilibrium double quantum dot in the Kondo regime is studied. In the region of negative differential resistance, it is shown that this system possesses a complex response to the applied potential characterized by a tristable solution for the current. Increasing the applied potential or reducing the inter-dot coupling, the system goes through a transition from a coherent inter-dot regime to an incoherent one. The different nature of the solutions are characterized and it is shown that the effects of the asymmetry in the dot-lead coupling can be used to control the region of multistability. The mean-field slave-boson formalism is used to obtain the solution of the problem.Comment: 4 pages, 4 figures. To appear in Sol. State. Com

The problem with Kappa

It is becoming clear that traditional evaluation measures used in Computational Linguistics (including Error Rates, Accuracy, Recall, Precision and F-measure) are of limited value for unbiased evaluation of systems, and are not meaningful for comparison of algorithms unless both the dataset and algorithm parameters are strictly controlled for skew (Prevalence and Bias). The use of techniques originally designed for other purposes, in particular Receiver Operating Characteristics Area Under Curve, plus variants of Kappa, have been proposed to fill the void. This paper aims to clear up some of the confusion relating to evaluation, by demonstrating that the usefulness of each evaluation method is highly dependent on the assumptions made about the distributions of the dataset and the underlying populations. The behaviour of a number of evaluation measures is compared under common assumptions. Deploying a system in a context which has the opposite skew from its validation set can be expected to approximately negate Fleiss Kappa and halve Cohen Kappa but leave Powers Kappa unchanged. For most performance evaluation purposes, the latter is thus most appropriate, whilst for comparison of behaviour, Matthews Correlation is recommended

Experimental study of bore-driven swash hydrodynamics on permeable rough slopes

Peer reviewedPublisher PD

The dependence of galaxy group star formation rates and metallicities on large scale environment

We construct a sample of 75,863 star forming galaxies with robust metallicity and star formation rate measurements from the Sloan Digital Sky Survey Data Release 7 (SDSS DR7), from which we select a clean sample of compact group (CG) galaxies. The CGs are defined to be close configurations of at least 4 galaxies that are otherwise apparently isolated. Our selection results in a sample of 112 spectroscopically identified compact group galaxies, which can be further divided into groups that are either embedded within a larger structure, such as a cluster or large group, or truly isolated systems. The compact groups then serve as a probe into the influence of large scale environment on a galaxy's evolution, while keeping the local density fixed at high values. We find that the star formation rates (SFRs) of star forming galaxies in compact groups are significantly different between isolated and embedded systems. Galaxies in isolated systems show significantly enhanced SFR, relative to a control sample matched in mass and redshift, a trend not seen in the embedded systems. Galaxies in isolated systems exhibit a median SFR enhancement at fixed stellar mass of +0.07 \pm 0.03 dex. These dependences on large scale environment are small in magnitude relative to the apparent influence of local scale effects found in previous studies, but the significance of the difference in SFRs between our two samples constrains the effect of large scale environment to be non-zero. We find no significant change in the gas-phase interstellar metallicity for either the isolated or embedded compact group sample relative to their controls. However, simulated samples that include artificial offsets indicate that we are only sensitive to metallicity changes of log O/H >0.13 dex (at 99% confidence), which is considerably larger than the typical metallicity differences seen in previous environmental studies.Comment: Accepted for publication in MNRAS. 16 pages, 9 figure

Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure

BACKGROUND AND AIMS: Induction of functional helper CD4+ T cells is the hallmark of a protective immune response against hepatitis C virus (HCV), associated with spontaneous viral clearance. Heterologous prime/boost viral vectored vaccination has demonstrated induction of broad and polyfunctional HCV-specific CD8+ T cells in healthy volunteers; however, much less is known about CD4+ T-cell subsets following vaccination. APPROACH AND RESULTS: We analyzed HCV-specific CD4+ T-cell populations using major histocompatibility complex class II tetramers in volunteers undergoing HCV vaccination with recombinant HCV adenoviral/modified vaccinia Ankara viral vectors. Peptide-specific T-cell responses were tracked over time, and functional (proliferation and cytokine secretion) and phenotypic (cell surface and intranuclear) markers were assessed using flow cytometry. These were compared to CD4+ responses in 10 human leukocyte antigen-matched persons with HCV spontaneous resolution and 21 chronically infected patients treated with directly acting antiviral (DAA) therapy. Vaccination induced tetramer-positive CD4+ T cells that were highest 1-4 weeks after boosting (mean, 0.06%). Similar frequencies were obtained for those tracked following spontaneous resolution of disease (mean, 0.04%). In addition, the cell-surface phenotype (CD28, CD127) memory subset markers and intranuclear transcription factors, as well as functional capacity of peptide-specific CD4+ T-cell responses characterized after vaccination, are comparable to those following spontaneous viral resolution. In contrast, helper responses in chronic infection were infrequently detected and poorly functional and did not consistently recover following HCV cure. CONCLUSIONS: Helper CD4+ T-cell phenotype and function following HCV viral vectored vaccination resembles "protective memory" that is observed following spontaneous clearance of HCV. DAA cure does not promote resurrection of exhausted CD4+ T-cell memory in chronic infection

Fluoxetine and thioridazine inhibitefflux and attenuate crystalline biofilm formation by Proteusmirabilis

Proteus mirabilis forms extensive crystalline biofilms on indwelling urethral catheters that block urineflow and lead to serious clinical complications. The Bcr/CflA efflux system has previously been identified as important for development of P. mirabilis crystalline biofilms, highlighting the potential for efflux pump inhibitors (EPIs) to control catheter blockage. Here we evaluate the potential for drugs already used in human medicine (fluoxetine and thioridazine) to act as EPIs in P. mirabilis, and control crystalline biofilm formation. Both fluoxetine and thioridazine inhibited efflux in P. mirabilis, and molecular modelling predicted both drugs interact strongly with the biofilm-associated Bcr/CflA efflux system.Both EPIs were also found to significantly reduce the rate of P. mirabilis crystalline biofilm formation on catheters, and increase the time taken for catheters to block. Swimming and swarming motilies inP. mirabilis were also significantly reduced by both EPIs. The impact of these drugs on catheter biofilm formation by other uropathogens (Escherichia coli, Pseudomonas aeruginosa) was also explored, and thioridazine was shown to also inhibit biofilm formation in these species. Therefore, repurposing of existing drugs with EPI activity could be a promising approach to control catheter blockage, or biofilmformation on other medical devices