Exploring the Longitudinal Relationship Between Short Sleep Duration, Temperament and Attention Deficit Hyperactivity Disorder Symptoms in a Biethnic Population of Children Aged Between 6 and 61 Months:A Born in Bradford Study

Objective: Examine the association between sleep duration, temperament and symptoms of Attention Deficit Hyperactivity Disorder (ADHD) in a biethnic child-population from The Born in Bradford cohort. Method: Parent-report sleep duration categorized children as: early short, late short, consistently short or consistently normal sleepers between 6 and 36 months. Temperament was measured using the Infant Characteristics Questionnaire at 6 months. The Strengths and Difficulties Questionnaire assessed symptoms of ADHD at 37, 54, and 61 months. Results: Normal sleepers before 18 months had significantly fewer ADHD symptoms at 37 months compared with consistently short sleepers. Fussiness at 6 months was significantly positively associated with ADHD symptoms at 37 and 54 months; but does not appear to mediate the relationship between sleep duration and ADHD symptoms. Conclusion: Awareness of the relationship between short sleep duration and fussiness in infancy and later ADHD symptomatology may support earlier identification of arising difficulties in children

School Mental Health Early Interventions and Academic Outcomes for At-risk High School Students: A Review of the Research

The current educational policy context in the United States necessitates that school-based programs prioritize students’ academic outcomes. This review examined the quantitative research on school mental health (SMH) early interventions and academic outcomes for at risk high school students. Seven articles met the inclusion criteria for this review. All articles were examined according to study design and demographics, early intervention characteristics, and outcomes. Of the studies included, most were conducted in urban settings, involved the implementation of group-based early intervention strategies, and monitored GPA as a distal academic outcome. Counselors were frequent implementers of these early interventions. A meta-analysis found no statistically significant effect on the academic outcomes most commonly assessed in the studies (i.e., GPA, attendance, and discipline). Findings suggest the need for more rigorous research in this area. Implications for SMH early intervention research and practice are discussed

Transitions in general practice training : quantifying epidemiological variation in trainees' experiences and clinical behaviours

Background: General Practice training in Australia is delivered through the apprenticeship model. General Practice supervisors support trainees transitioning from hospital-based work towards competent independent community-based practice. The timing and manner in which support should be provided is still not well understood. This study aimed to establish the variation in clinical and educational experiences and behaviours, and location, of general practice trainees’ consultations by stage of their vocational training. It was hypothesised that change is greater in earlier stages of training. Methods: A cross-sectional analysis of data (2010–2018) from the Registrar Clinical Encounters in Training (ReCEnT) study, an ongoing cohort study of Australian GP registrars’ in-consultation clinical and educational experience and behaviours. Multinomial logistic regression assessed the association of demographic, educational, and clinical factors in different stages of training. The outcome factor was the training term. Results: Two thousand four hundred sixteen registrars contributed data for 321,414 patient consultations. For several important variables (seeing patients with chronic disease; new patients; seeking in-consultation information or assistance; ordering pathology and imaging; and working in a small or regional practice), odds ratios were considerably greater for comparisons of Term 1 and 3, relative to comparisons of Term 2 and 3. Conclusion: Differences experienced in demographic, clinical and educational factors are significantly more pronounced earlier in registrars’ training. This funding has educational and training implications with respect to resource allocation, trainee supervision and curriculum design. Sociocultural learning theory enables an understanding of the impact of transitions on, and how to support, general practice trainees and supervisors

The dwarf galaxy population as revealed by ALFALFA

The combination of sensitivity and large sky coverage of the ALFALFA HI survey has enabled the detection of difficult to observe low mass galaxies in large numbers, including dwarf galaxies overlooked in optical surveys. Three different, but connected, studies of dwarf galaxies from the ALFALFA survey are of particular interest: SHIELD (Survey of HI in Extremely Low-mass Dwarfs), candidate gas-rich ultra- faint dwarf galaxies, and the (Almost) Dark population. SHIELD is a systematic multiwavelength study of all dwarf galaxies from ALFALFA with MHI < 107.2 M☉ and clear optical counterparts. Candidate gas-rich ultra-faint dwarf galaxies extend the dwarf galaxy population to even lower masses. These galaxies are identified as isolated HI clouds with no discernible optical counterpart but subsequent observations reveal that some are extremely faint, gas- dominated galaxies. Leo P, discovered first as an HI detection, and then found to be an actively star-forming galaxy, bridges the gap between these candidate galaxies and the SHIELD sample. The (Almost) Dark sample consists of galaxies whose optical counterparts are overlooked in current optical surveys but which are clear detections in ALFALFA. This sample includes field gas-rich ultra-diffuse galaxies. Coma P, with a peak surface brightness of only ~26.4 mag arcsec-2 in g', demonstrates the sort of extreme low surface brightness galaxy that can be discovered in an HI survey

The Environmental Impact of Lowering Dietary Crude Protein in Finishing Pig Diets—The Effect on Ammonia, Odour and Slurry Production

Publication history: Accepted - 20 September 2022; Published - 23 September 2022.Excess nitrogen excretion, ammonia and odour are environmental pollutants associated with pig production. Reducing dietary crude protein (CP) will lower the amount of nitrogen excreted, reducing the potential for ammonia emissions, if diets are adequately formulated to supply amino acids and production performance is maintained. Crude protein content in diets for finishing pigs has been lowered recently, but the quantitative effect of this reduction on ammonia, odour, and slurry output is not well-established. The relationship between ammonia and odour is equivocal, and the effect on slurry production is unclear. The objective of this study was to investigate the effect of lowering dietary CP on ammonia emission, odour emission and slurry output of finishing pigs. Thirty entire boar pigs were individually housed in groups of six, from 10 weeks of age (30 3.0 kg) and offered standard diets. At 75 kg ( 1.5 kg) pigs were assigned to one of three treatment diets; (1) 180 g/kg CP, 11.0 g/kg total lysine (High CP), (2) 150 g/kg CP, 11.1 g/kg total lysine (Medium CP), and (3) 130 g/kg CP, 9.0 g/kg total lysine (Low CP). After three weeks on the experimental diets pigs were moved, six each week, to individual calorimetry chambers to measure ammonia and odour emissions. Pigs were offered treatment diets ad libitum. At the end of the recording period, the pigs were removed from the chamber, weighed and feed disappearance recorded to calculate intake. The slurry in each chamber was collected and analysed. The reduction in CP in the diet from 180 g/kg to 150 g/kg resulted in a 22% reduction in ammonia emissions, and from 180 g/kg to 130 g/kg resulted in a 47% reduction (p < 0.001). Slurry output from pigs offered the 130 g/kg CP diet was reduced by 39% (p < 0.001) and dry matter increased by 35% compared to slurry from pigs offered the 180 g/kg CP diet (p < 0.05). Water usage (p = 0.017), slurry output and nitrogen and phosphate in the slurry (p < 0.05, respectively) were found to decrease linearly with decreasing dietary CP content. There was no significant effect of reducing CP on performance or odour emission but hydrogen sulphide emissions decreased linearly (p < 0.010) with decreasing dietary CP. There was a weak positive relationship between odour emission and ammonia (linear: R2 = 0.25, p = 0.005) with odour emission reduced as ammonia emission reduced. Reducing dietary CP in finishing pig diets could reduce ammonia emissions, water usage and slurry and nutrient output from pig production.This work was funded by the Department of Agriculture, Environment and Rural Affairs under Evidence and Innovation Project 15/01/01 with industry contribution from the partners of the Pig Research Consortium

Biofortification of Chicken Eggs with Vitamin K—Nutritional and Quality Improvements

peer reviewedNational nutrition surveys have shown that over half of all adults in Ireland, the United Kingdom (UK), and the United States of America (USA) have low vitamin K intakes. Thus, dietary strategies to improve vitamin K intakes are needed, and vitamin K biofortification of food may be one food-based approach. The primary aim of our study was to establish whether increasing the vitamin K3 content of hen feed can increase the vitamin K content of eggs, and the secondary aims were to examine the effects on hen performance parameters, as well as egg and eggshell quality parameters. A 12 week hen feeding trial was conducted in which Hyline chickens were randomized into four treatment groups (n = 32/group) and fed diets containing vitamin K3 (as menadione nicotinamide bisulfite) at 3 (control), 12.9, 23.7, and 45.7 mg/kg feed. Vitamin K1, menaquinone (MK)-4, MK-7, and MK-9 were measured in raw whole eggs via a liquid chromatography tandem mass spectrometry method. MK-4 was the most abundant form of vitamin K (91–98%) found in all eggs. Increasing the vitamin K3 content of hen feed over the control level significantly (p < 0.001) enhanced the MK-4 content of eggs (mean range: 46–51 µg/100 g, representing ~42–56% of US Adequate Intake values). Vitamin K biofortification also led to significant (p < 0.05) increases in the yellowness of egg yolk and in eggshell weight and thickness, but no other changes in egg quality or hen performance parameters. In conclusion, high-quality vitamin K-biofortified eggs can be produced with at least double the total vitamin K content compared to that in commercially available eggs

The Enigmatic (Almost) Dark Galaxy Coma P: Distance Measurement and Stellar Populations from HST Imaging

We present Hubble Space Telescope (HST) observations of the low surface brightness (SB) galaxy Coma P. This system was first discovered in the Arecibo Legacy Fast ALFA HI survey and was cataloged as an (almost) dark galaxy because it did not exhibit any obvious optical counterpart in the available survey data (e.g., Sloan Digital Sky Survey). Subsequent WIYN pODI imaging revealed an ultra-low SB stellar component located at the center of the HI detection. We use the HST images to produce a deep color-magnitude diagram (CMD) of the resolved stellar population present in Coma P. We clearly detect a red stellar sequence that we interpret to be a red giant branch, and use it to infer a tip of the red giant branch (TRGB) distance of 5.50$^{+0.28}_{-0.53}$ Mpc. The new distance is substantially lower than earlier estimates and shows that Coma P is an extreme dwarf galaxy. Our derived stellar mass is only 4.3 $\times$ 10$^5$ $M_\odot$, meaning that Coma P has an extreme HI-to-stellar mass ratio of 81. We present a detailed analysis of the galaxy environment within which Coma P resides. We hypothesize that Coma P formed within a local void and has spent most of its lifetime in a low-density environment. Over time, the gravitational attraction of the galaxies located in the void wall has moved it to the edge, where it had a recent "fly-by" interaction with M64. We investigate the possibility that Coma P is at a farther distance and conclude that the available data are best fit by a distance of 5.5 Mpc.Comment: 22 pages, 11 figures. Accepted for publication in the Astronomical Journa

A genetic locus complements resistance to Bordetella pertussis-induced histamine sensitization.

Histamine plays pivotal role in normal physiology and dysregulated production of histamine or signaling through histamine receptors (HRH) can promote pathology. Previously, we showed that Bordetella pertussis or pertussis toxin can induce histamine sensitization in laboratory inbred mice and is genetically controlled by Hrh1/HRH1. HRH1 allotypes differ at three amino acid residues with