Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases

Purpose: Objective of the study was to find out if there is any relation of number, size and type of gall stones and patient’s lipid profile with the occurrence of gall bladder carcinoma (GBC) as presence of gall stones is considered to be the most important risk factor for gall bladder cancer.Methods: 200 specimens of post-cholecystectomy gallbladder were studied. The number, size and type of stones and lipid profile were compared in all these cases. Gross as well as histopathological examination of gall bladders specimens was done.Results: 185 (92.5%) gall bladders were associated with gall stones. On histopathological examination, malignancy was found in 6 cases (3%) only and rest 194 cases (97%) revealed inflammatory/ non-neoplastic pathology. A statistically significant difference was observed in the number of stones in gall bladders with malignancy than those with benign lesions (P < 0.001). Similarly, a statistically significant difference was seen in terms of stone size between gallbladder cancer (GBC) cases and those with benign pathology (P < 0.005). Benign lesions of gall bladders were mostly associated with mixed type of stones whereas malignant cases were associated with pure cholesterol type of stones. No significant relation was found between the patient’s lipid profile and occurrence of gallbladder carcinoma (GBC) (p > 0.005). Conclusion: Thus we concluded that as the number, size and cholesterol gall stone increase the risk of gall bladder cancer also increases without any relation with lipid profile................................................Cite this article as:Narang S, Goyal P, Bal MS, Bandlish U, Goyal S. Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases. Int J Cancer Ther Oncol 2014; 2(3):020310. DOI: 10.14319/ijcto.0203.1

A Comparative Analysis of Personality Traits of Jumpers: A Key to Towards Success

Abstract Thus the aim of this study was to determine the comparative analysis of personality traits of jumpers. To obtain data, the investigators had selected Sixty (N=60), Male Inter-College and Inter-University Level Sprinters between the age group of 18-25 years (Mean ± SD: age 20.683±2.02 years, height 5.7449±26.3 m, body mass 76.400±14.3 kg) were selected. The subjects were purposively assigned into thre

Detection of abnormal cervical cytology in Papanicolaou smears

Background: Cervical cytology by Papanicolaou (Pap) smears is an effective means of screening for cervical premalignant and malignant conditions. Cervical intra-epithelial neoplasia (CIN) and cervical cancer remain important health problems for women worldwide. Aim: To study the role of Pap smear in detecting premalignant and malignant lesions of cervix; and to determine the prevalence of various lesions. Materials and Methods: This study is based on 300 patients who attended the out-patient Department of Obstetrics and Gynaecology. Pap smears were prepared from patients presenting with complaints like vaginal discharge, post-coital bleeding, inter-menstrual bleeding, dyspareunia, and pain lower abdomen. After fixation and staining, each smear was carefully examined. Results: Epithelial cell abnormalities were found in 5% smears, atypical squamous cells of undetermined significance (ASCUS) in 0.3%, squamous intraepithelial lesion (SIL) in 3.4% which includes low grade squamous intraepithelial lesion (LSIL) (2.7%) and high grade squamous intraepithelial lesion (HSIL) 0.7%. Invasive carcinoma was seen in 1.3% cases. Mean age of the patients with diagnosis of LSIL was 32.3 years and for HSIL, it was 40.5 years. The mean age of the patients with invasive carcinoma was 57 years. Conclusion: Premalignant and malignant lesions of cervix are not uncommon in our set up and can be diagnosed early by Pap smears

Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases

Purpose: Objective of the study was to find out if there is any relation of number, size and type of gall stones and patient’s lipid profile with the occurrence of gall bladder carcinoma (GBC) as presence of gall stones is considered to be the most important risk factor for gall bladder cancer.Methods: 200 specimens of post-cholecystectomy gallbladder were studied. The number, size and type of stones and lipid profile were compared in all these cases. Gross as well as histopathological examination of gall bladders specimens was done.Results: 185 (92.5%) gall bladders were associated with gall stones. On histopathological examination, malignancy was found in 6 cases (3%) only and rest 194 cases (97%) revealed inflammatory/ non-neoplastic pathology. A statistically significant difference was observed in the number of stones in gall bladders with malignancy than those with benign lesions (P &lt; 0.001). Similarly, a statistically significant difference was seen in terms of stone size between gallbladder cancer (GBC) cases and those with benign pathology (P &lt; 0.005). Benign lesions of gall bladders were mostly associated with mixed type of stones whereas malignant cases were associated with pure cholesterol type of stones. No significant relation was found between the patient’s lipid profile and occurrence of gallbladder carcinoma (GBC) (p &gt; 0.005). Conclusion: Thus we concluded that as the number, size and cholesterol gall stone increase the risk of gall bladder cancer also increases without any relation with lipid profile................................................Cite this article as:Narang S, Goyal P, Bal MS, Bandlish U, Goyal S. Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases. Int J Cancer Ther Oncol 2014; 2(3):020310. DOI: 10.14319/ijcto.0203.10 </p

Estimation of ESR, CRP, TLC and DLC in 200 Suspected Cases of Acute Appendicitis

ABSTRACT The most common cause of acute abdomen even today is acute appendicitis. An inflammatory disorder, several laboratory factors contributing to its inflammatory responses are used for diagnosis. To estimate the value of ESR, CRP, TLC and DLC in 200 suspected patients of acute appendicitis in both sex of different age groups. The present study were performed on 200 patients who have been clinically diagnosed as a case of acute appendicitis and were taken up for emergency appendectomy.Apart from the routine investigations all the 200 cases were subjected specifically to the following four investigations i.e. ESR, CRP, TLC and DLC. All cases were subjected for histopathological examinations, which is considered as gold standard for the final diagnosis. Age wise maximum number of patients were in third decade (35%), followed by second decade. Male predominance (60%) was seen in study. Negative appendectomy was done in 20% cases. In present study association of ESR, CRP, TLC and DLC and acute appendicitis was shown to be significant with value. Acute appendicitis remains a diagnosis based primarily on history and clinical examination. Clinical examination is indispensable in diagnosing acute appendicitis and all the above investigations complement clinical skills and cannot replace it