Ecocardiografía con contraste

La ecocardiografía es una técnica de diagnóstico cardiológico que utiliza como método de estudio la emisión de haces de ultrasonido (US). Una de sus principales limitaciones es la mala propagación que tienen los US ante la presencia de grasa o aire, dificultando la visualización de las estructuras cardiacas, situación conocida como "mala ventana ecocardiográfica

Acuity, nurse staffing and workforce, missed care and patient outcomes. A cluster-unit-level descriptive comparison

Aim: To compare patient acuity, nurse staffing and workforce, missed nursing care and patient outcomes among hospital unit-clusters. Background: Relationships among acuity, nurse staffing and workforce, missed nursing care and patient outcomes, are not completely understood. Method: Descriptive design with data from four unit-clusters: medical, surgical, combined and stepdown units. Descriptive statistics were used to compare acuity, nurse staffing coverage, education and expertise, missed nursing care, and selected nurse-sensitive outcomes. Results: Patient acuity in general (medical, surgical and combined) floors is similar to step-down units, with an average of 5.6 required RN hours per patient day. In general wards, available RN hours per patient day reach only 50% of required RN hours to meet patient needs. Workforce measures are comparable among unit-clusters, and average missed nursing care is 21%. Patient outcomes vary among unit-clusters. Conclusion:Patient acuity is similar among unit-clusters, whilst nurse staffing coverage is halved in general wards. While RN education, expertise and missed care are comparable among unitclusters, mortality, skin injuries and risk of family compassion fatigue rates are higher in general wards. Implications for nursing management: Nurse managers play a pivotal role in hustling policy-makers to address structural understaffing in general wards, to maximize patient safety outcomes

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Ecocardiografía con contraste

La ecocardiografía es una técnica de diagnóstico cardiológico que utiliza como método de estudio la emisión de haces de ultrasonido (US). Una de sus principales limitaciones es la mala propagación que tienen los US ante la presencia de grasa o aire, dificultando la visualización de las estructuras cardiacas, situación conocida como "mala ventana ecocardiográfica

Ecocardiografía con contraste

La ecocardiografía es una técnica de diagnóstico cardiológico que utiliza como método de estudio la emisión de haces de ultrasonido (US). Una de sus principales limitaciones es la mala propagación que tienen los US ante la presencia de grasa o aire, dificultando la visualización de las estructuras cardiacas, situación conocida como "mala ventana ecocardiográfica

G‐protein‐coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas

Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal lining of the upper aerodigestive tract and display few treatment options in advanced stages. Despite increased knowledge of HNSCC molecular biology, the identification of new players involved in triggering HNSCC recurrence and metastatic disease is needed. We uncover that G‐protein‐coupled receptor kinase‐2 (GRK2) expression is reduced in undifferentiated, high‐grade human HNSCC tumors, whereas its silencing in model human HNSCC cells is sufficient to trigger epithelial‐to‐mesenchymal transition (EMT) phenotypic features, an EMT‐like transcriptional program and enhanced lymph node colonization from orthotopic tongue tumors in mice. Conversely, enhancing GRK2 expression counteracts mesenchymal cells traits by mechanisms involving phosphorylation and decreased functionality of the key EMT inducer Snail1. Our results suggest that GRK2 safeguards the epithelial phenotype, whereas its downregulation contributes to the activation of EMT programs in HNSCC.Our laboratories are supported by Agencia Estatal de Investigación of Spain (grants SAF2014‐55511‐R and SAF2017‐84125‐R to F.M.; SAF2015‐66015‐R and ISCIII PIE15/00081 to J.P.M.; SAF2016‐76504‐R to A.C. and BFU2014‐53128‐R to M.A.N.); CIBERCV‐Instituto de Salud Carlos III, Spain (grant CB16/11/00278 to F.M., co‐funded with European FEDER contribution), CIBERONC‐Instituto de Salud Carlos III (grant CB16/12/00228 and CB16/12/00295 to J.M.P. and A.C., respectively, co‐funded with European FEDER contribution); Instituto de Salud Carlos III, Spain (grant PI14/00201 and PI18/01662 to C.R.; PI18/00263 to R.G.E., co‐funded with European FEDER contribution) and Fundación Ramón Areces (to C.R and F.M.), Swiss National Science Foundation (grant 144637, 153099), Swiss Cancer League (grant KLS 3243‐08‐2013) and Fundacion Anemia de Fanconi (grant 2018/127) to R.G.E.; and Programa de Actividades en Biomedicina de la Comunidad de Madrid‐B2017/BMD‐3671‐INFLAMUNE to F.M. M.S.F. was recipient of a Postdoctoral fellowship from Comunidad de Madrid (PEFD‐2017‐POST/BMD‐4442) and A.A. holds a PhD Fellowship from FPI programme Agencia Estatal de Investigación (PRE2018‐084418). We also acknowledge institutional support to the CBMSO from Fundación Ramón Areces.Peer reviewe

X Premio Nacional Educación Para el Desarrollo "Vicente Ferrer" 2018 : buenas prácticas

La AECID junto con el Ministerio de Educación y Formación Profesional convoca anualmente los premios de educación para el desarrollo que están dirigidos a todos los centros docentes españoles sostenidos con fondos públicos que impartan educación infantil, educación primaria, educación secundaria obligatoria, bachillerato y formación profesional. Se recogen las buenas prácticas de los centros educativos premiados en esta novena edición. Docentes que en el ejercicio de su función educadora han con­vertido el proceso educativo en un proceso dinámico e interactivo que permite al alumnado desarrollar un conocimiento crítico de nuestro mundo. Profesores y profesoras que han estimulado la participación del alumnado en la construcción de estructuras sociales más justas y solidarias, y han promovido actuaciones basadas en el principio de la corresponsabilidad de todos los actores implicados.ES