Information system for image classification based on frequency curve proximity

With the size digital collections are currently reaching, retrieving the best match of a document from large collections by comparing hundreds of tags is a task that involves considerable algorithm complexity, even more so if the number of tags in the collection is not fixed. For these cases, similarity search appears to be the best retrieval method, but there is a lack of techniques suited for these conditions. This work presents a combination of machine learning algorithms put together to find the most similar object of a given one in a set of pre-processed objects based only on their metadata tags. The algorithm represents objects as character frequency curves and is capable of finding relationships between objects without an apparent association. It can also be parallelized using MapReduce strategies to perform the search. This method can be applied to a wide variety of documents with metadata tags. The case-study used in this work to demonstrate the similarity search technique is that of a collection of image objects in JavaScript Object Notation (JSON) containing metadata tags.This work has been done in the context of the project “ASASEC (Advisory System Against Sexual Exploitation of Children)” (HOME/2010/ISEC/AG/043) supported by the European Union with the program “Prevention and fight against crime”.info:eu-repo/semantics/publishedVersio

Subduction initiation in the Scotia Sea region and opening of the Drake Passage: When and why?

During evolution of the South Sandwich subduction zone, which has consumed South American Plate oceanic lithosphere, somehow continental crust of both the South American and Antarctic plates have become incorporated into its upper plate. Continental fragments of both plates are currently separated by small oceanic basins in the upper plate above the South Sandwich subduction zone, in the Scotia Sea region, but how fragments of both continents became incorporated in the same upper plate remains enigmatic. Here we present an updated kinematic reconstruction of the Scotia Sea region using the latest published marine magnetic anomaly constraints, and place this in a South America-Africa-Antarctica plate circuit in which we take intracontinental deformation into account. We show that a change in marine magnetic anomaly orientation in the Weddell Sea requires that previously inferred initiation of subduction of South American oceanic crust of the northern Weddell Sea below the eastern margin of South Orkney Islands continental crust, then still attached to the Antarctic Peninsula, already occurred around 80 Ma. Subsequently, between ~71–50 Ma, we propose that the trench propagated northwards into South America by delamination of South American lithosphere: this resulted in the transfer of delaminated South American continental crust to the overriding plate of the South Sandwich subduction zone. We show that continental delamination may have been facilitated by absolute southward motion of South America that was resisted by South Sandwich slab dragging. Pre-drift extension preceding the oceanic Scotia Sea basins led around 50 Ma to opening of the Drake Passage, preconditioning the southern ocean for the Antarctic Circumpolar Current. This 50 Ma extension was concurrent with a strong change in absolute plate motion of the South American Plate that changed from S to WNW, leading to upper plate retreat relative to the more or less mantle stationary South Sandwich Trench that did not partake in the absolute plate motion change. While subduction continued, this mantle-stationary trench setting lasted until ~30 Ma, after which rollback started to contribute to back-arc extension. We find that roll-back and upper plate retreat have contributed more or less equally to the total amount of ~2000 km of extension accommodated in the Scotia Sea basins. We highlight that viewing tectonic motions in a context of absolute plate motion is key for identifying slab motion (e.g., rollback, trench-parallel slab dragging) and consequently mantle-forcing of geological processes

Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease

In preclinical studies of fructose-induced NAFLD, endotoxin appears to play an important role. We retrospectively examined samples from three pediatric cohorts (1) to investigate whether endotoxemia is associated with the presence of hepatic steatosis; (2) to evaluate postprandial endotoxin levels in response to fructose beverage in an acute 24-hour feeding challenge, and (3) to determine the change of fasting endotoxin amounts in a 4-week randomized controlled trial comparing fructose to glucose beverages in NAFLD. We found that adolescents with hepatic steatosis had elevated endotoxin levels compared to obese controls and that the endotoxin level correlated with insulin resistance and several inflammatory cytokines. In a 24-hour feeding study, endotoxin levels in NAFLD adolescents increased after fructose beverages (consumed with meals) as compared to healthy children. Similarly, endotoxin was significantly increased after adolescents consumed fructose beverages for 2 weeks and remained high although not significantly at 4 weeks. In conclusion, these data provide support for the concept of low level endotoxemia contributing to pediatric NAFLD and the possible role of fructose in this process. Further studies are needed to determine if manipulation of the microbiome or other methods of endotoxin reduction would be useful as a therapy for pediatric NAFLD

The epidemiology of pertussis in Germany: past and present

<p>Abstract</p> <p>Background</p> <p>Current and past pertussis epidemiology in the two parts of Germany is compared in the context of different histories of vaccination recommendations and coverage to better understand patterns of disease transmission.</p> <p>Methods</p> <p>Available regional pertussis surveillance and vaccination coverage data, supplemented by a literature search for published surveys as well as official national hospital and mortality statistics, were analyzed in the context of respective vaccination recommendations from 1964 onwards.</p> <p>Results</p> <p>Routine childhood pertussis vaccination was recommended in the German Democratic Republic (GDR) from 1964 and in former West German states (FWG) from 1969, but withdrawn from 1974–1991 in FWG. Pertussis incidence declined to <1 case/100.000 inhabitants in GDR prior to reunification in 1991, while in FWG, where pertussis was not notifiable after 1961, incidence was estimated at 160–180 cases/100.000 inhabitants in the 1970s-1980s. Despite recommendations for universal childhood immunization in 1991, vaccination coverage decreased in former East German States (FEG) and increased only slowly in FWG. After introduction of acellular pertussis vaccines in 1995, vaccination coverage increased markedly among younger children, but remains low in adolescents, especially in FWG, despite introduction of a booster vaccination for 9–17 year olds in 2000. Reported pertussis incidence increased in FEG to 39.3 cases/100.000 inhabitants in 2007, with the proportion of adults increasing from 20% in 1995 to 68% in 2007. From 2004–2007, incidence was highest among 5–14 year-old children, with a high proportion fully vaccinated according to official recommendations, which did not include a preschool booster until 2006. Hospital discharge statistics revealed a ~2-fold higher pertussis morbidity among infants in FWG than FEG.</p> <p>Conclusion</p> <p>The shift in pertussis morbidity to older age groups observed in FEG is similar to reports from other countries with longstanding vaccination programs and suggests that additional booster vaccination may be necessary beyond adolescence. The high proportion of fully vaccinated cases in older children in FEG suggests waning immunity 5–10 years after primary immunisation in infancy. The higher incidence of pertussis hospitalisations in infants suggests a stronger force of infection in FWG than FEG. Nationwide pertussis reporting is required for better evaluation of transmission patterns and vaccination policy in both parts of Germany.</p

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives transporter proteins a unique gatekeeper function in controlling drug access to metabolizing enzymes and excretory pathways. This review seeks to discuss the influence intestinal and hepatic drug transporters have on pharmacokinetic parameters, including bioavailability, exposure, clearance, volume of distribution, and half-life, for orally dosed drugs. This review also describes in detail the Biopharmaceutics Drug Disposition Classification System (BDDCS) and explains how many of the effects drug transporters exert on oral drug pharmacokinetic parameters can be predicted by this classification scheme