Phylogenomics of the early-divergent angiosperm family Annonaceae: resolving intergeneric relationships in the recalcitrant Miliuseae tribe

Main Theme: Contributions of Flora Malesiana to the Welfare of People in AsiaOral Presentation - Session 1: Taxonoly & Biosystematic-1Evolutionary relationships among main lineages of the Annonaceae have become much clear in recent years. The still poorly resolved phylogeny of tribe Miliuseae (subfamily Malmeoideae), however, represents the largest impediment to understanding broad-scale evolutionary patterns within the family. The Miliuseae comprises 25 genera and ...postprin

Video-Assisted Thoracoscopy For Penetrating Cardiac Box Injury in Stable Patients

Introduction: In high-volume trauma centers, especially in developing countries, penetrating cardiac box injuries are frequent. Although many aspects of penetrating chest injuries have been well established, video-assisted thoracoscopy is still finding its place in cardiac box trauma and algorithmic approaches are still lacking. The purpose of this manuscript is to provide a streamlined recommendation for penetrating cardiac box injury in stable patients. Methods: Literature review was carried out using PubMed/ MEDLINE and Google Scholar databases to identify articles describing the characteristics and concepts of penetrating cardiac box trauma, including the characteristics of tamponade, cardiac ultrasound, indications and techniques of pericardial windows and, especially, the role of video-assisted thoracoscopy in stable patients. Results: Penetrating cardiac box injuries, whether by stab or gunshot wounds, require rapid surgical consultation. Unstable patients require immediate open surgery, however, determining which stable patients should be taken to thoracoscopic surgery is still controversial. Here, the classification of penetrating cardiac box injury used in Colombia is detailed, as well as the algorithmic approach to these types of trauma. Conclusion: Although open surgery is mandatory in unstable patients with penetrating cardiac box injuries, a more conservative and minimally invasive approach may be undertaken in stable patients. As rapid decision-making is critical in the trauma bay, surgeons working in high-volume trauma centers should expose themselves to thoracoscopy and always consider this possibility in the setting of penetrating cardiac box injuries in stable patients, always in the context of an experienced trauma team

The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover

Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has a high mortality and is responsible for huge health expenditure. The pathophysiology of sepsis is very complex and it is not well-understood yet. However, it is widely accepted that the initial phase of sepsis is characterized by a hyperinflammatory response while the late phase is characterized by immunosuppression and immune anergy, increasing the risk of secondary infections. Granzymes (Gzms) are a family of serine proteases classified according to their cleavage specificity. Traditionally, it was assumed that all Gzms acted as cytotoxic proteases. However, recent evidence suggests that GzmB is the one with the greatest cytotoxic capacity, while the cytotoxicity of others such as GzmA and GzmK is not clear. Recent studies have found that GzmA, GzmB, GzmK, and GzmM act as pro-inflammatory mediators. Specially, solid evidences show that GzmA and GzmK function as extracellular proteases that regulate the inflammatory response irrespectively of its ability to induce cell death. Indeed, studies in animal models indicate that GzmA is involved in the cytokine release syndrome characteristic of sepsis. Moreover, the GZM family also could regulate other biological processes involved in sepsis pathophysiology like the coagulation cascade, platelet function, endothelial barrier permeability, and, in addition, could be involved in the immunosuppressive stage of sepsis. In this review, we provide a comprehensive overview on the contribution of these novel functions of Gzms to sepsis and the new therapeutic opportunities emerging from targeting these proteases for the treatment of this serious health problem

Coffee maturity classification using convolutional neural networks and transfer learning

This work presents a framework for coffee maturity classification from multispectral image data based on Convolutional Neural Networks (CNNs). The system leverages the use of multispectral image acquisition systems that generate large amounts of data, by taking advantage of the ability of CNNs to extract meaningful patterns from very high-dimensional data. We validated the use of five different popular CNN architectures on the classification of cherry coffee fruits according to their ripening stage. The different models were trained on a training dataset balanced in different ways, which resulted in a top accuracy higher than 98% when applied to the classification of 600 coffee fruits in 5 different stages of ripening. This work has the potential of providing the farmer with a high-quality, optimized, accurate and viable method for classifying coffee fruits. In order to foster future research in this area, the data used in this work, which was acquired with a custom-developed multispectral image acquisition system, have been released

Propuesta de diseño de un simulador de un microscopio electrónico de barrido para el desarrollo de aprendizaje significativo en nanotecnología

Se hace un estudio donde se identifica la necesidad de herramientas virtuales de aprendizaje de bajo coste para la enseñanza en nanotecnología y se propone el diseño de un simulador educativo para un equipo de microscopía electrónica de barrido SEM referencia JEOL NeoScope JCM 5000 para implementarse en el entorno de desarrollo de videojuegos Unity para el fomento del  aprendizaje significativo con estudiantes de básica secundaria, tomando como población de estudio los aprendices del programa de la Tecnoacademia nodo Cazuca del Servicio Nacional de Aprendizaje SENA. Se espera lograr identificar la diferencia en la implementación de éstas herramientas en el aprendizaje de técnicas de caracterización y el impacto que pueden generar éstas en el área de influencia

Cigarette smoking and metabolic syndrome components: a cross-sectional study from Maracaibo City, Venezuela [version 3; referees: 2 approved]

Background: A growing body of evidence suggests that cigarette smoking can cause the onset of metabolic syndrome prior to cardiovascular diseases. Therefore, the objective of this study was to evaluate the relationship between smoking habit and metabolic syndrome components in an adult population from Maracaibo city, Venezuela. Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multi-stage sampling. In this sub-study, 2212 adults from both genders were selected. On the basis of their medical background, they were classified as smokers, non-smokers and former smokers. Metabolic syndrome was defined according to Harmonizing 2009 criteria, using population-specific abdominal circumference cut-off points. The association between risk factors was evaluated using a logistic regression model. Results: In the studied population, 14.8% were smokers, 15.4% were former smokers. In the multivariate analysis, the presence of metabolic syndrome (smokers: OR, 1.54; 95% CI, 1.11–2.14; p=0.010) and its components were related to cigarette smoking, with the exception of hyperglycemia. High blood pressure was inversely associated with current smoking status (smokers: OR, 0.70 (0.51–0.95); p=0.025). Conclusion: Cigarette smoking represents a related factor with metabolic syndrome, being associated with low high-density lipoprotein-cholesterol, increased abdominal circumference and elevated triacylglyceride levels. Former smokers did not present a greater risk for developing this metabolic disease when compared to non-smokers. The effect of avoiding this habit should be evaluated in future studies in our population

Policy implications of achievement testing using multilevel models: the case of Brazilian elementary schools

Large-scale educational assessment has been established as source of descriptive, evaluative and interpretative information that influence educational policies worldwide throughout the last third of the twentieth century. In the 1990s the Brazilian Ministry of Education developed the National Basic Education Assessment System (SAEB) that regularly measures management, resource and contextual school features and academic achievement in public and private institutions. In 2005, after significant piloting and review of the SAEB, a new sampling strategy was taken and Prova Brasil became the new instrument used by the Ministry to assess skills in Portuguese (reading comprehension) and Mathematics (problem solving), as well as collecting contextual information concerning the school, principal, teacher, and the students. This study aims to identify which variables are predictors of academic achievement of fifth grade students on Prova Brasil. Across a large sample of students, multilevel models tested a large number of variables relevant to student achievement. This approach uncovered critical variables not commonly seen as significant in light of other achievement determinants, including student habits, teacher ethnicity, and school technological resources. As such, this approach demonstrates the value of MLM to appropriately nuanced educational policies that reflect critical influences on student achievement. Its implications for wider application for psychology studies that may have relevant impacts for policy are also discussed

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