5,708 research outputs found
Entropy-based parametric estimation of spike train statistics
We consider the evolution of a network of neurons, focusing on the asymptotic
behavior of spikes dynamics instead of membrane potential dynamics. The spike
response is not sought as a deterministic response in this context, but as a
conditional probability : "Reading out the code" consists of inferring such a
probability. This probability is computed from empirical raster plots, by using
the framework of thermodynamic formalism in ergodic theory. This gives us a
parametric statistical model where the probability has the form of a Gibbs
distribution. In this respect, this approach generalizes the seminal and
profound work of Schneidman and collaborators. A minimal presentation of the
formalism is reviewed here, while a general algorithmic estimation method is
proposed yielding fast convergent implementations. It is also made explicit how
several spike observables (entropy, rate, synchronizations, correlations) are
given in closed-form from the parametric estimation. This paradigm does not
only allow us to estimate the spike statistics, given a design choice, but also
to compare different models, thus answering comparative questions about the
neural code such as : "are correlations (or time synchrony or a given set of
spike patterns, ..) significant with respect to rate coding only ?" A numerical
validation of the method is proposed and the perspectives regarding spike-train
code analysis are also discussed.Comment: 37 pages, 8 figures, submitte
Dissipative Dynamics of Collisionless Nonlinear Alfven Wave Trains
The nonlinear dynamics of collisionless Alfven trains, including resonant
particle effects is studied using the kinetic nonlinear Schroedinger (KNLS)
equation model. Numerical solutions of the KNLS reveal the dynamics of Alfven
waves to be sensitive to the sense of polarization as well as the angle of
propagation with respect to the ambient magnetic field. The combined effects of
both wave nonlinearity and Landau damping result in the evolutionary formation
of stationaryOA S- and arc-polarized directional and rotational
discontinuities. These waveforms are freqently observed in the interplanetary
plasma.Comment: REVTeX, 6 pages (including 5 figures). This and other papers may be
found at http://sdphpd.ucsd.edu/~medvedev/papers.htm
Insectos de la "una de gato" (Uncaria guianenesis y U. tomentosa : Rubiaceae), planta medical de la Amazonia peruana
Two species of #Rubiaceae$ known as "una de gato", vernaculate name, are medicinal plants very used in the Peruvian Amazonia. Its excessive exploitation in the natural environment has made its cultivation necessary. Different species of phytophagous insects have been observed on "una de gato" in an experimental plantation in Iquitos, Peru. (Résumé d'auteur
Convective Fingering of an Autocatalytic Reaction Front
We report experimental observations of the convection-driven fingering
instability of an iodate-arsenous acid chemical reaction front. The front
propagated upward in a vertical slab; the thickness of the slab was varied to
control the degree of instability. We observed the onset and subsequent
nonlinear evolution of the fingers, which were made visible by a {\it p}H
indicator. We measured the spacing of the fingers during their initial stages
and compared this to the wavelength of the fastest growing linear mode
predicted by the stability analysis of Huang {\it et. al.} [{\it Phys. Rev. E},
{\bf 48}, 4378 (1993), and unpublished]. We find agreement with the thickness
dependence predicted by the theory.Comment: 11 pages, RevTex with 3 eps figures. To be published in Phys Rev E,
[email protected], [email protected], [email protected]
Modification of the eikonal relation for chemical waves to include fluid flow
Propagating wave fronts resulting from autocatalytic chemical reactions have been the focus of much recent research. For the most part, the hydrodynamics resulting from such reactions has been neglected. In this work, a relation is derived for the normal speed of a propagating wave front as a function of the local curvature when fluid motion is allowed. This ‘‘eikonal’’ equation is a generalization of one which was derived in the absence of fluid flow. It is also shown that small variations in the fluid density due to the chemical reaction do not change the form of the relation
Back-engineering of spiking neural networks parameters
We consider the deterministic evolution of a time-discretized spiking network
of neurons with connection weights having delays, modeled as a discretized
neural network of the generalized integrate and fire (gIF) type. The purpose is
to study a class of algorithmic methods allowing to calculate the proper
parameters to reproduce exactly a given spike train generated by an hidden
(unknown) neural network. This standard problem is known as NP-hard when delays
are to be calculated. We propose here a reformulation, now expressed as a
Linear-Programming (LP) problem, thus allowing to provide an efficient
resolution. This allows us to "back-engineer" a neural network, i.e. to find
out, given a set of initial conditions, which parameters (i.e., connection
weights in this case), allow to simulate the network spike dynamics. More
precisely we make explicit the fact that the back-engineering of a spike train,
is a Linear (L) problem if the membrane potentials are observed and a LP
problem if only spike times are observed, with a gIF model. Numerical
robustness is discussed. We also explain how it is the use of a generalized IF
neuron model instead of a leaky IF model that allows us to derive this
algorithm. Furthermore, we point out how the L or LP adjustment mechanism is
local to each unit and has the same structure as an "Hebbian" rule. A step
further, this paradigm is easily generalizable to the design of input-output
spike train transformations. This means that we have a practical method to
"program" a spiking network, i.e. find a set of parameters allowing us to
exactly reproduce the network output, given an input. Numerical verifications
and illustrations are provided.Comment: 30 pages, 17 figures, submitte
Survey of Pest Management Practices on Washington Dairy Farms
Washington state dairy producers were surveyed to determine pest and parasite prevalence and range of current pest management strategies. Nearly all respondents reported treating their cattle or premises for flies, while 62% reported treating their animals for external parasites. Use of pyrethroid and pyrethrins insecticides was common throughout the state. Results indicated that use of non-chemical options to control flies are commonly used by Washington dairy producers and may have become more widespread since the late 1990s. Extension professionals could improve outreach education to dairies by partnering with farm supply stores, veterinarians, and feed distributors
Twisted topological structures related to M-branes
Studying the M-branes leads us naturally to new structures that we call
Membrane-, Membrane^c-, String^K(Z,3)- and Fivebrane^K(Z,4)-structures, which
we show can also have twisted counterparts. We study some of their basic
properties, highlight analogies with structures associated with lower levels of
the Whitehead tower of the orthogonal group, and demonstrate the relations to
M-branes.Comment: 17 pages, title changed on referee's request, minor changes to
improve presentation, typos correcte
Mini-DSAEK for Macro Corneal Perforations
PURPOSE: We present a technique that preserves good vision in paracentral macroperforations and avoids challenges of tectonic lamellar or penetrating keratoplasty in eyes with poor visual potential. METHOD: A wet laboratory was implemented for mini-Descemet stripping endothelial keratoplasty to seal macroperforations ab interno. This included a suture support technique designed to prevent graft herniation. We also present 3 cases who were treated successfully with this technique. RESULTS: The laboratory test confirmed that mini-Descemet stripping endothelial keratoplasty can successfully seal macroperforations without the need of large incisions. The minidisc is introduced through the perforation, and a double mattress suture prevents graft herniation. The technique allowed us to preserve 20/15 unaided vision in a case with paracentral macroperforation. It also restored eye globe integrity and achieved long-term stability in 2 cases with limbal stem-cell deficiency. CONCLUSIONS: Mini-Descemet stripping-automated endothelial keratoplasty technique can be an alternative approach to avoid poor visual outcomes of tectonic keratoplasty in paracentral perforations. It also offers host tissue preservation in eyes with high risk of rejection for tectonic grafts
Statistical analysis of quality control measurements in IMRT for head and neck and prostate cancer
Intensity Modulated Radiotherapy (IMRT) is a technique introduced to shape more precisely the dose distributions to the tumour, providing a higher dose escalation in the volume to irradiate and simultaneously decreasing the dose in the organs at risk which consequently reduces the treatment toxicity. This technique is widely used in prostate and head and neck (H&N) tumours. Given the complexity and the use of high doses in this technique it’s necessary to ensure as a safe and secure administration of the treatment, through the use of quality control programmes for IMRT. The purpose of this study was to evaluate statistically the quality control measurements that are made for the IMRT plans in prostate and H&N patients, before the beginning of the treatment, analysing their variations, the percentage of rejected and repeated measurements, the average, standard deviations and the proportion relations
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