Spin Observables in Antilambda-Lambda Production from Antiproton-Proton Annihilation with a Transverse Inital State Polarization

The formalism describing the scattering of two spin-1/2 objects is reviewed for the case of antilambda-lambda production from antiproton-proton annihilation. It is shown that an experiment utilizing a transverse target polarization can, in principle, completely determine the spin structure of the reaction. Additional measurements, even those using both beam and target polarizations, would not be sensitive to any additional spin dynamics. Thus, the transverse target polarization allows access to the complete set of spin observables, not just the subset upon which the literature has previously focused. This discussion is especially relevant in light of the data collected by PS185/3 at LEAR.Comment: 7 pages, no figure

Differential gene expression in cells with different p53 mutations identifies genome-wide p53 targets and shows distinct modulation of cellular pathways in response to DNA damage

© 2024 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (CC BY-NC), https://creativecommons.org/licenses/by-nc/4.0/The fundamental transcription factor p53 regulates cellular processes and integrates signals of cellular stress, triggering a coordinated response to ensure survival of cells restored to healthy function and programmed death of those that couldn’t be repaired. Unsurprisingly, this is one of the most mutated genes in human cancers, with most changes occurring in the DNA-binding domain of the protein. In this work, we take a genome-wide approach and use available resources to identify high confidence p53-target genes, that we examine in three breast cancer cell lines with different p53 status, wild type (MCF-7) and different mutations in the DNA-binding domain (MDA-MB231, T47D). Comparison of p53-targets expression in response to DNA damage by RNAseq and cellular assays reveals that MDA-MB231 have a severely impaired p53-dependent pathway functionality while T47D are much less affected. MDA-MB231 are more resistant to DNA damage yet unable to repair and able to override cell cycle arrest leading to survival while T47D are sensitive only to high dose and exposure to genotoxic agents. This data shows the variability of effects of different p53 mutations and highlight the importance of understanding the mechanisms of p53 in the context of genotoxicity-based treatment

A multifrequency angular power spectrum analysis of the Leiden polarization surveys

The Galactic synchrotron emission is expected to be the most relevant source of astrophysical contamination in cosmic microwave background polarization measurements, at least at frequencies 30'. We present a multifrequency analysis of the Leiden surveys, linear polarization surveys covering essentially the Northern Celestial Hemisphere at five frequencies between 408 MHz and 1411 MHz. By implementing specific interpolation methods to deal with these irregularly sampled data, we produced maps of the polarized diffuse Galactic radio emission with pixel size of 0.92 deg. We derived the angular power spectrum (APS) (PI, E, and B modes) of the synchrotron dominated radio emission as function of the multipole, l. We considered the whole covered region and some patches at different Galactic latitudes. By fitting the APS in terms of power laws (C_l = k l^a), we found spectral indices that steepen with increasing frequency: from a = -(1-1.5) at 408 MHz to a = -(2-3) at 1411 MHz for 10 < l < 100 and from a = -0.7 to a = -1.5 for lower multipoles (the exact values depending on the considered sky region and polarization mode). The bulk of this steepening can be interpreted in terms of Faraday depolarization effects. We then considered the APS at various fixed multipoles and its frequency dependence. Using the APSs of the Leiden surveys at 820 MHz and 1411 MHz, we determined possible ranges for the rotation measure, RM, in the simple case of an interstellar medium slab model. Taking also into account the polarization degree at 1.4 GHz, we could break the degeneracy between the identified RM intervals. The most reasonable of them turned out to be RM = 9-17 rad/m^2.Comment: 18 pages, 14 figures. Astronomy and Astrophysics, in pres

Therapeutic efficacy of sulfadoxine-pyrimethamine for plasmodium falciparum malaria

Objectives. To assess the therapeutic efficacy of sulfadoxinepyrimethamine (SP) after 5 years of use as first-line treatment of uncomplicated Plasmodium falciparum malaria, and thus guide the selection of artemisinin-based combination therapy in Mpumalanga, South Africa. Design. An open-label, in vivo therapeutic efficacy study of patients with uncomplicated P. falciparum malaria treated with a single oral dose of SP, with response to treatment monitored clinically and parasitologically on days 1, 2, 3, 7, 14, 21, 28 and 42. Setting. Mangweni and Naas public health care clinics, Tonga district in rural Mpumalanga. Subjects, outcome measures and results. Of 152 patients recruited sequentially, 149 (98%) were successfully followed up for 42 days. One hundred and thirty-four patients (90%) demonstrated adequate clinical and parasitological response. Of the 15 patients (10%) who failed treatment, 2 (1.3%) had an early treatment failure, and polymerase chain reaction confirmed recrudescent infection in all 13 patients (8.7%) who had late parasitological (N = 11) or clinical (N = 2) failure. Gametocyte carriage was prevalent following SP treatment (84/152) and this has increased significantly since implementation in 1998 (relative risk 2.77 (confidence interval 1.65 - 4.66); p = 0.00004). Conclusion. Asexual P. falciparum parasites in Mpumalanga remain sensitive to SP, with no significant difference between the baseline cure rate (94.5%) at introduction in 1998, and the present 90% cure rate (p = 0.14). However, since gametocyte carriage has increased significantly we recommend that SP be combined with artesunate in Mpumalanga to reduce gametocyte carriage and thus decrease malaria transmission and potentially delay antimalarial resistance. S Afr Med J 2005; 95: 346-349

Merging of Low-Mass Systems and the Origin of the Fundamental Plane

We present a new set of dissipationless N-body simulations to examine the feasibility of creating bright ellipticals (following the Kormendy relation) by hierarchically merging present-day early-type dwarf galaxies, and to study how the encounter parameters affect the location of the end-product in the $- R_{e}$ plane. We investigate the merging of one-component galaxies of both equal and different masses, the merging of two-component galaxy models to explore the effect of dark halos on the final galaxy characteristics, and the merging of ultracompact dwarf galaxies. We find that the increase of $$ with $R_e$ is attributable to an increase in the initial orbital energy. The merger remnants shift down in the $- R_{e}$ plane and fail to reach the KR. Thus, the KR is not reproducable by mergers of dwarf early-type systems, rendering untenable the theory that present-day dwarfs are responsible for even a small fraction of the present-day ellipticals, unless a considerable amount of dissipation is invoked. However, we do find that present-day dwarfs can be formed by the merger of ultra-compact dwarfs.Comment: 10 pages, 8 figures. Accepted for publication in MNRA

Biodiesel Production by Heterogeneous Catalysis and Eco-friendly Routes

Biodiesel is produced on a large scale as an eco-friendly substitute and additive to fossil fuels. Catalytic homogeneous processes using strong acids, alkalis, and natural oils have been realized in industry. However, these traditional methods have several disadvantages, such as the generation of large volumes of waste, high water and reagent needs, use of hazardous reagents, high operation costs, and utilization of valuable feedstocks and catalysis, respectively. Different solutions have subsequently been investigated, such as cheap alternative feedstocks, co-solvents and catalysts, sustainable operational conditions, advanced reactor designs and scales, and advantageous pre- and post-reaction treatments. This review explores and analyzes the main aspects of current biodiesel technologies and opportunities. It also describes some advanced improvement strategies

Constraints on spin observables in antiproton-proton to antiLambda-Lambda

It is recalled that spin-observables in the strangeness-exchange reaction $\bar{p}{p} \to \bar{\Lambda}{\Lambda}$ are not independent but are related to each other by simple algebraic relations. This provides constraints on the existing data on polarization and spin-correlation coefficients, and also on the forthcoming data obtained using a polarized proton target.Comment: RevTex, 9 page

Manners and method in classical criticism of the early eighteenth century

This article explores a neglected period in the history of classical scholarship: the first decades of the eighteenth century. It focuses on the tension between an evolving idea of method, and the tradition of personal polemic which had been an important part of the culture of scholarship since the Renaissance. There are two case studies: the conflict between Jean Le Clerc and Pieter Burman, and the controversy that followed Richard Bentley's edition of Horace's Odes. Both demonstrate the need to revise current paradigms for writing the history of scholarship, and invite us to reconsider the role of methodology in producing of scholarly authority

Terrestrial exposure of a fresh Martian meteorite causes rapid changes in hydrogen isotopes and water concentrations

Determining the hydrogen isotopic compositions and H2O contents of meteorites and their components is important for addressing key cosmochemical questions about the abundance and source(s) of water in planetary bodies. However, deconvolving the effects of terrestrial contamination from the indigenous hydrogen isotopic compositions of these extraterrestrial materials is not trivial, because chondrites and some achondrites show only small deviations from terrestrial values such that even minor contamination can mask the indigenous values. Here we assess the effects of terrestrial weathering and contamination on the hydrogen isotope ratios and H2O contents of meteoritic minerals through monitored terrestrial weathering of Tissint, a recent Martian fall. Our findings reveal the rapidity with which this weathering affects nominally anhydrous phases in extraterrestrial materials, which illustrates the necessity of sampling the interiors of even relatively fresh meteorite falls and underlines the importance of sample return missions