Thinking like a consumer: Linking aquatic basal metabolism and consumer dynamics

The increasing availability of high-frequency freshwater ecosystem metabolism data provides an opportunity to identify links between metabolic regimes, as gross primary production and ecosystem respiration patterns, and consumer energetics with the potential to improve our current understanding of consumer dynamics (e.g., population dynamics, community structure, trophic interactions). We describe a conceptual framework linking metabolic regimes of flowing waters with consumer community dynamics. We use this framework to identify three emerging research needs: (1) quantifying the linkage of metabolism and consumer production data via food web theory and carbon use efficiencies, (2) evaluating the roles of metabolic dynamics and other environmental regimes (e.g., hydrology, light) in consumer dynamics, and (3) determining the degree to which metabolic regimes influence the evolution of consumer traits and phenology. Addressing these needs will improve the understanding of consumer biomass and production patterns as metabolic regimes can be viewed as an emergent property of food webs

Comisión de terapias biológicas. ¿Qué nos aporta?

Objetivo: Evaluar el impacto general a nivel asistencial de una comisión de terapias biológicas, en enfermedades inflamatorias inmunomediadas, mediante los hábitos de prescripción, los estudios prebiológicos y la inmunización. Método: Se realizó un estudio cuasiexperimental sobre todos los pacientes naïve mayores de edad que iniciaron tratamiento con un medicamento biológico por enfermedad inflamatoria inmunomediada el año anterior y el año posterior a la creación de la comisión de terapias biológicas. Resultados: Se incluyeron un total de 31 pacientes estudiados en 2016 y 40 pacientes estudiados en 2018. La prescripción de medicamentos inhibidores del factor de necrosis tumoral α se redujo en 2018 (80,6% versus 45,0%;

Search for supersymmetry with a dominant R-parity violating LQDbar couplings in e+e- collisions at centre-of-mass energies of 130GeV to 172 GeV

A search for pair-production of supersymmetric particles under the assumption that R-parity is violated via a dominant LQDbar coupling has been performed using the data collected by ALEPH at centre-of-mass energies of 130-172 GeV. The observed candidate events in the data are in agreement with the Standard Model expectation. This result is translated into lower limits on the masses of charginos, neutralinos, sleptons, sneutrinos and squarks. For instance, for m_0=500 GeV/c^2 and tan(beta)=sqrt(2) charginos with masses smaller than 81 GeV/c^2 and neutralinos with masses smaller than 29 GeV/c^2 are excluded at the 95% confidence level for any generation structure of the LQDbar coupling.Comment: 32 pages, 30 figure

The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles

A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to impute the remainder. However, identifying the best imputation methods and what measures meaningfully evaluate performance are open questions. We address these questions by comprehensively analyzing 23 methods from the ENCODE Imputation Challenge. We find that imputation evaluations are challenging and confounded by distributional shifts from differences in data collection and processing over time, the amount of available data, and redundancy among performance measures. Our analyses suggest simple steps for overcoming these issues and promising directions for more robust research

The ENCODE Imputation Challenge: a critical assessment of methods for cross-cell type imputation of epigenomic profiles

A promising alternative to comprehensively performing genomics experiments is to, instead, perform a subset of experiments and use computational methods to impute the remainder. However, identifying the best imputation methods and what measures meaningfully evaluate performance are open questions. We address these questions by comprehensively analyzing 23 methods from the ENCODE Imputation Challenge. We find that imputation evaluations are challenging and confounded by distributional shifts from differences in data collection and processing over time, the amount of available data, and redundancy among performance measures. Our analyses suggest simple steps for overcoming these issues and promising directions for more robust research

All Quiet on the Protest Scene? Repertoires of Contention and Protest Actors During the Great Recession

The choice of specific action repertoires allows protesters to increase their visibility and eventually their success. A rise in protest, i.e. a protest wave, often comes with a qualitative expansion of the conflict, which can take two forms: changes in the action repertoire and a growing diversity of involved actors. In this chapter, we examine the types of protest and the types of actors over time. In so doing, we ask whether and how the Great Recession transformed customary action repertoires in southern, north-western, and eastern Europe. Hence, we show variations in the use of commonplace action forms, i.e. demonstrations, strikes, and confrontational and violent actions. We find that demonstrations and strikes remain the dominant form of protest across regions and time periods, while transformations in the action repertoire of contention, in the form of violent events, took place only in some parts of the south and were short lived. Lastly, we turn to actors and we show that protest events increasingly feature social groups without formal organizational structures. We conclude by arguing that contention repertoires remained largely unaffected by the Great Recession; demonstrations were and remained the prevailing form of protest in all three regions during the whole period under study

Electoral Punishment and Protest Politics in Times of Crisis

This chapter links the political consequences of the Great Recession on protest and electoral politics. The economic voting literature offers important insights on how and under what conditions economic crises play out in the short run. However, it tends to ignore the closely connected dynamics of opposition in the electoral and protest arena. Therefore, this chapter combines the literature on economic voting with social movement research. It argues that economic protests act as a ‘signalling mechanism’ by attributing blame to decision-makers and by highlighting the political dimension of deteriorating economic conditions. Ultimately, massive protest mobilization should thus amplify the impact of economic hardship on electoral punishment. The empirical analysis to study this relationship combines the data on protest with a dataset of electoral outcomes in thirty European countries from 2000 to 2015. The results indicate that the dynamics of economic protests and electoral punishment are closely related and that protests contributed to the destabilisation of European party systems during the Great Recession

Are Political Parties Recapturing the Streets of Europe?

Political mobilization in the electoral and protest arenas have long been studied as separate phenomena, following their own, independent dynamic. Parties and protests are rarely examined within the same framework, although the protest engagement of political parties is often assumed to be one of the main driving forces of the wave of protest in southern European countries, those most exposed to the economic crisis. The chapter provides the first large-scale study of protests sponsored by political parties across Europe before and after the Great Recession. It relies on a novel protest event dataset, collected by semi-automated content analysis of news agencies. The data cover protests in thirty countries, from 2000 to 2015. The results show the ‘crowding out’ of political parties as the driving force of the protest wave in southern Europe. We find the highest share of party sponsored protest in eastern Europe, where unlike in north-western and southern Europe, right-wing and non-mainstream parties are also active in protest. In line with the overall findings of the book, our results confirm the distinctive dynamic of protest in the three European macro-regions and put the link between social movements and the new challenger parties in perspective

Eosinophils in glioblastoma biology

Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. The development of this malignant glial lesion involves a multi-faceted process that results in a loss of genetic or epigenetic gene control, un-regulated cell growth, and immune tolerance. Of interest, atopic diseases are characterized by a lack of immune tolerance and are inversely associated with glioma risk. One cell type that is an established effector cell in the pathobiology of atopic disease is the eosinophil. In response to various stimuli, the eosinophil is able to produce cytotoxic granules, neuromediators, and pro-inflammatory cytokines as well as pro-fibrotic and angiogenic factors involved in pathogen clearance and tissue remodeling and repair. These various biological properties reveal that the eosinophil is a key immunoregulatory cell capable of influencing the activity of both innate and adaptive immune responses. Of central importance to this report is the observation that eosinophil migration to the brain occurs in response to traumatic brain injury and following certain immunotherapeutic treatments for GBM. Although eosinophils have been identified in various central nervous system pathologies, and are known to operate in wound/repair and tumorstatic models, the potential roles of eosinophils in GBM development and the tumor immunological response are only beginning to be recognized and are therefore the subject of the present review