A new site with Neandertal lineage fossil remains: the Sima I of the Polvorín cave (Karrantza, Biscay, Northern Iberian Peninsula)

We present 16 new human fossil remains found at the Sima I of the Polvorín cave (Karrantza, Northern Iberian Peninsula). The remains probably belong to a single adult gracile individual, that possessed some Neandertal morphological features. The Sima I paleontological site is located in a gallery c. 33 m below the cave entrance. In 2020 we identified 10 human remains in the Arkeologi Museoa (Bilbao). These human remains were found in a purely paleontological assemblage recovered by speleolog..

Liquid Chromatography-Mass Spectrometry-Based Parallel Metabolic Profiling of Human and Mouse Model Serum Reveals Putative Biomarkers Associated with the Progression of Nonalcoholic Fatty Liver Disease

Keywords: NAFLD, steatosis, NASH, metabolomics, biomarkers. FOOTNOTE

Somos diversidad. Actividades para la formación de profesionales de la educación formal y no formal en diversidad sexual, familiar, corporal y de expresión e identidad de género

Este manual se presenta como una “caja de herramientas” donde acudir en busca de recursos y actividades didácticas para elaborar formaciones en diversidad sexual, familiar, corporal y de expresión e identidad de género, dirigidas a profesionales que trabajan con jóvenes. En este sentido, son materiales que se pueden adaptar a las necesidades de cada formación y a distintos niveles de conocimiento, tanto de los grupos participantes, como de la persona que dinamice las actividades y que son lo suficientemente flexibles para que puedan ser moldeados y utilizados según los recursos temporales y espaciales que presente cada propuestaformativa. “Somos diversidad” ofrece un total de 44 actividades articuladas en 5 módulos temáticos. Abrazar la diversidad como una oportunidad educativa Transformarse para transformar: afectividad, diferencia y diversidad Sexualidades Corporalidades, identidades y expresiones de género Diversidad familiar Cada módulo ofrece un índice inicial, una breve bienvenida donde se reflejan la justificación y objetivos del módulo, una serie de actividades y un apartado de bibliografía citada y consultada. En cada actividad se detalla su duración estimada, los objetivos propuestos, los recursos necesarios, las indicaciones para su desarrollo, y se aportan finalmente los materiales específicos necesarios para realizarlas. Este manual es el resultado de la actividad “Juventud y LGTBI+: abrazar la diversidad en la educación no formal y formal” dentro del Plan de Actividades Transnacionales (TCA) del programa Erasmus+: Juventud en Acción, organizada por el Injuve y el Grupo de Investigación “Antropología, Diversidad y Convivencia” de la Universidad Complutense de Madrid

Pseudociencia en Netflix: análisis de The goop lab with Gwyneth Paltrow (Netflix, 2020)

In the last decades of the XXth Century and the early years of the XXIst Century there has been unparalleled development in the field of science and technology; yet the dissemination of misleading pseudo-scientific content has proliferated with the advent of digital media. Through a quantitative analysis, the paper analyzes The Goop Lab (Netflix, 2020), the informative series on alternative therapies conducted and produced by actress, entrepreneur, and influencer Gwyneth Paltrow, and aimed at an eminently female audience. The aim is to show how the business and transmedia bet of goop, a brand created by Paltrow around the lifestyle (which covers nutrition guidelines, therapies of oriental spirituality, beauty products, exercise, sexual advice ... ), proposes an aspirational discourse based on an implicit promise of physical and/or psychological. It is concluded that this space appropriates the rhetorical strategies of scientific discourse as well as feminist postulates in order to obtain social validation and increase the audience and sales of its products and treatments. Finally, a taxonomy of the pseudoscientific rhetorical resources is made in order to promote an efficient and responsible use in the transmission of media informative contents.   En las últimas décadas del siglo XX y comienzos del siglo XXI se ha producido un intenso desarrollo en el campo científico y tecnológico; aun así, la difusión de contenidos pseudocientíficos engañosos ha proliferado con la llegada de los medios digitales. En este artículo, mediante un análisis cuantitativo, se analiza la serie divulgativa sobre terapias alternativas The Goop Lab with Gwyneth Paltrow (Netflix, 2020), conducida y producida por la actriz, empresaria e influencer Gwyneth Paltrow y dirigida a un público eminentemente femenino. Se pretende demostrar cómo la apuesta empresarial y transmedia de goop, marca creada por Paltrow en torno al lifestyle (que abarca pautas de nutrición, terapias de espiritualidad oriental, productos de belleza, tablas de ejercicios, consejos sexuales…) propone un discurso aspiracional basado en una promesa implícita de mejora física y/o psíquica. Se concluye que este espacio se apropia de las estrategias retóricas del discurso científico, así como de postulados feministas con el fin de obtener validación social e incrementar la audiencia y venta de sus productos y tratamientos. Finalmente se desglosa una taxonomía con los recursos retóricos pseudocientíficos utilizados en este espacio, con el que se pretende promover un uso eficiente y responsable en la transmisión de contenidos divulgativos mediáticos

Pasar la batería. Guion de Emilio Gutiérrez Caba

Proyecto I+D+i “Cine y televisión 1986-1995: modernidad y emergencia de la cultura global" (CSO2016-78354-P). Ministerio de Economía y Competitividad, Gobierno de España

LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study.

Phosphorylation is the most commonly studied protein post-translational modification (PTM) in biological systems due to its importance in controlling cell division, survival, growth, etc. Despite the thorough research in phosphoproteomics of cells and tissues there is little information on circulating phosphoproteins. We compared serum from 10 healthy dogs and 10 dogs affected by B. canis-caused babesiosis with no organ dysfunctions by employing gel-free LC-MS/MS analysis of individual samples and tandem mass tag (TMT) label-based quantitative analyses of pools, both supported by phosphopeptide enrichment. Results showed a moderate number of phosphorylated proteins (50-55), with 89 phosphorylation sites not previously published for dogs although a number of them matched phosphorylation sites found in mammalian orthologs. Three phosphopeptides showed significant variation in babesiosis-affected dog sera compared to controls: Serum amyloid A (SAA) phosphorylated at serine 101 (up-regulation), kininogen 1 phosphorylated at threonine 326, and fibrinogen α phosphorylated at both threonine 20 and serine 22 (down-regulation). 71.9% of the detected phosphorylated sites were phosphoserine, 16.8% phosphothreonine and only 11.2% phosphotyrosine residues. TMT label-based quantitative analysis showed α-2-HS-glycoprotein / Fetuin A to be the most abundant phosphoprotein (50-70% of all phosphoproteins) followed by kininogen-1 (10-20%). The alterations of phosphorylated proteins observed in canine babesiosis caused by Babesia canis suggest new insights into the largely neglected role of extracellular protein phosphorylation in health and disease, encouraging urgent further research on this area. To the best of our knowledge the present study represents the first attempt to characterize canine serum phosphoproteome

MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by Babesia canis.

Canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by Babesia canis upon treatment with Imizol®. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease. Sixteen healthy dogs and 31 dogs infected with Babesia canis, of which 18 showed complications, were treated with Imizol®. One dog died during the study (3.2%). Longitudinal study was perfomed by monitoring dogs at the first day of presentation (day 1) and 6 days later (day 7). Our results show that higher MCP-1 levels on day 1 are positively associated with the occurrence of complications, (complicated vs. uncomplicated; p = 0.00016). A similar pattern was observed for KC-like on day 1 (p = 0.0326) and day 7 (p = 0.044). Moreover, babesiosis caused by B. canis produced a steady increase in IL-8 levels with a moderate to strong negative correlation with erythrocyte counts and hematocrit in uncomplicated diseased dogs only (Spearman's rank correlation coefficient rs = -0.582 and rs = -0.598 respectively). Like for MCP-1, KC-like levels also differed in complicated and uncomplicated diseased dogs on day 1 (p = 0.03236) and day 7 (p = 0.044). Furthermore, KC-like levels were strongly correlated with IL-8 levels (rs = 0.663-0.7) and non-segmented neutrophil counts (rs = 0.572-0.732) in both diseased groups. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983. Cytokine cluster analysis presented in this study can contribute to a better understanding of the pathogenesis of babesiosis and serve as a prognostic tool for the early detection of cases with highest likelihood of developing complications. Overall, our studies show that infection by B. canis elicits a cytokine pattern that is distinct from that observed with B. rossi, and that some of the inflammatory mediators can be useful to predict complications. Our results also suggest targets for the development of novel therapeutic strategies in babesiosis caused by B. canis

MCP-1, KC-like and IL-8 as critical mediators of pathogenesis caused by <i>Babesia canis</i>

<div><p>Canine babesiosis caused by the intraerythrocytic protozoan parasite <i>Babesia canis</i> is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by <i>Babesia canis</i> upon treatment with Imizol<b>®</b>. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease. Sixteen healthy dogs and 31 dogs infected with <i>Babesia canis</i>, of which 18 showed complications, were treated with Imizol<b>®</b>. One dog died during the study (3.2%). Longitudinal study was perfomed by monitoring dogs at the first day of presentation (day 1) and 6 days later (day 7). Our results show that higher MCP-1 levels on day 1 are positively associated with the occurrence of complications, (complicated vs. uncomplicated; p = 0.00016). A similar pattern was observed for KC-like on day 1 (p = 0.0326) and day 7 (p = 0.044). Moreover, babesiosis caused by <i>B</i>. <i>canis</i> produced a steady increase in IL-8 levels with a moderate to strong negative correlation with erythrocyte counts and hematocrit in uncomplicated diseased dogs only (Spearman's rank correlation coefficient r_s = -0.582 and r_s = -0.598 respectively). Like for MCP-1, KC-like levels also differed in complicated and uncomplicated diseased dogs on day 1 (p = 0.03236) and day 7 (p = 0.044). Furthermore, KC-like levels were strongly correlated with IL-8 levels (r_s = 0.663–0.7) and non-segmented neutrophil counts (rs = 0.572–0.732) in both diseased groups. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983. Cytokine cluster analysis presented in this study can contribute to a better understanding of the pathogenesis of babesiosis and serve as a prognostic tool for the early detection of cases with highest likelihood of developing complications. Overall, our studies show that infection by <i>B</i>. <i>canis</i> elicits a cytokine pattern that is distinct from that observed with <i>B</i>. <i>rossi</i>, and that some of the inflammatory mediators can be useful to predict complications. Our results also suggest targets for the development of novel therapeutic strategies in babesiosis caused by <i>B</i>. <i>canis</i>.</p></div