George Henry Thomas: As True as Steel.

A Fresh Analysis of the Rock of Chickamauga When the state of his birth seceded, Virginian Robert E. Lee elected to fight for the South; when his home state seceded, Virginian Georgia Henry Thomas chose to go with the North. In defeat Lee became arguably the most famous of Civil War gen...

Demon of the Lost Cause: Sherman and Civil War History

Understanding the Origins of a Controversial Sherman This is not just a book about the Lost Cause; this is a book about the continuing legacy of the Lost Cause. This is a story of how myth becomes history and that history then becomes accepted by the general public and is eventually some...

Randomization-based models for multitiered experiments: I. A chain of randomizations

We derive randomization-based models for experiments with a chain of randomizations. Estimation theory for these models leads to formulae for the estimators of treatment effects, their standard errors, and expected mean squares in the analysis of variance. We discuss the practicalities in fitting these models and outline the difficulties that can occur, many of which do not arise in two-tiered experiments.Publisher PDFPeer reviewe

Using the Big Ideas in Cosmology to Teach College Students

Recent advances in our understanding of the Universe have revolutionized our view of its structure, composition and evolution. However, these new ideas have not necessarily been used to improve the teaching of introductory astronomy students. In this project, we have conducted research into student understanding of cosmological ideas so as to develop effective web-based tools to teach basic concepts important to modern cosmology. The tools are intended for use at the introductory college level. Our research uses several instruments, including open-ended and multiple choice surveys conducted at multiple institutions, as well as interviews and course artifacts at one institution, to ascertain what students know regarding modern cosmological ideas, what common misunderstandings and misconceptions they entertain, and what sorts of materials can most effectively overcome student difficulties in learning this material. These data are being used to create a suite of interactive, web-based tutorials that address the major ideas in cosmology using real data. Having students engage with real data is a powerful means to help students overcome certain misconceptions. Students master the scientific concepts and reasoning processes that lead to our current understanding of the universe through interactive tasks, prediction and reflection, experimentation, and model building.Comment: 2012 Fermi Symposium proceedings - eConf C12102

The effect of heterogeneity on invasion in spatial epidemics: from theory to experimental evidence in a model system

Heterogeneity in host populations is an important factor affecting the ability of a pathogen to invade, yet the quantitative investigation of its effects on epidemic spread is still an open problem. In this paper, we test recent theoretical results, which extend the established “percolation paradigm” to the spread of a pathogen in discrete heterogeneous host populations. In particular, we test the hypothesis that the probability of epidemic invasion decreases when host heterogeneity is increased. We use replicated experimental microcosms, in which the ubiquitous pathogenic fungus Rhizoctonia solani grows through a population of discrete nutrient sites on a lattice, with nutrient sites representing hosts. The degree of host heterogeneity within different populations is adjusted by changing the proportion and the nutrient concentration of nutrient sites. The experimental data are analysed via Bayesian inference methods, estimating pathogen transmission parameters for each individual population. We find a significant, negative correlation between heterogeneity and the probability of pathogen invasion, thereby validating the theory. The value of the correlation is also in remarkably good agreement with the theoretical predictions. We briefly discuss how our results can be exploited in the design and implementation of disease control strategies

Attitudes towards the use and acceptance of eHealth technologies : a case study of older adults living with chronic pain and implications for rural healthcare

Acknowledgements The research described here is supported by the award made by the RCUK Digital Economy programme to the dot.rural Digital Economy Hub; award reference: EP/G066051/1. MC’s time writing the paper is funded by the Scottish Government’s Rural and Environmental Science and Analytical Services Division (RESAS) under Theme 8 ‘Vibrant Rural Communities’ of the Food, Land and People Programme (2011–2016). MC is also an Honorary Research Fellow at the Division of Applied Health Sciences, University of Aberdeen. The input of other members of the TOPS research team, Alastair Mort, Fiona Williams, Sophie Corbett, Phil Wilson and Paul MacNamee who contributed to be wider study and discussed preliminary findings reported here with the authors of the paper is acknowledged. We acknowledge the feedback on earlier versions of this paper provided by members of the Trans-Atlantic Rural Research Network, especially Stefanie Doebler and Carmen Hubbard. We also thank Deb Roberts for her comments.Peer reviewedPublisher PD

Ethanol reversal of tolerance to the respiratory depressant effects of morphine

Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different effects of the drugs. Many opioid addicts regularly consume alcohol (ethanol), and post-mortem analyses of opioid overdose deaths have revealed an inverse correlation between blood morphine and ethanol levels. In the present study, we determined whether ethanol reduced tolerance to the respiratory depressant effects of opioids. Mice were treated with opioids (morphine, methadone, or buprenorphine) for up to 6 days. Respiration was measured in freely moving animals breathing 5% CO(2) in air in plethysmograph chambers. Antinociception (analgesia) was measured as the latency to remove the tail from a thermal stimulus. Opioid tolerance was assessed by measuring the response to a challenge dose of morphine (10 mg/kg i.p.). Tolerance developed to the respiratory depressant effect of morphine but at a slower rate than tolerance to its antinociceptive effect. A low dose of ethanol (0.3 mg/kg) alone did not depress respiration but in prolonged morphine-treated animals respiratory depression was observed when ethanol was co-administered with the morphine challenge. Ethanol did not alter the brain levels of morphine. In contrast, in methadone- or buprenorphine-treated animals no respiratory depression was observed when ethanol was co-administered along with the morphine challenge. As heroin is converted to morphine in man, selective reversal of morphine tolerance by ethanol may be a contributory factor in heroin overdose deaths