T1T_1- and T2T_2-spin relaxation time limitations of phosphorous donor electrons near crystalline silicon to silicon dioxide interface defects

A study of donor electron spins and spin--dependent electronic transitions involving phosphorous ($^{31}$P) atoms in proximity of the (111) oriented crystalline silicon (c-Si) to silicon dioxide (SiO$_{2}$) interface is presented for [$^{31}$P] = 10$^{15}$ $\mathrm{cm}^{-3}$ and [$^{31}$P] = 10$^{16}$ $\mathrm{cm}^{-3}$ at about liquid $^4$He temperatures ($T = 5$ $\mathrm{K} - 15$ $\mathrm{K}$). Using pulsed electrically detected magnetic resonance (pEDMR), spin--dependent transitions between the \Phos donor state and two distinguishable interface states are observed, namely (i) \Pb centers which can be identified by their characteristic anisotropy and (ii) a more isotropic center which is attributed to E$^\prime$ defects of the \sio bulk close to the interface. Correlation measurements of the dynamics of spin--dependent recombination confirm that previously proposed transitions between \Phos and the interface defects take place. The influence of these electronic near--interface transitions on the \Phos donor spin coherence time $T_2$ as well as the donor spin--lattice relaxation time $T_1$ is then investigated by comparison of spin Hahn--echo decay measurements obtained from conventional bulk sensitive pulsed electron paramagnetic resonance and surface sensitive pEDMR, as well as surface sensitive electrically detected inversion recovery experiments. The measurements reveal that both $T_2$ and $T_1$ of \Phos donor electrons spins in proximity of energetically lower interface states at $T\leq 13$ K are reduced by several orders of magnitude

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori-Induced Metaplasia in the Stomach

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gas-tric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s2/i2 form of VacA colonized mice more efficiently than mutants null for VacA or producing more active forms of it, providing the first evidence of a positive role for the minimally active s2/i2 toxin. Strains producing more active toxin forms induced more severe and extensive metaplasia and in flammation in the mouse stomach than strains producing weakly active (s2/i2) toxin. We also examined the association in humans, controlling for cag PAI status. In human gastric biopsy specimens, the vacA i1 allele was strongly associated with precancerous intestinal metaplasia, with almost complete absence of intestinal metaplasia in subjects infected with i2-type strains, even in a vacA s1, cagA+ background

Loss of MIR15A and MIR16-1 at 13q14 is associated with increased TP53 mRNA, de-repression of BCL2 and adverse outcome in chronic lymphocytic leukaemia.

This study was conducted to investigate the possibility that TP53 mRNA is variably expressed in chronic lymphocytic leukaemia (CLL) and that under-expression is associated with TP53 dysfunction and adverse outcome. Although TP53 mRNA levels did indeed vary among the 104 CLL samples examined, this variability resulted primarily from over-expression of TP53 mRNA in 18 samples, all of which lacked TP53 deletion/mutation. These patients had higher lymphocyte counts and shorter overall and treatment-free survival times compared to cases with low TP53 mRNA expression and no TP53 deletion/mutation. Furthermore, TP53 mRNA levels did not correlate with levels of TP53 protein or its transcriptional target CDKN1A. We speculated that the adverse outcome associated with TP53 mRNA over-expression might reflect variation in levels of MIR15A and MIR16-1, which are encoded on chromosome 13q14 and target TP53 and some oncogenes including BCL2. In keeping with our hypothesis, 13q14 copy number and levels of MIR15A/MIR16-1 correlated positively with one another but negatively with levels of TP53 mRNA and BCL2 mRNA. Our findings support a model in which loss of MIR15A/MIR16-1 at chromosome 13q14 results in adverse outcome due to de-repression of oncogenes such as BCL2, and up-regulation of TP53 mRNA as a bystander effect

Chronic elevation of systemic glucagon-like peptide-1 following surgical weight loss: association with nausea and vomiting and effects on adipokines.

We determined whether persistent nausea and vomiting (N/V) symptoms following Roux-en-Y gastric bypass surgery is due to elevated systemic glucagon-like peptide-1 (GLP-1) and leptin in female non-diabetic subjects. Subjects with N/V post-Roux-en-Y gastric bypass (RYGB) surgery had significantly elevated fasting GLP-1 levels compared to that with post-operative asymptomatic subjects and to morbidly obese, obese and lean subjects not undergoing surgery. Weight loss, glycaemia, insulin and post-prandial GLP-1 levels were similar in all post-operative subjects. Despite comparable BMI, leptin was significantly lower in symptomatic subjects. Furthermore, leptin secretion from subcutaneous adipose tissue was inhibited by GLP-1 (0.1-1.0 nM; n = 6). Persistent N/V following RYGB surgery is associated with elevated fasting GLP-1, but lower leptin levels. The latter may be a consequence of the direct GLP-1 inhibition of leptin secretion from adipose tissue

MMTF: The Maryland-Magellan Tunable Filter

This paper describes the Maryland-Magellan Tunable Filter (MMTF) on the Magellan-Baade 6.5-meter telescope. MMTF is based on a 150-mm clear aperture Fabry-Perot (FP) etalon that operates in low orders and provides transmission bandpass and central wavelength adjustable from ~5 to ~15 A and from ~5000 to over ~9200 A, respectively. It is installed in the Inamori Magellan Areal Camera and Spectrograph (IMACS) and delivers an image quality of ~0.5" over a field of view of 27' in diameter (monochromatic over ~10'). This versatile and easy-to-operate instrument has been used over the past three years for a wide variety of projects. This paper first reviews the basic principles of FP tunable filters, then provides a detailed description of the hardware and software associated with MMTF and the techniques developed to observe with this instrument and reduce the data. The main lessons learned in the course of the commissioning and implementation of MMTF are highlighted next, before concluding with a brief outlook on the future of MMTF and of similar facilities which are soon coming on line.Comment: 38 pages, 12 figures, 3 tables, now accepted for publication to the Astronomical Journa

On the optimal relative orientation of radicals in the cryptochrome magnetic compass

This is the author accepted manuscript. The final version is available from AIP Publishing via the DOI in this record.Birds appear to be equipped with an innate magnetic compass. One biophysical model of this sense relies on spin dynamics in photogenerated radical pairs in the protein cryptochrome. This study employs a systematic approach to predict the dependence of the compass sensitivity on the relative orientation of the constituent radicals for spin systems comprising up to 21 hyperfine interactions. Evaluating measures of compass sensitivity (anisotropy) and precision (optimality) derived from the singlet yield, we find the ideal relative orientations for the radical pairs consisting of the flavin anion (F•-) coupled with a tryptophan cation (W•+) or tyrosine radical (Y•). For the geomagnetic field, the two measures are found to be anticorrelated in [F•- W•+]. The angle spanned by the normals to the aromatic planes of the radicals is the decisive parameter determining the compass sensitivity. The third tryptophan of the tryptophan triad/tetrad, which has been implicated with magnetosensitive responses, exhibits a comparably large anisotropy, but unfavorable optimality. Its anisotropy could be boosted by an additional ∼50% by optimizing the relative orientation of the radicals. For a coherent lifetime of 1 μs, the maximal relative anisotropy of [F•- W•+] is 0.27%. [F•- Y•] radical pairs outperform [F•- W•+] for most relative orientations. Furthermore, anisotropy and optimality can be simultaneously maximized. The entanglement decays rapidly, implicating it as a situational by-product rather than a fundamental driver within the avian compass. In magnetic fields of higher intensity, the relative orientation of radicals in [F•- W•+] is less important than for the geomagnetic field.Engineering and Physical Sciences Research Council (EPSRC

The need for a marker predicting benefit following cardiovascular disease risk reduction treatment

Developing a robust method to study characteristics of vascular flow using ultrasound may be useful to assess endothelial function and vasodilatation. There are four stages in this proposal. 1.The first stage is to standardise and validate the methodology to enable computational risk flow data and other flow characteristics to be used clinically. (Current Study). Further development of fluid modelling methods will enable particulate haemodynamics to be investigated, and incorporate detailed endothelial structure together with cellular pathways. 2. This should be followed up by studies in different patient groups investigating the association between the derived values and estimated risk (using other methods such as Framingham risk score). 3. Then, associated with underlying cardiovascular risk, prospective studies would be made to establish whether computational flow dynamic data can predict outcome. If successful it could prove to be a very useful marker of benefit following treatment in a clinical setting

Nonlinear Spin Dynamics in Ferromagnets with Electron-Nuclear Coupling

Nonlinear spin motion in ferromagnets is considered with nonlinearity due to three factors: (i) the sample is prepared in a strongly nonequilibrium state, so that evolution equations cannot be linearized as would be admissible for spin motion not too far from equilibrium, (ii) the system considered consists of interacting electron and nuclear spins coupled with each other via hyperfine forces, and (iii) the sample is inserted into a coil of a resonant electric circuit producing a resonator feedback field. Due to these nonlinearities, coherent motion of spins can develop, resulting in their ultrafast relaxation. A complete analysis of mechanisms triggering such a coherent motion is presented. This type of ultrafast coherent relaxation can be used for studying intrinsic properties of magnetic materials.Comment: 1 file, LaTex, 23 page

Survey of Planetary Nebulae at 30 GHz with OCRA-p

We report the results of a survey of 442 planetary nebulae at 30 GHz. The purpose of the survey is to develop a list of planetary nebulae as calibration sources which could be used for high frequency calibration in future. For 41 PNe with sufficient data, we test the emission mechanisms in order to evaluate whether or not spinning dust plays an important role in their spectra at 30 GHz. The 30-GHz data were obtained with a twin-beam differencing radiometer, OCRA-p, which is in operation on the Torun 32-m telescope. Sources were scanned both in right ascension and declination. We estimated flux densities at 30 GHz using a free-free emission model and compared it with our data. The primary result is a catalogue containing the flux densities of 93 planetary nebulae at 30 GHz. Sources with sufficient data were compared with a spectral model of free-free emission. The model shows that free-free emission can generally explain the observed flux densities at 30 GHz thus no other emission mechanism is needed to account for the high frequency spectra.Comment: 10 pages, 7 Postscript figures, to be published in A&

Heart failure following cancer treatment: characteristics, survival and mortality of a linked health data analysis

Background: Cardiotoxicity resulting in heart failure is a devastating complication of cancer therapy. A patient may survive cancer only to develop heart failure (HF), which has a higher mortality rate than some cancers. Aim: This study aimed to describe the characteristics and outcomes of HF in patients with blood or breast cancer after chemotherapy treatment. Methods: Queensland Cancer Registry, Death Registry and Hospital Administration records were linked (1996–2009). Patients were categorised as those with an index HF admission (that occurred after cancer diagnosis) and those without an index HF admission (non-HF). Results: A total of 15 987 patients was included, and 1062 (6.6%) had an index HF admission. Median age of HF patients was 67 years (interquartile range 58–75) versus 54 years (interquartile range 44–64) for non-HF patients. More men than women developed HF (48.6% vs 29.5%), and a greater proportion in the HF group had haematological cancer (83.1%) compared with breast cancer (16.9%). After covariate adjustment, HF patients had increased mortality risk compared with non-HF patients (hazard ratios 1.67 (95% confidence interval, 1.54–1.81)), and 47% of the index HF admission occurred within 1 year from cancer diagnosis and 70% within 3 years. Conclusion: Cancer treatment may place patients at a greater risk of developing HF. The onset of HF occurred soon after chemotherapy, and those who developed HF had a greater mortality risk