COLOMBO (Sri Lanka) (Puerto). Cartas náuticas (1885). 1:10000

Escala también dada de forma gráfica, en 1 milla. Coordenadas de San Fernando (E 86°02'58''/N 6°55'40''). Orientado con estrella en gráfico de declinación magnéticaIndica sondas e isolíneas batimétricas expresadas en metros, veriles, bajos enfilaciones y faros, destacados en rojo y amarilloClave hidrográfica para determinar la calidad del fondoNota referente a las característicasdel puertoConsta el sello en seco de la Dirección de Hidrografí

PORTSMOUTH (Estados Unidos). New Hampshire. Puerto de. Cartas náuticas. 1887. 1:20000

Escala también dada de forma gráfica en 1 milla ó 10 cables. Coordenadas del faro de Porstmouth referidas al merididano de San Fernando (O 64°30'08''/N 43°04'15''). Orientado con estrella en gráfico de declinación magnéticaIndica sondas e isolíneas batimétricas, veriles, bajos, bancos de arena y faros, destacados en rojo y amarilloClave hidrográfica para determinar la calidad del fondoConsta el sello de la Dirección de Hidrografí

KITI (Estados Federados de Micronesia) (Ponapé) (Puerto). Cartas náuticas (1886). 1:8000

Escala gráfica de 10 cables o 1 milla [= 22,4 cm]. Coordenadas de la Isla Narmaur referidas posiblemente al meridiano de S. Fernando (E 164°20'24"/N6°47'00"). Orientado con lis en gráfico de declinación magnéticaOrografía por normalesIndica sondas batimétricas expresadas en metros, veriles, arrecifes y calidad de fondoNota indicando las características del puertoConsta el sello en seco de la Dirección de Hidrografí

PUJADA (Filipinas). Mindanao. Bahía de. Cartas náuticas. 1886 (1885). 1:38000

Escala gráfica de 1 milla [= 4,9 cm ]. Orientado con estrella en nudo de cuatro rumbosRelieve representado por normalesIndica sonda batimétrica expresada en metros, veriles y bajosToponimia costera de los principales accidentes geográficosConsta el sello en seco de la Dirección de Hidrografí

TOMIL (Estados Federados de Micronesia) (Yap) (Puerto). Cartas nákuticas. 1887 (1885). 1:7500

Escala también dada de forma gráfica en 1000 metros y 5 cables. Coordenadas del muelle de la Isla Bartola referidas al meridiano de san Fernando (E 144°16'38"/N 9°30'10"). Orientado con lisOrografía por normales y puntos acotadosIndica sondas batimétricas determinadas en metros, veriles, bajos, derrotas, fondeaderos, arrecifes y coralesClave hidrográfica para determinar la calidad del fondoSobre el mapa se intercalan notas que informan de algunas características de la islaConsta el sello en seco de la Dirección de Hidrografí

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease

TAMPA (Estados Unidos) (Florida) (Bahía). Cartas náuticas. 1886 (1877-1879). 1:125125

Escalas gráficas de 10 millas [= 14,8 cm] y 10 minutos [= 13,1 cm]. Coordenadas del faro de Cayo Cruz referidas al meridiano de San Fernando (O 76°33'16"/N 27°36'04"). Orientado con estrellas en tres gráficos de declinación magnéticaIndica sondas e isolíneas batimétricas expresadas en metros, veriles y bancos de arenaToponimia costera de los principales accidentes geográficosClave hidrográfica para determinar la calidad del fondoConsta el sello del Depósito Hidrográfic

Covalent Modification of Lipids and Proteins in Rat Hepatocytes, and In Vitro, by Thioacetamide Metabolites

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemical Research in Toxicology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/tx3001658Thioacetamide (TA) is a well-known hepatotoxin in rats. Acute doses cause centrilobular necrosis and hyperbilirubinemia while chronic administration leads to biliary hyperplasia and cholangiocarcinoma. Its acute toxicity requires its oxidation to a stable S-oxide (TASO) that is oxidized further to a highly reactive S,S-dioxide (TASO2). To explore possible parallels between the metabolism, covalent binding and toxicity of TA and thiobenzamide (TB) we exposed freshly isolated rat hepatocytes to [14C]-TASO or [13C2D3]-TASO. TLC analysis of the cellular lipids showed a single major spot of radioactivity that mass spectral analysis showed to consist of N-acetimidoyl PE lipids having the same side chain composition as the PE fraction from untreated cells; no carbons or hydrogens from TASO were incorporated into the fatty acyl chains. Many cellular proteins contained N-acetyl- or N-acetimidoyl lysine residues in a 3:1 ratio (details to be reported separately). We also oxidized TASO with hydrogen peroxide in the presence of dipalmitoyl phosphatidylenthanolamine (DPPE) or lysozyme. Lysozyme was covalently modified at five of its six lysine side chains; only acetamide-type adducts were formed. DPPE in liposomes also gave only amide-type adducts, even when the reaction was carried out in tetrahydrofuran with only 10% water added. The exclusive formation of N-acetimidoyl PE in hepatocytes means that the concentration or activity of water must be extremely low in the region where TASO2 is formed, whereas at least some of the TASO2 can hydrolyze to acetylsulfinic acid before it reacts with cellular proteins. The requirement for two sequential oxidations to produce a reactive metabolite is unusual, but it is even more unusual that a reactive metabolite would react with water to form a new compound that retains a high degree of chemical reactivity toward biological nucleophiles. The possible contribution of lipid modification to the hepatotoxicity of TA/TASO remains to be determined

Navarra. Mapas generales. 1861

Contiene: Mapa de la provincia (1:200.000). -- Inserta: Plano de Pamplona (1:10.000) ; Mapa de contornos de Pamplona (1:100.000) ; Plano de Estella (1:10.000) / por Anselmo Vicuña ; Plano de Tudela (1:10.000) / por Pío de MenaEn el margen superior: Diccionario geográfico-estadístico-histórico. Atlas de España y sus posesiones de ultramarEscala expresada también en otras unidadesInserta: leyenda de símbolosRelieve indicado por sombreadoLeyenda representada por símbolosMárgenes graduado

Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25

Recent genome-wide association studies (GWAS) and subsequent meta-analyses have identified over 25 SNPs at 18 loci, together accounting for >15% of the genetic susceptibility to testicular germ cell tumour (TGCT). To identify further common SNPs associated with TGCT, here we report a three-stage experiment, involving 4098 cases and 18 972 controls. Stage 1 comprised previously published GWAS analysis of 307 291 SNPs in 986 cases and 4946 controls. In Stage 2, we used previously published customised Illumina iSelect genotyping array (iCOGs) data across 694 SNPs in 1064 cases and 10 082 controls. Here, we report new genotyping of eight SNPs showing some evidence of association in combined analysis of Stage 1 and Stage 2 in an additional 2048 cases of TGCT and 3944 controls (Stage 3). Through fixed-effects meta-analysis across three stages, we identified a novel locus at 3q25.31 (rs1510272) demonstrating association with TGCT [per-allele odds ratio (OR) = 1.16, 95% confidence interval (CI) = 1.06-1.27; P = 1.2 × 10-9]