Efficacy and safety of mascara dyeing as an adjunct to Alexandrite and Nd:YAG laser applications for removing thin and white-colored facial and axillary hair

WOS: 000391344600010PubMed ID: 27762642Introduction: There is no satisfactory and efficient method for long-term removal of white-colored and thin hair. Methods: We conducted a randomised clinical trial of hirsute patients with excessive white and/or thin hair on the face and/or axilla. In Group I (n: 16), the facial hair on one side of the face was painted with a black eyelash mascara immediately before Nd:YAG laser and the other half was only treated by Nd:YAG. In Group II (n: 20), the axillary hair on one side was painted with the mascara before the Alexandrite laser with the other side being only treated by Alexandrite. Results: The terminal hair counts on the painted facial and axillary sides were significantly lower than those on the control sides throughout the study except for the first month. The decrease in the terminal hair count was significant from the beginning of treatment to the second and sixth months on the painted and control facial sides and to the first and sixth months on the axillary sides. Conclusion: Hair coloring with black eyelash mascara is a simple, efficient and safe adjunct to Alexandrite and Nd:YAG laser applications to enhance their clinical efficacy in eliminating white and thin facial or axillary hair

Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea

Diarrhea in calves can be caused by bacteria, viruses, and parasites. Among bacteria, Escherichia coli is considered responsible for the appearance of enteric diarrhea and septicemia in these animals, conditions that require immediate attention. Among E. coli infections of calves, more focus is placed on intestinal pathogenic (InPEC) infections, and extra – intestinal pathogenic (ExPEC) infections are ignored. This study aims to reveal which E. coli pathotype causes the infection as molecular and serotype and to reveal the differences according to the age groups of the factors in the herd. Blood and fecal samples of 10 calves aged 3 – 15 d with diarrhea were analyzed. The primary agent causing enteritis was determined by examining the stool samples with BoviD – 5 Ag. Then, samples were subjected to culture and identification processes. It was determined that the stool samples had 2/10 with E. coli K99, 4/10 with rotavirus, and 4/10 with mixed rotavirus infections and Cryptosporidium spp. E. coli was detected from all blood samples by hemoculture. The study isolated only the SepEC and ETEC groups from samples. All SepEC isolates were determined to carry type 1 pilus responsible for adhesion. In addition, it was determined that 9/10 of the SepEC group carried the colicin V gene responsible for pathogenicity. Also, all E. coli isolated from calves aged 3 – 15 d were found to be resistant to antibiotics. In conclusion, primary enteritis is caused by rotavirus Cryptosporidium spp. and ETEC. However, it was determined that SepEC group E. coli causing septicemia showed different antigenic and genetic features than E. coli in the intestinal tract. The virulence factors of the SepEC group may vary due to genomic plasticity, and their antigenic structures should be more closely examined and added to vaccine test studies

The efficacy and safety of omalizumab in refractory chronspontaneous urticaria: Real-life experience in Turkey

Introduction: This study used real-world data to evaluate the effectiveness and reliability of omalizumab in treating recalcitrant chronic spontaneous urticaria in Turkish patients. Methods: Study data were collected retrospectively from eight tertiary-care hospitals in Turkey. This study included 132 patients with chronic spontaneous urticaria that were resistant to H1 antihistamine treatment in a dose up to four times the licensed dose and were treated with 300 mg/month of omalizumab for 6 months. Results: The mean weekly urticarial activity score (UAS7) after omalizumab treatment improved significantly compared to the pretreatment score (p <0.001). Treatment response was detected primarily in the 1st and 2nd months after treatment. No significant association was observed between omalizumab’s treatment effectiveness and disease-related parameters or laboratory data. The mean dermatology life quality index was 23.12 ± 6.15 before treatment and decreased to 3.55 ± 3.60 6 months after treatment (p <0.001). No side effects were reported in 89.4% (118) of the patients. Conclusion: This study showed that UAS7 decreased significantly and quality of life improved in omalizumab-treated patients. Moreover, treatment effectiveness was mainly observed in the first 2 months after treatment. However, no association was observed between omalizumab treatment effectiveness and disease-related parameters or laboratory data

Serum levels of mmp- 2, mmp-9, NSE, s-100 in psoriasis patients

Psoriasis patogenezinde nöral etkinin önemi, ilk olarak distal sinirlerde meydana gelen travma sonrasında ilgili alanda psoriasis plaklarında tamamen gerileme meydana gelmesiyle ilişkili vakalar ile anlaşılmaya başlanmıştır. Psoriasis ile periferik sinir lifleri arasındaki ilişkiyi inceleyen çalışmalar son derece sınırlıdır. Çeşitli nörolojik hastalıkların patogenezinde, mmp-2, mmp-9, NSE, s100 markerları rol oynamaktadır. Çalışmamızdaki amaç psoriasis hastalarında periferik sinir liflerini değerlendirmek ve bu markerların psoriasis ile olan ilişkilerini saptamaktı.Materyal ve Metod: Pası skoru 10 ve üzeri olan 25 hasta, pası skoru 10'un altında olan 24 hasta ve 25 sağlıklı kontrol çalışmaya alındı. Her bir hastanın yaş, cinsiyet, aile öyküsü , PASI, tırnak tutulumu ve eklem tutulumu kaydedildi. Çalışmaya alınan tüm olgulara emg testi uygulandı. Markırlar ELİSA yöntemiyle çalışıldı.Bulgular: 3 grup arasında marker düzeyleri açısından fark tesbit edilmedi ancak psoriasisli hastalar ve kontrol grubu arasında yapılan karşılaştırmada; serum mmp-9 düzeyleri psoriasis grubunda yüksek çıkarken, serum NSE ve mmp-2 düzeyleri kontrol grubunda yüksek çıktı. 2 grup arasında s100B düzeyleri açısından fark tesbit edilmedi. Tüm olgularda emg sonuçları normal laboratuar sınırlarındaydı.Sonuç: Çalışmamızdan elde edilen veriler, psöriazisde kalın miyelinli lif tutulumundan çok ince lif nöropatisinin ortaya çıkabileceğini düşündürmektedir. Bu yönde yapılacak araştırmalar, psöriazisde ince lif nöropatisine ışık tutaacaktır.Evidence for the role of neural influence in the maintenance of psoriasis comes first from case reports in which injury to cutaneous nerves resulted in complete remission of psoriasis at the distal site. There are only a few reports which analyse the relationship between psoriasis and nerves fibrils. Mmp-2, mmp-9, NSE and s100 play role in some neurological disease. Our aim in this study was to examine the periferal nerves in psoriasis patients and to examine the relationship between psoriasis and these markers.Material and methods: 25 psoriasis patients whose pasi scores are above 10, 24 psoriasis patients whose pasi scores of less than 10 and 25 healthy volunteers those compatible with age and gender and were enrolled in this study. Age, gender, family history, pasi scores, nail involvement and joint involvement of each patient were recorded. Emg test was used for each subject. Markers were studied with ELISA.Results: There was no significant difference among three groups. However sera mmp-9 levels in psoriasis patients were higher than mmp-9 levels in healthy controls, sera mmp-2 and NSE levels were increased in healthy controls compared with psoriasis patients. There was no significant difference in s100B levels between psoriasis patients and healthy controls. All values of the examined. Neurophysiological parameters were within normal limits; comparisons of the corresponding mean values in psoriasis patients and the control group showed no statistically significant differences.Conclusions: According to data from our study, small nevre fibers might play more important role than large nevre fibers in psoriasis. The researches about this issue will shed light on small fiber neuropathy in psoriasis

Hidradenitissüpürativa tedavisinde adalimumabın etkinliği

Objectives: Hidradenitis suppurativa is seen as a result of the occlusion, constriction and bacterial infection of the apocrine glands in bilateral axillas, submammarian areas, neck, inguinal regions, flexural surfaces of the thighs and anogenital areas. Among the biological agents adalimumab is a recombinant human IgG1 monoclonal antibody; TNF-? antagonist approved to be used in the treatment of hidradenitissuppurativa. Methods: In this study, 12 patients resistant to conventional treatments with moderate severity, Hurley stage 2 or 3 were started subcutaneous adalimumab treatment. The disease activities upon the hidradenitis suppurativa, clinical severity index and life quality index of the patients were examined both before and 1 year after the treatment. Results: Twelve patients were recruited. In the examination of the hidradenitis suppurativa clinical severity scores, significant clinical responses were noted in 9 (75%) patients. While the mean value of the life quality index was 14.4&plusmn;6.9 before the treatment, it was determined to be significantly decreased to 4.3&plusmn;3.8 after the treatment. Conclusion: We concluded that adalimumab; the unique biological agent approved to be used in the treatment of treatment-resistant, moderate-severe hidradenitis suppurativa is efficient and safe in similar ratios with the previous clinical studies in the literature.Amaç: Hidradenitis suppurativa; her iki koltuk altı, göğüs altları, boyun, kasıklar, bacakların birbirine sürten yüzünde ve anogenital bölgelerde apokrin bez kanalında tıkanma, daralma ve bakteriyel enfeksiyon sonucu görülmektedir. Biyolojik ajanlar arasında adalimumab; hidradenitis süpürativa tedavisinde kullanımı onaylanmış TNF-? antagonisti rekombinant insan IgG1 monoklonal antikorudur. Yöntemler: Bu çalışmada klasik tedavilere dirençli, orta-şiddetli tutulumlu, Hurley stage 2 veya 3, klasik tedavilere direnç/yetersizlik olan 12 hastaya adalimumab tedavisi uygulandı. Hastaların tedavi öncesi ve 1 yıllık tedavi sonrası hidradenitis süpürativa klinik şiddet indeksine göre hastalık aktiviteleri ve yaşam kalite indeksleri incelendi. Bulgular: Oniki hasta çalışmaya alındı. 7 hastada Hurley 3, geriye kalan 5 hastada Hurley 2 seviyesinde tutulum mevcuttu. Hidradenitis süpürativa klinik şiddet skorlaması incelendiğinde 9 hastada (%75) anlamlı klinik yanıt tespit edildi. Tedavi öncesi yaşam kalite indeksi ortalamasının 14.4±6.9 iken, tedavi sonrası anlamlı oranda gerileyerek 4.3±3.8'a düştüğü saptandı. Sonuç: Tedaviye dirençli orta-şiddetli hidradenitis süpürativa tedavisinde kullanımı onay almış tek biyolojik ajan olan adalimumabın literatürdeki önceki klinik çalışmalarla benzer oranda etkin ve güvenilir olduğu sonucuna vardık

El tırnak psöriasisinin tedavisinde intralezyonel triamsinolon asetonit ve metotreksat enjeksiyonlarının etkinlik ve güvenilirliğinin karşılaştırılması

Objectives: Studies have demonstrated that the clinical efficacy and remission duration of intralesional corticosteroids in nail psoriasis are highly variable. Moreover, good clinical results have been reported after methotrexate injection in a case study with nail psoriasis. This study aimed to investigate the efficacy and safety of intralesional injection of triamcinolone acetonide and methotrexate in patients with fingernail psoriasis. Materials and Methods: Thirty-two patients diagnosed with fingernail psoriasis with at least three affected nails were included. Diluted triamcinolone acetonide, methotrexate and serum physiologic solution were randomly injected into three different fingernails having similar nail area psoriasis severity index (NAPSI) scores for four sessions. We compared the signs of nail matrix and nail bed involvement. The severity of fingernail psoriasis was investigated using NAPSI and modified NAPSI. Results: The responses evaluated by the NAPSI scores were similar in nails treated with methotrexate and triamcinolone acetonide. The improvement of the signs of nail matrix involvement was significantly higher in nails treated with methotrexate, but the improvement of the signs of nail bed involvement was similar in all groups. The improvement of onycholysis was significant only in nails treated with triamcinolone. On the other hand, the improvement of pitting and leukonychia were significant only in nails treated with methotrexate. Conclusion: Methotrexate injection might be a better treatment choice for fingernail psoriasis with the signs of nail matrix involvement and triamcinolone acetonide injection for the fingernail psoriasis with the signs of nail bed involvement.Amaç: Çalışmalar tırnak psöriasisinde intralezyonel kortikosteroidlerin klinik etkinliği ve remisyon süresinin oldukça değişken olduğunu göstermektedir. Ayrıca, tırnak psöriasisli bir olgu raporunda metotreksat enjeksiyonundan sonra iyi klinik sonuçlar bildirilmiştir. Bu çalışma el tırnak psöriasisli hastalarda intralezyonel triamsinolon asetonit ve metotreksat enjeksiyonunun etkinlik ve güvenilirliğini araştırmayı amaçlamaktadır. Gereç ve Yöntem: En az üç tırnak tutulumu olan el tırnaklarında psöriasis tanısı olan otuz iki hasta çalışmaya dahil edildi. Benzer tırnak alan psoriasis şiddet indeks (NAPSI) skorları olan üç farklı el tırnağına sulandırılmış triamsinolon asetonit, metotreksat ve serum fizyolojik dört seans süresince rastgele enjekte edildi. Tırnak matriks ve tırnak yatak tutulum bulgularını karşılaştırdık. El tırnaklarının psoriasis şiddeti NAPSI ve modifiye NAPSI kullanılarak araştırıldı. Bulgular: Metotreksat ve triamsinolon asetonit ile tedavi alan tırnaklarda NAPSI skorları ile değerlendirilen yanıtlar benzer idi. Tırnak matriks tutulumu bulgularının iyileşmesi metotreksat ile tedavi edilen tırnaklarda anlamlı oranda daha fazla idi, ancak tırnak yatak tutulumu bulgularının iyileşmesi tüm gruplarda benzer idi. Onikolizin iyileşmesi yanlızca triamsinolon ile tedavi gören tırnaklarda anlamlı idi. Diğer yandan, pitting ve lökonişinin iyileşmeleri yanlızca metotreksat tedavisi alan tırnaklarda anlamlı idi. Sonuç: Metotreksat enjeksiyonu tırnak matriks tutulumu bulguları olan el tırnak psöriasisinde ve triamsinolon asetonit enjeksiyonu ise tırnak yatak tutulumu bulguları olan el tırnak psöriasisinde daha iyi bir tedavi seçeneği olabilir

Eritemotelenjiektatik ve papülopüstüler rozasea tedavisinde q-anahtarlı potassium titanyl phosphate lazer ve uzun atımlı neodymiumdoped yttrium aluminum garnet lazerin etkinliği ve güvenilirliğinin karşılaştırması

WOS: 000437821200004Objective: The best laser for patients with erythematotelangiectatic rosacea is still a controversial topic. The efficacy and safety of Q-switched potassium titanyl phosphate (KTP) and long-pulsed neodymium-doped yttrium aluminum garnet (lpNd:YAG) lasers were compared in the treatment of erythematotelangiectatic and papulopustular rosacea. Methods: Thirty patients aged 16-70 years who had multiple telangiectasias on both sides of the face and a diagnosis of stage 1-2 rosacea were included in a split-face, double-blinded, randomized clinical trial. Lasers were applied to two different sides of the face for four sessions at one-month intervals. The number of papules and pustules were investigated before treatment and at each visit. The erythematotelangiectatic rosacea severity scores, thickness of telangiectasias, clinician's assessment of treatment response, patient satisfaction, and adverse effects were examined. Results: In the third and fourth months, the number of papules on the side treated with lpNd: YAG laser was significantly lower than the other side. In the fourth month, the mild or severe erythematotelangiectatic rosacea score rate was significantly lower on the side treated with lpNd: YAG laser. The clinician's assessment was similar for both treatments. Conclusion: We recommend lpNd: YAG laser for erythema and Q-switched KTP laser for thin and superficial telangiectasias for the highest treatment efficacy.Amaç: Eritemotelenjiektatik rozasealı hastalar için en iyi lazer halen tartışmalı bir konudur. Q-anahtarlı potassium titanyl phosphate (KTP) ve uzun atımlı neodymium-doped yttrium aluminum garnet (lpNd:YAG) lazerlerin eritemotelenjiektatik ve papülopüstüler rozasea tedavisinde etkinliği ve güvenilirliği karşılaştırıldı. Yöntemler: Yüzünün her iki yanında çok sayıda telenjiektazileri olan ve evre 1-2 rozasea tanısı bulunan 16-70 yaşları arasında 30 hasta yarım-yüz, çift-kör, randomize klinik çalışmaya alındı. Lazerler yüzün iki farklı yanına bir aylık aralıklarla 4 seans uygulandı. Tedavi öncesinde ve her takipte papül ve püstül sayısı araştırıldı. Eritemotelenjiektatik rozasea şiddet skoru, telenjiektazi kalınlığı, klinisyenin tedavi yanıtını değerlendirmesi, hasta memnuniyeti ve yan etkiler incelendi. Bulgular: Üçüncü ve dördüncü aylarda, lpNd:YAG lazer ile tedavi edilen taraftaki papüllerin sayısı diğer tarafa oranla anlamlı oranda daha düşük idi. Dördüncü ayda hafif veya şiddetli eritemotelenjiektatik rozasea skor oranı lpNd:YAG lazer ile tedavi edilen tarafta anlamlı oranda daha düşük idi. Klinisyenin değerlendirmeleri her iki tedavi için benzer idi. Sonuç: En yüksek tedavi etkinliği için eritemde lpNd:YAG lazeri, ince ve yüzeyel telenjiektazilerde Q-anahtarlı KTP lazeri önermekteyiz

Bilateral half-head comparison of 1% anthralin ointment in children with alopecia areata

WOS: 000398113000016PubMed ID: 28044367Background/Objectives: Alopecia areata (AA) is one of the most difficult skin diseases to manage well. In children, anthralin is commonly used for the treatment of AA. Available research consists of a limited number of uncontrolled trials that assessed the effectiveness of anthralin in promoting hair growth in patients with AA. The objective of this study was to validate the clinical effectiveness of short-contact anthralin 1% ointment in children with AA. Methods: Thirty children with chronic, severe, treatment-refractory, extensive AA were treated with 1% anthralin ointment. One side of the scalp was treated with anthralin for 12 months and the other side was left untreated. Outcomes were evaluated according to the Severity of Alopecia Tool (SALT) score. Results: The mean time to first response in terms of new hair growth was 3 months and the mean time to maximal response was 9 months. In the first 12-month period, 10 patients (33.4%) achieved complete response to treatment and 11 patients (36.6%) had a partial response. Of the 11 patients with partial response at the end of the first year, 6 achieved a complete response before the end of the study. Total SALT scores for the entire scalp decreased from the end of the first year to the end of the 2-year period. No serious adverse events were observed. Conclusion: Anthralin 1% is an effective therapy for AA and should be continued at least 9 months. At 9 months of topical anthralin therapy, the patients with at least a 50% reduction in their pretreatment SALT scores should continue the same treatment for at least 1 year. Anthralin is safe in children with chronic, severe, treatment-refractory, extensive AA

Folliculotropic mycosis fungoides associated with alopecia in a case

Mycosis fungoides (MF) is the most common type of cutaneous lymphoma and characterized by proliferation of small to medium T lymphocytes with cerebriform nuclei in most cases. However, the diagnosis of MF may be very difficult in certain cases, particularly in those variants of MF such assyringotropic MF, granulomatous MF and folliculotropic MF. The classic histopathologic feature is the presence of atypical T-cells with a tropism to hair follicle epithelium. The clinical presentation of folliculotropic MF often differs from the patches and plaques of classic MF and may be associated with decreased clinical suspicion for folliculotropic MF. The average time interval from onset of lesions till diagnosis of folliculotropic MF was 2 years. Folliculotropic MF displays resistance to standard treatment modalities, has an unfavourable course and diversity in the histological spectrum. Here we reported a rare case who presented to our dermatology polyclinic with a complaint of hair loss on his back firstly. On the follow-up, the case was diagnosed as folliculotropic MF and treated with interferon-i2a and PUVA successfully.Mikozis fungoides (MF); birçok olguda, küçük ve orta boyuttaki serebriform çekirdekçikleres sahip T lenfositlerinin çoğalmasıyla karakterize en sık olarak görülen kutanöz lenfoma tipidir. Bu-n unla birlikte; özellikle asiringotropik, granülomatöz ve follikülotropik MF gibi olgularda tanı koy-m ak güç olabilmektedir. Folikülotropik MF’de klasik histopatolojik görünüm; atipik T hücrelerininf olliküler epitele tropizmi ile karakterizedir. Folikülotropik MF’in klinik görünümü özellikle kla-s ik MF’de görülen yama ve plaklardan farklılık arz etmektedir ve bu durum da klinik olarak foli-k ülotropik MF öntanısını güçleştirmektedir. Hastalığın başladığı dönemle tanı arasındaki süreo rtalama 2 yıldır. Folikülotropik MF, standart tedavi seçeneklerine dirençlidir, istenmeyen klinikg idişata sahiptir ve histopatolojik olarak farklılıklar arz etmektedir. Biz burada; sırtta kıl dökülena lanlar şikayeti ile polikliniğimize başvuran, takiplerinde Folikülotropik MF gelişen ve PUVA ve in-t erferon- α2a ile başarıyla tedavi edilen oldukça nadir görülen bir olguyu sunduk

Successful treatment of classic kaposi sarcoma with long-pulse neodymium-doped yttrium aluminum garnet laser: A preliminary study

WOS: 000398047200007PubMed ID: 28157730BACKGROUND Kaposi sarcoma (KS) is a systemic disease that can present with cutaneous lesions with or without internal involvement, mostly caused by infection with human herpesvirus-8. The treatment options include surgical excision, cryotherapy, radiotherapy, intralesional chemotherapy, laser, and elastic stockings for the prevention of lymphedema. OBJECTIVE This article presents 7 cases with classic KS treated with the long-pulse neodymium: yttriumaluminum- garnet (Nd:YAG) laser. METHODS Forty-nine lesions of 7 KS patients (5 stage 1, 2 stage 2A) were treated with Nd: YAG laser with a spot size of 4 to 6 mm and a fluence of 180 J/cm(2) increased by 10 J/cm(2) in the neighboring area to a maximum of 260 J/cm(2). The pulse sequencing was 1.5, and delay time was 5 milliseconds. Sessions were continued at 4-week intervals for 2 to 4 sessions. RESULTS All patients exhibited clinical and histological improvement. One session was sufficient for small lesions, whereas coalescing and multicentric lesions required up to 4 sessions. All the lesions healed in 2 to 4 weeks, with the only complication being mild atrophic scars. CONCLUSION With the advantage of penetrating into deeper sites than other lasers, long-pulse Nd:YAG is an efficient and safe local treatment alternative especially for papulonodular and deeper lesions located on bony structures