655 research outputs found
Effect of HER2 Expression on NUPL2 Protein in Cervical Cancer Cells
Recurring cervical cancer patients frequently present overexpressed Human Epidermal Growth Factor Receptor 2 (HER2) protein, which promotes the growth of the cancer. Some HER2-expressing cells and cervical cancer patients have enhanced gene expression of Nucleoporin-like 2 (NUPL2). As part of the nuclear pore complex, the NUPL2 protein serves to selectively export substances from the nucleus to the cytoplasm. In this experiment, HER2 was expressed in cervical cancer cells to examine its effect on NUPL2 protein expression and localization. Interestingly, there was no difference in NUPL2 protein levels between HER2-expressing and non-expressing cells. Importantly, consistent instances of NUPL2 protein localization specific to the nucleus occurred in a large sampling of HER2-expressing cells. This is significant because it suggests a mechanism as to how HER2 promotes excessive cell growth, via changes in NUPL2 localization, potentially impacting its function and ability to selectively export substances that modulate cell growth
Spectral functions in itinerant electron systems with geometrical frustration
The Hubbard model with geometrical frustration is investigated in a metallic
phase close to half-filling. We calculate the single particle spectral function
for the triangular lattice within dynamical cluster approximation, which is
further combined with non-crossing approximation and fluctuation exchange
approximation to treat the resulting cluster Anderson model. It is shown that
frustration due to non-local correlations suppresses short-range
antiferromagnetic fluctuations and thereby assists the formation of heavy
quasi-particles near half-filling.Comment: 4 pages, 5 eps figure
Magnetic fluctuations in frustrated Laves hydrides R(Mn_{1-x}Al_{x})_{2}H_{y}
By neutron scattering, we have studied the spin correlations and spin
fluctuations in frustrated Laves hydrides, where magnetic disorder sets in the
topologically frustrated Mn lattice. Below the transition towards short range
magnetic order, static spin clusters coexist with fluctuating and alsmost
uncorrelated spins. The magnetic response shows a complexe lineshape, connected
with the presence of the magnetic inhomogeneities. Its analysis shows the
existence of two different processes, relaxation and local excitations, for the
spin fluctuations below the transition. The paramagnetic fluctuations are
discussed in comparison with classical spin glasses, cluster glasses, and non
Fermi liquid itinerant magnets
Unique Spin Dynamics and Unconventional Superconductivity in the Layered Heavy Fermion Compound CeIrIn_5:NQR Evidence
We report measurements of the ^{115}In nuclear spin-lattice relaxation rate
(1/T_1) between T=0.09 K and 100 K in the new heavy fermion (HF) compound
CeIrIn_5. At 0.4 K < T < 100 K, 1/T_1 is strongly T-dependent, which indicates
that CeIrIn_5 is much more itinerant than known Ce-based HFs. We find that
1/T_1T, subtracting that for LaIrIn_5, follows a 1/(T+\theta)^{3/4} variation
with \theta=8 K. We argue that this novel feature points to anisotropic, due to
a layered crystal structure, spin fluctuations near a magnetic ordering. The
bulk superconductivity sets in at 0.40 K below which the coherence peak is
absent and 1/T_1 follows a T^3 variation, which suggests unconventional
superconductivity with line-node gap.Comment: minor changes, appeared in PRL (4 pages, 4 figures
Final report on ARPA fission yield project work at Battelle-Northwest, April 1970--April 1973
Magnetoelectric MnPS3 thiophosphate as a new candidate for ferrotoroidicity
We have revisited the magnetic structure of manganese phosphorus trisulfide
MnPS3 using neutron diffrac- tion and polarimetry. MnPS3 undergoes a transition
toward a collinear antiferromagnetic order at 78 K. The resulting magnetic
point-group breaks both the time reversal and the space inversion thus allowing
a linear magnetoelectric coupling. Neutron polarimetry was subsequently used to
prove that this coupling provides a way to manipulate the antiferromagnetic
domains simply by cooling the sample under crossed magnetic and electrical
fields, in agreement with the nondiagonal form of the magnetoelectric tensor.
In addition, this tensor has, in principle, an antisymmetric part that results
in a toroidic moment and provides with a pure ferrotoroidic compound
Magnetic susceptibility of diluted pyrochlore and SCGO antiferromagnets
We investigate the magnetic susceptibility of the classical Heisenberg
antiferromagnet with nearest-neighbour interactions on the geometrically
frustrated pyrochlore lattice, for a pure system and in the presence of
dilution with nonmagnetic ions. Using the fact that the correlation length in
this system for small dilution is always short, we obtain an approximate but
accurate expression for the magnetic susceptibility at all temperatures. We
extend this theory to the compound SrCr_{9-9x}Ga_{3+9x}O_{19} (SCGO) and
provide an explanation of the phenomenological model recently proposed by
Schiffer and Daruka [Phys. Rev. B56, 13712 (1997)].Comment: 4 pages, Latex, 4 postscript figures automatically include
Synthesis, Characterization and Magnetic Susceptibility of the Heavy Fermion Transition Metal Oxide LiV_{2}O_{4}
The preparative method, characterization and magnetic susceptibility \chi
measurements versus temperature T of the heavy fermion transition metal oxide
LiV_{2}O_{4} are reported in detail. The intrinsic \chi(T) shows a nearly
T-independent behavior below ~ 30 K with a shallow broad maximum at about 16 K,
whereas Curie-Weiss-like behavior is observed above 50-100 K. Field-cooled and
zero-field-cooled magnetization M measurements in applied magnetic fields H =
10 to 100 G from 1.8 to 50 K showed no evidence for spin-glass ordering.
Crystalline electric field theory for an assumed cubic V point group symmetry
is found insufficient to describe the observed temperature variation of the
effective magnetic moment. The Kondo and Coqblin-Schrieffer models do not
describe the magnitude and T dependence of \chi with realistic parameters. In
the high T range, fits of \chi(T) by the predictions of high temperature series
expansion calculations provide estimates of the V-V antiferromagnetic exchange
coupling constant J/k_{B} ~ 20 K, g-factor g ~ 2 and the T-independent
susceptibility. Other possible models to describe the \chi(T) are discussed.
The paramagnetic impurities in the samples were characterized using isothermal
M(H) measurements with 0 < H <= 5.5 Tesla at 2 to 6 K. These impurities are
inferred to have spin S_{imp} ~ 3/2 to 4, g_{imp} ~ 2 and molar concentrations
of 0.01 to 0.8 %, depending on the sample.Comment: 19 typeset RevTeX pages, 16 eps figures included, uses epsf; to be
published in Phys. Rev.
Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area
This study advances the clinical development of the RTS,S/AS01B candidate malaria vaccine to malaria endemic populations. As a primary objective it compares the safety and reactogenicity of RTS,S/AS01B to the more extensively evaluated RTS,S/AS02A vaccine.A Phase IIb, single centre, double-blind, controlled trial of 6 months duration with a subsequent 6 month single-blind follow-up conducted in Kisumu West District, Kenya between August 2005 and August 2006. 255 healthy adults aged 18 to 35 years were randomized (1ratio1ratio1) to receive 3 doses of RTS,S/AS02A, RTS,S/AS01B or rabies vaccine (Rabipur; Chiron Behring GmbH) at months 0, 1, 2. The primary objective was the occurrence of severe (grade 3) solicited or unsolicited general (i.e. systemic) adverse events (AEs) during 7 days follow up after each vaccination.Both candidate vaccines had a good safety profile and were well tolerated. One grade 3 systemic AE occurred within 7 days of vaccination (RTS,S/AS01B group). No unsolicited AEs or SAEs were related to vaccine. A marked increase in anti-CS antibody GMTs was observed post Dose 2 of both RTS,S/AS01B (31.6 EU/mL [95% CI: 23.9 to 41.6]) and RTS,S/AS02A (16.7 EU/mL [95% CI: 12.9 to 21.7]). A further increase was observed post Dose 3 in both the RTS,S/AS01B (41.4 EU/mL [95% CI: 31.7 to 54.2]) and RTS,S/AS02A (21.4 EU/mL [95% CI: 16.0 to 28.7]) groups. Anti-CS antibody GMTs were significantly greater with RTS,S/AS01B compared to RTS,S/AS02A at all time points post Dose 2 and Dose 3. Both candidate vaccines produced strong anti-HBs responses. Vaccine efficacy in the RTS,S/AS01B group was 29.5% (95% CI: -15.4 to 56.9, p = 0.164) and in the RTS,S/AS02A group 31.7% (95% CI: -11.6 to 58.2, p = 0.128).Both candidate malaria vaccines were well tolerated over a 12 month surveillance period. A more favorable immunogenicity profile was observed with RTS,S/AS01B than with RTS,S/AS02A.Clinicaltrials.gov NCT00197054
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