Programa de Educación Tutorial en salud bucal : la experiencia en atención primaria en el centro de salud de Itapoã-DF

Este artigo apresenta o relato de experiência do Programa de Educação Tutorial em Odontologia da Universidade de Brasília, durante o período de março a dezembro de 2010. O cenário de prática das atividades de campo é a Regional Administrativa do Itapoã, no Distrito Federal, e a atuação do grupo tutorial acontece junto às Equipes de Saúde da Família por meio de rotinas educativo-preventivas em saúde bucal durante as visitas domiciliares, atividades clínicas e desenvolvimento de pesquisas. Alunos e preceptores estão sendo capazes de reconhecer os determinantes sociais do processo saúdedoença, analisar os indicadores de saúde bucal da população, aprimorar práticas educativas utilizadas na Estratégia Saúde da Família e promover saúde no âmbito da comunidade. As principais dificuldades encontradas dizem respeito a limitação de espaço físico e de recursos capazes de atender a demanda do grupo tutorial e das famílias assistidas. Esta experiência tutorial junto à Estratégia Saúde da Família possibilita um aprendizado que vai muito mais além do que a tradição de ensino bio-tecnicista da odontologia, bem como permite aos discentes de odontologia da UnB ‘vivenciar uma experiência real’ e refletir sobre os conhecimentos teóricos obtidos nos ‘bancos da universidade’. _________________________________________________________________________________________________________________ ABSTRACTThis paper presents an experience report of the Tutorial Program in Dentistry from the University of Brasília, during the period from March to December, 2010. The scenario of practice is the Itapoã - an Administrative Area of the Distrito Federal - and the activities of the tutorial group take place in partnership with the Family Health Team through a preventive educational oral health routine during home visits, as well as clinical activities and development of research. Students and preceptors are being able to recognize the social determinants of the health-disease process, analyze oral health indicators of the population, improve educational practices and promote health within the community. The main barriers of the tutorial group are the lack of physical space and dental equipment capable of meeting the demand of the tutorial group and assisted families. This tutorial experience within the Family Health Strategy provides a learning experience that goes far beyond the tradition of teaching bio-technicalities of dentistry, as well as allows dental students real to live through a real field experience and reflect on the theoretical knowledge obtained from the ‘university seats’. _________________________________________________________________________________________________________________ RESUMENEste documento presenta el relato de la experiencia del Programa de Educación Tutorial en Odontología de la Universidad de Brasília, durante el período de Marzo a Diciembre de 2010. El escenário de práctica de las actividades de campo es el Sector Regional Administrativo de Itapoã, en el Distrito Federal, donde el trabajo del grupo tutorial acompaña el trabajo de los Equipos de Salud de la Família a través de la educación preventiva de rutina en la salud bucal de la población, mejorando las prácticas educativas utilizadas en la estrategia de salud familiar y promoviendo la salud en la comunidad. Las principales dificultades se refieren a la limitación del espacio físico y el equipo dental capaces de satisfacer la demanda del grupo tutorial y de las famílias atendidas. Esta actividad tutorial con la Estrategia de Salud de la Família ofrece una experiencia de aprendizaje que vá más allá de la tradición de la enseñanza de técnicas bio-odontológicas, así como permite a los estudiantes de odontología de la UnB “pasar una verdadera experiencia” y reflexionar sobre el conocimiento teórico obtenido en “los bancos de datos de la universidad”

Individually tailored dosage regimen of full-spectrum Cannabis extracts for autistic core and comorbid symptoms: a real-life report of multi-symptomatic benefits

Autism Spectrum Disorders (ASD) may significantly impact the well-being of patients and their families. The therapeutic use of cannabis for ASD has gained interest due to its promising results and low side effects, but a consensus on treatment guidelines is lacking. In this study, we conducted a retrospective analysis of 20 patients with autistic symptoms who were treated with full-spectrum cannabis extracts (FCEs) in a response-based, individually-tailored dosage regimen. The daily dosage and relative proportions of cannabidiol (CBD) and tetrahydrocannabinol (THC) were adjusted based on treatment results following periodic clinical evaluation. Most patients (80%) were treated for a minimum of 6 months. We have used a novel, detailed online patient- or caregiver-reported outcome survey that inquired about core and comorbid symptoms, and quality of life. We also reviewed patients’ clinical files, and no individual condition within the autistic spectrum was excluded. This real-life approach enabled us to gain a clearer appraisal of the ample scope of benefits that FCEs can provide for ASD patients and their families. Eighteen patients started with a CBD-rich FCE titrating protocol, and in three of them, the CBD-rich (CBD-dominant) FCE was gradually complemented with low doses of a THC-rich (THC-dominant) FCE based on observed effects. Two other patients have used throughout treatment a blend of two FCEs, one CBD-rich and the other THC-rich. The outcomes were mainly positive for most symptoms, and only one patient from each of the two above-mentioned situations displayed important side effects one who has used only CBD-rich FCE throughout the treatment, and another who has used a blend of CBD-Rich and THC-rich FCEs. Therefore, after FCE treatment, 18 out of 20 patients showed improvement in most core and comorbid symptoms of autism, and in quality of life for patients and their families. For them, side effects were mild and infrequent. Additionally, we show, for the first time, that allotriophagy (Pica) can be treated by FCEs. Other medications were reduced or completely discontinued in most cases. Based on our findings, we propose guidelines for individually tailored dosage regimens that may be adapted to locally available qualified FCEs and guide further clinical trials

Fumaça ambiental do tabaco e transtornos neurocomportamentais em crianças: evidências atuais e mecanismos propostos

Introduction: Pre- and postnatal exposure to environmental tobacco smoke (ETS) is associated with cognitive, behavioral, and possibly motor impairments in children, affecting neurodevelopment through multifactorial mechanisms. Beyond compromising respiratory and metabolic functions, ETS increases long-term neuropsychological risks, especially in vulnerable populations such as pregnant women and infants, demanding scientific attention and preventive public policies.Objectives:To investigate the effects of pre- and postnatal exposure to environmental tobacco smoke on child neurodevelopment, including motor aspects.Methodology:This narrative review analyzed studies published between 2014 and 2025 on the effects of pre- and postnatal exposure to environmental tobacco smoke on child neurodevelopment. Cognitive, motor, and behavioral alterations were investigated, as well as the biological mechanisms involved. The search was conducted in recognized scientific databases, addressing clinical evidence and highlighting gaps for future research.Results and Discussion:Recent studies indicate that prenatal exposure to environmental tobacco smoke and indoor pollutants is associated with cognitive, language, and in some cases, motor deficits in child development. Despite methodological limitations, the findings reinforce the need for public policies focused on improving indoor air quality to protect child neurodevelopment.Conclusion:The data suggest that prenatal exposure to tobacco smoke and indoor pollutants compromises cognitive and language development in children. Preventive interventions and future research using biomarkers and longitudinal designs are necessary to clarify these associations.Introdução: A exposição pré e pós-natal à fumaça ambiental do tabaco (FAT) associa-se a prejuízos cognitivos, comportamentais e possivelmente motores em crianças, afetando o neurodesenvolvimento de forma multifatorial. Além de comprometer funções respiratórias e metabólicas, a FAT potencializa riscos neuropsicológicos duradouros, sobretudo em populações vulneráveis, como gestantes e lactentes, exigindo atenção científica e políticas preventivas.Objetivos: Investigar os efeitos da exposição pré e pós-natal à fumaça ambiental do tabaco no neurodesenvolvimento infantil, incluindo aspectos motores.Metodologia: Esta revisão narrativa analisou estudos publicados entre 2014 e 2025 sobre os efeitos da exposição pré e pós-natal à fumaça ambiental do tabaco no neurodesenvolvimento infantil. Foram investigadas alterações cognitivas, motoras e comportamentais, além dos mecanismos biológicos envolvidos. A busca utilizou bases científicas reconhecidas, abordando evidências clínicas e destacando lacunas para futuras pesquisas. Resultados e Discussão: Estudos recentes apontam que a exposição pré-natal à fumaça ambiental do tabaco e a poluentes internos está associada a déficits cognitivos, linguísticos e, em alguns casos, motores no desenvolvimento infantil. Apesar das limitações metodológicas, os achados reforçam a necessidade de políticas públicas focadas na melhoria da qualidade do ar domiciliar para proteger o neurodesenvolvimento infantil. Conclusão:Os dados indicam que a exposição pré-natal à fumaça do tabaco e poluentes internos compromete o desenvolvimento cognitivo e linguístico infantil. Reforça-se a necessidade de intervenções preventivas e pesquisas futuras com biomarcadores e delineamentos longitudinais para esclarecer essas associações

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt