Using LES to Study Reacting Flows and Instabilities in Annular Combustion Chambers

Great prominence is put on the design of aeronautical gas turbines due to increasingly stringent regulations and the need to tackle rising fuel prices. This drive towards innovation has resulted sometimes in new concepts being prone to combustion instabilities. In the particular field of annular combustion chambers, these instabilities often take the form of azimuthal modes. To predict these modes, one must compute the full combustion chamber, which remained out of reach until very recently and the development of massively parallel computers. Since one of the most limiting factors in performing Large Eddy Simulation (LES) of real combustors is estimating the adequate grid, the effects of mesh resolution are investigated by computing full annular LES of a realistic helicopter combustion chamber on three grids, respectively made of 38, 93 and 336 million elements. Results are compared in terms of mean and fluctuating fields. LES captures self-established azimuthal modes. The presence and structure of the modes is discussed. This study therefore highlights the potential of LES for studying combustion instabilities in annular gas turbine combustors

Translithospheric Mantle Diapirism: Geological Evidence and Numerical Modelling of the Kondyor Zoned Ultramafic Complex (Russian Far-East)

We report new structural, microstructural, petrological, and major- and trace-element data on ultramafic rocks from the Kondyor zoned ultramafic complex in Far-East Russia. The ultramafic rocks are subdivided into three subconcentric lithologies, from core to rim: (1) a metasomatic domain where generally phlogopite-rich dykes pervasively intrude dunite; (2) a main dunite core; (3) a pyroxenite rim. The ultramafic rocks have nearly vertical contacts with the surrounding Archaean basement (gneisses, quartzites and marbles) and hornfelsed Riphean sediments. The hornfelsed sediments show a relatively steep (> 60°), outward dipping layering, which rapidly flattens to horizontal away from the inner contact. Although the Riphean sediments define a dome-like structure, the inward, shallow dipping foliation of the dunites indicates a synformal structure. Detailed petro-structural investigations indicate that the Kondyor dunites were deformed by solid-state flow under asthenospheric mantle conditions. The outward textural change from coarse- to fine-grained equigranular dunite and the outward-increasing abundance of subgrains and recrystallized olivine grains suggest dynamic recrystallization while fluid circulation was channelized within the core metasomatic zone, with a decreasing melt fraction from core to rim, and also suggest that solid-state deformation induced grain-size reduction towards the cooling border of the Kondyor massif. Based on their geochemistry, the dunites are interpreted as mantle rocks strongly affected by reaction with melts similar to the Jurassic-Cretaceous Aldan Shield lamproites. Rim pyroxenites were formed by a melt-consuming peritectic reaction, implying the existence of at least a small, conductive thermal gradient around the dunite body while the latter was still at near-solidus temperature conditions. This suggests that the zoned structure of Kondyor was initiated at mantle depths, most probably within the subcontinental lithosphere. Upon cooling, the lamproitic melts were progressively focused in the central part of the massif and drained into vein conduits where they reacted with the wall-rock dunite. Two-dimensional numerical modelling based on finite-differences with a marker-in-cell technique incorporates temperature-dependent rheologies for both molten and non-molten host rocks. The modelling consolidates the structural, petrological and geochemical interpretations, which show that the dunites represent the synformal, flat-lying apex of an asthenospheric mantle diapir, triggered by fluid pressure channelized in the core, which nearly reached the Earth's surface. We conclude that translithospheric mantle diapirism is an important mode of mass transfer in theEart

Petrogenesis of crustal wehrlites in the Oman ophiolite: Experiments and natural rocks

In the Wadi Haymiliyah of the Oman ophiolite (Haylayn block), discordant wehrlite bodies ranging in size from tens to hundreds of meters intrude the lower crust at different levels. We combined investigations on natural wehrlites from the Wadi Haymiliyah section with an experimental study on the phase relations in a wehrlitic system in order to constrain the petrogenesis of the crustal wehrlites of the Oman ophiolite. Secondary ion mass spectrometry analyses of clinopyroxenes from different wehrlite bodies imply that the clinopyroxenes were crystallized from tholeiitic, mid-ocean ridge (MORB)–type melts. The presence of primary magmatic amphiboles in some wehrlites suggests a formation under hydrous conditions. Significantly enhanced 87Sr/86Sr isotope ratios of separates from these amphiboles imply that the source of the corresponding magmatic fluids was either seawater or subduction zone–related. The experiments revealed that under wet conditions at relatively low temperatures, a MORB magma has the potential to produce wehrlite in the ocean crust by accumulation of early olivine and clinopyroxene. These show typically high Mg# which is a consequence of the oxidizing effect of the prevailing high aH2O. First plagioclases crystallizing after clinopyroxene under wet conditions are high in An content, in contrast to the corresponding dry system. Trace element compositions of clinopyroxenes of those wehrlites from the Moho transition zone are too depleted in HREE to be in equilibrium with present-day MORB, implying a genetic relation to the V2 lavas of the Oman ophiolite, which are interpreted to be the result of fluidenhanced melting of previously depleted mantle. We present a model on the petrogenesis of the crustal wehrlites in an upper mantle wedge above an initial, shallow subduction zone at the beginning of the intraoceanic thrusting

Frozen magma lenses below the oceanic crust

Author Posting. © The Authors, 2005. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature 436 (2005): 1149-1152, doi:10.1038/nature03944.The Earth's oceanic crust crystallizes from magmatic systems generated at mid-ocean ridges. Whereas a single magma body residing within the mid-crust is thought to be responsible for the generation of the upper oceanic crust, it remains unclear if the lower crust is formed from the same magma body, or if it mainly crystallizes from magma lenses located at the base of the crust. Thermal modelling, tomography, compliance and wide-angle seismic studies, supported by geological evidence, suggest the presence of gabbroic-melt accumulations within the Moho transition zone in the vicinity of fast- to intermediate-spreading centres. Until now, however, no reflection images have been obtained of such a structure within the Moho transition zone. Here we show images of groups of Moho transition zone reflection events that resulted from the analysis of approximately 1,500 km of multichannel seismic data collected across the intermediate-spreading-rate Juan de Fuca ridge. From our observations we suggest that gabbro lenses and melt accumulations embedded within dunite or residual mantle peridotite are the most probable cause for the observed reflectivity, thus providing support for the hypothesis that the crust is generated from multiple magma bodies

Impact of geocoding methods on associations between long-term exposure to urban air pollution and lung function

Background: Errors in address geocodes may affect estimates of the effects of air pollution on health.Objective: We investigated the impact of four geocoding techniques on the association between urban air pollution estimated with a fine-scale (10 m × 10 m) dispersion model and lung function in adults.Methods: We measured forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC) in 354 adult residents of Grenoble, France, who were participants in two well-characterized studies, the Epidemiological Study on the Genetics and Environment on Asthma (EGEA) and the European Community Respiratory Health Survey (ECRHS). Home addresses were geocoded using individual building matching as the reference approach and three spatial interpolation approaches. We used a dispersion model to estimate mean PM10 and nitrogen dioxide concentrations at each participant's address during the 12 months preceding their lung function measurements. Associations between exposures and lung function parameters were adjusted for individual confounders and same-day exposure to air pollutants. The geocoding techniques were compared with regard to geographical distances between coordinates, exposure estimates, and associations between the estimated exposures and health effects.Results: Median distances between coordinates estimated using the building matching and the three interpolation techniques were 26.4, 27.9, and 35.6 m. Compared with exposure estimates based on building matching, PM10 concentrations based on the three interpolation techniques tended to be overestimated. When building matching was used to estimate exposures, a one-interquartile range increase in PM10 (3.0 μg/m3) was associated with a 3.72-point decrease in FVC% predicted (95% CI: -0.56, -6.88) and a 3.86-point decrease in FEV1% predicted (95% CI: -0.14, -3.24). The magnitude of associations decreased when other geocoding approaches were used [e.g., for FVC% predicted -2.81 (95% CI: -0.26, -5.35) using NavTEQ or 2.08 (95% CI -4.63, 0.47, p = 0.11) using Google Maps].Conclusions: Our findings suggest that the choice of geocoding technique may influence estimated health effects when air pollution exposures are estimated using a fine-scale exposure model.Citation: Jacquemin B, Lepeule J, Boudier A, Arnould C, Benmerad M, Chappaz C, Ferran J, Kauffmann F, Morelli X, Pin I, Pison C, Rios I, Temam S, Künzli N, Slama R, Siroux V. 2013. Impact of geocoding methods on associations between long-term exposure to urban air pollution and lung function. Environ Health Perspect 121:1054-1060; http://dx.doi.org/10.1289/ehp.1206016

Nucleic Acids Res

The HIV-1 transactivator of transcription (Tat) protein is thought to stimulate reverse transcription (RTion). The Tat protein and, more specifically, its (44-61) domain were recently shown to promote the annealing of complementary DNA sequences representing the HIV-1 transactivation response element TAR, named dTAR and cTAR, that plays a key role in RTion. Moreover, the kinetic mechanism of the basic Tat(44-61) peptide in this annealing further revealed that this peptide constitutes a representative nucleic acid annealer. To further understand the structure-activity relationships of this highly conserved domain, we investigated by electrophoresis and fluorescence approaches the binding and annealing properties of various Tat(44-61) mutants. Our data showed that the Tyr47 and basic residues of the Tat(44-61) domain were instrumental for binding to cTAR through stacking and electrostatic interactions, respectively, and promoting its annealing with dTAR. Furthermore, the annealing efficiency of the mutants clearly correlates with their ability to rapidly associate and dissociate the complementary oligonucleotides and to promote RTion. Thus, transient and dynamic nucleic acid interactions likely constitute a key mechanistic component of annealers and the role of Tat in the late steps of RTion. Finally, our data suggest that Lys50 and Lys51 acetylation regulates Tat activity in RTion

Rapport préliminaire sur les activités de la mission archéologique franco-syrienne dans la micro-région d'Al-Rawda (Shamiyeh) : quatrième et cinquième campagnes (2005 et 2006)

This preliminary report presents the results of two campaigns of excavation and survey in 2005and 2006 on the site of AI-Rawda (West-Central Syria) and in the micro-region of 100 km2 around it. Thesite is a pre-planned circular new town. It was founded around 2400 BCE, in the steppe zone and was inhabitedonly during EB IV, until the end of the 3rd millennium. The work of 2005 and 2006 involved furtherextensive excavation of a sanctuary consisting of two temples and a temenos togeiher with aIl associatedinstallations (including a betyl in situ). The eastem gate of the town was excavated and four lines of defencehave been identified. A stratigraphie sounding in the southwest clarifies the origin of the town. In the necropolisassociated with the site, the excavation of a collective pit burial is presented. Intensive survey wascontinued outside the ancient town, with particular attention to sites that were occupied at the same time asAI-Rawda, to burials, which have been classified by type, and to installations that can be linked to agricultureor pastoralism. This work was supplemented by archaeobotanical, archaeozoological and geo-archaeologicalresearch, as weIl as a study of the environment.Ce rapport préliminaire présente les résultats de deux campagnes de fouilles et de prospection conduites en 2005 et 2006 sur le site d’Al-Rawda (Syrie du centre-ouest) et dans la microrégion de 100 km2 qui l’entoure. Le site, une ville neuve circulaire au plan d’urbanisme préconçu fondé vers 2500 av. J.-C., se trouve en zone steppique. Il n’est habité que durant le Bronze ancien IV, jusqu’à la fin du 3e millénaire.Les travaux en 2005 et 2006 ont porté sur la poursuite du dégagement extensif d’un sanctuaire qui regroupe deux temples et un temenos, avec l’ensemble des installations qu’ils contiennent (dont un bétyle in situ). À l’est, a été mise au jour la porte orientale de la ville tandis que quatre lignes de défense ont été identifiées. Un sondage stratigraphique au sud-ouest éclaire l’origine de la ville. Dans la nécropole associée au site, la fouille d’une tombe en puits collective est présentée.Parallèlement, la prospection intensive autour de la ville antique a été poursuivie en mettant l’accent sur les sites d’habitat contemporains d’Al-Rawda, les tombes caractérisées par type et les aménagements qui peuvent être liés à une mise en valeur agricole du territoire et au pastoralisme. Ces travaux ont été complétés par des études archéobotanique, archéozoologique, géoarchéologique et par une étude des milieux

The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease

Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allow them to efficiently inhibit target enzymes, such as neutrophil elastase, released into the interstitium. Historically, in the lung, these inhibitors were first purified from secretions of patients with chronic obstructive pulmonary disease and cystic fibrosis. This suggested that they might be important in controlling excessive neutrophil elastase release in these pathologies. They are upregulated by 'alarm signals' such as bacterial lipopolysaccharides, and cytokines such as interleukin-1 and tumor necrosis factor and have been shown to be active against Gram-positive and Gram-negative bacteria, so that they have joined the growing list of antimicrobial 'defensin-like' peptides produced by the lung. Their site of synthesis and presumed functions make them very attractive candidates as potential therapeutic agents under conditions in which the excessive release of elastase by neutrophils might be detrimental. Because of its natural tropism for the lung, the use of adenovirus-mediated gene transfer is extremely promising in such applications

Association between cognition and the retinal microvasculature in 11-year old children born preterm or at term

Background: Retinal microvessels can be visualized non-invasively and mirror the status of the cerebral microvasculature. Aims: To investigate whether in young children born prematurely or at term cognitive performance is related to retinal microvascular traits. Study design, subjects: In 93 prematurely born infants (birth weight < 1000 g) and 87 controls born at term, we measured head circumference (HC) and determined intelligence quotient (IQ) by combining matrix reasoning and spatial span (Wechsler Non-Verbal test, Dutch version) and post-processed retinal photographs using Singapore I Vessel Assessment software (version 3.6). Outcome measures, results: Compared with controls, cases had smaller HC (51.7 vs 53.4 cm; p < 0.001), lower IQ (93.9 vs 109.2; p < 0.001), smaller retinal arteriolar (CRAE; 162.7 vs 174.0 μm; p < 0.001) and venular (CRVE; 234.9 vs 242.8 μm; p = 0.003) diameters and CRAE/CRVE ratio (0.69 vs 0.72; p = 0.001). A 1-SD decrease in CRAE was associated with smaller HC (−0.53 cm; p < 0.001) and lower total IQ (−3.74; p < 0.001), matrix reasoning (−1.77; p = 0.004) and spatial span (−2.03; p = 0.002). These associations persisted after adjustment for sex and age and risk factors for cognitive impairment, including blood pressure, body mass index and parental educational attainment. Conclusions: HC, total IQ, matrix reasoning and spatial span decrease with smaller retinal arteriolar diameter. Our findings suggest that maldevelopment of the cerebral microcirculation, as mirrored by the retinal microvasculature, has lasting effects on the growth of the brain and cognitive performance of prematurely born children