Effect of HER2 Expression on NUPL2 Protein in Cervical Cancer Cells

Recurring cervical cancer patients frequently present overexpressed Human Epidermal Growth Factor Receptor 2 (HER2) protein, which promotes the growth of the cancer. Some HER2-expressing cells and cervical cancer patients have enhanced gene expression of Nucleoporin-like 2 (NUPL2). As part of the nuclear pore complex, the NUPL2 protein serves to selectively export substances from the nucleus to the cytoplasm. In this experiment, HER2 was expressed in cervical cancer cells to examine its effect on NUPL2 protein expression and localization. Interestingly, there was no difference in NUPL2 protein levels between HER2-expressing and non-expressing cells. Importantly, consistent instances of NUPL2 protein localization specific to the nucleus occurred in a large sampling of HER2-expressing cells. This is significant because it suggests a mechanism as to how HER2 promotes excessive cell growth, via changes in NUPL2 localization, potentially impacting its function and ability to selectively export substances that modulate cell growth

Spectral functions in itinerant electron systems with geometrical frustration

The Hubbard model with geometrical frustration is investigated in a metallic phase close to half-filling. We calculate the single particle spectral function for the triangular lattice within dynamical cluster approximation, which is further combined with non-crossing approximation and fluctuation exchange approximation to treat the resulting cluster Anderson model. It is shown that frustration due to non-local correlations suppresses short-range antiferromagnetic fluctuations and thereby assists the formation of heavy quasi-particles near half-filling.Comment: 4 pages, 5 eps figure

Magnetic fluctuations in frustrated Laves hydrides R(Mn_{1-x}Al_{x})_{2}H_{y}

By neutron scattering, we have studied the spin correlations and spin fluctuations in frustrated Laves hydrides, where magnetic disorder sets in the topologically frustrated Mn lattice. Below the transition towards short range magnetic order, static spin clusters coexist with fluctuating and alsmost uncorrelated spins. The magnetic response shows a complexe lineshape, connected with the presence of the magnetic inhomogeneities. Its analysis shows the existence of two different processes, relaxation and local excitations, for the spin fluctuations below the transition. The paramagnetic fluctuations are discussed in comparison with classical spin glasses, cluster glasses, and non Fermi liquid itinerant magnets

Unique Spin Dynamics and Unconventional Superconductivity in the Layered Heavy Fermion Compound CeIrIn_5:NQR Evidence

We report measurements of the ^{115}In nuclear spin-lattice relaxation rate (1/T_1) between T=0.09 K and 100 K in the new heavy fermion (HF) compound CeIrIn_5. At 0.4 K < T < 100 K, 1/T_1 is strongly T-dependent, which indicates that CeIrIn_5 is much more itinerant than known Ce-based HFs. We find that 1/T_1T, subtracting that for LaIrIn_5, follows a 1/(T+\theta)^{3/4} variation with \theta=8 K. We argue that this novel feature points to anisotropic, due to a layered crystal structure, spin fluctuations near a magnetic ordering. The bulk superconductivity sets in at 0.40 K below which the coherence peak is absent and 1/T_1 follows a T^3 variation, which suggests unconventional superconductivity with line-node gap.Comment: minor changes, appeared in PRL (4 pages, 4 figures

Magnetoelectric MnPS3 thiophosphate as a new candidate for ferrotoroidicity

We have revisited the magnetic structure of manganese phosphorus trisulfide MnPS3 using neutron diffrac- tion and polarimetry. MnPS3 undergoes a transition toward a collinear antiferromagnetic order at 78 K. The resulting magnetic point-group breaks both the time reversal and the space inversion thus allowing a linear magnetoelectric coupling. Neutron polarimetry was subsequently used to prove that this coupling provides a way to manipulate the antiferromagnetic domains simply by cooling the sample under crossed magnetic and electrical fields, in agreement with the nondiagonal form of the magnetoelectric tensor. In addition, this tensor has, in principle, an antisymmetric part that results in a toroidic moment and provides with a pure ferrotoroidic compound

Magnetic susceptibility of diluted pyrochlore and SCGO antiferromagnets

We investigate the magnetic susceptibility of the classical Heisenberg antiferromagnet with nearest-neighbour interactions on the geometrically frustrated pyrochlore lattice, for a pure system and in the presence of dilution with nonmagnetic ions. Using the fact that the correlation length in this system for small dilution is always short, we obtain an approximate but accurate expression for the magnetic susceptibility at all temperatures. We extend this theory to the compound SrCr_{9-9x}Ga_{3+9x}O_{19} (SCGO) and provide an explanation of the phenomenological model recently proposed by Schiffer and Daruka [Phys. Rev. B56, 13712 (1997)].Comment: 4 pages, Latex, 4 postscript figures automatically include

Synthesis, Characterization and Magnetic Susceptibility of the Heavy Fermion Transition Metal Oxide LiV_{2}O_{4}

The preparative method, characterization and magnetic susceptibility \chi measurements versus temperature T of the heavy fermion transition metal oxide LiV_{2}O_{4} are reported in detail. The intrinsic \chi(T) shows a nearly T-independent behavior below ~ 30 K with a shallow broad maximum at about 16 K, whereas Curie-Weiss-like behavior is observed above 50-100 K. Field-cooled and zero-field-cooled magnetization M measurements in applied magnetic fields H = 10 to 100 G from 1.8 to 50 K showed no evidence for spin-glass ordering. Crystalline electric field theory for an assumed cubic V point group symmetry is found insufficient to describe the observed temperature variation of the effective magnetic moment. The Kondo and Coqblin-Schrieffer models do not describe the magnitude and T dependence of \chi with realistic parameters. In the high T range, fits of \chi(T) by the predictions of high temperature series expansion calculations provide estimates of the V-V antiferromagnetic exchange coupling constant J/k_{B} ~ 20 K, g-factor g ~ 2 and the T-independent susceptibility. Other possible models to describe the \chi(T) are discussed. The paramagnetic impurities in the samples were characterized using isothermal M(H) measurements with 0 < H <= 5.5 Tesla at 2 to 6 K. These impurities are inferred to have spin S_{imp} ~ 3/2 to 4, g_{imp} ~ 2 and molar concentrations of 0.01 to 0.8 %, depending on the sample.Comment: 19 typeset RevTeX pages, 16 eps figures included, uses epsf; to be published in Phys. Rev.

Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area

This study advances the clinical development of the RTS,S/AS01B candidate malaria vaccine to malaria endemic populations. As a primary objective it compares the safety and reactogenicity of RTS,S/AS01B to the more extensively evaluated RTS,S/AS02A vaccine.A Phase IIb, single centre, double-blind, controlled trial of 6 months duration with a subsequent 6 month single-blind follow-up conducted in Kisumu West District, Kenya between August 2005 and August 2006. 255 healthy adults aged 18 to 35 years were randomized (1ratio1ratio1) to receive 3 doses of RTS,S/AS02A, RTS,S/AS01B or rabies vaccine (Rabipur; Chiron Behring GmbH) at months 0, 1, 2. The primary objective was the occurrence of severe (grade 3) solicited or unsolicited general (i.e. systemic) adverse events (AEs) during 7 days follow up after each vaccination.Both candidate vaccines had a good safety profile and were well tolerated. One grade 3 systemic AE occurred within 7 days of vaccination (RTS,S/AS01B group). No unsolicited AEs or SAEs were related to vaccine. A marked increase in anti-CS antibody GMTs was observed post Dose 2 of both RTS,S/AS01B (31.6 EU/mL [95% CI: 23.9 to 41.6]) and RTS,S/AS02A (16.7 EU/mL [95% CI: 12.9 to 21.7]). A further increase was observed post Dose 3 in both the RTS,S/AS01B (41.4 EU/mL [95% CI: 31.7 to 54.2]) and RTS,S/AS02A (21.4 EU/mL [95% CI: 16.0 to 28.7]) groups. Anti-CS antibody GMTs were significantly greater with RTS,S/AS01B compared to RTS,S/AS02A at all time points post Dose 2 and Dose 3. Both candidate vaccines produced strong anti-HBs responses. Vaccine efficacy in the RTS,S/AS01B group was 29.5% (95% CI: -15.4 to 56.9, p = 0.164) and in the RTS,S/AS02A group 31.7% (95% CI: -11.6 to 58.2, p = 0.128).Both candidate malaria vaccines were well tolerated over a 12 month surveillance period. A more favorable immunogenicity profile was observed with RTS,S/AS01B than with RTS,S/AS02A.Clinicaltrials.gov NCT00197054