7 research outputs found
Reconstructing pedigrees: some identifiability questions for a recombination-mutation model
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/09/2011
- Field of study
Pedigrees are directed acyclic graphs that represent ancestral relationships
between individuals in a population. Based on a schematic recombination
process, we describe two simple Markov models for sequences evolving on
pedigrees - Model R (recombinations without mutations) and Model RM
(recombinations with mutations). For these models, we ask an identifiability
question: is it possible to construct a pedigree from the joint probability
distribution of extant sequences? We present partial identifiability results
for general pedigrees: we show that when the crossover probabilities are
sufficiently small, certain spanning subgraph sequences can be counted from the
joint distribution of extant sequences. We demonstrate how pedigrees that
earlier seemed difficult to distinguish are distinguished by counting their
spanning subgraph sequences.Comment: 40 pages, 9 figure
Haplotypes versus genotypes on pedigrees
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Abstract. Genome sequencing will soon produce haplotype data for individuals. For pedigrees of related individuals, sequencing appears to be an attractive alternative to genotyping. However, methods for pedigree analysis with haplotype data have not yet been developed, and the computational complexity of such problems has been an open question. Furthermore, it is not clear in which scenarios haplotype data would provide better estimates than genotype data for quantities such as recombination rates. To answer these questions, a reduction is given from genotype problem instances to haplotype problem instances, and it is shown that solving the haplotype problem yields the solution to the genotype problem, up to constant factors or coefficients. The pedigree analysis problems we will consider are the likelihood, maximum probability haplotype, and minimum recombination haplotype problems. Two algorithms are introduced: an exponential-time hidden Markov model (HMM) for haplotype data where some individuals are untyped, and a linear-time algorithm for pedigrees having haplotype data for all individuals. Recombination estimates from the general haplotype HMM algorithm are compared to recombination estimates produced by a genotype HMM. Having haplotype data on all individuals produces better estimates. However, having several untyped individuals can drastically reduce the utility of haplotype data. Pedigree analysis, both linkage and association studies, has a long history of important contributions to genetics, including disease-gene finding and some of the first genetic maps for humans. Recent contributions include fine-scale recombination maps in humans [4], regions linked to Schizophrenia that might be missed by genome-wide association studies [11], and insights into the relationship between cystic fibrosis and fertility [13]. Algorithms for pedigree problems are of great interest to the computer science community, in part because of connections to machine learning algorithms, optimization methods, and combinatorics [7, 16
Posterior interosseous nerve syndrome secondary to compression by an intramuscular hemangioma
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Historical Pedigree Reconstruction from Extant Populations Using PArtitioning of RElatives (PREPARE)
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Integrating Chinese and Western Medicine in Cancer Treatment
- Author
- A Hill
- A Lee
- A White
- B Oh
- B Pan
- BD Lawenda
- BK Piao
- CM Witt
- D Alimi
- E Nedstrand
- G Porzio
- GY Li
- H MacPherson
- J Ezza
- JL Nortier
- JW Yuen
- KJ Block
- KK Chu
- KY Tan
- L Lao
- L Xu
- M McCulloch
- M Zhang
- MB Meng
- MH Wu
- ML Yeh
- MS Lee
- N Li
- NI Weijl
- O Huang
- QT Gao
- R Chang
- RK Wong
- RW Moss
- S Clement-Kruzel
- S Endo
- SC Gautam
- SL Zheng
- T Efferth
- T Suehiro
- TK Lee
- TS Mok
- U Thatte
- W Dang
- W Taixiang
- WC Cho
- WC Cho
- WC Cho
- WC Cho
- WY Wu
- X Chen
- X Shu
- Y Zhou
- ZY Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Reliable, Resilient, and Sustainable Water Management in Different Water Use Sectors
- Author
- A Agathokleous
- A Benzerra
- A Inocencio
- A Rajagopal-Durbin
- AB Dixon
- AH Arthington
- AJ Melloul
- AK Kivaisi
- AS Tanner
- B Biazin
- B Ness
- BA de Oliveira
- BD Richter
- C Chou
- CD Thatte
- D Butler
- D Butler
- D Hellström
- D Loucks
- D Pimentel
- D Tilman
- D Todd
- D Voza
- D Wichelns
- DD Mwanza
- DR Marlow
- DR Steward
- EI Mbah
- F Ward
- FA Ward
- G Brunetti
- G Peter
- GD Schaible
- GP Cimellaro
- H Hussein
- H Hwang
- H Yang
- HML Chaves
- I Angin
- I Juwana
- J Araus
- J Bredehoeft
- J Carrera
- J Niemczynowicz
- J Rockstrom
- JB Ellis
- K Mori
- K Töpfer
- K Woldearegay
- KD Schuyt
- KRDS Nascimento
- L Horlemann
- L Horrigan
- L Mays
- L Stroosnijder
- L Wainger
- LS Pereira
- M Falkenmark
- M Herrera
- M Qadir
- M Rosegrant
- NL Poff
- NL Poff
- O Al-Jayyousi
- P Fox
- PC Tiwari
- RE Ulanowicz
- RI McDonald
- S Dawadi
- S Irmak
- S Khan
- S Shin
- SB Grant
- SN Ngigi
- T Dawson
- T Larsen
- T Russo
- UN WCED
- W Brack
- W Falcon
- WWDR3
- X Xue
- Y Jiang
- Y Xiao
- ZJU Malley
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Schwingungen und Rotationen der Molekeln
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- A Ciccone
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- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Ananthakrishnan
- R Aynard
- R AĂ«lion
- R Barer
- R Barnes
- R Barnes
- R Barnes
- R Barnes
- R Brill
- R Brill
- R Brunetti
- R Brunetti
- R Brunetti
- R Bär
- R Bär
- R Bär
- R Candel-Vila
- R Cantarel
- R Courtel
- R Dalmon
- R Dalmon
- R Delaby
- R Duval
- R Duval
- R Fichter
- R Fichter
- R Fichter
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Fonteyne
- R Frank
- R Freymann
- R Freymann
- R Freymann
- R Freymann
- R Freymann
- R Freymann
- R Freymann
- R Heerdt
- R Hofstadter
- R Högler
- R Karplus
- R Kishore
- R Langenberg
- R Lespieau
- R Lespieau
- R Livingston
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Manzoni-Ansidei
- R Mathis
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Mecke
- R Norris
- R Norris
- R Norris
- R Pajeau
- R Pajeau
- R Pajeau
- R Pajeau
- R Pajeau
- R Pajeau
- R Pajeau
- R Pohlman
- R Pohlman
- R Rambaud
- R Rambaud
- R Rambaud
- R Rambaud
- R Rambaud
- R Rambaud
- R Robertson
- R Sabathy
- R Samuel
- R Schaffert
- R Schaffert
- R Signer
- R Signer
- R Skrabal
- R Skrabal
- R Stair
- R Stair
- R Suhrmann
- R Suhrmann
- R Suhrmann
- R Taschek
- R Titeica
- R Tomaschek
- R Truchet
- R Vogel-Högler
- R Vogel-Högler
- R Ziegler
- RA Frieder
- RA Oetjen
- RA Oetjen
- RB Angier
- RB Barnes
- RB Barnes
- RB Barnes
- RB Barnes
- RB Barnes
- RB Barnes
- RB Barnes
- RB Barnes
- RB Woodward
- RC Herman
- RC Herman
- RC Herman
- RC Herman
- RC Herman
- RC Lord
- RC Lord
- RC Lord
- RC Lord
- RC Lord
- RC Nelson
- RC Nelson
- RC Williamson
- RC Williamson
- RD Cowan
- RE Chernitzkaya
- RE Chernitzkaya
- RE Foster
- RE Hillger
- RE Richards
- RE Tschernitzkaja
- RF Furchgott
- RF Furchgott
- RF Furchgott
- RF Furchgott
- RF Stamm
- RF Stamm
- RG Beaman
- RG Dickinson
- RG Dickinson
- RG Dickinson
- RG Owens
- RG Owens
- RG Owens
- RG Parr
- RG Shulman
- RG Shulman
- RG Shulman
- RG Shulman
- RH Betts
- RH Gillette
- RH Gillette
- RH Gillette
- RH Kienle
- RH Saunders
- RH Saunders
- RH Saunders
- RH Saunders
- RJ Watts
- RL Frank
- RL Frank
- RL Gore
- RL Henry
- RL Letsinger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Badger
- RM Fuoss
- RM Hainer
- RM Hainer
- RM Langer
- RN Jones
- RN Jones
- RP Bell
- RP Bell
- RP Bell
- RP Bell
- RP Bell
- RR Brattain
- RR Brattain
- RR Brattain
- RR Brattain
- RR Gordon
- RR Haun
- RS Halford
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Krishnan
- RS Rasmussen
- RS Rasmussen
- RS Rasmussen
- RS Rasmussen
- RS Rasmussen
- RS Rasmussen
- RS Rasmussen
- RT Lagemann
- RT Lagemann
- RT Lagemann
- RW Mitchell
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RW Wood
- RWB Johnston
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bhagavantam
- S Bogdan
- S David
- S Golden
- S Gradstein
- S Imanishi
- S Lemaitre
- S Lieberman
- S Lorillard
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Mizushima
- S Parthasarathy
- S Parthasarathy
- S Pienkowski
- S Silver
- S Silver
- S Sirkar
- S Ställberg-Stenhagen
- S Suti
- S Tolksdorf
- S Venkov
- S Venkov
- S Ziemecki
- SA Aziz
- Saksena
- Saksena
- Saksena
- Saksena
- Saksena
- SB Hendricks
- SB Hendricks
- SB Hendricks
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Sirkar
- SC Stanford
- SC Stanford
- SC Woo
- SD Gehman
- SD Gehman
- SE Darmon
- SE Whitcomb
- SF Kapff
- SH Bauer
- SH Bauer
- SH Chao
- SI Weissmann
- SK Mukerji
- SKK Jatkar
- SKK Jatkar
- SKK Jatkar
- SL Gerhard
- SM Mitra
- SM Mitra
- SM Mitra
- SM Mitra
- SM Mitra
- SM Mitra
- SM Naudé
- SP Sinka
- SS Kriwitsch
- SS Kriwitsch
- ST Shen
- T Cujumzelis
- T Doehaerd
- T Dreisch
- T Dreisch
- T Förster
- T Förster
- T Kubota
- T Simanouti
- TA Ford
- TAS Balakrishnan
- TF Anderson
- TF Anderson
- TF Anderson
- TF Anderson
- TF Parkinson
- TG Cowling
- TG Kujumzelis
- TG Kujumzelis
- TG Kujumzelis
- TG Kujumzelis
- Thompson
- Thompson
- Thompson
- Thompson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- Thomson
- TKL Woo
- TKL Woo
- TM Wentink
- TMK Nedungadi
- TMK Nedungadi
- TMK Nedungadi
- TMK Nedungadi
- TP Wilson
- TW Dakin
- TW Dakin
- TY Wu
- TY Wu
- TY Wu
- TY Wu
- TY Wu
- TY Wu
- TY Wu
- TY Wu
- U Liddel
- U Liddel
- V Brustier
- V Henri
- V Hirshberg
- V Kondratjew
- V Polara
- V Schomaker
- V Tatevskij
- VI Mališev
- VI Mališev
- VL Wu
- VM Kudrjavtzeva
- VM McConaghie
- VM McConaghie
- VN Ipatieff
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VN Thatte
- VW Cohen
- VZ Williams
- VZ Williams
- VZ Williams
- VZ Williams
- W Bacher
- W Baumann
- W Czapska-Narkiewicz
- W Dahlke
- W Engler
- W Engler
- W Engler
- W Finkelstem
- W Fresenius
- W Gerlach
- W Gerlach
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Gordy
- W Hanle
- W Hanle
- W Hanle
- W Hanle
- W Hanle
- W Hunsman
- W HĂĽckel
- W Krabbe
- W Kutzner
- W Low
- W Lyon
- W LĂĽttke
- W Scheib
- W West
- W West
- W West
- W West
- W West
- W West
- W West
- W West
- W West
- W West
- W Zandt van
- WB Plum
- WB Plum
- WB Steward
- WB Steward
- WC Price
- WC Price
- WC Price
- WC Sears
- WC Sears
- WD Harkins
- WD Harkins
- WD Stallcup
- WE Anderson
- WE Good
- WE Keller
- WE Singer
- WF Busse
- WF Colby
- WF Edgell
- WF Edgell
- WF Edgell
- WF Edgell
- WG Appleby
- WG Brown
- WG Penney
- WG Penney
- WH Avery
- WH Avery
- WH Bennet
- WH Rodebush
- WH Shaffer
- WHJ Childs
- WHJ Childs
- WHJ Childs
- WHJ Childs
- Wilson Jr.
- Wilson Jr.
- Wilson Jr.
- Wilson Jr.
- Wilson Jr.
- WJ Sweeney
- WL Hyde
- WM Cohn
- WM Dabadghao
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Angus
- WR Harp
- WS Baird
- WS Benedict
- WS Gallaway
- WS Gallaway
- WV Norris
- WV Norris
- WV Norris
- WV Smith
- WW Coblentz
- WW Coblentz
- WW Sleater
- WW Watson
- Y Morino
- Y Morino
- Y Ta
- Y Ta
- Y Ta
- YL Tschang
- YP Rao
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- YR Naves
- Z Ollano
- Z Ollano
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study