The Differential Effect of Anxiety and ADHD Symptoms on Inhibitory Control and Sustained Attention for Threat Stimuli: A Go/No-Go Eye-Movement Study

Objective: This study examined the synergistic effects of ADHD and anxiety symptoms on attention and inhibitory control depending on the emotional content of the stimuli. Method: Fifty-four typically developing individuals (27 children/adolescents and 27 adults) completed an eye-movement based emotional Go/No-Go task, using centrally presented (happy, angry) faces and neutral/symbolic stimuli. Sustained attention was measured through saccade latencies and saccadic omission errors (Go trials), and inhibitory control through saccadic commission errors (No-Go trials). ADHD and anxiety were assessed dimensionally. Results: Elevated ADHD symptoms were associated with more commission errors and slower saccade latencies for angry (vs. happy) faces. In contrast, angry faces were linked to faster saccade onsets when anxiety symptoms were high, and this effect prevailed when both anxiety and ADHD symptoms were high. Conclusion: Social threat impacted performance in individuals with sub-clinical anxiety and ADHD differently. The effects of anxiety on threat processing prevailed when both symptoms were high

Executive control and emotional processing in ADHD and anxiety. Evidence from eye-tracking experiments

Attention-deficit/hyperactivity disorder (ADHD) and anxiety co-occur at above chance levels in both clinical and sub-clinical cases. However, little is known about the underlying neuropsychological basis of this overlap. In this thesis, we addressed this question by exploring a pattern of dysfunctional cognitive control linked to these conditions. Our hypothesis was that ADHD would be associated with core deficits in cognitive control in both non-emotional and emotional contexts. In addition, we anticipated cognitive control deficits in anxiety to manifest in situations involving processing of emotional stimuli and particularly in threat contexts. Furthermore, we predicted that the combination of these cognitive control challenges would be exacerbated in the case of co-occurring ADHD and anxiety. We investigated these hypotheses using eye-movement measurements in a Go/NoGo paradigm to examine inhibitory control (i.e., suppression of reflexive saccades) and sustained attention (i.e., saccadic execution) in emotional and non-emotional contexts. We also designed an eye-movement version of the Spatial Cueing paradigm to examine attentional orienting in the presence of emotional cue distractors using representations of another person’s eye-gaze. The current thesis contains four empirical chapters discussing the relationship between ADHD and anxiety symptom dimensions (and their interaction) on task performance. We examined the Go/No-Go task using symptoms of ADHD and anxiety in typically developing (TD) children/adolescents (n= 27) and healthy adults (n=27) (Chapter 3), and symptoms of ADHD and Generalised Anxiety Disorder (GAD) in a larger sample of children and adolescents (n=68), that included both TD children/adolescents and clinical cases of ADHD and anxiety (Chapter 4). We then examined the Spatial Cueing task in the same samples across Chapters 5 and 6. High levels of ADHD were associated with impaired inhibitory control and disrupted processing, in the context of threat (such as angry faces) (Chapter 3) with reduced sustained attention regardless of the emotional valence of the stimuli used (Chapter 4). Individuals with ADHD did not effectively use social cues (i.e., poorer attentional orienting), especially in the presence of negative emotional expressions (such as angry and fearful faces) relative to other emotional expressions (Chapters 5 and 6). Anxiety symptoms were associated with faster processing of negative facial expressions (Chapter 3) and improved attentional orienting following social cues of negative emotional expressions, relative to other facial expressions (Chapter 5). Anxiety was also associated with better attentional orienting following social cues of angry faces relative to fearful faces (Chapter 6). In terms of the interactions between anxiety and ADHD, elevated anxiety symptoms were associated with attenuation of disrupted attentional processes found in ADHD including faster processing of negative emotional expressions relative to positive ones (Chapter 3 and 4), improved sustained attention (Chapter 4) and better attentional orienting processes (Chapters 5 and 6). Overall, our results showed that ADHD was associated with deficits in cognitive control, particularly in emotionally charged contexts. However, anxiety was associated with improved attentional processes in response to negative emotional stimuli. Contrary to our predictions, we found that co-occurring ADHD and anxiety were associated with improved attentional control and emotional processing. Overall, the synergistic effects between ADHD and anxiety provide evidence towards a potentially distinct cognitive phenotype

Dataset for: The Differential Effect of Anxiety and ADHD Symptoms on Inhibitory Control and Sustained Attention for Threat Stimuli: A Go/No-Go Eye-Movement Study

Dataset supports: Manoli, Athina (2019). The Differential Effect of Anxiety and ADHD Symptoms on Inhibitory Control and Sustained Attention for Threat Stimuli: A Go/No-Go Eye-Movement Study. Journal of Attention Disorders </span

Topical prebiotics/postbiotics and PRURISCORE validation in atopic dermatitis. International study of 396 patients

Aim: To investigate the efficacy and tolerability of a cream (Rilastil Xerolact PB) containing a mixture of prebiotics and postbiotics, and to validate the PRURISCORE itch scale in the management of atopic dermatitis. Methods: The study is based on 396 subjects of both sexes in three age groups (i.e., infants, children, adults) suffering from mild/moderate Atopic Dermatitis, recruited from 8 European countries and followed for 3 months. Results: The product demonstrated good efficacy combined with good/very good tolerability in all age groups. In particular, SCORAD, PRURISCORE and IGA scores decreased significantly over the course of the study. The PRURISCORE was preferred to VAS by the vast majority of patients. Conclusion: Even though the role of prebiotics and postbiotics was not formally demonstrated since these substances were part of a complex formulation, it can be reasonably stated that prebiotics and postbiotics have safety and standardization features that probiotics do not have. In addition they are authorized by regulatory authorities, whereas topical probiotics are not