1,834 research outputs found
Exponential torsion growth for random 3-manifolds
We show that a random 3-manifold with positive first Betti number admits a tower of cyclic covers with exponential torsion growth
Random walks and random fixed-point free involutions
A bijection is given between fixed point free involutions of
with maximum decreasing subsequence size and two classes of vicious
(non-intersecting) random walker configurations confined to the half line
lattice points . In one class of walker configurations the maximum
displacement of the right most walker is . Because the scaled distribution
of the maximum decreasing subsequence size is known to be in the soft edge GOE
(random real symmetric matrices) universality class, the same holds true for
the scaled distribution of the maximum displacement of the right most walker.Comment: 10 page
Dynamics of a tagged particle in the asymmetric exclusion process with the step initial condition
The one-dimensional totally asymmetric simple exclusion process (TASEP) is
considered. We study the time evolution property of a tagged particle in TASEP
with the step-type initial condition. Calculated is the multi-time joint
distribution function of its position. Using the relation of the dynamics of
TASEP to the Schur process, we show that the function is represented as the
Fredholm determinant. We also study the scaling limit. The universality of the
largest eigenvalue in the random matrix theory is realized in the limit. When
the hopping rates of all particles are the same, it is found that the joint
distribution function converges to that of the Airy process after the time at
which the particle begins to move. On the other hand, when there are several
particles with small hopping rate in front of a tagged particle, the limiting
process changes at a certain time from the Airy process to the process of the
largest eigenvalue in the Hermitian multi-matrix model with external sources.Comment: 48 pages, 8 figure
Nonvolatile memory with molecule-engineered tunneling barriers
We report a novel field-sensitive tunneling barrier by embedding C60 in SiO2
for nonvolatile memory applications. C60 is a better choice than ultra-small
nanocrystals due to its monodispersion. Moreover, C60 provides accessible
energy levels to prompt resonant tunneling through SiO2 at high fields.
However, this process is quenched at low fields due to HOMO-LUMO gap and large
charging energy of C60. Furthermore, we demonstrate an improvement of more than
an order of magnitude in retention to program/erase time ratio for a metal
nanocrystal memory. This shows promise of engineering tunnel dielectrics by
integrating molecules in the future hybrid molecular-silicon electronics.Comment: to appear in Applied Physics Letter
Opposite carrier dynamics and optical absorption characteristics under external electric field in nonpolar vs. polar InGaN/GaN based quantum heterostructures
Cataloged from PDF version of article.We report on the electric field dependent carrier dynamics and optical absorption in nonpolar a-plane GaN-based quantum heterostructures grown on r-plane sapphire, which are surprisingly observed to be opposite to those polar ones of the same materials system and similar structure grown on c-plane. Confirmed by their time-resolved photoluminescence measurements and numerical analyses, we show that carrier lifetimes increase with increasing external electric field in nonpolar InGaN/GaN heterostructure epitaxy, whereas exactly the opposite occurs for the polar epitaxy. Moreover, we observe blue-shifting absorption spectra with increasing external electric field as a result of reversed quantum confined Stark effect in these polar structures, while we observe red-shifting absorption spectra with increasing external electric field because of standard quantum confined Stark effect in the nonpolar structures. We explain these opposite behaviors of external electric field dependence with the changing overlap of electron and hole wavefunctions in the context of Fermi's golden rule. (C) 2011 Optical Society of Americ
Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium
SummaryObjectivesArthritis with intra-articular inflammation was accompanied by joint pain, swelling, and stiffness leading to significant functional impairment. Thus, regulation of joint inflammation is a good therapeutic approach for patients with arthritis. In this study, the effect of low intensity ultrasound (LIUS) applied to an adjuvant-induced arthritic rat model on the synovium was investigated.DesignSynovial inflammation was induced by complete Freund's adjuvant (CFA)-injection into the rat knee joint. LIUS (200 mW/cm2) was applied on the ipsilateral knee everyday for 10 min beginning 1 day after inflammation induction. The expression of proinflammatory factors and immunohistochemical staining pattern of the synovium were assessed.ResultsCFA induced an increase of the knee circumference that was significantly diminished by LIUS. Synovial membrane hyperplasia in the ipsilateral joint was also affected by LIUS. The inflammatory mediators, COX-1/2, IL-1β, and iNOS, but not TNF-α, in the synovial membrane were induced after 3 days, and they closely correlated with the degree of edema. In the synovial membrane, the expression of inflammatory mediators was reduced by LIUS. The chemoattractant chemokine receptor CCR5 also was involved. On immunohistochemical analysis, CFA caused increased infiltration of CD11b-positive cells in the synovium. After 3 days, neutrophils, myeloperoxidase (MPO)-positive cells filled the inflammatory core; later, monocytes and macrophages, ionized calcium binding adaptor molecule 1 (Iba1)-positive cells in the periphery infiltrated the core by day 5. LIUS markedly reduced CFA-induced inflammatory cells infiltration.ConclusionLIUS showed a potent anti-inflammatory effect in this animal arthritis model with reduced infiltration of inflammatory cells into the synovium
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AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals
Although previous studies have proposed plausible mechanisms of the activation of transforming growth factor-β-activated kinase 1 (TAK1) in inflammatory signals, including Toll-like receptors (TLRs), its activating kinase still remains to be unclear. In the present study, we have provided evidences that AMP-activated protein kinase (AMPK)-α1 has a pivotal role for activating TAK1, and thereby regulate NF-κB-dependent gene expressions in inflammatory signaling mediated by TLR4 and TNF-α stimulation. AMPK-α1 specifically interacts with TAK1 and reciprocally regulates their kinase activities. Upon the stimulation of lipopolysaccharide, AMPK-α1-knockdown (AMPK-) or TAK1-knockdown human monocytic THP-1 cells exhibit a dramatic reduction in the TAK1 or AMPK-α1 kinase activity, respectively, and subsequent suppressions of its downstream signaling cascades, which further leads to inhibitions of NF-κB and thereby productions of proinflammatory cytokines, such as TNF-α, IL-1β, and IL-6. Importantly, the microarray analysis of AMPK- cells revealed a dramatic reduction in the NF-κB-dependent genes induced by TLR4 and TNF-α stimulation, and the observation was in significant correlation with the results of quantitative real-time PCR. Moreover, AMPK- cells are highly sensitive to the TNF-α-induced apoptosis, which is accompanied with dramatic reductions in the NF-κB-dependent and anti-apoptotic genes. As a result, our data demonstrate that AMPK-α1 as an activating kinase of TAK1 has a key role in mediating inflammatory signals triggered by TLR4 and TNF-α
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