Could cellular proliferation be a predictive index for the relapse of nasal polyposis and down-regulated by nasal steroid treatment?

The aim of this article is to identify the cellular mitotic activity using Ki-67 monoclonal antibody for predicting relapses of nasal polyposis after surgery. A prospective study was conducted at Kartal Training and Research Hospital Otolaryngology Department between January 2006 and September 2008. Nasal polyps were obtained from all patients and pathological materials were analyzed for the Ki-67 staining using immunohistochemistry. Patients were followed after surgery for 12 months for relapse. There was no statistically significant difference between recurrent and nonrecurrent polyps. Polyp recurrence has a multifactorial origin. Ki-67 index alone does not provide sufficient information about polyp recurrence before the operation. © 2012 Association of Otolaryngologists of India

Population abundance and growth parameters of an exotic bivalve species, Anadara kagoshimensis, in the Southwestern Black Sea

Blood cockle (Anadara kagoshimensis ) is an Indo-Pacific species that later entered the Black Sea. The abundance of A. kagoshimensis, which is not subjected to commercial fishing, is important in terms of food competition with other bivalvia species. Baby clam (Chamelea gallina) together with the A. kagoshimensis are dominant bivalve species found in the sandy and muddy areas off the coastal waters of the Black Sea. In this study, specimens of A. kagoshimensis have been recognized by morphological analysis and also confirmed by molecular characterization. Furthermore, the abundance and growth parameters of A. kagoshimensis were investigated in the Southwestern Black Sea. Blood cockles were sampled between February 2011 and December 2012, seasonally. According to the Von Bertalanffy Growth Parameters (VBGP) the results were L infinity = 81.96 mm, K = 0.32 year-1, t0 = -0.22 year, and nonseasonal L infinity = 84.32 mm, K = 0.31 year-1, t0 = -0.21, WP = 0.65, ts = 0.15. The growth pattern showed the slope [b] = 2.96-3.01 in 2011 and 2012. The stock size was estimated according to two different years in 5 different subareas (Cide, Inebolu, Turkeli, Ayancik, and Sarikum) and by 4 different strata (0-5 m, 5-10 m, 10-15 m, and 15-20 m). Considering subareas, the A. kagoshimensis population in all subareas increased significantly in a single year. Compared to other regions, Inebolu was the main highly distributed area of the A. kagoshimensis, and also the estimated stock size was the highest in the region. Due to food competition with other commercial species (mainly Chamelea gallina) A. kagoshimensis is an ecology important species for the Southern Black Sea habitats. It is aimed to make contributions to Good Environmental Status (GES) and fisheries management in the region

Hyperbaric oxygen as adjuvant therapy in cervical necrotizing fasciitis

Nekrotizan fasiit önemli derecede morbidite ve mortalite ile ilişkili deri ve fasyanın ciddi bir enfeksiyonudur. Nekrotizan fasiit, baş ve boyunda tutulumu nadir olarak gözlenir. Servikal nekrotizan fasiitin standart tedavisi, intravenöz antibiyotik ve acil olarak cerrahi debridman uygulamayı içerir. Hiperbarik oksijen terapisi, nekrotizan fasiitin kontrolünde adjuvant olarak kullanılmaktadır. Birçok çalışmada hiperbarik oksijen kullanıldığında daha kısa hastanede kalma süresinin olduğu, mortalitenin ve cerrahi debridman sayısınının azaldığı ileri sürülmektedir. Bu çalışmada servikal nekrotizan fasiit tanısı konmuş olup boyunda geniş bir doku defekti olu- şan ve intravenöz antibiyotik, cerrahi debridman yanında adjuvant olarak hiperbarik oksijen terapisi uygulanan bir hasta sunulmuş ve ilgili literatür gözden geçirilmiştir.Necrotizing fasciitis is a serious infection of the fascia and skin associated with considerable morbidity and mortality. Necrotizing fasciitis rarely in- volves the head and neck. The standard treatment for cervical necrotizing fasciitis includes intravenous antibiotics and prompt surgical debridement. Hyperbaric oxygen therapy is used as adjunctive therapy in managing nec- rotizing fasciitis. Several reports suggest shorter hospital duration, reduced mortality, and decreased surgical debridement when hyperbaric oxygen is used. In this report, a patient who was diagnosed with cervical necrotizing fasciitis having a large tissue defect on her neck and was administered intra- venous antibiotics, surgical debridement, and adjuvant hyperbaric oxygen therapy is presented, and the related literature has been looked through

Effects of Clinoptilolite on the Digestibility of Nutrients and Relative Organ Weights in Rat Diets

This study was conducted to compare the effects of dietary clinoptilolite on nutrient digestibility and relative organweights in rats. In this study, 24 adult male Sprague-Dawley rats were divided into 4 groups with 3 replicates, accordingto a randomized split plots design. In addition to a control group (0% clinoptilolit), 3 levels of clinoptilolite (2%, 4%, and6%) were used in the diets, and the rats were fed (individually in cages) these diets for 56 days. Statistically significantdifferences were found among the groups for the digestibility rates of nutrients (P<0.05), except for crude fibre (CF) andacid detergent fibre (ADF). The addition of clinoptilolite in rats’ feeds reduced the digestibility of crude fibre, crude ash(CA), neutral detergent fibre (NDF) and acid detergent fibre (ADF), but increased the digestibility of other nutrients.Slaughter live, organs (liver, kidney, heart, and stomach) and relative organ weights were not affected significantly by theclinoptilolite contents (P>0.05). In conclusion, clinoptilolites can be used in animal feed as natural toxin binders whenstored under suitable conditions

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin‑induced epileptiform activity: an electrophysiological and biochemical study

Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin‑induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis in blood samples were evaluated. According to the electrocorticogram analysis, the effective dose was detected as 10 mg/kg for both C. mas and M. rubra. This dose decreased the spike frequencies of convulsions while amplitude wasn't changed by both substances. In erythrocyte studies, there were significant differences regarding nitric oxide in the control, sham and penicillin groups. There were significant differences regarding malondialdehyde in all groups. In the plasma, there were significant differences among groups regarding xanthine oxidase in the penicillin‑C. mas and penicillin‑M. rubra groups. There were differences regarding malondialdehyde in the penicillin‑C. mas and M. rubra‑C. mas groups. Both extracts reduced the frequency of epileptiform activity. After administration of the extracts malondialdehyde levels decreased also in both erythrocytes and plasma

Effects of Cornus mas L. and Morus rubra L. extracts on penicillin‑induced epileptiform activity: an electrophysiological and biochemical study

Traditionally, Morus rubra L. (Moraceae) (red mulberry) and Cornus mas L. (Cornacea) (cornelian cherry) fruits are eaten fresh and are also used in marmalades, juices, jam, natural dyes in Turkey and are believed to have beneficial effects in case of multiple health issues such as antipyretic, diarrhea and intestinal parasites. However, the effects of M. rubra and C. mas on epilepsy has not been known. This study evaluates the effects of M. rubra and C. mas extracts on penicillin‑induced epileptiform activity. Sixty Wistar rats randomly divided into ten groups (n=6): control, sham, penicillin, penicillin+M. rubra extract (2.5, 5, 10, 20 mg/kg) and penicillin+C. mas extract (2.5, 5, 10 mg/kg). Epileptiform activity was induced by using penicillin (500 IU, i.c.) and electrocorticogram records (150 min) were obtained. Also, biochemical analysis in blood samples were evaluated. According to the electrocorticogram analysis, the effective dose was detected as 10 mg/kg for both C. mas and M. rubra. This dose decreased the spike frequencies of convulsions while amplitude wasn't changed by both substances. In erythrocyte studies, there were significant differences regarding nitric oxide in the control, sham and penicillin groups. There were significant differences regarding malondialdehyde in all groups. In the plasma, there were significant differences among groups regarding xanthine oxidase in the penicillin‑C. mas and penicillin‑M. rubra groups. There were differences regarding malondialdehyde in the penicillin‑C. mas and M. rubra‑C. mas groups. Both extracts reduced the frequency of epileptiform activity. After administration of the extracts malondialdehyde levels decreased also in both erythrocytes and plasma

Tonsillektomi spesmenlerinin Histopatolojik Retrospektif Analizi.

Amaç: Tonsillektomi, özellikle pediyatrik yaş grubunda sıkça yapılan bir ameliyattır. Tonsillektomi spesmenlerinin rutin histopatolojik incelemesinin gerekliliği ise hala tartışmalı bir konudur. Çalışmamızda kliniğimizde son 5,5 yılda tonsillektomi operasyonu olmuş 12 yaş ve üstü hastaların tonsil materyallerinin histopatolojik dağılımını ve rutin patolojik incelemenin gerekliliği sorgulanmaktadır.Gereç ve Yöntem: Hastanemiz kulak burun boğaz kliniğinde 2013 ocak ayı ve 2018 temmuz ayı tarihleri arasında çeşitli endikasyonlar ile tonsillektomi operasyonu olmuş 856 hastanın (452 erkek, 404 kadın; ortalama yaş: 34.6, yaş aralığı: 12-92 yaş) anamnezi, şikayetleri, fizik muayene sonuçları ve patolojik sonuçları incelenmiştir.Bulgular: 856 hastanın patoloji sonuçları değerlendirildiğinde; 50 hastada (%6) malignite saptanmış olup bu hastaların 36’sında (%4) lenfoma, 11’inde (%1) skuamoz hücreli karsinom (SCC), 2’sinde (%0.2) adenokarsinom metastazı (akciğer ve pankreas adenokarsinomu metastazı), 1’inde (%0.1) malign melanom, 1’inde (%0.1) nöroendokrin tümör metastazı olduğu görülmüştür. Çalışmaya dahil edilen hastaların hiçbirinde rastlantısal malignite saptanmamıştır.Sonuç: Literatürdeki çoğu çalışmada en sık görülen tonsil malignitesi skuamoz hücreli karsinom ikinci en sık görülen tonsil malignitesi ise lenfoma olarak belirtilmiştir. Çalışmamızda bu bilginin aksine %72’lik bir oranla en sık görülen tonsil malignitesi lenfoma, ikinci en sık görülen tonsil malignitesi ise skuamoz hücreli karsinom (SCC) olarak bulunmuştur. Lenfoma saptanan 36 hastanın 19’unda (%52) ise Diffüz Büyük B Hücreli Lenfoma (DBBHL) alt tipi görülmüş olup bu oran literatür verileri ile uyumlu bulunmuştur. Malignite saptanmış olan hastaların hepsinde malignite risk faktörü (asimetrik büyümüş, ülsere olmuş veya obsturiktif boyutlara ulaşmış tonsil dokusu, boyunda şişlik, yutma güçlüğü vs) olduğu görülmüş olup ve 856 hastanın hiçbirinde rastlantısal malignite saptanmamıştır. Sonuç olarak tonsillektomi spesmenlerinin rutin histopatolojik incelenmesi gerekli olmayabilir ancak risk faktörü taşıyan hastalarda mutlaka histopatolojik inceleme yapılmalıdır