Role of molecular tools and serology tests in the diagnosis of the novel coronavirus: SARS-CoV-2

Since the emergenceof severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), it has become increasingly clear that bats are important reservoirs of coronaviruses. This investigation, with the apparition of the new coronavirus SARS-CoV-2 in Wuhan (China, December 2019), has shown 96.2% sequence similarity with the bat coronavirus. Through this review, we report the characterization of a SARS-CoV-2. The virus belongs to the Betacoronavirusgenera and shares less than 80% of identity with the SARS-CoV. This similarity was helpful to develop RT-PCR and other tools involved in SARS-CoV-2 RNA detection. We also report the importance of the different molecular tools and, the possible use of serology tests in the diagnosis of COVID-19. We discussed the strengths and weaknesses of each of these methods

Management of Viral Hepatitis C: Therapeutic and Economic Study in Morocco

Viral hepatitis C is not only a major public health problem by its significant morbidity and mortality worldwide, but also a medical and economical burden. Over the last 5 years, numerous research laboratories have enabled the development of several direct acting anti-HCV molecules whose effectiveness is well established. Great progress has been made in particular in the field of therapy although the cost of these treatments is today the focus of discussions, dissemination of new antiviral treatments to direct action should be a priority for public powers to heal and reduce the complications of this disease, thus the line ministry has given permission to market a generic of sofosbuvir drugs at an affordable price, acceptable and 80 times cheaper than the princeps. The first part of this paper elucidates the news of new drugs available to treat HCV, in the second part economical study aspects of the different therapeutical strategies currently available in Morocco. Thus we will study impacts of economical consequences of the therapy used against chronic hepatitis C. Keywords: Sofosbuvir; hepatitis C; direct-acting antiviral; guideline and management of viral hepatitis C; therapeutic and economic study in morocco; sustained virological respons