Improved Reference Genome Sequence of Coccidioides immitis Strain WA_211, Isolated in Washington State.

Coccidioides fungi are widely distributed in the American continents, with an expanding western range documented by a recently discovered cryptic population of Coccidioides immitis in Washington State. The assembled and annotated reference genome sequence of the soil-derived C. immitis strain WA_211 will support population and functional genomics studies

Linking early geospatial documents, one place at a time: annotation of geographic documents with Recogito

Recogito is an open source tool for the semi-automatic annotation of place references in maps and texts. It was developed as part of the Pelagios 3 research project, which aims to build up a comprehensive directory of places referred to in early maps and geographic writing predating the year 1492. Pelagios 3 focuses specifically on sources from the Classical Latin, Greek and Byzantine periods; on Mappae Mundi and narrative texts from the European Medieval period; on Late Medieval Portolans; and on maps and texts from the early Islamic and early Chinese traditions. Since the start of the project in September 2013, the team has harvested more than 120,000 toponyms, manually verifying almost 60,000 of them. Furthermore, the team held two public annotation workshops supported through the Open Humanities Awards 2014. In these workshops, a mixed audience of students and academics of different backgrounds used Recogito to add several thousand contributions on each workshop day. A number of benefits arise out of this work: on the one hand, the digital identification of places – and the names used for them – makes the documents' contents amenable to information retrieval technology, i.e. documents become more easily search- and discoverable to users than through conventional metadata-based search alone. On the other hand, the documents are opened up to new forms of re-use. For example, it becomes possible to “map” and compare the narrative of texts, and the contents of maps with modern day tools like Web maps and GIS; or to analyze and contrast documents’ geographic properties, toponymy and spatial relationships. Seen in a wider context, we argue that initiatives such as ours contribute to the growing ecosystem of the “Graph of Humanities Data” that is gathering pace in the Digital Humanities (linking data about people, places, events, canonical references, etc.), which has the potential to open up new avenues for computational and quantitative research in a variety of fields including History, Geography, Archaeology, Classics, Genealogy and Modern Languages

A Combined Preconditioning Strategy for Nonsymmetric Systems

We present and analyze a class of nonsymmetric preconditioners within a normal (weighted least-squares) matrix form for use in GMRES to solve nonsymmetric matrix problems that typically arise in finite element discretizations. An example of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. A variable preconditioner, combining the original nonsymmetric one and a weighted least-squares version of it, is shown to be convergent and provides a viable strategy for using nonsymmetric preconditioners in practice. Numerical results are included to assess the theory and the performance of the proposed preconditioners.Comment: 26 pages, 3 figure

Farmer-based financing of operations in the Niger Valley irrigation schemes.

Irrigation management / Water balance / River basins / Basin irrigation / Water use efficiency / Water supply / Water requirements / Domestic water / Water scarcity / Water demand / Water shortage / Irrigated farming / Productivity / Food security / Recycling / Rice

Loss of survivin in intestinal epithelial progenitor cells leads to mitotic catastrophe and breakdown of gut immune homeostasis

A tightly regulated balance of proliferation and cell death of intestinal epithelial cells (IECs) is essential for maintenance of gut homeostasis. Survivin is highly expressed during embryogenesis and in several cancer types, but little is known about its role in adult gut tissue. Here, we show that Survivin is specifically expressed in transit-amplifying cells and Lgr5(+) stem cells. Genetic loss of Survivin in IECs resulted in destruction of intestinal integrity, mucosal inflammation, and death of the animals. Survivin deletion was associated with decreased epithelial proliferation due to defective chromosomal segregation. Moreover, Survivin-deficient animals showed induced phosphorylation of p53 and H2AX and increased levels of cell-intrinsic apoptosis in IECs. Consequently, induced deletion of Survivin in Lgr5(+) stem cells led to cell death. In summary, Survivin is a key regulator of gut tissue integrity by regulating epithelial homeostasis in the stem cell niche

Modeling the variability of shapes of a human placenta

While it is well-understood what a normal human placenta should look like, a deviation from the norm can take many possible shapes. In this paper we propose a mechanism for this variability based on the change in the structure of the vascular tree

What do dynamical cluster masses really tell us about dynamics?

The diagnostic age versus mass-to-light ratio diagram is often used in attempts to constrain the shape of the stellar initial mass function, and the stability and the potential longevity of extragalactic young to intermediate-age massive star clusters. Here, we explore the pitfalls associated with this approach and its potential for use with Galactic open clusters. We conclude that for an open cluster to survive for any significant fraction of a Hubble time (in the absence of substantial external perturbations), it is a necessary but not a sufficient condition to be located close to the predicted photometric evolutionary sequences for "normal" simple stellar populations.Comment: 4 pages (incl. 3 postscript figures), in: Galactic and stellar dynamics in the era of high-resolution surveys, Boily C., Combes F., Hensler G., eds., Strasbourg (France), March 2008, in press (Astron. Nachr.

Timing and nature of AMOC recovery across Termination 2 and magnitude of deglacial CO2 change

Large amplitude variations in atmospheric CO 2 were associated with glacial terminations of the Late Pleistocene. Here we provide multiple lines of evidence suggesting that the B 20 p.p.m.v. overshoot in CO 2 at the end of Termination 2 (T2) B 129 ka was associated with an abrupt ( r 400 year) deepening of Atlantic Meridional Overturning Circulation (AMOC). In contrast to Termination 1 (T1), which was interrupted by the Bølling-Allerød (B-A), AMOC recovery did not occur until the very end of T2, and was characterized by pronounced formation of deep waters in the NW Atlantic. Considering the variable influences of ocean circulation change on atmospheric CO 2 , we suggest that the net change in CO 2 across the last 2 terminations was approximately equal if the transient effects of deglacial oscillations in ocean circulation are taken into account

Exact two-particle eigenstates in partially reduced QED

We consider a reformulation of QED in which covariant Green functions are used to solve for the electromagnetic field in terms of the fermion fields. It is shown that exact few-fermion eigenstates of the resulting Hamiltonian can be obtained in the canonical equal-time formalism for the case where there are no free photons. These eigenstates lead to two- and three-body Dirac-like equations with electromagnetic interactions. Perturbative and some numerical solutions of the two-body equations are presented for positronium and muonium-like systems, for various strengths of the coupling.Comment: 33 pages, LaTex 2.09, 4 figures in EPS forma