Patients that are having Covid-19 Disease After the First Dose of Covid-Vaccine

There is no effective treatment for the Covid-19 disease that is still impacting the whole world. It considered that vaccines, one of the effective means to prevent infectious diseases, will play a significant role in protecting from the Covid-19 Disease. Vaccinations generals performed before exposure. We aimed to follow the clinical and laboratory progress of patients who got Covid-19 after the first dose of the Covid-19 vaccine and to evaluate the changes that may occur in antibody formation. 13 patients, who received the first dose of COVID 19 vaccine Coronovac as of 14.01.2021 when vaccination started in Adıyaman University Training and Research Hospital/Turkey, who had symptoms after the vaccine and whose real-time PCR found to be positive, were included in the study. After the first dose of the Covid-19 vaccine, 13 patients exam. Three of our patients were female, and 10 of them were male. The average age was 38.8. British variant detected in 4 of our patients; 1 of them was female. Contact times differed between 3 and 5 days. The most common symptoms were muscle-joint pain (53.8), weakness-fatigue (46.2), fever (38.5), and headache (30.8). Three of our patients, being one female, received inpatient treatment. Furthermore, our five patients who checked regarding Sars cov-2 IgG became positive in the first month. No adverse changes in the course of the illness observed in the patients were RT-PCR positive after the first dose of the Covid-19 vaccine. Antibody response detected at the end of the first month.  Vaccination is an effective method for taking infectious diseases under control but adhering to personal protective measures still maintains their importance

Case Report 36-Year-Old Female with Catastrophic Antiphospholipid Syndrome Treated with Eculizumab: A Case Report and Review of Literature

Catastrophic antiphospholipid syndrome (CAPS) is a rare but potentially life-threatening condition characterized by diffuse vascular thrombosis, leading to multiple organ failure developing over a short period of time in the presence of positive antiphospholipid antibodies (aPL). CAPS is a severe form of antiphospholipid syndrome, developing in about 1% of cases of classic antiphospholipid syndrome, manifesting as microangiopathy, affecting small vessels of multiple organs. It is acute in onset, with majority of cases developing thrombocytopenia and less frequently hemolytic anemia and disseminated intravascular coagulation. Lupus anticoagulant and anticardiolipin antibodies have been reported as predominant antibodies associated with CAPS. Treatment options often utilized in CAPS include anticoagulation, steroids, plasma exchange, cyclophosphamide therapy, and intravenous immunoglobulin therapy. Even though the reported incidence of this condition is considered to be low, the mortality rate is approaching 50%. The high rate of mortality should warrant greater awareness among clinicians for timely diagnosis and treatment of this life-threatening condition. Studies have shown that complement activation plays a key role in the pathogenesis of aPL mediated thrombosis in CAPS. We report a case of a 36-year-old female admitted with clinical and laboratory findings consistent with CAPS successfully treated with eculizumab, a terminal complement inhibitor. Case Presentation We would like to present a case of a 36-year-old female who was admitted to our hospital after being found in the bathtub with decreased responsiveness and profound weakness. The patient had no medical problems and had been in her usual state of health until one month before admission when she developed frequent headaches and blurry vision. Per family the patient had become more withdrawn recently and was not allowing anyone to visit her home. On examination in the Emergency Department, the patient was found to be hypertensive, to have blood pressure of 207/148 mmHg, to have heart rate of 110 beats per minute, and appeared confused and dehydrated, with multiple bruises over her body. Laboratory examination revealed white blood cell (WBC) count of 20.5/nL, hemoglobin of 12.3 g/dL, and platelets of 44,000/ L. Patient's renal function was altered, presenting anion gap metabolic acidosis (suspected starvation ketosis) and respiratory alkalosis. Creatinine on admission was noted to be 7.0 mg/dL. Prothrombin time (PT) was 11.6 sec (reference range: 9.5-12.2 sec), activated partial thromboplastin time (aPTT) was 21.5 sec (reference range: 20.1-31.2 sec), and fibrinogen was 345 mg/dL. Mixing study was not performed at the time, since coagulation panel did not show prolongation of PTT. Troponins were elevated with no ST segment changes on electrocardiography compatible with non-ST segment myocardial infarction (NSTEMI). Ophthalmology was consulted and stated that visual loss and color blindness was likely secondary to intraretinal hemorrhage. A computed tomography (CT) of the brain was performed, whic

The Effects of Age On Static and Dynamic Postural Balance After Total Knee Arthroplasty

Purpose: With age, the dysfunctions in somatosensory system cause increases in postural sway. It is not known how static and dynamic balance parameters and postural sway are affected after Total Knee Arthroplasty (TKA) in elderly people. The aim of this study is to investigate the effects of age on static and dynamic postural balance after TKA

The effect of obesity on human reproductive health and foetal life

WOS:000652994000001 PubMed ID: 34020572Obesity in both women and men is regarded as one of the many factors that may contribute to impaired reproductive health. Obesity can be accompanied by several neuroendocrine and ovarian dysfunctions, including chronic oligo/anovulation, menstrual irregularities, subfertility, and the increased risk of pregnancy in women. Insulin resistance, elevated triglyceride and fatty acid levels, and the secretion of adipocytokines caused by the excessive accumulation of adipose tissue associated with obesity adversely affect reproductive functions. Alterations in sperm quality and motility and hormone levels related to a rise in body mass index (BMI) may predispose men to infertility. The mechanisms of action of obesity on male infertility include endocrinopathy, erectile dysfunction, epididymitis, increased leptin and adipocytes, increased aromatase, inflammatory cytokines secreted by fat tissue, and sperm DNA fragmentation. This study reports that an increased BMI may lead to low semen quality, poor sperm motility, and reduced fertilization rates in men as well as anovulation, pregnancy loss, diminished pregnancy, and low live birth rates in women. Having optimal weight with balanced nutrition enables one to maintain a continuity of reproductive health throughout the entire life cycle, which is extremely important in terms of having a healthy embryo, including pre-foetal life, in the continuity of pregnancy and having a live birth

Effects of two different continuous passive motion protocols on the functional activities of total knee arthroplasty inpatients

Objective: The aim of this study was to compare the effects of two different continuous passive motion (CPM) application protocols (low- and high-angle) on the early phase functional activities of total knee arthroplasty inpatients

Comparison of early postoperative functional activity levels of patients undergoing unilateral and bilateral total knee arthroplasty

Objectives: We compared early postoperative functional activities of patients undergoing unilateral and bilateral total knee arthroplasty (TKA)

Does a weight-training exercise programme given to patients four or more years after total knee arthroplasty improve mobility: A randomized controlled trial

Aim: To investigate the effects of the home exercise therapy performed after at least four years postoperatively on skeletal muscle strength and functionality in patients with total knee arthroplasty (TKA)