Testing the Short-Term Efficacy of a Lipid-Lowering Nutraceutical in the Setting of Clinical Practice: A Multicenter Study

The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat\uc2\uae, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50\uc2\ub118.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6\uc2\ub113.6mg/dL), triglycerides (TG; -19.8\uc2\ub125.1mg/dL), and non-HDL-C (-43.1\uc2\ub117.7mg/dL) (all P<.001). In the phytosterol-treated group, compared to the baseline level, we observed a significant decrease in TC (-13.7\uc2\ub14.3mg/dL), LDL-C (-17.6\uc2\ub18.5mg/dL), and non-HDL-C (-14.1\uc2\ub15.6mg/dL) (all P<.001). When comparing the combined nutraceutical effect with that of phytosterols, we observed that the combined nutraceutical intake was associated with a significantly higher decrease in TC, LDL-C, TG, and non-HDL-C (all P<.001). In the short term, a combined nutraceutical containing red yeast rice and PUFAs is well tolerated and efficacious in reducing plasma lipid levels in subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome

Sex-Related Differences in Mortality, Delayed Cerebral Ischemia, and Functional Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

Background/Objective: Sex-related differences among patients with aneurysmal subarachnoid hemorrhage (aSAH) and their potential clinical implications have been insufficiently investigated. To address this knowledge gap, we conduct a comprehensive systematic review and meta-analysis. Methods: Sex-specific differences in patients with aSAH, including mortality, delayed cerebral ischemia (DCI), and functional outcomes were assessed. The functional outcome was dichotomized into favorable or unfavorable based on the modified Rankin Scale (mRS), Glasgow Outcome Scale (GOS), and Glasgow Outcome Scale Extended (GOSE). Results: Overall, 2823 studies were identified in EMBASE, MEDLINE, PubMed, and by manual search on 14 February 2024. After an initial assessment, 74 studies were included in the meta-analysis. In the analysis of mortality, including 18,534 aSAH patients, no statistically significant differences could be detected (risk ratio (RR) 0.99; 95% CI, 0.90–1.09; p = 0.91). In contrast, the risk analysis for DCI, including 23,864 aSAH patients, showed an 11% relative risk reduction in DCI in males versus females (RR, 0.89; 95% CI, 0.81–0.97; p = 0.01). The functional outcome analysis (favorable vs. unfavorable), including 7739 aSAH patients, showed a tendency towards better functional outcomes in men than women; however, this did not reach statistical significance (RR, 1.02; 95% CI, 0.98–1.07; p = 0.34). Conclusions: In conclusion, the available data suggest that sex/gender may play a significant role in the risk of DCI in patients with aSAH, emphasizing the need for sex-specific management strategies

A survey of the aphid fauna in the Italian regions of Latium and Campania

A survey of the biodiversity of the aphid fauna for the two administrative Italian regions of Latium and Campania indicated the presence of 269 and 324 species or subspecies, respectively, and a total of 390 taxa for both regions. Host plant, collection locations, and bibliographic references, if any, are provided for each aphid taxon listed. Additional notes on the taxonomic status, local distribution, and ecology are provided for a few taxa. Five aphid species are new records for Italy. Short biogeographical accounts are also provided and compared to the corresponding data of the Italian aphid fauna as a whole

Evaluation of herbaceous crops irrigated with treated wastewater for ethanol production

The competition for freshwater between agricultural, industrial, and civil uses has greatly increased in Mediterranean basin characterized by prolonged dry seasons. The aim of this study was to evaluate biomass production and the potential ethanol production of promising “no-food” herbaceous crops irrigated with low quality water at different ETc restitutions (0%, 50 and 100%). The research was carried out, in 2011 and 2012, in an open field near the full-scale constructed wetland (CW) municipal treatment plant located in the Eastern Sicily (Italy). The CW effluent has been applied in a experimental irrigation field of Vetiveria zizanoides (L.) Nash, Miscanthus x giganteus Greef et Deu. and Arundo donax (L.). Physical, chemical and microbiological analyses were carried out on wastewater samples collected at inlet and outlet of CW and pollutant removal efficiencies were calculated for each parameter. Bio-agronomical analysis on herbaceous species were made with the goal to evaluate the main parameters such as the plant dimension, the growth response and the biomass production. Biomass dry samples were processed with a three-step chemical pretreatment, hydrolysed with a mix of commercial enzymes and next fermented to obtain the yield of ethanol production. Average TSS, COD and TN removal for CW were about 74%, 67% and 68%, respectively. Although the satisfactory Escherichia coli removal, about 3.5 log unit for both beds on average, CW didn’t achieve the restrictive Italian law limits for wastewater reuse. As expected, irrigation was beneficial and the full ET replenishment increase the biomass productivity as compared to the other two treatment. The mean productivity of Vetiveria zizanoides and Myscanthus x giganteus were about 9, 26 and 38 t ha–1 and 3, 7 and 12 t ha–1 respectively in 0%, 50% and 100% ETc restitutions. Arundo donax gave higher values of dry biomass (78 t ha–1 in 100% ETc restitution in 2011 season), and potential ethanol production (about 3,744 kg ha–1). These results suggest the interest in the use of constructed wetland effluents for the irrigation of energy crops to obtain second generation ethanol, particularly in semiarid regions such as the Mediterranean area

Effectiveness of a Sustainable Training Program Combining Supervised Outdoor Exercise with Telecoaching on Physical Performance in Elderly People

The decrease in functional abilities can negatively influence quality of life and autonomy in elderly people, and physical exercise plays a crucial role regardless of the type. Among the latter, also due to the COVID-19 pandemic, outdoor exercise and telecoaching are settings that have been widely implemented. Hence, the aim of this study was to investigate the effectiveness of a sustainable training program combining supervised outdoor exercise with telecoaching on physical performance in elderly people. A total of 60 participants were recruited and divided into two groups: a trained group (TG) and an untrained group (UG), based on their participation in an 8-week sustainable training program consisted of five sessions/week, which included two sessions/week of supervised outdoor exercise and three sessions/week of telecoaching. Participants were evaluated before and at the end of the training program using the handgrip test, Timed Up and Go (TUG) test, short physical performance battery (SPPB), and Tinetti scale. In the TG, we found a significant improvement in the following tests: right handgrip (p &lt; 0.001); left handgrip (p &lt; 0.001); TUG (p &lt; 0.001); SPPB (p = 0.01); and Tinetti scale (p = 0.006). A detailed analysis of the SPPB and Tinetti scale showed the lack of significant changes in walking ability: gait speed (p &gt; 0.05) and walking parameters in the Tinetti scale (p &gt; 0.05). Based on our results, we suggest that a sustainable training program combining supervised outdoor exercise with telecoaching could be effective in the elderly population for improving balance capacity and strength