A mechanistic-empirical based overlay design method for reflective cracking

This paper describes a new and innovative mechanistically based pavement overlay design method that considers the most predominant type of overlay distress observed in the field: Reflective cracking above old cracks in the underlying pavement surface. Both dense-graded hot mix asphalt and gap-graded asphalt rubber (wet process) mixes were studied, in the laboratory and in the field, to derive the necessary mechanistic relationships and statistically based equations. The models proposed are based on a finite element model that closely approximates actual field phenomena. Many field test sections, in Arizona, California and Portugal, were studied during the course of the research. Other HMA mixes used for overlays may also be calibrated and used through the proposed method. However, the relevant mix properties of any additional materials or environmental zones must first be determined. The two mix types studied are mainly used in the desert southwest region of Arizona and California. The overlay design program is available from the Rubber Pavements Association or Arizona Department of Transportation in the form of an Excel spreadsheet with an easy-to-use visual basic computer program (macro)

X-ray Over-Luminous Elliptical Galaxies: A New Class of Mass Concentrations in the Universe?

We detect four isolated, X-ray over-luminous (Lx>2e43 [h/0.5]**-2 erg/s) elliptical galaxies (OLEGs) in our 160 square degree ROSAT PSPC survey. The extent of their X-ray emission, total X-ray luminosity, total mass, and mass of the hot gas in these systems correspond to poor clusters, and the optical luminosity of the central galaxies (M_R<-22.5 + 5 lg h) is comparable to that of cluster cDs. However, there are no detectable fainter galaxy concentrations around the central elliptical. The mass-to-light ratio within the radius of detectable X-ray emission is in the range 250-450 Msun/Lsun, which is 2-3 times higher than typically found in clusters or groups. These objects can be the result of galaxy merging within a group. However, their high M/L values are difficult to explain in this scenario. OLEGs must have been undisturbed for a very long time, which makes them the ultimate examples of systmes in hydrostatic equilibrium. The number density of OLEGs is n=2.4(+3.1-1.2}x10**-7 (h/0.5)**-3 Mpc**-3 at the 90% confidence. They comprise 20% of all clusters and groups of comparable X-ray luminosity, and nearly all galaxies brighter than M_R=-22.5. The estimated contirubution of OLEGs to the total mass density in the Universe is close to that of T>7 keV clusters.Comment: 4 pages, 2 figures, uses emulateapj.sty, submitted to ApJ Letter

Note and Comment

The Ownership of Sunken Logs; Combination Among Physicians to Fix Prices for Professional Services; The Issuance of Receivers\u27 Certificates to pay Interest, Etc.; The Federal Constitution is Not Violated by a State Law Compelling one Accused of Crime to Testify Against Himself; Transfer of Negotiable Instrument Without Endorsemen

Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.

CD38 genetic variation has been associated with autism spectrum disorders and social anxiety disorder, which may result from CD38's regulation of oxytocin secretion. Converging evidence has found that the rs3796863 A-allele contributes to increased social sensitivity compared to the CC genotype. The current study examined the moderating role of CD38 genetic variants (rs3796863 and rs6449182) that have been associated with enhanced (or reduced) social sensitivity on neural activation related to neuroticism, which is commonly elevated in individuals with social anxiety and depression. Adults (n = 72) with varying levels of social anxiety and depression provided biological samples for DNA extraction, completed a measure of neuroticism, and participated in a standardized emotion processing task (affect matching) while undergoing fMRI. A significant interaction effect was found for rs3796863 x neuroticism that predicted right amygdala-subgenual anterior cingulate cortex (sgACC) functional connectivity. Simple slopes analyses showed a positive association between neuroticism and right amygdala-sgACC connectivity among rs3796863 A-allele carriers. Findings suggest that the more socially sensitive rs3796863 A-allele may partially explain the relationship between a known risk factor (i.e. neuroticism) and promising biomarker (i.e. amygdala-sgACC connectivity) in the development and maintenance of social anxiety and depression

Novel Methods for Predicting Photometric Redshifts from Broad Band Photometry using Virtual Sensors

We calculate photometric redshifts from the Sloan Digital Sky Survey Main Galaxy Sample, The Galaxy Evolution Explorer All Sky Survey, and The Two Micron All Sky Survey using two new training-set methods. We utilize the broad-band photometry from the three surveys alongside Sloan Digital Sky Survey measures of photometric quality and galaxy morphology. Our first training-set method draws from the theory of ensemble learning while the second employs Gaussian process regression both of which allow for the estimation of redshift along with a measure of uncertainty in the estimation. The Gaussian process models the data very effectively with small training samples of approximately 1000 points or less. These two methods are compared to a well known Artificial Neural Network training-set method and to simple linear and quadratic regression. Our results show that robust photometric redshift errors as low as 0.02 RMS can regularly be obtained. We also demonstrate the need to provide confidence bands on the error estimation made by both classes of models. Our results indicate that variations due to the optimization procedure used for almost all neural networks, combined with the variations due to the data sample, can produce models with variations in accuracy that span an order of magnitude. A key contribution of this paper is to quantify the variability in the quality of results as a function of model and training sample. We show how simply choosing the "best" model given a data set and model class can produce misleading results.Comment: 36 pages, 12 figures, ApJ in Press, modified to reflect published version and color figure

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

BACKGROUND: Filaggrin, encoded by the FLG gene, is an important component of the skin’s barrier to the external environment and genetic defects in FLG strongly associate with Atopic Dermatitis (AD). However, not all AD patients have FLG mutations. OBJECTIVE: We hypothesised that these patients may possess other defects in filaggrin expression and processing, contributing to barrier disruption and AD, and therefore present novel therapeutic targets for this disease. RESULTS: We describe the relationship between the mTORC1 protein subunit RAPTOR, the serine/threonine kinase AKT1 and the protease cathepsin H, for which we establish a role in filaggrin expression and processing. Increased RAPTOR levels correlated with decreased filaggrin expression in AD. In keratinocyte cell culture, RAPTOR up-regulation or AKT1 shRNA knockdown reduced the expression of the protease cathepsin H. Skin of cathepsin H-deficient mice and CTSH shRNA knockdown keratinocytes showed reduced filaggrin processing and the mouse showed both impaired skin barrier function and a mild proinflammatory phenotype. CONCLUSION: Our findings highlight a novel, potentially treatable, signalling axis controlling filaggrin expression and processing which is defective in AD

Components of Antineutrino Emission in Nuclear Reactor

New ${\bar{\nu}_e},e$ scattering experiments aimed for sensitive searches of the ${\nu}_e$ magnetic moment and projects to explore small mixing angle oscillations at reactors call for a better understanding of the reactor antineutrino spectrum. Here we consider six components, which contribute to the total ${\bar{\nu}_e}$ spectrum generated in nuclear reactor. They are: beta decay of the fission fragments of $^{235}$U, $^{239}$Pu, $^{238}$U and $^{241}$Pu, decay of beta-emitters produced as a result of neutron capture in $^{238}$U and also due to neutron capture in accumulated fission fragments which perturbs the spectrum. For antineutrino energies less than 3.5 MeV we tabulate evolution of ${\bar{\nu}_e}$ spectra corresponding to each of the four fissile isotopes vs fuel irradiation time and their decay after the irradiation is stopped and also estimate relevant uncertainties. Small corrections to the ILL spectra are considered.Comment: LaTex 8 pages, 2 ps figure

Moisture susceptibility of high and low compaction dry process crumb rubber modified asphalt mixtures

The field performance of dry process crumb rubber-modified (CRM) asphalt mixtures has been reported to be inconsistent with stripping and premature cracking on the surfacing. One of the concerns is that, because achieving field compaction of CRM material is difficult due to the inherent resilient nature of the rubber particle, nonuniform field compaction may lead to a deficient bond between rubber and bitumen. To assess the influence of compaction, a series of CRM and control mixtures was produced and compacted at two levels: 4% (low, optimum laboratory compaction) and 8% (high, field experience) air void content. The long-term durability, in regard to moisture susceptibility of the mixtures, was assessed by conducting repeated moisture conditioning cycles. Mechanical properties (stiffness, fatigue, and resistance to permanent deformation) were determined in the Nottingham Asphalt Tester. Results indicated that compared with conventional mixtures, the CRM mixtures, regardless of compaction effort, are more susceptible to moisture with the degree of susceptibility primarily depending on the amount of rubber in the mixture, rather than the difference in compaction. This behavior is different from that of conventional mixtures in which, as expected, poorly compacted mixtures were found to be more susceptible to moisture than were well-compacted mixtures

Tides on Other Earths: Implications for Exoplanet and Palaeo-Tidal Simulations

A key controller of a planet's rotational evolution, and hence habitability, is tidal dissipation, which on Earth is dominated by the ocean tides. Because exoplanet or deep‐time Earth topographies are unknown, a statistical ensemble is used to constrain possible tidal dissipation rates on an Earth‐like planet. A dedicated tidal model is used together with 120 random continental configurations to simulate Earth's semidiurnal lunar tide. The results show a possible ocean tidal dissipation range spanning 3 orders of magnitude, between 2.3 GWto 1.9 TW (1 TW=1012 W). When model resolution is considered, this compares well with theoretical limits derived for the energetics of Earth's present‐day deep ocean. Consequently, continents exert a fundamental control on tidal dissipation rates and we suggest that plate tectonics on a planet will induce a time‐varying dissipation analogous to Earth's. This will alter rotational periods over millions of years and further complicate the role of tides for planetary evolution. Plain Language Summary The daylength of a planet is key for habitability because it regulates the rate with which solar radiation is received and redistributed at the surface. A main controller of a planet's daylength is the ocean tide, because the dissipation of tidal energy works as a brake on the planet's spin, increasing the daylength. Tides are sensitive to the continental arrangement on a planet, but there are no details of the surface of any exoplanet and only limited information of what Earth looked like in the distant past. The change in Earth's daylength forces the Moon to recede into a higher orbit, but the present‐day recession rate is very high and does not fit our age models of the moon, implying that the tides must have been much weaker in the distant past. Here, we use a series of tidal predictions for random continental configurations of Earth to provide a range of tidal dissipation rates and thus an estimate of how the tides in the deep past may have evolved as Earth's continents grew more and more complex. This research also provides a range of dissipation rates that can be used for simulations of the rotational and orbital evolution of exoplanets