205 research outputs found
A room of one\u27s own, revisited: An existential-hermeneutic study of female solitude
This study presents an existential-hermeneutic analysis of nine women\u27s first-person accounts of extended periods of solitude. The accounts were analyzed along the five existential dimensions of spatiality, temporality, embodiment, language, and co-existentiality, producing a rich portrait of the women\u27s lived experience of solitude. One of the first-person accounts was provided by the author of the study, who underwent three solitary retreats in the interest of this project, adding an autoethnographic component to the work. Theory from the existential-phenomenological, monastic, ecopsychological, and feminist literatures was applied to the data, enabling us to interpret the significance of the shifts the women experienced through an interdisciplinary set of lenses. The women experienced both subtle and profound shifts in their senses of self and modes of being in the world over the course of their retreats. In the absence of direct human relations, the women developed greater intimacy with things, non-human beings, and the Divine. Through the practice of simplicity, the women cultivated humility and more contemplative modes of seeing, revealing previously hidden contours of the material world and fostering a child-like sense of wonder. By leaving clock time and slowing down, the women became increasingly oriented toward the present moment, entrained to the rhythms of the natural world, and attuned to their desire. By retreating from the gaze of the (human) other, the women worked to heal a sense of alienation from their own bodies, experienced a respite from feminine performativity, and came to move through the world more seamlessly and comfortably. And by observing silence, the women cultivated the ability to listen beyond the human conversation and the chattering of their own minds, developed a more sacred relationship to language, confronted their emotional demons, and found themselves increasingly drawn toward the poetic. Overall, through their solitudes, the women developed a greater stance of receptivity toward the more-than-human world, deconstructed elements of identity and modes of being aligned with the false self, and recovered aspects of their lived experience which had been neglected or suppressed over the course of becoming an adult, and especially a woman, in the context of contemporary American culture
Mononuclear and dinuclear heteroleptic Cu(I) complexes based on pyridyl-triazole and DPEPhos with long-lived excited-state lifetimes
A mononuclear and two dinuclear heteroleptic Cu(I) complexes have been successfully prepared, using the chelating bis [(2-diphenylphosphino)phenyl] ether (DPEPhos) and pyrid-2'-yl-1H-1,2,3-triazole as chelating ligands. They show good luminescence in solution at room temperature with long-lived excited states. Furthermore, bimolecular quenching experiments of these new complexes with the catalyst Ni(cyclam)Cl-2 encourage the use of such compounds as photosensitizers for the photoreduction of carbon dioxide. (C) 2018 Elsevier B.V. All rights reserved.Peer reviewe
R-esp1, a rat homologue of Drosophila Groucho, is differentially expressed after optic nerve crush and mediates NGF-induced survival of PC12 cells
AbstractThe differential display reverse transcription polymerase chain reaction method was used to detect alterations in gene expression in the superior colliculus after optic nerve crush in adult rats. One of the most prominent changes observed was the selective induction of R-esp1, a homologue of the Drosophila enhancer of split locus (Groucho). Therefore, we studied the influence of R-esp1 on nerve growth factor (NGF)-induced cell survival of PC12 cells. Overexpression of R-esp1 promotes cell survival even in the absence of NGF and, conversely, it is reduced by antisense-mediated inhibition of R-esp1 expression. In conclusion, we propose a novel model in which R-esp1 protein mediates the NGF-signaling pathway
SPIRITUAL NEEDS OF PTSD PATIENTS IN CROATIA AND BOSNIA-HERZEGOVINA: A QUANTITATIVE PILOT STUDY
Background: As a result of the wars in Croatia and Bosnia-Herzegovina, many people have been affected by post-traumatic
stress disorder (PTSD). Considering that religion plays an important role in both of these countries and that religiosity/spirituality
can be a positive coping resource, we were interested in investigating the spiritual needs of PTSD patients in these countries. Also,
we aimed to compare the spiritual needs of war veterans and civilians with PTSD.
Methods: In this cross-sectional study, 120 questionnaires were distributed to civilians and veterans with PTSD at one university
hospital in Croatia and in Bosnia-Herzegovina, respectively (response rate: 52.2%). The sample ranged in age from 35-61 years
(average age: 49±1 years) and was mostly male (77.8%). The Spiritual Needs Questionnaire (SpNQ 2.1) was used. Data analysis
was conducted using SPSS.
Results: Two-thirds of participants identified themselves as religious and exhibited a variety of spiritual needs. The intensity of
spiritual needs (i.e., Religious Needs, Existential Needs, Inner Peace Needs, Giving / Generativity Needs; but also Social Support
needs) did not significantly differ between veterans and civilians. PTSD patients who identified themselves as non-religious had
significantly lower Religious Needs and Existential Needs; there was also a trend to lower Inner Peace Needs.
Conclusion: Regardless of religious identity, PTSD patients in our study expressed several psychosocial, existential and spiritual
needs. A holistic approach to treatment of these patients, which includes psychosocial and spiritual aspects, appears meaningful
Personal Prayer in Patients Dealing with Chronic Illness: A Review of the Research Literature
Background. Prayer is commonly used among patients for health purposes. Therefore, this review focused on three main questions: (1) why do people turn to prayer in times of illness?, (2) what are the main topics of their prayers?, and (3) how do they pray? Method. We undertook a systematic review of the literature by searching the databases PubMed, Medline, and PsycINFO. The following inclusion criteria were used: (1) participants in the study were patients dealing with an illness, (2) the study examined the use of private rather than intercessory prayer, and (3) the content and purpose of prayer rather than its effects were investigated. Results. 16 articles were included in the final review. Participants suffered from a variety of chronic diseases, mostly cancer. Five main categories for the reasons and topics of prayer were found: (1) disease-centered prayer, (2) assurance-centered prayer, (3) God-centered prayer, (4) others-centered prayer, and (5) lamentations. Among these, disease-centered prayer was most common. Conclusions. Although most patients with chronic diseases do pray for relief from their physical and mental suffering, the intention of their prayers is not only for healing. Rather, prayer can be a resource that allows patients to positively transform the experience of their illness
Deriving Historical Temperature and Precipitation Time Series For Alaska Climate Divisions Via Climatologically Aided Interpolation
This paper describes the construction of temperature and precipitation time series for climate divisions in Alaska for 1925-2015. Designed for NOAA climate monitoring applications, these new series build upon the divisional data of Bieniek et al. (2014) through the inclusion of additional observing stations, temperature bias adjustments, supplemental temperature elements, and enhanced computational techniques (i.e., climatologically aided interpolation). The new NOAA series are in general agreement with Bieniek et al. (2014), differences being attributable to the underlying methods used to compute divisional averages in each dataset. Trends in minimum temperature are significant in most divisions whereas trends in maximum temperature are generally not significant in the eastern third of the state. Likewise, the statewide rate of warming in minimum temperature (0.158°C dec-1) is roughly 50% larger than that of maximum temperature (0.101 °C dec-1). Trends in precipitation are not significant for most divisions or for the state as a whole
Financial toxicity in sarcoma patients and survivors in Germany : results from the multicenter PROSa study
Purpose
Cancer patients have been shown to frequently suffer from financial burden before, during, and after treatment. However, the financial toxicity of patients with sarcoma has seldom been assessed. Therefore, the aim of this study was to evaluate whether financial toxicity is a problem for sarcoma patients in Germany and identify associated risk factors.
Methods
Patients for this analysis were obtained from a multicenter prospective cohort study conducted in Germany. Using the financial difficulties scale of the EORTC QLQ-C30, financial toxicity was considered to be present if the score exceeded a pre-defined threshold for clinical importance. Comparisons to an age- and sex-matched norm population were performed. A multivariate logistic regression using stepwise backward selection was used to identify factors associated with financial toxicity.
Results
We included 1103 sarcoma patients treated in 39 centers and clinics; 498 (44.7%) patients reported financial toxicity. Sarcoma patients had 2.5 times the odds of reporting financial difficulties compared to an age- and sex-matched norm population. Patient age  52.5 years, higher education status, higher income, and disease progression (compared to patients with complete remission) were associated with lower odds of reporting financial toxicity. Receiving a disability pension, being currently on sick leave, and having a disability pass were statistically significantly associated with higher odds of reporting financial toxicity.
Conclusion
Financial toxicity is present in about half of German sarcoma patients, making it a relevant quality of life topic for patients and decision-makers
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