AN OVERVIEW ON THE BIOLOGICAL PERSPECTIVES OF SIDA CORDIFOLIA LINN

Plants have been used since ancient times to heal and cure diseases and to improve health and well being. Sida cordifolia Linn belonging to family Malvaceae is widely distributed throughout the plains of India. The various parts of Sida cordifolia possess different biological perspectives such as antidiabetic, anti stress, anti-inflammatory, analgesic, hepatoprotective and anticancer activity. This plant has great potential for development of ayurvedic and modern medicines. The present study is focused on pharmacological review of Sida cordifolia L

SKILL ACQUISITION FOR ENHANCING EMPLOYABILITY THROUGH MULTIPLE LEARNING EXPERIENCE INSTRUCTIONAL STRATEGY (MLEIS) – TOWARDS ENSURING INCLUSIVE AND EQUITABLE TECHNOLOGY EDUCATION

Matching skills to jobs has long been one of the important goals of education. The National Employability Report (2016) has highlighted the fact that engineering graduates do not fulfill the basic criteria of employability. It has been reported the current strategies do not address multiple modes and levels of numeracy, programming, computer literacy, algorithm and programming. It was revealed that students find certain subjects quite difficult and the objective based achievement test revealed failure to realize learning objectives and learning outcomes. Theory based instructional strategies and lecture mode of instructional delivery has been found to be not suited for engineering education [1]. In this study, the effectiveness of a Multiple Learning Experience based Instructional strategy (MLEIS) is explored. MLEIS is based on theories of learning, instruction design, learning styles and techno pedagogies. MLEIS envisages a skill based curricular strategy which addresses diversity, inclusiveness focusing on aspects like skill development, skill acquisition, professional competency and subject comprehension.  Article visualizations

Dual Tree Complex Wavelet based Regularized Deconvolution for Medical Images

Deblurring in the presence of noise is a hard problem, especially in Ultrasound and CT images. In this paper, we propose a hybrid approach of wavelet-based image deconvolution that incorporates Fourier-domain system inversion followed by wavelet-domain noise suppression. In contrast to conventional wavelet-based deconvolution methods, the algorithm employs a regularized inverse filter to operate when the system is non-invertible as well as exploits the properties of dual tree complex wavelet transform (DT-CWT) to remove blur and noise without the need for assuming a specific noise model. Furthermore, the proposed approach uses an adaptive shrinkage function based on median, mean and standard deviation of wavelet coefficients to suppress noise while preserving the sharpness of the image. Its application on ultrasound and CT images has shown a clear improvement over alternative methods

Combinational siRNA Delivery Using Hyaluronic Acid Modified Amphiphilic Polyplexes Against Cell Cycle and Phosphatase Proteins to Inhibit Growth and Migration of Triple-Negative Breast Cancer Cells

Triple-negative breast cancer is an aggressive form of breast cancer with few therapeutic options if it recurs after adjuvant chemotherapy. RNA interference could be an alternative therapy for metastatic breast cancer, where small interfering RNA (siRNA) can silence the expression of aberrant genes critical for growth and migration of malignant cells. Here, we formulated a siRNA delivery system using lipid-substituted polyethylenimine (PEI) and hyaluronic acid (HA), and characterized the size, ζ-potential and cellular uptake of the nanoparticulate delivery system. Higher cellular uptake of siRNA by the tailored PEI/HA formulation suggested better interaction of complexes with breast cancer cells due to improved physicochemical characteristics of carrier and HA-binding CD44 receptors. The siRNAs against specific phosphatases that inhibited migration of MDA-MB-231 cells were then identified using library screen against 267 protein-tyrosine phosphatases and siRNAs to inhibit cell migration were further validated. We then assessed the combinational delivery of a siRNA against CDC20 to decrease cell growth and a siRNA against several phosphatases shown to decrease migration of breast cancer cells. Combinational siRNA therapy against CDC20 and identified phosphatases PPP1R7, PTPN1, PTPN22, LHPP, PPP1R12A and DUPD1 successfully inhibited cell growth and migration, respectively, without interfering with the functional effect of the co-delivered siRNA. The identified phosphatases could serve as potential targets to inhibit migration of highly aggressive metastatic breast cancer cells. Combinational siRNA delivery against cell cycle and phosphatases could be a promising strategy to inhibit both growth and migration of metastatic breast cancer cells, and potentially other types of metastatic cancer

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Not AvailableAPMS 6B is the stable maintainer of the CMS line APMS 6A, which is the female parent of the popular Indian rice hybrid DRRH 3. APMS 6B has good combining ability and plant stature but is highly susceptible to bacterial blight (BB) disease. In order to improve the BB resistance of APMS 6B, we pyramided two major, dominant BB resistance genes, Xa21 and Xa38, through marker-assisted backcross breeding (MABB). Improved Samba Mahsuri (ISM) was used as the donor for Xa21 while PR 114 (Xa38) served as the donor for Xa38. Individual crosses [APMS 6B/ISM and APMS 6B/PR 114 (Xa38)] were performed, and true F1 plants were then backcrossed with APMS 6B and the MABB process was continued till BC3. A single positive BC3F1 plant identified from both the crosses with maximum genotypic and phenotypic similarity with APMS 6B was selfed to generate BC3F2s. At BC3F2 generation, plants homozygous for either Xa21 or Xa38 were identified and further confirmed for the absence of two major fertility restorer genes, Rf3 and Rf4. A single such homozygous BC3F2 plant, each from both the crosses, was then inter-mated to generate ICF1s (inter-cross F1s). Selected ICF1 plants possessing both the BB resistance genes were selfed to generate ICF2s. A total of 42 ICF2 plants homozygous for both Xa21 and Xa38 were identified and screened with parental polymorphic SSR markers to identify the best F2 plants having the maximum recurrent parent genome recovery. Twelve best ICF2 plants were advanced up to ICF5. The ICF5 lines displayed very high level of BB resistance and were similar to APMS 6B in terms of agro-morphological characters. Further, most of these lines also showed complete maintenance ability and such lines are being advanced for conversion to WA-CMS lines.Not Availabl

Not Available

Not AvailableAPMS 6B is the stable maintainer of the CMS line APMS 6A, which is the female parent of the popular Indian rice hybrid DRRH 3. APMS 6B has good combining ability and plant stature but is highly susceptible to bacterial blight (BB) disease. In order to improve the BB resistance of APMS 6B, we pyramided two major, dominant BB resistance genes, Xa21 and Xa38, through marker-assisted backcross breeding (MABB). Improved Samba Mahsuri (ISM) was used as the donor for Xa21 while PR 114 (Xa38) served as the donor for Xa38. Individual crosses [APMS 6B/ISM and APMS 6B/PR 114 (Xa38)] were performed, and true F1 plants were then backcrossed with APMS 6B and the MABB process was continued till BC3. A single positive BC3F1 plant identified from both the crosses with maximum genotypic and phenotypic similarity with APMS 6B was selfed to generate BC3F2s. At BC3F2 generation, plants homozygous for either Xa21 or Xa38 were identified and further confirmed for the absence of two major fertility restorer genes, Rf3 and Rf4. A single such homozygous BC3F2 plant, each from both the crosses, was then inter-mated to generate ICF1s (inter-cross F1s). Selected ICF1 plants possessing both the BB resistance genes were selfed to generate ICF2s. A total of 42 ICF2 plants homozygous for both Xa21 and Xa38 were identified and screened with parental polymorphic SSR markers to identify the best F2 plants having the maximum recurrent parent genome recovery. Twelve best ICF2 plants were advanced up to ICF5. The ICF5 lines displayed very high level of BB resistance and were similar to APMS 6B in terms of agro-morphological characters. Further, most of these lines also showed complete maintenance ability and such lines are being advanced for conversion to WA-CMS linesICAR, DB