Results of a Randomized, Open-Label, Clinical Trial Investigating the Effects of Supplementation with Heracleum persicum

The present study evaluated the potential benefit of supplementation with Heracleum persicum as an adjunctive therapy to atorvastatin in dyslipidemic subjects. In a randomized, open-label, clinical trial, 100 dyslipidemic subjects were randomly assigned to: (1) H. persicum group (n = 50, completers = 18), receiving H. persicum extract (500 mg/day) + atorvastatin (10 mg/day) for 8 weeks, or (2) atorvastatin group (n =50, completers= 34), receiving only atorvastatin (20 mg/day) for 8 weeks. Weight, body mass index (BMI), lipid profile, and biomarkers of hepatic and renal injury were determined at baseline and at the end of the trial. There were significant reductions in serum total cholesterol and LDL-C in both the H. persicum (p = 0.001) and atorvastatin (p 0.05). Serum triglyceride levels remained statistically unchanged by the end of the trial in both groups (p > 0.05). Serum alanine (p = 0.049) and aspartate aminotransferase (p = 0.013) levels rose in the atorvastatin, but not the H. persicum (p > 0.05) group. In comparison with baseline values, no significant change was observed in weight and BMI, as well as serum levels of creatinine, blood urea nitrogen, and fasting blood sugar in either of the groups (p > 0.05). Apart from HDL-C, the effects of atorvastatin (20 mg/day) on other lipid profile parameters do not appear to be significantly superior to those achieved by combination therapy with H. persicum + atorvastatin (10 mg/day)

Taksim A Square of Encounters, Urban Design Proposal submitted to Taksim Urban Design Competition organized by Istanbul Planning Agency

Our goal is to design Taksim as a multifunctional public space of everyday encounters. A public space of encounters, capable of overcoming the current social and ecological deficits by empowering the embedded urban identity and the socio-cultural histories of the Square. In other words, cultural identity, the quality of the green spaces, the accessibility, and inclusiveness – that is a youth- as well as elderly-friendly Square, welcoming permanent residents and visitors, are as important as economic development of those using Taksim to conduct their business such as flowers or simit sellers. Engaging people to create the kinds of places that reflect their artistic expressions, identity, vision, needs, and desires is a central tenet of our design