Beyond Critical Period Learning: Striatal FoxP2 Affects the Active Maintenance of Learned Vocalizations in Adulthood.

In humans, mutations in the transcription factor forkhead box P2 (FOXP2) result in language disorders associated with altered striatal structure. Like speech, birdsong is learned through social interactions during maturational critical periods, and it relies on auditory feedback during initial learning and on-going maintenance. Hearing loss causes learned vocalizations to deteriorate in adult humans and songbirds. In the adult songbird brain, most FoxP2-enriched regions (e.g., cortex, thalamus) show a static expression level, but in the striatal song control nucleus, area X, FoxP2 is regulated by singing and social context: when juveniles and adults sing alone, its levels drop, and songs are more variable. When males sing to females, FoxP2 levels remain high, and songs are relatively stable: this "on-line" regulation implicates FoxP2 in ongoing vocal processes, but its role in the auditory-based maintenance of learned vocalization has not been examined. To test this, we overexpressed FoxP2 in both hearing and deafened adult zebra finches and assessed effects on song sung alone versus songs directed to females. In intact birds singing alone, no changes were detected between songs of males expressing FoxP2 or a GFP construct in area X, consistent with the marked stability of mature song in this species. In contrast, songs of males overexpressing FoxP2 became more variable and were less preferable to females, unlike responses to songs of GFP-expressing control males. In deafened birds, song deteriorated more rapidly following FoxP2 overexpression relative to GFP controls. Together, these experiments suggest that behavior-driven FoxP2 expression and auditory feedback interact to precisely maintain learned vocalizations

Maternal short stature does not predict their children's fatness indicators in a nutritional dual-burden sample of urban Mexican Maya.

The co-existence of very short stature due to poor chronic environment in early life and obesity is becoming a public health concern in rapidly transitioning populations with high levels of poverty. Individuals who have very short stature seem to be at an increased risk of obesity in times of relative caloric abundance. Increasing evidence shows that an individual is influenced by exposures in previous generations. This study assesses whether maternal poor early life environment predicts her child's adiposity using cross sectional design on Maya schoolchildren aged 7-9 and their mothers (n = 57 pairs). We compared maternal chronic early life environment (stature) with her child's adiposity (body mass index [BMI] z-score, waist circumference z-score, and percentage body fat) using multiple linear regression, controlling for the child's own environmental exposures (household sanitation and maternal parity). The research was performed in the south of Merida, Yucatan, Mexico, a low socioeconomic urban area in an upper middle income country. The Maya mothers were very short, with a mean stature of 147 cm. The children had fairly high adiposity levels, with BMI and waist circumference z-scores above the reference median. Maternal stature did not significantly predict any child adiposity indicator. There does not appear to be an intergenerational component of maternal early life chronic under-nutrition on her child's obesity risk within this free living population living in poverty. These results suggest that the co-existence of very short stature and obesity appears to be primarily due to exposures and experiences within a generation rather than across generations

Agent-based homeostatic control for green energy in the smart grid

With dwindling non-renewable energy reserves and the adverse effects of climate change, the development of the smart electricity grid is seen as key to solving global energy security issues and to reducing carbon emissions. In this respect, there is a growing need to integrate renewable (or green) energy sources in the grid. However, the intermittency of these energy sources requires that demand must also be made more responsive to changes in supply, and a number of smart grid technologies are being developed, such as high-capacity batteries and smart meters for the home, to enable consumers to be more responsive to conditions on the grid in real-time. Traditional solutions based on these technologies, however, tend to ignore the fact that individual consumers will behave in such a way that best satisfies their own preferences to use or store energy (as opposed to that of the supplier or the grid operator). Hence, in practice, it is unclear how these solutions will cope with large numbers of consumers using their devices in this way. Against this background, in this paper, we develop novel control mechanisms based on the use of autonomous agents to better incorporate consumer preferences in managing demand. These agents, residing on consumers' smart meters, can both communicate with the grid and optimise their owner's energy consumption to satisfy their preferences. More specifically, we provide a novel control mechanism that models and controls a system comprising of a green energy supplier operating within the grid and a number of individual homes (each possibly owning a storage device). This control mechanism is based on the concept of homeostasis whereby control signals are sent to individual components of a system, based on their continuous feedback, in order to change their state so that the system may reach a stable equilibrium. Thus, we define a new carbon-based pricing mechanism for this green energy supplier that takes advantage of carbon-intensity signals available on the internet in order to provide real-time pricing. The pricing scheme is designed in such a way that it can be readily implemented using existing communication technologies and is easily understandable by consumers. Building upon this, we develop new control signals that the supplier can use to incentivise agents to shift demand (using their storage device) to times when green energy is available. Moreover, we show how these signals can be adapted according to changes in supply and to various degrees of penetration of storage in the system. We empirically evaluate our system and show that, when all homes are equipped with storage devices, the supplier can significantly reduce its reliance on other carbon-emitting power sources to cater for its own shortfalls. By so doing, the supplier reduces the carbon emission of the system by up to 25% while the consumer reduces its costs by up to 14.5%. Finally, we demonstrate that our homeostatic control mechanism is not sensitive to small prediction errors and the supplier is incentivised to accurately predict its green production to minimise costs

Search for a Radio Pulsar in the Remnant of Supernova 1987A

We have observed the remnant of supernova SN~1987A (SNR~1987A), located in the Large Magellanic Cloud (LMC), to search for periodic and/or transient radio emission with the Parkes 64\,m-diameter radio telescope. We found no evidence of a radio pulsar in our periodicity search and derived 8$\sigma$ upper bounds on the flux density of any such source of $31\,\mu$Jy at 1.4~GHz and $21\,\mu$Jy at 3~GHz. Four candidate transient events were detected with greater than $7\sigma$ significance, with dispersion measures (DMs) in the range 150 to 840\,cm$^{-3}\,$pc. For two of them, we found a second pulse at slightly lower significance. However, we cannot at present conclude that any of these are associated with a pulsar in SNR~1987A. As a check on the system, we also observed PSR~B0540$-$69, a young pulsar which also lies in the LMC. We found eight giant pulses at the DM of this pulsar. We discuss the implications of these results for models of the supernova remnant, neutron star formation and pulsar evolution.Comment: 7 pages, 3 figures, 2 tables. Accepted for publication in MNRA

Rotor redesign for a highly loaded 1800 ft/sec tip speed fan. 3: Laser Doppler velocimeter report

Laser Doppler velocimeter (LDV) techniques were employed for testing a highly loaded, 550 m/sec (1800 ft/sec) tip speed, test fan stage, the objective to provide detailed mapping of the upstream, intrablade, and downstream flowfields of the rotor. Intrablade LDV measurements of velocity and flow angle were obtained along four streamlines passing through the leading edge at 45%, 69%, 85%, and 95% span measured from hub to tip, at 100% of design speed, peak efficiency; 100% speed, near surge; and 95% speed, peak efficiency. At the design point, most passages appeared to have a strong leading edge shock, which moved forward with increasing strength near surge and at part speeds. The flow behind the shock was of a complex mixed subsonic and supersonic form. The intrablade flowfields were found to be significantly nonperiodic at 100% design speed, peak efficiency

Does risk aversion affect transmission and generation planning? A Western North America case study

We investigate the effects of risk aversion on optimal transmission and generation expansion planning in a competitive and complete market. To do so, we formulate a stochastic model that minimizes a weighted average of expected transmission and generation costs and their conditional value at risk (CVaR). We show that the solution of this optimization problem is equivalent to the solution of a perfectly competitive risk-averse Stackelberg equilibrium, in which a risk-averse transmission planner maximizes welfare after which risk-averse generators maximize profits. This model is then applied to a 240-bus representation of the Western Electricity Coordinating Council, in which we examine the impact of risk aversion on levels and spatial patterns of generation and transmission investment. Although the impact of risk aversion remains small at an aggregate level, state-level impacts on generation and transmission investment can be significant, which emphasizes the importance of explicit consideration of risk aversion in planning models

Integrating short-term demand response into long-term investment planning

Planning models have been used for many years to optimize generation investments in electric power systems. More recently, these models have been extended in order to treat demand-side management on an equal footing. This paper stresses the importance of integrating short-term demand response to time-varying prices into those investment models. Three different methodologies are suggested to integrate short-term responsiveness into a long-term model assuming that consumer response can be modelled using price-elastic demand and that generators behave competitively. First, numerical results show that considering operational constraints in an investment model results in less inflexible base load capacity and more mid-range capacity that has higher ramp rates. Then, own-price and cross-price elasticities are included in order to incorporate consumers’ willingness to adjust the demand profile in response to price changes. Whereas own-price elasticities account for immediate response to price signals, cross-price elasticities account for shifting loads to other periods. As energy efficiency programs sponsored by governments or utilities also influence the load profile, the interaction of energy efficiency expenditures and demand response is also modelled. In particular, reduced responsiveness to prices can be a side effect when consumers have become more energy efficient. Comparison of model results for a single year optimization with and without demand response shows the peak reduction and valley filling effects of response to real-time prices for an illustrative example with a large amount of wind power injections. Additionally, increasing demand elasticity increases the optimal amount of installed wind power capacity. This suggests that demand-side management can result in environmental benefits not only through reducing energy use, but also by facilitating integration of renewable energy

Gravitational wave detection using pulsars: status of the Parkes Pulsar Timing Array project

The first direct detection of gravitational waves may be made through observations of pulsars. The principal aim of pulsar timing array projects being carried out worldwide is to detect ultra-low frequency gravitational waves (f ~ 10^-9 to 10^-8 Hz). Such waves are expected to be caused by coalescing supermassive binary black holes in the cores of merged galaxies. It is also possible that a detectable signal could have been produced in the inflationary era or by cosmic strings. In this paper we review the current status of the Parkes Pulsar Timing Array project (the only such project in the Southern hemisphere) and compare the pulsar timing technique with other forms of gravitational-wave detection such as ground- and space-based interferometer systems.Comment: Accepted for publication in PAS

A possible signature of cosmic neutrino decoupling in the nHz region of the spectrum of primordial gravitational waves

In this paper we study the effect of cosmic neutrino decoupling on the spectrum of cosmological gravitational waves (GWs). At temperatures T>>1 MeV, neutrinos constitute a perfect fluid and do not hinder GW propagation, while for T<<1 MeV they free-stream and have an effective viscosity that damps cosmological GWs by a constant amount. In the intermediate regime, corresponding to neutrino decoupling, the damping is frequency-dependent. GWs entering the horizon during neutrino decoupling have a frequency f ~ 1 nHz, corresponding to a frequency region that will be probed by Pulsar Timing Arrays (PTAs). In particular, we show how neutrino decoupling induces a spectral feature in the spectrum of cosmological GWs just below 1 nHz. We briefly discuss the conditions for a detection of this feature and conclude that it is unlikely to be observed by PTAs.Comment: 11 pages, 2 figures. V2: References Adde

3-D kinematic comparison of treadmill and overground running.

Studies investigating the mechanics of human movement are often conducted using the treadmill. The treadmill is an attractive device for the analysis of human locomotion. Studies comparing overground and treadmill running have analyzed discrete variables, however differences in excursion from footstrike to peak angle and range of motion during stance have yet to be examined. This study aimed to examine the 3-D kinematics of the lower extremities during overground and treadmill locomotion to determine the extent to which the two modalities differ. Twelve participants ran at 4.0m/s in both treadmill and overground conditions. 3-D angular kinematic parameters during the stance phase were collected using an eight camera motion analysis system. Hip, knee and ankle joint kinematics were quantified in the sagittal, coronal and transverse planes, then compared using paired t-tests. Of the parameters analyzed hip flexion at footstrike 12° hip range of motion 17°, peak hip flexion 12.7°, hip transverse plane range of motion 8° peak knee flexion 5° and peak ankle excursion range 6.6°, coronal plane ankle angle at toe-off 6.5° and peak ankle eversion 6.3° were found to be significantly different. These results lead to the conclusion that the mechanics of treadmill locomotion cannot be generalized to overground