REMOTE AGENT-BASED OBSERVABILITY TECHNIQUE FOR IOT APPLICATION TELEMETRY DATA COLLECTION

Techniques are presented herein that support a remote observability capability (comprising remote visibility, monitoring, and troubleshooting) for Internet of things (IoT) devices that are connected behind an IoT gateway (by agnostic network connectivity) through a dynamically deployed Enterprise Agent that is able to monitor all of the underlying state changes (through a southbound interface in an operational technology (OT) protocol agnostic manner) in IoT devices and then relay the collected telemetry data to a cloud-based facility. Aspects of the presented techniques leverage an embedded Subscriber Identity Module (eSIM)-based Java Card facility to collect telemetry data through a metrics, events, logs, and traces (MELT) framework and an OpenTelemetry (OTel) application programming interface (API) along with a wireless modem. Further aspects of the presented techniques leverage an IoT SIM Applet For Secure End-2-End Communication (SAFE) agent

PORTABLE NETWORK NAMESPACES: TRAFFIC COLORING FOR PORTABILITY

Techniques are described herein to add a “color” marker as a namespace to packets per service/microservice/container. This causes the namespace to be used within or between the cloud(s) for additional treatments

Development and Design of Energy Efficient Oil-Flooded Screw Compressors

It is estimated that about 17% of the world's generated power is used for compression. Thus all, even minor improvement of the efficiency of compressors will substantially reduce CO2 emission. This paper presents development of family of energy efficient oil-flooded screw compressors for Kirloskar Pneumatic Company Ltd. The developmental techniques adopted to improve efficiency such as introduction of superior 'N' rotor profile, rotor clearance management, performance calculation using 3D CCM (Computational Continuum Mechanics), direct parametric interface to CAD (Computer Aided Design), which contains bearing selection for complete 3D solid modelling. Also, contemporary prototyping and experimental investigation is supported by the fully computerised data acquisition and processing. The cumulative improvement of all these elements of the design process resulted in a very efficient machine which guarantees the competitive position of Kirloskar Pneumatic Company Limited in the screw compressor market

Bioadhesive or Mucoadhesive Drug Delivery System: A Potential Alternative to Conventional Therapy

The term bioadhesive describes materials that bind to biological substrates, such as mucosal membranes and in bioadhesive drug delivery systems, the term bioadhesion is used to describe the bonding or adhesion between a synthetic or natural polymer and soft tissues such as epithelial cells. The bioadhesive drug delivery formulation highlights the fact that readily accessible sites are utilized with the eye, oral cavity and vegina being targeted. The GI tract and the nasal cavity have also been extensively examined as a site for bioadhesive drug delivery. The term mucoadhesion is the subgroup of bioadhesion and in the mucoadhesion formulation attaches with the mucus membrane. The mucoadhesion can be defined as the adhesion between the two materials in which one is biological material and other one is polymeric materials with the help of interfacial forces to increase the residence time. Over the past few decades, mucosal drug delivery has received a great deal of attention. The mucoadhesion drug delivery system is better than the traditional drug delivery systems. Mucoadhesion is a useful strategy for drug delivery systems, such as tablets, patches, gels, liposomes, micro/nanoparticles, nanosuspensions, microemulsions and colloidal dispersions. The mucoadhesion bypasses the first pass metabolism and used for localized delivery of biomolecules such as peptides, proteins and oligonucleotides. Mucoadhesion drug delivery system engages much attention due to their benefits such as prolong retention time, fast uptake and increased bioavailability of active substance. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, theories of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, mucoadhesive polymers and herbal drugs. Keywords: Bioadhesive, bioadhesive drug delivery, Mucoadhesion, Patches, Herbal drug

Analytical Purity Method Development and Validation by gas Chromatography of L-valine Methyl Ester Hydrochloride for Production of Anti-hypertensive Drugs

Gas chromatography is the most widely used technique in pharmaceutical industry. Analytical chemistry research is largely driven by performance of sensitivity, selectivity, robustness, linear range, accuracy, precision. Validation is founded on but not specifically prescribed by regulatory requirements and is best viewed as an important and integral part of GMP (Good Manufacturing Practice). Gas chromatography method has been developed for L-valine methyl ester hydrochloride. It is used for production of anti-hypertensive drug. The Gas Chromatography system was used for method development and method validation with an auto injector and detection was performed by means of flame ionization detector (FID) with capillary column DB-624, 30m length, 0.53mm diameter and 1.0µm thickness. Nitrogen an inert gas was used as carrier gas. The method was validated for precision (system precision and method repeatability), recovery, linearity range, robustness and sample solution stability. The high recovery and low relative standard deviation confirms the suitability of the method for purity of L-valine methyl ester hydrochlride. It has been found from data of validation criteria that the proposed method has adequate reproducibility and specificity therefore suitable in pharmaceutical industry. Key words: Validation, Gas chromatography, FID, GMP, Pharmaceutical industry

Analysis of rolling bearing power loss models for twin screw oil injected compressor

The mechanical losses inside a screw compressor limit the performance of the compressor in terms of efficiency. These losses arise due to relative motion between elements inside the screw compressor. The estimation of mechanical losses predicted in the literature is around 10-15% of the total shaft power. One of the elements which contribute significantly to these losses is rolling element bearings. There are numerous mathematical models available which predict power losses in the rolling bearings. The objective of this paper is to study different models to predict power loss for rolling bearings and to predict the power losses for the bearings used for oil injected, twin screw compressor. A comparison between different power loss models for different operating conditions of compressor is also presented in this paper and results of analysis are compared with available experimental observations. The analysis helps to determine suitable power loss model for different operating conditions and more realistic predictions of the power losses. This allows designers for more accurate estimation of the performance of screw compressors

Accurate Iris Localization Using Edge Map Generation and Adaptive Circular Hough Transform for Less Constrained Iris Images

This paper proposes an accurate iris localization algorithm for the iris images acquired under near infrared (NIR) illuminations and having noise due to eyelids, eyelashes, lighting reflections, non-uniform illumination, eyeglasses and eyebrow hair etc. The two main contributions in the paper are an edge map generation technique for pupil boundary detection and an adaptive circular Hough transform (CHT) algorithm for limbic boundary detection, which not only make the iris localization more accurate but faster also. The edge map for pupil boundary detection is generated on intersection (logical AND) of two binary edge maps obtained using thresholding, morphological operations and Sobel edge detection, which results in minimal false edges caused by the noise. The adaptive CHT algorithm for limbic boundary detection searches for a set of two arcs in an image instead of a full circle that counters iris-occlusions by the eyelids and eyelashes. The proposed CHT and adaptive CHT implementations for pupil and limbic boundary detection respectively use a two-dimensional accumulator array that reduces memory requirements. The proposed algorithm gives the accuracies of 99.7% and 99.38% for the challenging CASIA-Iris-Thousand (version 4.0) and CASIA-Iris-Lamp (version 3.0) databases respectively. The average time cost per image is 905 msec. The proposed algorithm is compared with the previous work and shows better results

Liveness-Based Garbage Collection for Lazy Languages

We consider the problem of reducing the memory required to run lazy first-order functional programs. Our approach is to analyze programs for liveness of heap-allocated data. The result of the analysis is used to preserve only live data---a subset of reachable data---during garbage collection. The result is an increase in the garbage reclaimed and a reduction in the peak memory requirement of programs. While this technique has already been shown to yield benefits for eager first-order languages, the lack of a statically determinable execution order and the presence of closures pose new challenges for lazy languages. These require changes both in the liveness analysis itself and in the design of the garbage collector. To show the effectiveness of our method, we implemented a copying collector that uses the results of the liveness analysis to preserve live objects, both evaluated (i.e., in WHNF) and closures. Our experiments confirm that for programs running with a liveness-based garbage collector, there is a significant decrease in peak memory requirements. In addition, a sizable reduction in the number of collections ensures that in spite of using a more complex garbage collector, the execution times of programs running with liveness and reachability-based collectors remain comparable