107 research outputs found
Modeling Flocks and Prices: Jumping Particles with an Attractive Interaction
We introduce and investigate a new model of a finite number of particles
jumping forward on the real line. The jump lengths are independent of
everything, but the jump rate of each particle depends on the relative position
of the particle compared to the center of mass of the system. The rates are
higher for those left behind, and lower for those ahead of the center of mass,
providing an attractive interaction keeping the particles together. We prove
that in the fluid limit, as the number of particles goes to infinity, the
evolution of the system is described by a mean field equation that exhibits
traveling wave solutions. A connection to extreme value statistics is also
provided.Comment: 35 pages, 9 figures. A shortened version appears as arXiv:1108.243
Erdos-Renyi random graphs + forest fires = self-organized criticality
We modify the usual Erdos-Renyi random graph evolution by letting connected
clusters 'burn down' (i.e. fall apart to disconnected single sites) due to a
Poisson flow of lightnings. In a range of the intensity of rate of lightnings
the system sticks to a permanent critical state.Comment: Version 3, dated 18 May 2009, final version, revised after referees'
report
Collective awareness platforms and digital social innovation mediating consensus seeking in problem situations
In this paper we show the results of our studies carried out in the framework of the European Project SciCafe2.0 in the area of Participatory Engagement models. We present a methodological approach built on participative engagements models and holistic framework for problem situation clarification and solution impacts assessment. Several online platforms for social engagement have been analysed to extract the main patterns of participative engagement. We present our own experiments through the SciCafe2.0 Platform and our insights from requirements elicitation
Proteome-wide landscape of solubility limits in a bacterial cell
Proteins are prone to aggregate when expressed above their solubility limits. Aggregation may occur rapidly, potentially as early as proteins emerge from the ribosome, or slowly, following synthesis. However, in vivo data on aggregation rates are scarce. Here, we classified the Escherichia coli proteome into rapidly and slowly aggregating proteins using an in vivo image-based screen coupled with machine learning. We find that the majority (70%) of cytosolic proteins that become insoluble upon overexpression have relatively low rates of aggregation and are unlikely to aggregate co-translationally. Remarkably, such proteins exhibit higher folding rates compared to rapidly aggregating proteins, potentially implying that they aggregate after reaching their folded states. Furthermore, we find that a substantial fraction (similar to 35%) of the proteome remain soluble at concentrations much higher than those found naturally, indicating a large margin of safety to tolerate gene expression changes. We show that high disorder content and low surface stickiness are major determinants of high solubility and are favored in abundant bacterial proteins. Overall, our study provides a global view of aggregation rates and hence solubility limits of proteins in a bacterial cell.Peer reviewe
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