199 research outputs found
Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.
Charge-State Equilibrium and Nonequilibrium Modeling of the Carbon-Pellet Plasma Interaction
Self-consistent equilibrium and nonequilibrium charge-state models are formulated for the spherical expansion of low-Z pellet vapor as an inviscid perfect gas of constant ratio of specific heats being heated volumetrically by the incident electrons of a thermonuclear plasma. The two models are found to be in agreement in the region where the ratio of the ionization length ζj to pellet radius rp is less than unity, but a single parameter, such as the magnitude of this ratio on the sonic surface, is insufficient to determine whether an equilibrium model will be valid for all regions of the ablatant for carbon pellets. Thus a nonequilibrium model is necessary to model the outer regions of the ablatant cloud even for thermonuclear plasma conditions when the cloud is very dense. Also, the effect of the ionization of the ablatant by the incident plasma electrons is found to be 10% or less for even the C+3 region in the thermonuclear regime. Finally, although the model used for the healing of the ablatant by the plasma electrons is that for a neutral carbon ablatant, it is shown that the differences in heating by the plasma electrons between this model and that for an ionized ablatant are small
Application of the Results of Carbon Pellet Modeling to The Problem of Plasma Penetration
The assumptions of the evaporation model for low-Z pellets interacting with magnetic fusion plasmas developed by Parks are tested. These assumptions are that the vapor density profile in the region adjacent to the pellet surface falls off with radial distance as r-α , where 5 \u3cα\u3c6, and that the ionization time for the transition between charge states זf (i.e., for r \u3c ~3 sonic radii). The first assumption is tested by solving a two-parameter eigenvalue problem for the evaporation cloud in the region interior to the sonic radius; the results are found to be consistent with the low-Z evaporation model. The second assumption, that זzi «זf, is tested at the sonic radius using the results from atomic physics and the low-Z evaporation model. It is found that indeed זzi «זf for plasmas with parameters close to thermonuclear conditions (e.g. CIT), but not for those of smaller Tokamaks such as TEXT. The results of pellet penetration calculations for the conditions of the carbon-pellet injection experiments into TEXT and low-density TFTR plasmas are presented that show better agreement with experiment if the shielding fraction is calculated at each step of the pellet penetration calculation, the effect of ionization is ignored, and if the effect of possible uncertainties in the background plasma parameters is included
1-(2-Hydroxy-5-methylphenyl)-3-(3-methylthiophen-2-yl)prop-2-en-1-one
In the structure of the title compound, C15H14O2S, the benzene ring is nearly coplanar with the thiophene ring. The hydroxy group substituted at C2 position is in an antiperiplanar conformation with respect to the phenyl ring. The crystal structure exhibits weak intramolecular O—H⋯O hydrogen bonding
The relationship between childhood body weight and dental caries experience:an umbrella systematic review protocol
Abstract Background Obesity and dental caries are global public health problems which can impact in childhood and throughout the life course. In simple terms, childhood dental caries and body weight are linked via the common risk factor of diet. An association between dental caries and obesity has been described in a number of studies and reviews. However, similarly, a relationship has also been noted between low body weight and caries experience in children. This protocol will provide the framework for an umbrella review to address the following question: Does the available evidence support a relationship between dental caries experience and body weight in the child population? Methods This review protocol outlines the process to carry out an umbrella systematic review which will synthesise previous reviews of childhood dental caries experience and body weight. An umbrella review methodology will be used to examine the methodological and reporting quality of existing reviews. Discussion The final umbrella review aims to aggregate the available evidence in order to provide a summary for policymakers and to inform healthcare interventions. Systematic review registration PROSPERO CRD4201604730
Fear causes tears - Perineal injuries in home birth settings. A Swedish interview study
<p>Abstract</p> <p>Background</p> <p>Perineal injury is a serious complication of vaginal delivery that has a severe impact on the quality of life of healthy women. The prevalence of perineal injuries among women who give birth in hospital has increased over the last decade, while it is lower among women who give birth at home. The aim of this study was to describe the practice of midwives in home birth settings with the focus on the occurrence of perineal injuries.</p> <p>Methods</p> <p>Twenty midwives who had assisted home births for between one and 29 years were interviewed using an interview guide. The midwives also had experience of working in a hospital delivery ward. All the interviews were tape-recorded and transcribed. Content analysis was used.</p> <p>Results</p> <p>The overall theme was "No rushing and tearing about", describing the midwives' focus on the natural process taking its time. The subcategories 1) preparing for the birth; 2) going along with the physiological process; 3) creating a sense of security; 4) the critical moment and 5) midwifery skills illuminate the management of labor as experienced by the midwives when assisting births at home.</p> <p>Conclusions</p> <p>Midwives who assist women who give birth at home take many things into account in order to minimize the risk of complications during birth. Protection of the woman's perineum is an act of awareness that is not limited to the actual moment of the pushing phase but starts earlier, along with the communication between the midwife and the woman.</p
Body mass index and dental caries in children and adolescents : a systematic review of literature published 2004 to 2011
The objectiveThe authors undertook an updated systematic review of the relationship between body mass index and dental caries in children and adolescents.MethodThe authors searched Medline, ISI, Cochrane, Scopus, Global Health and CINAHL databases and conducted lateral searches from reference lists for papers published from 2004 to 2011, inclusive. All empirical papers that tested associations between body mass index and dental caries in child and adolescent populations (aged 0 to 18 years) were included.ResultsDental caries is associated with both high and low body mass index.ConclusionA non-linear association between body mass index and dental caries may account for inconsistent findings in previous research. We recommend future research investigate the nature of the association between body mass index and dental caries in samples that include a full range of body mass index scores, and explore how factors such as socioeconomic status mediate the association between body mass index and dental caries.<br /
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a broad range of traits. We found that hitherto unpublished genes were as likely to reveal phenotypes as known genes, suggesting that novel genes represent a rich resource for investigating the molecular basis of disease. We found many unexpected phenotypes detected only because we screened for them, emphasizing the value of screening all mutants for a wide range of traits. Haploinsufficiency and pleiotropy were both surprisingly common. Forty-two percent of genes were essential for viability, and these were less likely to have a paralog and more likely to contribute to a protein complex than other genes. Phenotypic data and more than 900 mutants are openly available for further analysis. PAPERCLIP
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