HyperCLOVA X Technical Report

We introduce HyperCLOVA X, a family of large language models (LLMs) tailored to the Korean language and culture, along with competitive capabilities in English, math, and coding. HyperCLOVA X was trained on a balanced mix of Korean, English, and code data, followed by instruction-tuning with high-quality human-annotated datasets while abiding by strict safety guidelines reflecting our commitment to responsible AI. The model is evaluated across various benchmarks, including comprehensive reasoning, knowledge, commonsense, factuality, coding, math, chatting, instruction-following, and harmlessness, in both Korean and English. HyperCLOVA X exhibits strong reasoning capabilities in Korean backed by a deep understanding of the language and cultural nuances. Further analysis of the inherent bilingual nature and its extension to multilingualism highlights the model's cross-lingual proficiency and strong generalization ability to untargeted languages, including machine translation between several language pairs and cross-lingual inference tasks. We believe that HyperCLOVA X can provide helpful guidance for regions or countries in developing their sovereign LLMs.Comment: 44 pages; updated authors list and fixed author name

Ameliorating Fibrotic Phenotypes of Keloid Dermal Fibroblasts through an Epidermal Growth Factor-Mediated Extracellular Matrix Remodeling

Keloid and hypertrophic scars are skin fibrosis-associated disorders that exhibit an uncontrollable proliferation of fibroblasts and their subsequent contribution to the excessive accumulation of extracellular matrix (ECM) in the dermis. In this study, to elucidate the underlying mechanisms, we investigated the pivotal roles of epidermal growth factor (EGF) in modulating fibrotic phenotypes of keloid and hypertrophic dermal fibroblasts. Our initial findings revealed the molecular signatures of keloid dermal fibroblasts and showed the highest degree of skin fibrosis markers, ECM remodeling, anabolic collagen-cross-linking enzymes, such as lysyl oxidase (LOX) and four LOX-like family enzymes, migration ability, and cell–matrix traction force, at cell–matrix interfaces. Furthermore, we observed significant EGF-mediated downregulation of anabolic collagen-cross-linking enzymes, resulting in amelioration of fibrotic phenotypes and a decrease in cell motility measured according to the cell–matrix traction force. These findings offer insight into the important roles of EGF-mediated cell–matrix interactions at the cell–matrix interface, as well as ECM remodeling. Furthermore, the results suggest their contribution to the reduction of fibrotic phenotypes in keloid dermal fibroblasts, which could lead to the development of therapeutic modalities to prevent or reduce scar tissue formation.</jats:p

Simulation study for the energy and position reconstruction performances of the beam monitoring system of Carbon Ion Radiation Therapy using GEANT4.

Carbon Ion Radiation Therapy is operated in several countries because of its advantage to have high dose concentration and/or high linear energy transfer (LET). To estimate the beam performance of Carbon Ion Radiation Therapy, we target the 1% energy and 1 mm2 position resolutions of the beam monitoring system. The beam monitoring system consists of a scintillation crystal and fiber hodoscope. The scintillation crystal is 20 × 20 × 120mm3 and its candidates are LYSO, CsI and BGO. The fiber hodoscope is composed of 1 mm thickness scintillation fibers and the fibers are arranged vertically for 2D reconstruction. With GEANT4 simulation, we verify the performance of our beam monitoring system. The energy response of the LYSO and BGO scintillators is linear within ± 2%. The energy resolution of each crystal candidate achieves the goal; LYSO (0.061%), CsI (0.20%) and BGO (0.10%). The position is reconstructed via fiber hodoscope within 5% uncertainty

Graphene-based nanocomposites and their fabrication, mechanical properties and applications

Graphene, the thinnest two-dimensional atomic material, has immerged as a revolutionary material and sparked a flurry of research and innovation owing to its outstanding mechanical, electrical, optical and thermal properties as well as high specific surface area. Graphenebased materials and their composites possess promising applications in a wide range of fields such as sensors, actuators, electronics, biomedical aids and membranes. In this review paper, a critical and comprehensive review has been carried out on the synthesis process and mechanical properties of graphene and graphene-based nanocomposites. Firstly, the concept and structure of graphene materials are discussed then different synthesis techniques and their advantages and limitations have been reviewed. The addition of graphene and its derivatives in producing different polymer and metal-based nanocomposite as well as fabricating hybrid nanocomposite has been thoroughly reviewed. Almost all the papers show that the presence of graphene even at very low loadings can provide significant improvement to the final material. Besides, other parameters that affect the nanocomposite are thoroughly reviewed. Furthermore, the perspective application of graphene materials and its nanocomposite in different promising fields has been discussed

Femtoscopic study of the proton-proton and proton-deuteron systems in heavy-ion collisions at the LHC

This work reports femtoscopy correlations of p$-$p (p$-$p) and p$-$d (p$-$d) pairs measured in Pb$-$Pb collisions at center-of-mass energy $\sqrt{s_{\rm NN}} = 5.02$ TeV by the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source as a function of the pair transverse mass ($m_{\rm T}$) and of the average charge particle multiplicity $\langle {\rm d}N_{\rm ch}/{\rm d}\eta \rangle^{1/3}$ for three centrality intervals (0$-$10%, 10$-$30%, 30$-$50%). In both cases, the expected power-law and liner scalings are observed, respectively. The measured p$-$d correlations can be described by both two- and three-body calculations, indicating that the femtoscopy observable is not sensitive to the short-distance features of the dynamics of the p$-$(p$-$n) system, due to the large inter-particle distances in Pb$-$Pb collisions at the LHC. Indeed, in this study, the minimum measured femtoscopic source sizes for protons and deuterons start at $2.73^{+0.05}_{−0.05}$ and $3.10^{+1.04}_{−0.86}$ fm, respectively, for the 30$-$50% centrality of the collisions. Moreover, the $m_{\rm T}$-scaling obtained for the p$-$p and p$-$d systems is compatible within $1\sigma$ of the uncertainties. These findings provide new input for fundamental studies on the production of light (anti)nuclei under extreme conditions.This work reports femtoscopic correlations of p$-$p ($\bar{\rm p}-\bar{\rm p}$) and p$-$d ($\bar{\rm p}-\bar{\rm d}$) pairs measured in Pb$-$Pb collisions at center-of-mass energy $\sqrt{s_{\rm NN}}$ = 5.02 TeV by the ALICE Collaboration. A fit to the measured proton-proton correlation functions allows one to extract the dependence of the nucleon femtoscopic radius of the particle-emitting source on the pair transverse mass ($m_\text{T}$) and on the average charge particle multiplicity $\langle\text{dN}_\text{ch}/\text{d}\eta\rangle^{1/3}$ for three centrality intervals (0$-$10$\%$, 10$-$30$\%$, 30$-$50$\%$). In both cases, the expected power-law and linear scalings are observed, respectively. The measured p$-$d correlations can be described by both two- and three-body calculations, indicating that the femtoscopy observable is not sensitive to the short-distance features of the dynamics of the p$-$(p$-$n) system, due to the large inter-particle distances in Pb$-$Pb collisions at the LHC. Indeed, in this study, the minimum measured femtoscopic source sizes for protons and deuterons have a minimum value at $2.73^{+0.05}_{-0.05}$ and $3.10^{+1.04}_{-0.86}$ fm, respectively, for the 30$-$50$\%$ centrality collisions. Moreover, the $m_{\rm{T}}$-scaling obtained for the p$-$p and p$-$d systems is compatible within 1$\sigma$ of the uncertainties. These findings provide new input for fundamental studies on the production of light (anti)nuclei under extreme conditions

Medium-induced modification of azimuthal correlations of electrons from heavy-flavor hadron decays with charged particles in Pb--Pb collisions at sNN=5.02\mathbf{\sqrt{s_{\rm{NN}}} = 5.02} TeV

The azimuthal-correlation distributions between electrons from the decays of heavy-flavor hadrons and associated charged particles in Pb-Pb collisions at $\sqrt{s_{\mathrm{NN}}} = 5.02$ TeV are reported for the 0-10% and 30-50% centrality classes. This is the first measurement to provide access to the azimuthal-correlation observables in the heavy-flavor sector in Pb-Pb collisions. The analysis is performed for trigger electrons from heavy-flavor hadron decays with transverse momentum $4 4$ GeV/$c$ on the away side. The $I_\mathrm{AA}$ for electron triggers from heavy-flavor hadron decays is compared with that for light-flavor and strange-particle triggers to investigate the dependence on different fragmentation processes and parton-medium dynamics, and is found to be the same within uncertainties.The azimuthal-correlation distributions between electrons from the decays of heavy-flavor hadrons and associated charged particles in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 5.02$ TeV are reported for the 0-10% and 30-50% centrality classes. This is the first measurement to provide access to the azimuthal-correlation observables in the heavy-flavor sector in Pb-Pb collisions. The analysis is performed for trigger electrons from heavy-flavor hadron decays with transverse momentum $4 4$ GeV/$c$ on the away side. The $I_{\rm AA}$ for electron triggers from heavy-flavor hadron decays is compared with that for light-flavor and strange-particle triggers to investigate the dependence on different fragmentation processes and parton-medium dynamics, and is found to be the same within uncertainties