HABILIDADES DE RACIOCÍNIO CRÍTICO DE ALUNOS DE CONTABILIDADE

Educational systems around the world judge student academic performance based upon reading and writing abilities, with evidence of critical thinking playing an essential role. In order to improve business education, a better understanding of students’ critical thinking and communication skill is required. This study aimed at assessing reading, writing, and critical thinking skills of accounting students using validated instruments: (a) Motivated Strategies for Learning Questionnaire, (b) Ennis-Weir Critical Thinking Essay Test, and (c) Flesch Reading Ease (English and Portuguese). Students wrote a short essay that was evaluated for writing quality and critical thinking based on the EW-CTET. Scores provided indications of good writing quality and evidence of high levels of critical thinking. No significant differences (i.e., gender, parenthood, program level, and program stage) of measured reading levels of the written products were found. Elements for improving learners’ performance aligned with their critical thinking skills are discussed along with a deep reflection on how educators would behave as agents of change in the reported scenario. Observed cultural differences in critical thinking related to perception of authority should be examined in further investigations.Sistemas educacionales alrededor del mundo evalúan el desempeño académico de los alumnos con base en habilidades de lectura y redacción, con evidencias sobre el papel esencial del raciocinio crítico. Para mejorar la educación en el área de negocios es necesario mejor entendimiento sobre el raciocinio crítico de los alumnos, así como sobre sus habilidades de comunicación. Esta investigación se centró en la evaluación de habilidades de lectura, redacción y raciocinio crítico de alumnos de contabilidad utilizando instrumentos validados: (a) Cuestionario de Estrategias Motivadoras para Aprendizaje (Motivated Strategies for Learning Questionnaire, MSLQ), (b) Prueba Escrita de Raciocinio Crítico de Ennis-Weir (Ennis-Weir Critical Thinking Essay Test, EW-CTET), y (c) Indicador Flesch de Facilidad de Lectura (Flesch Reading Ease, en Inglés y versión adaptada al Portugués). Los participantes escribieron una pequeña redacción que fue evaluada en términos de calidad de escrita y de raciocinio crítico con base en el EW-CTET. Los resultados mostraron la buena calidad de la escrita e hicieron evidentes los niveles elevados de raciocinio crítico. Diferencias significativas (por ejemplo: género, maternidad / paternidad, nivel de estudios, y nivel en el programa) no fueron observadas en las métricas sobre niveles de facilidad de lectura de los productos escritos generados por los participantes. Elementos para la mejora del desempeño de los participantes alineados con sus habilidades de raciocinio crítico son discutidos juntamente con la reflexión profunda sobre el comportamiento de educadores como agentes de cambio en este escenario. Se sugiere que las diferencias culturales sobre raciocinio crítico observadas en este estudio relacionadas con la percepción de autoridad sean examinadas en futuras investigaciones.Sistemas educacionais ao redor do mundo avaliam o desempenho acadêmico de alunos com base em habilidades de leitura e redação, com evidências sobre o papel essencial do raciocínio crítico. Para aprimorar a educação na área de negócios é necessário melhor entendimento sobre o raciocínio crítico dos alunos, bem como sobre suas habilidades de comunicação. Esta pesquisa focou na avaliação de habilidades de leitura, redação e raciocínio crítico de alunos de contabildiade utilizando instrumentos validados: (a) Questionário de Estratégias Motivadoras para Aprendizagem (Motivated Strategies for Learning Questionnaire, MSLQ), (b) Teste Escrito de Raciocínio Crítico de Ennis-Weir (Ennis-Weir Critical Thinking Essay Test, EW-CTET), e (c) Indicador Flesch de Facilidade de Leitura (Flesch Reading Ease, em Inglês e versão adaptada para o Português). Os participantes escreveram uma pequena redação que foi avaliada em termos de qualidade de escrita e raciocínio crítico com base no EW-CTET. Os resultados trouxeram indicações de boa qualidade de escrita e evidência de níveis elevados de raciocínio crítico. Diferenças significativas (e.g., gênero, maternidade/paternidade, nível de estudos, e estágio no programa) não foram observadas nas métricas sobre níveis de facilidade de leitura dos produtos escritos gerados pelos participantes. Elementos para o aprimoramento de desempenho dos participantes alinhados com suas habilidades de raciocínio crítico são discutidos juntamente com reflexão profunda sobre comportamento de educadores como agentes de mudança neste cenário. Sugere-se que diferenças culturais sobre raciocínio crítico observadas neste estudo relacionadas com a percepção de autoridade sejam examinadas em futuras investigações

ARC‐1, a sequence element complementary to an internal 18S rRNA segment, enhances translation efficiency in plants when present in the leader or intercistronic region of mRNAs

The sequences of different plant viral leaders with known translation enhancer ability show partial complementarity to the central region of 18S rRNA. Such complementarity might serve as a means to attract 40S ribosomal subunits and explain in part the translation‐enhancing property of these sequences. To verify this notion, we designed β‐glucuronidase (GUS) mRNAs differing only in the nature of 10 nt inserts in the center of their 41 base leaders. These were complementary to consecutive domains of plant 18S rRNA. Sucrose gradient analysis revealed that leaders with inserts complementary to regions 1105-1114 and 1115-1124 (‘ARC‐1') of plant 18S rRNA bound most efficiently to the 40S ribosomal subunit after dissociation from 80S ribosomes under conditions of high ionic strength, a treatment known to remove translation initiation factors. Using wheat germ cell‐free extracts, we could demonstrate that mRNAs with these leaders were translated more than three times more efficiently than a control lacking such a complementarity. Three linked copies of the insert enhanced translation of reporter mRNA to levels comparable with those directed by the natural translation enhancing leaders of tobacco mosaic virus and potato virus Y RNAs. Moreover, inserting the same leaders as intercistronic sequences in dicistronic mRNAs substantially increased translation of the second cistron, thereby revealing internal ribosome entry site activity. Thus, for plant systems, the complementary interaction between mRNA leader and the central region of 18S rRNA allows cap‐independent binding of mRNA to the 43S pre‐initiation complex without assistance of translation initiation factor

Occult axillary node metastases in breast cancer: their detection and prognostic significance.

Although the presence of axillary node metastases in breast cancer is a key prognostic indicator and may influence treatment decisions, a significant proportion of patients diagnosed as axillary node negative (ANN) using standard histopathological techniques may have occult nodal metastases (OMs). A combination of limited step-sectioning (4 x 100 microns intervals) and immunohistochemical staining (with cytokeratin (MNF.116) and MUC1 (BC2) antibodies) was used to detect OM in a retrospective series of 208 ANN patients. OMs were found in 53 patients (25%), and both step-sectioning and immunohistochemical detection significantly improved detection (P < 0.05). Detection using BC2 (25%) was superior to MNF.116 (18%) and haematoxylin and eosin (H&E) (8%). OMs were found in 51 patients using only the first and deepest sectioning levels and BC2 staining. OMs were more frequently found in lobular (38%) than ductal carcinoma (25%), and more frequently in women less than 50 years (41%) than in older women (19%). Univariate overall and disease-free survival analyses showed that the presence, size and number of OM had prognostic significance as did tumour size (disease-free only) and histological and nuclear grade (P > 0.05). Cox multivariate proportional hazard regression analyses showed that the presence and increasing size of OMs were significantly associated with poorer disease-free survival, independently of other prognostic factors (P < 0.05). However there was not a significant independent association of the presence of occult metastases with overall survival (P = 0.11). These findings have important implications with regard to selection of ANN patients for adjuvant therapy

Imaging stress and magnetism at high pressures using a nanoscale quantum sensor

Pressure alters the physical, chemical and electronic properties of matter. The development of the diamond anvil cell (DAC) enables tabletop experiments to investigate a diverse landscape of high-pressure phenomena ranging from the properties of planetary interiors to transitions between quantum mechanical phases. In this work, we introduce and utilize a novel nanoscale sensing platform, which integrates nitrogen-vacancy (NV) color centers directly into the culet (tip) of diamond anvils. We demonstrate the versatility of this platform by performing diffraction-limited imaging (~600 nm) of both stress fields and magnetism, up to pressures ~30 GPa and for temperatures ranging from 25-340 K. For the former, we quantify all six (normal and shear) stress components with accuracy $<0.01$ GPa, offering unique new capabilities for characterizing the strength and effective viscosity of solids and fluids under pressure. For the latter, we demonstrate vector magnetic field imaging with dipole accuracy $<10^{-11}$ emu, enabling us to measure the pressure-driven $\alpha\leftrightarrow\epsilon$ phase transition in iron as well as the complex pressure-temperature phase diagram of gadolinium. In addition to DC vector magnetometry, we highlight a complementary NV-sensing modality using T1 noise spectroscopy; crucially, this demonstrates our ability to characterize phase transitions even in the absence of static magnetic signatures. By integrating an atomic-scale sensor directly into DACs, our platform enables the in situ imaging of elastic, electric and magnetic phenomena at high pressures.Comment: 18 + 50 pages, 4 + 19 figure

100 kV Schottky electron gun

We present a comparison between experimental results and computer calculations on a high current, high resolution single lens electrostatic 100 kV Schottky electron gun. One promising application for such an electron gun is for direct electron‐beam patterning of x‐ray masks. The high energy helps provide precise patterning of the thick resist, maintains vertical resist profiles, and minimizes the proximity effect. The gun was designed to operate from 25 to 100 kV, capable of focus at a distance of 145–245 mm with a magnification of 1.15. The emitter, of apex radius ∼0.6 μm operated at 1800 K in the extended Schottky regime, provides an angular intensity of 0.5 mA/sr for an extraction voltage of 5000 V and with a beam limiting aperture of 2.2 mrad, the gun delivers 7 nA of probe current. The gun consists of a replaceable high voltage optic module mounted on a precision insulator with the main acceleration occurring between the exit of the optic module and the grounded anode. A provision is made for alignment of the emitter with respect to the central optical axis of the optic module in a special alignment chamber eliminating the need for high voltage emitter alignment. Final gun alignment is achieved by X–Y motion of the grounded anodeaperture. The gun is constructed to allow ease of replacement of the emitter, the beam defining aperture, and the differential pumping aperture. The beam supply has 10 ppm of ripple while lens supplies have supply, cabling, connectors,insulator, and optic module draw 1 μA of ground leakage current. Pressured SF6 chambers are used for high voltage connector interfaces within the power supply and on the gun

Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses

Efforts to assess the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and chronic fatigue syndrome have relied heavily on PCR-based testing of clinical samples and have yielded widely divergent findings. This week in Retrovirology, reports from four independent research groups illustrate the extreme care needed to exclude DNA or RNA contamination in PCR analyses of XMRV. In addition, phylogenetic evidence suggesting that previously-published XMRV sequences originated from a commonly-used prostate carcinoma cell line (22Rv1) is presented. These findings raise important questions regarding the provenance of XMRV and its potential connection to human disease

High rates of carbon and dinitrogen fixation suggest a critical role of benthic pioneer communities in the energy and nutrient dynamics of coral reefs

Following coral mortality in tropical reefs, pioneer communities dominated by filamentous and crustose algae efficiently colonize substrates previously occupied by coral tissue. This phenomenon is particularly common after mass coral mortality following prolonged bleaching events associated with marine heatwaves. Pioneer communities play an important role for the biological succession and reorganization of reefs after disturbance. However, their significance for critical ecosystem functions previously mediated by corals, such as the efficient cycling of carbon (C) and nitrogen (N) within the reef, remains uncertain. We used 96 carbonate tiles to simulate the occurrence of bare substrates after disturbance in a coral reef of the central Red Sea. We measured rates of C and dinitrogen (N-2) fixation of pioneer communities on these tiles monthly over an entire year. Coupled with elemental and stable isotope analyses, these measurements provide insights into macronutrient acquisition, export and the influence of seasonality. Pioneer communities exhibited high rates of C and N(2)fixation within 4-8 weeks after the introduction of experimental bare substrates. Ranging from 13 to 25 mu mol C cm(-2) day(-1)and 8 to 54 nmol N cm(-2) day(-1), respectively, C and N(2)fixation rates were comparable to reported values for established Red Sea coral reefs. This similarity indicates that pioneer communities may quickly compensate for the loss of benthic productivity by corals. Notably, between 40% and 85% of fixed organic C was exported into the environment, constituting a vital source of energy for the coral reef food web. Our findings suggest that benthic pioneer communities may play a crucial, yet overlooked role in the C and N dynamics of oligotrophic coral reefs by contributing to the input of new C and N after coral mortality. While not substituting other critical ecosystem functions provided by corals (e.g. structural habitat complexity and coastal protection), pioneer communities likely contribute to maintaining coral reef nutrient cycling through the accumulation of biomass and import of macronutrients following coral loss. A freePlain Language Summarycan be found within the Supporting Information of this article.Peer reviewe

A Fokker-Planck formalism for diffusion with finite increments and absorbing boundaries

Gaussian white noise is frequently used to model fluctuations in physical systems. In Fokker-Planck theory, this leads to a vanishing probability density near the absorbing boundary of threshold models. Here we derive the boundary condition for the stationary density of a first-order stochastic differential equation for additive finite-grained Poisson noise and show that the response properties of threshold units are qualitatively altered. Applied to the integrate-and-fire neuron model, the response turns out to be instantaneous rather than exhibiting low-pass characteristics, highly non-linear, and asymmetric for excitation and inhibition. The novel mechanism is exhibited on the network level and is a generic property of pulse-coupled systems of threshold units.Comment: Consists of two parts: main article (3 figures) plus supplementary text (3 extra figures

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence

Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody. Consequently, each year a new vaccine must be developed to combat the current recirculating strains. A universal influenza vaccine that primes specific memory cells that recognise conserved parts of the virus could prove to be effective against both annual influenza variants and newly emergent potentially pandemic strains. Such a vaccine will have to contain a safe and effective adjuvant that can be used in individuals of all ages. We examine protection from viral challenge in mice vaccinated with the nucleoprotein from the PR8 strain of influenza A, a protein that is highly conserved across viral subtypes. Vaccination with nucleoprotein delivered with a universally used and safe adjuvant, composed of insoluble aluminium salts, provides protection against viruses that either express the same or an altered version of nucleoprotein. This protection correlated with the presence of nucleoprotein specific CD8 T cells in the lungs of infected animals at early time points after infection. In contrast, immunization with NP delivered with alum and the detoxified LPS adjuvant, monophosphoryl lipid A, provided some protection to the homologous viral strain but no protection against infection by influenza expressing a variant nucleoprotein. Together, these data point towards a vaccine solution for all influenza A subtypes