Gestational hemostasis: a natural model for hemostasis resuscitation of major periprocedural blood loss

Early goal-directed treatment is an evidence-based approach to guide hemostatic therapy during major periprocedural bleeding. If viscoelastic coagulation tests are not available, an algorithm, termed the pyramid of hemostatic interventions, can help manage severe bleeding. Pregnant women accumulate huge reserves of prothrombotic and antifibrinolytic hemostatic elements to avoid peripartum blood loss. We provide comparison of therapeutic hemostatic approaches and natural gestational process and identified remarkable analogy between early goal-directed management of bleeding and hemostatic adaptation of pregnant woman. Therefore, gestational hemostasis serves as a natural model for goal-directed hemostasis resuscitation and can foster understanding of hemostatic management of periprocedural bleeding

Functional diversification of heat shock factors

Heat shock transcription factors (HSFs) are widely known as master regulators of the heat shock response. In invertebrates, a single heat shock factor, HSF1, is responsible for the maintenance of protein homeostasis. In vertebrates, seven members of the HSF family have been identified, namely HSF1, HSF2, HSF3, HSF4, HSF5, HSFX, and HSFY, of which HSF1 and HSF2 are clearly associated with heat shock response, while HSF4 is involved in development. Other members of the family have not yet been studied as extensively. Besides their role in cellular proteostasis, HSFs influence a plethora of biological processes such as aging, development, cell proliferation, and cell differentiation, and they are implicated in several pathologies such as neurodegeneration and cancer. This is achieved by regulating the expression of a great variety of genes including chaperones. Here, we review our current knowledge on the function of HSF family members and important aspects that made possible the functional diversification of HSFs

Random noise can help to improve synchronization of excimer laser pulses

Recently we have reported on a compact microcontroller-based unit developed to accurately synchronise excimer laser pulses (Robert Mingesz et al, Fluct. Noise Lett. 11, 1240007 (2012), DOI: 10.1142/S021947751240007X, arXiv:1109.2632). We have shown that dithering based on the random jitter noise plus pseudorandom numbers can be used in the digital control system to radically reduce the long-term drift of the laser pulse from the trigger and to improve the accuracy of the synchronisation. In this update paper we present our new experimental results obtained by the use of the delay controller unit to tune the timing of a KrF excimer laser as an addition to our previous numerical simulation results. The hardware was interfaced to the laser using optical signal paths in order to reduce sensitivity to electromagnetic interference and the control algorithm tested by simulations were applied in the experiments. We have found that the system is able to reduce the delay uncertainty very close to the theoretical limit and performs well in real applications. The simple, compact and flexible system is universal enough to be used in various multidisciplinary applications as well

A ló- és lovassportokhoz, oktatásukhoz kapcsolható marketing és vidékfejlesztés kérdései : Példák Ausztriából, Erdélyből és Magyarországról

The human-animal relation is the most "personal" at horse species. The authors present some basic information about the horse breeding and try to give an overview about the topics of the title, based on their own professional experiences. They give standpoints for marketing, educational and labour ethics, for the cultured recreation, and for the rural development and tourism. They give examples from the past and present situation (in Austria and Hungary), and future trends (in Romania, Transylvania). These are very different from the conceptions, which use to consider this topic mainly as sport subject

A ló- és lovassportokhoz, oktatásukhoz kapcsolható marketing és vidékfejlesztés kérdései : Példák Ausztriából, Erdélyből és Magyarországról

The human-animal relation is the most "personal" at horse species. The authors present some basic information about the horse breeding and try to give an overview about the topics of the title, based on their own professional experiences. They give standpoints for marketing, educational and labour ethics, for the cultured recreation, and for the rural development and tourism. They give examples from the past and present situation (in Austria and Hungary), and future trends (in Romania, Transylvania). These are very different from the conceptions, which use to consider this topic mainly as sport subject