Construction delays causing risks on time and cost - a critical review

There is an increase in the number of construction projects experiencing extensive delays leading to exceeding initial time and cost budget.  This paper reviews 41 studies around the world which surveyed the delay factors and classified them into Groups.  The main purpose of this paper is to review literature, each of which have categorized the causes that are responsible for time delays and cost overrun in projects. The collected list has 113 causes for delays categorized in to 18 different groups.  Most of the researches have analysed the responses from the Questionnaire survey.    The collected data are used to rank the problem.  The data are further used to investigate and analyse Important Index, Frequency Index, Severity Index, Relative Important Index, Relative Importance Weight, Weighted Average, Mean, Standard Deviation and Variance.  The collective comparison has revealed that the ranking given by all the researchers is not the same.  Further each and every study has different rank ratings for the different group of the delays.  This review paper attempts to provide an updated compilation of the earlier studies on ranking of the delay causers, which are never similar and constant for universal projects.  It is concluded that a separate study is required for identifying the factors causing delay for projects operated in Sabah, East Malaysia

Integrated urine proteomics and renal single-cell genomics identify an interferon-γ response gradient in lupus nephritis.

Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation. For example, proliferative nephritis identifies a more aggressive disease class that requires immunosuppression. However, the current classification system relies on the static appearance of histopathological morphology which does not capture differences in the inflammatory response. Therefore, a biomarker grounded in the disease biology is needed to understand the molecular heterogeneity of lupus nephritis and identify immunologic mechanism and pathways. Here, we analyzed the patterns of 1000 urine protein biomarkers in 30 patients with active lupus nephritis. We found that patients stratify over a chemokine gradient inducible by interferon-gamma. Higher values identified patients with proliferative lupus nephritis. After integrating the urine proteomics with the single-cell transcriptomics of kidney biopsies, it was observed that the urinary chemokines defining the gradient were predominantly produced by infiltrating CD8 T cells, along with natural killer and myeloid cells. The urine chemokine gradient significantly correlated with the number of kidney-infiltrating CD8 cells. These findings suggest that urine proteomics can capture the complex biology of the kidney in lupus nephritis. Patient-specific pathways may be noninvasively tracked in the urine in real time, enabling diagnosis and personalized treatment

Understanding the mechanisms of nuclear collisions: A complete study of the 10 B + 120 Sn reaction

Background: Reactions involving exotic and stable weakly bound nuclei have been extensively studied in recent years. Although several models have been successfully used to explain particular reaction outcomes, the answers to many questions remain elusive. In previous works, we presented elastic, inelastic, and transfer angular distributions for the 10B + 120Sn system measured at ELab = 31.5, 33.0, 35.0, and 37.5 MeV. The data set was analyzed through coupled reaction channels calculations in the context of the double-folding São Paulo potential. Purpose: We investigate nuclear reaction mechanisms for systems involving weakly bound projectiles. Method: Angular distributions for several nuclear reaction processes were measured for the 10B + 120Sn system at ELab = 39.70 MeV. Results: The new data set involves angular distributions for elastic scattering, projectile and target inelastic excitations, one-neutron pickup transfer, one-proton stripping transfer, deuteron pickup transfer, and 3,4 He stripping transfer. We have also observed 10Be nuclei. The effect of the couplings to some nonelastic states on the angular distributions is discussed. Conclusion: The theoretical calculations within the coupled reaction channels formalism provide an overall good agreement with the corresponding inelastic, one-neutron stripping, one-proton pickup, one-deuteron pickup, and 3 He stripping transfer data. However, to improve the description of the elastic scattering angular distribution, the inclusion of additional channels in the coupling scheme might be necessary.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2018/09998-8, 2019/07767-1, 2019/05769-7 y 2017/05660-0;Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 304056/2019-7, 302160/2018-3 y 306433/2017- 6Instituto Nacional de Ciência e Tecnologia-Física Nuclear e Aplicações (INCT-FNA) 464898/2014-5Ministerio de Ciencia, Innovación y Universidades de España. PGC2018-096994-B-C21Ministerio de Economía de España y Competitividad y fondos FEDER. FIS2017-88410-

Understanding the mechanisms of nuclear collisions: A complete study of the B 10 + Sn 120 reaction

Background: Reactions involving exotic and stable weakly bound nuclei have been extensively studied in recent years. Although several models have been successfully used to explain particular reaction outcomes, the answers to many questions remain elusive. In previous works, we presented elastic, inelastic, and transfer angular distributions for the B10+Sn120 system measured at ELab=31.5, 33.0, 35.0, and 37.5 MeV. The data set was analyzed through coupled reaction channels calculations in the context of the double-folding São Paulo potential. Purpose: We investigate nuclear reaction mechanisms for systems involving weakly bound projectiles. Method: Angular distributions for several nuclear reaction processes were measured for the B10+Sn120 system at ELab=39.70 MeV. Results: The new data set involves angular distributions for elastic scattering, projectile and target inelastic excitations, one-neutron pickup transfer, one-proton stripping transfer, deuteron pickup transfer, and He3,4 stripping transfer. We have also observed Be10 nuclei. The effect of the couplings to some nonelastic states on the angular distributions is discussed. Conclusion: The theoretical calculations within the coupled reaction channels formalism provide an overall good agreement with the corresponding inelastic, one-neutron stripping, one-proton pickup, one-deuteron pickup, and He3 stripping transfer data. However, to improve the description of the elastic scattering angular distribution, the inclusion of additional channels in the coupling scheme might be necessary.Fil: Gasques, L. R.. Universidade de Sao Paulo; BrasilFil: Alvarez, M. A. G.. Universidad de Sevilla; EspañaFil: Arazi, Andres. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia Física (Centro Atómico Constituyentes). Proyecto Tandar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Carlson, B. V.. Instituto Tecnológico de Aeronáutica; BrasilFil: Chamon, L. C.. Universidade de Sao Paulo; BrasilFil: Fernández García, J. P.. Universidad de Sevilla; EspañaFil: Lépine Szily, A.. Universidade de Sao Paulo; BrasilFil: Lubian, J.. Universidade Federal Fluminense; BrasilFil: Rangel, J.. Universidade Federal Fluminense; BrasilFil: Rodríguez Gallardo, M.. Universidad de Sevilla; EspañaFil: Scarduelli, V.. Universidade de Sao Paulo; BrasilFil: Zagatto, V. A. B.. Universidade Federal Fluminense; Brasi

Investigation of the fusion process for B 10 + Au 197 at near-barrier energies

In a previous work, we presented data for the B10+Au197 system, corresponding to quasielastic and elastic scattering, Au197 inelastic excitation, and one neutron pickup transfer, measuring the angular distribution of scattered beam-like ejectiles at several energies around the Coulomb barrier. In this paper, we present data for the fusion process of the same system, at several energies around the Coulomb barrier, as well as new data for one neutron pickup and stripping transfer. In this case, we detected offline γ rays stemming from the β-delayed decay chain of fusion-evaporation residues and heavy transfer products. As in our previous work, we analyzed this data set with coupled reaction channels calculations using the São Paulo potential. We show that the coupling to the one neutron transfer channel is quite important to describe the fusion data at the sub-barrier energy region. We also provide a comparison of the experimental fusion cross sections obtained for B10+Au197 with data for several other systems involving the same target nucleus.Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET, Argentina) PIP00786COFondo para la Investigacin Cientfica y Tecnolgica (FONCYT, Argentina) PICT-2017-4088Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Brazil) 2018/09998-8, 2019/07767-1, 2019/05769-7Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) 302160/2018-3, 304056/2019-7Ministerio de Ciencia, Innovación y Universidades PGC2018-096994-B-C2

THGEM-based detectors for sampling elements in DHCAL: laboratory and beam evaluation

We report on the results of an extensive R&D program aimed at the evaluation of Thick-Gas Electron Multipliers (THGEM) as potential active elements for Digital Hadron Calorimetry (DHCAL). Results are presented on efficiency, pad multiplicity and discharge probability of a 10x10 cm2 prototype detector with 1 cm2 readout pads. The detector is comprised of single- or double-THGEM multipliers coupled to the pad electrode either directly or via a resistive anode. Investigations employing standard discrete electronics and the KPiX readout system have been carried out both under laboratory conditions and with muons and pions at the CERN RD51 test beam. For detectors having a charge-induction gap, it has been shown that even a ~6 mm thick single-THGEM detector reached detection efficiencies above 95%, with pad-hit multiplicity of 1.1-1.2 per event; discharge probabilities were of the order of 1e-6 - 1e-5 sparks/trigger, depending on the detector structure and gain. Preliminary beam tests with a WELL hole-structure, closed by a resistive anode, yielded discharge probabilities of <2e-6 for an efficiency of ~95%. Methods are presented to reduce charge-spread and pad multiplicity with resistive anodes. The new method showed good prospects for further evaluation of very thin THGEM-based detectors as potential active elements for DHCAL, with competitive performances, simplicity and robustness. Further developments are in course.Comment: 15 pages, 11 figures, MPGD2011 conference proceedin

Systematic study of optical potential strengths in reactions on Sn 120 involving strongly bound, weakly bound, and exotic nuclei

We present new experimental angular distributions for the elastic scattering of Li6+Sn120 at three bombarding energies. We include these data in a wide systematic involving the elastic scattering of He4,6,Li7, Be9,B10, and O16,18 projectiles on the same target at energies around the respective Coulomb barriers. Considering this data set, we report on optical model analyses based on the double-folding São Paulo potential. Within this approach, we study the sensitivity of the data fit to different models for the nuclear matter densities and to variations in the optical potential strengths.Fil: Alvarez, M. A. G.. Universidad de Sevilla; EspañaFil: Fernández García, J. P.. Universidad de Sevilla; EspañaFil: León García, J. L.. Universidad de Sevilla; EspañaFil: Rodríguez Gallardo, M.. Universidad de Sevilla; EspañaFil: Gasques, L. R.. Universidade de Sao Paulo; BrasilFil: Chamon, L. C.. Universidade de Sao Paulo; BrasilFil: Zagatto, V. A. B.. Universidade de Sao Paulo; BrasilFil: Lépine Szily, A.. Universidade de Sao Paulo; BrasilFil: Oliveira, J. R. B.. Universidade de Sao Paulo; BrasilFil: Scarduelli, V.. Universidade Federal Fluminense; BrasilFil: Carlson, B. V.. Instituto Tecnologico de Aeronautica.; BrasilFil: Casal, J.. Istituto Nazionale Di Fisica Nucleare.; ItaliaFil: Arazi, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaFil: Torres, D. A.. Universidad Nacional de Colombia; ColombiaFil: Ramirez, F.. Universidad Nacional de Colombia; Colombi