571 research outputs found
The role of GDNF family ligand signalling in the differentiation of sympathetic and dorsal root ganglion neurons
The diversity of neurons in sympathetic ganglia and dorsal root ganglia (DRG) provides intriguing systems for the analysis of neuronal differentiation. Cell surface receptors for the GDNF family ligands (GFLs) glial cell-line-derived neurotrophic factor (GDNF), neurturin and artemin, are expressed in subpopulations of these neurons prompting the question regarding their involvement in neuronal subtype specification. Mutational analysis in mice has demonstrated the requirement for GFL signalling during embryonic development of cholinergic sympathetic neurons as shown by the loss of expression from the cholinergic gene locus in ganglia from mice deficient for ret, the signal transducing subunit of the GFL receptor complex. Analysis in mutant animals and transgenic mice overexpressing GFLs demonstrates an effect on sensitivity to thermal and mechanical stimuli in DRG neurons correlating at least partially with the altered expression of transient receptor potential ion channels and acid-sensitive cation channels. Persistence of targeted cells in mutant ganglia suggests that the alterations are caused by differentiation effects and not by cell loss. Because of the massive effect of GFLs on neurite outgrowth, it remains to be determined whether GFL signalling acts directly on neuronal specification or indirectly via altered target innervation and access to other growth factors. The data show that GFL signalling is required for the specification of subpopulations of sensory and autonomic neurons. In order to comprehend this process fully, the role of individual GFLs, the transduction of the GFL signals, and the interplay of GFL signalling with other regulatory pathways need to be deciphered
Differential limit on the extremely-high-energy cosmic neutrino flux in the presence of astrophysical background from nine years of IceCube data
We report a quasi-differential upper limit on the extremely-high-energy (EHE)
neutrino flux above GeV based on an analysis of nine years of
IceCube data. The astrophysical neutrino flux measured by IceCube extends to
PeV energies, and it is a background flux when searching for an independent
signal flux at higher energies, such as the cosmogenic neutrino signal. We have
developed a new method to place robust limits on the EHE neutrino flux in the
presence of an astrophysical background, whose spectrum has yet to be
understood with high precision at PeV energies. A distinct event with a
deposited energy above GeV was found in the new two-year sample, in
addition to the one event previously found in the seven-year EHE neutrino
search. These two events represent a neutrino flux that is incompatible with
predictions for a cosmogenic neutrino flux and are considered to be an
astrophysical background in the current study. The obtained limit is the most
stringent to date in the energy range between and GeV. This result constrains neutrino models predicting a three-flavor
neutrino flux of $E_\nu^2\phi_{\nu_e+\nu_\mu+\nu_\tau}\simeq2\times 10^{-8}\
{\rm GeV}/{\rm cm}^2\ \sec\ {\rm sr}10^9\ {\rm GeV}$. A significant part
of the parameter-space for EHE neutrino production scenarios assuming a
proton-dominated composition of ultra-high-energy cosmic rays is excluded.Comment: The version accepted for publication in Physical Review
Search for transient optical counterparts to high-energy IceCube neutrinos with Pan-STARRS1
In order to identify the sources of the observed diffuse high-energy neutrino
flux, it is crucial to discover their electromagnetic counterparts. IceCube
began releasing alerts for single high-energy ( TeV) neutrino
detections with sky localisation regions of order 1 deg radius in 2016. We used
Pan-STARRS1 to follow-up five of these alerts during 2016-2017 to search for
any optical transients that may be related to the neutrinos. Typically 10-20
faint ( mag) extragalactic transients are found within the
Pan-STARRS1 footprints and are generally consistent with being unrelated field
supernovae (SNe) and AGN. We looked for unusual properties of the detected
transients, such as temporal coincidence of explosion epoch with the IceCube
timestamp. We found only one transient that had properties worthy of a specific
follow-up. In the Pan-STARRS1 imaging for IceCube-160427A (probability to be of
astrophysical origin of 50 %), we found a SN PS16cgx, located at 10.0'
from the nominal IceCube direction. Spectroscopic observations of PS16cgx
showed that it was an H-poor SN at z = 0.2895. The spectra and light curve
resemble some high-energy Type Ic SNe, raising the possibility of a jet driven
SN with an explosion epoch temporally coincident with the neutrino detection.
However, distinguishing Type Ia and Type Ic SNe at this redshift is notoriously
difficult. Based on all available data we conclude that the transient is more
likely to be a Type Ia with relatively weak SiII absorption and a fairly normal
rest-frame r-band light curve. If, as predicted, there is no high-energy
neutrino emission from Type Ia SNe, then PS16cgx must be a random coincidence,
and unrelated to the IceCube-160427A. We find no other plausible optical
transient for any of the five IceCube events observed down to a 5
limiting magnitude of mag, between 1 day and 25 days after
detection.Comment: 20 pages, 6 figures, accepted to A&
Book Reviews
With the observation of high-energy astrophysical neutrinos by the IceCube Neutrino Observatory, interest has risen in models of PeV-mass decaying dark matter particles to explain the observed flux. We present two dedicated experimental analyses to test this hypothesis. One analysis uses 6 years of IceCube data focusing on muon neutrino âtrackâ events from the Northern Hemisphere, while the second analysis uses 2 years of âcascadeâ events from the full sky. Known background components and the hypothetical flux from unstable dark matter are fitted to the experimental data. Since no significant excess is observed in either analysis, lower limits on the lifetime of dark matter particles are derived: we obtain the strongest constraint to date, excluding lifetimes shorter than s at 90% CL for dark matter masses above 10 TeV
Neutrinos below 100 TeV from the southern sky employing refined veto techniques to IceCube data
Many Galactic sources of gamma rays, such as supernova remnants, are expected
to produce neutrinos with a typical energy cutoff well below 100 TeV. For the
IceCube Neutrino Observatory located at the South Pole, the southern sky,
containing the inner part of the Galactic plane and the Galactic Center, is a
particularly challenging region at these energies, because of the large
background of atmospheric muons. In this paper, we present recent advancements
in data selection strategies for track-like muon neutrino events with energies
below 100 TeV from the southern sky. The strategies utilize the outer detector
regions as veto and features of the signal pattern to reduce the background of
atmospheric muons to a level which, for the first time, allows IceCube
searching for point-like sources of neutrinos in the southern sky at energies
between 100 GeV and several TeV in the muon neutrino charged current channel.
No significant clustering of neutrinos above background expectation was
observed in four years of data recorded with the completed IceCube detector.
Upper limits on the neutrino flux for a number of spectral hypotheses are
reported for a list of astrophysical objects in the southern hemisphere.Comment: 19 pages, 17 figures, 2 table
Measurement of the multi-TeV neutrino cross section with IceCube using Earth absorption
Neutrinos interact only very weakly, so they are extremely penetrating.
However, the theoretical neutrino-nucleon interaction cross section rises with
energy such that, at energies above 40 TeV, neutrinos are expected to be
absorbed as they pass through the Earth. Experimentally, the cross section has
been measured only at the relatively low energies (below 400 GeV) available at
neutrino beams from accelerators \cite{Agashe:2014kda, Formaggio:2013kya}. Here
we report the first measurement of neutrino absorption in the Earth, using a
sample of 10,784 energetic upward-going neutrino-induced muons observed with
the IceCube Neutrino Observatory. The flux of high-energy neutrinos transiting
long paths through the Earth is attenuated compared to a reference sample that
follows shorter trajectories through the Earth. Using a fit to the
two-dimensional distribution of muon energy and zenith angle, we determine the
cross section for neutrino energies between 6.3 TeV and 980 TeV, more than an
order of magnitude higher in energy than previous measurements. The measured
cross section is (stat.) (syst.)
times the prediction of the Standard Model \cite{CooperSarkar:2011pa},
consistent with the expectation for charged and neutral current interactions.
We do not observe a dramatic increase in the cross section, expected in some
speculative models, including those invoking new compact dimensions
\cite{AlvarezMuniz:2002ga} or the production of leptoquarks
\cite{Romero:2009vu}.Comment: Preprint version of Nature paper 10.1038/nature2445
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