No association between the DAT1 10-repeat allele and ADHD in the Iranian population

Association studies between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations. We performed a case/control study to clarify the contribution of this allele with ADHD in the Iranian population. No association was observed between the 10-allele and disease (�2 = 0.081, P < 0.9). Furthermore, no significant difference was observed in the homozygosity of this allele between the case and control groups (�2 = 0.022, P < 0.9). Implication of the dopamine transporter gene in the pathophysiology of ADHD warrants investigation of other functional polymorphisms within this gene in the Iranian ADHD patients. © 2007 Wiley-Liss, Inc

Lack of association between interferon‐gamma receptor‐1 polymorphism and pulmonary TB in Iranian population sample

Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN-γR1. Determination of susceptibility to tuberculosis with polymorphism of IFN-γR1 gene. Study was prospective case–control. Fifty patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN-γR1 gene was detected with Newport method. Data were analysed with SPSS version 11. Mean age of patients and control were 55±20 and 53±13.5 years, respectively. Demographic characteristic had no difference within two groups. One patient in case group had heterozygote mutation at IFN-γR1 gene. In control group there were no mutations. Genetically susceptibility to TB is not in 395 colon of IFN-γR1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population