Una nueva especie de Atelopus A.M.C. Dumeril and Bibron 1841 (Amphibia: Bulonidae) de la cordillera occidental, Colombia

Se nomina y describe una nueva especie de atelopus del grupo longirostris: A.negreti del flanco occidental de la Cordillera Occidental, límite S. del Parque Nacional Natural Munchique, Cauca, 1470-1580m.A new species of the genus Atelopus of the longirostris Group (A.negreti) is nomined and described from the Eastern slope of the Cordillera Occidental, S. P.N.N. Munchique, Cauca, at 1470-1580m

CONSENSO SOBRE EL USO DE PROTEÍNA EN EL PACIENTE CRÍTICO – ACNC

El paciente crítico tiene una pérdida de masa muscular significativa, observando frecuentemente sarcopenia en estos pacientes. Su presencia aumenta los desenlaces adversos, estancias hospitalarias, mayor riesgo de infecciones, aumento del tiempo de asistencia ventilatoria mecánica, mayor discapacidad al alta hospitalaria, menor posibilidad del retorno normal a la vida habitual de los pacientes, incremento en gastos en salud y mayor mortalidad. Objetivo: Indicar el uso oportuno y adecuado de la proteína en el paciente crítico. Métodos: la Asociación Colombiana De Nutrición Clínica (ACNC) y la Asociación Colombiana de Medicina Critica y Cuidados Intensivos (AMCI) mediante metodología de consenso realizaron unas recomendaciones con un grupo de expertos. Resultados: 46 recomendaciones fueron aprobadas con consenso superior al 80%. Conclusiones: La intervención óptima proteica temprana y progresiva en el paciente crítico, es importante para obtener los mejores desenlaces clínicos, disminuir complicaciones e impactar en costos de atención hospitalaria.

CONSENSO SOBRE O USO DE PROTEÍNA EM PACIENTES CRÍTICOS – ACNC

The critical patient has a significant loss of muscle mass, frequently observing sarcopenia in these patients. Its presence increases adverse outcomes, hospital stays, increased risk of infections, increased time on mechanical ventilatory assistance, greater disability at hospital discharge, less possibility of return to normal life for patients, increased health costs, and higher mortality. Objective: Indicate the opportune and adequate use of the protein in the critically ill patient. Methods: the Colombian Association of Clinical Nutrition (ACNC) and the Colombian Association of Critical Medicine and Intensive Care (AMCI), using a consensus methodology, made recommendations with a group of experts. Results: 46 recommendations were approved with a consensus greater than 80%. Conclusions: Optimal early and progressive protein intervention in critically ill patients is important to obtain the best clinical outcomes, reduce complications, and have an impact on hospital care costs.El paciente crítico tiene una pérdida de masa muscular significativa, observando frecuentemente sarcopenia en estos pacientes. Su presencia aumenta los desenlaces adversos, estancias hospitalarias, mayor riesgo de infecciones, aumento del tiempo de asistencia ventilatoria mecánica, mayor discapacidad al alta hospitalaria, menor posibilidad del retorno normal a la vida habitual de los pacientes, incremento en gastos en salud y mayor mortalidad. Objetivo: Indicar el uso oportuno y adecuado de la proteína en el paciente crítico. Métodos: la Asociación Colombiana De Nutrición Clínica (ACNC) y la Asociación Colombiana de Medicina Critica y Cuidados Intensivos (AMCI) mediante metodología de consenso realizaron unas recomendaciones con un grupo de expertos. Resultados: 46 recomendaciones fueron aprobadas con consenso superior al 80%. Conclusiones: La intervención óptima proteica temprana y progresiva en el paciente crítico, es importante para obtener los mejores desenlaces clínicos, disminuir complicaciones e impactar en costos de atención hospitalaria. O paciente crítico apresenta perda importante de massa muscular, observando-se frequentemente sarcopenia nesses pacientes. Sua presença aumenta os desfechos adversos, internações hospitalares, aumento do risco de infecções, aumento do tempo de assistência ventilatória mecânica, maior incapacidade na alta hospitalar, menor possibilidade de retorno à vida normal dos pacientes, aumento dos custos de saúde e maior mortalidade. Objetivo: Indicar o uso oportuno e adequado da proteína no paciente crítico. Métodos: a Associação Colombiana de Nutrição Clínica (ACNC) e a Associação Colombiana de Medicina Crítica e Terapia Intensiva (AMCI), utilizando uma metodologia de consenso, fizeram recomendações com um grupo de especialistas. Resultados: 46 recomendações foram aprovadas com consenso superior a 80%. Conclusões: A intervenção proteica precoce e progressiva ideal em pacientes críticos é importante para obter os melhores resultados clínicos, reduzir complicações e impactar nos custos hospitalares

Una nueva especie de Atelopus A.M.C. Dumeril & Bibron 1841 (Amphibia: Bulonidae) de la cordillera Occidental, Colombia

A new species of the genus Atelopus of the longirostris Group (A.negreti) is nomined and described from the Eastern slope of the Cordillera Occidental, S. P.N.N. Munchique, Cauca, at 1470-1580m.Se nomina y describe una nueva especie de atelopus del grupo longirostris: A.negreti del flanco occidental de la Cordillera Occidental, límite S. del Parque Nacional Natural Munchique, Cauca, 1470-1580m

Una nueva especie de Atelopus A.M.C. Dumeril & Bibron 1841 (Amphibia: Bulonidae) de la cordillera Occidental, Colombia

A new species of the genus Atelopus of the longirostris Group (A.negreti) is nomined and described from the Eastern slope of the Cordillera Occidental, S. P.N.N. Munchique, Cauca, at 1470-1580m.Se nomina y describe una nueva especie de atelopus del grupo longirostris: A.negreti del flanco occidental de la Cordillera Occidental, límite S. del Parque Nacional Natural Munchique, Cauca, 1470-1580m

59 Mild cognitive impairment among older adults with diabetes: A pilot study in San Juan, Puerto Rico

OBJECTIVES/GOALS: Research on mild cognitive impairment (MCI) risk factors in type 2 diabetes mellitus (T2DM) is scarce; however, MCI is a concern in T2DM as it can adversely impact self-care behaviors. This study aims to estimate the proportion of MCI and describe its sociodemographic, clinical, psychosocial, and lifestyle characteristics in older adults with T2DM. METHODS/STUDY POPULATION: Cross-sectional pilot study of 60 adults (aged ≥50yrs) with a diagnosis of T2DM will be recruited at a diabetes center located in San Juan, Puerto Rico. Data on sociodemographic, clinical, psychosocial (depressive symptoms and social support), and lifestyle characteristics related to diabetes self-management (diabetes self-care activities and activities of daily living) will be collected through face-to-face interviews using validated questionnaires. Our primary outcome will be MCI assessed via the Spanish-language version of the Montreal Cognitive Assessment (MoCA-S). The proportion of adults with MCI (MoCA-S score<26) will be estimated, and the sociodemographic, lifestyle, psychosocial, and clinical characteristics of older adults will be compared across MCI status using bivariate analysis. RESULTS/ANTICIPATED RESULTS: Expected results include an estimate of the proportion of MCI among older adults with T2DM, which we hypothesize will be higher in our study than in Puerto Rico’s older adult population (previously reported as 17%). Additionally, we will describe the sociodemographic, clinical, psychosocial, and lifestyle characteristics that significantly differ by MCI status in older adults with T2DM. We expect that those with MCI will be more likely to be females, have lower education and annual income, longer time with a diabetes diagnosis, worse psychosocial profiles (higher levels of depressive symptoms and lower levels of social support), and worse lifestyle profiles (poorer glycemic control and lower activities of daily living score) than those without MCI. DISCUSSION/SIGNIFICANCE: This pilot study is a first step to understanding MCI among older adults with T2DM in Puerto Rico, a Hispanic population with a higher prevalence of T2DM than their US non-Hispanic White counterparts. Its findings can guide the design and implementation of a larger epidemiological study aimed at understanding MCI risk factors among adults with T2DM

88 Feasibility of a Home-based Physiotherapy Program to Increase Physical Activity Levels in Older Adults with Diabetes Mellitus

OBJECTIVES/GOALS: The objective of this study is to assess the feasibility and preliminary impact of a physiotherapy protocol for developing an individualized home-based physical activity program to increase physical activity (PA) levels in sedentary older adults with Type II Diabetes Mellitus (T2DM) living in Puerto Rico (PR). METHODS/STUDY POPULATION: This will be a pilot study with two phases. In phase 1, we will design a novel patient-centered home-based PA program protocol for adults ≥65 years with T2DM based on the Information-Motivation-Behavioral Skills model. Its content validity will be assessed through focus groups with 10 experts and 10 older adults and analyzed using a directed content analysis. Phase 2 we will be program implementation using a one-group, repeated measures design with 12 adults ≥65 years with T2DM. PA levels will be assessed by recording active minutes with a Fitbit. Risk of falls, balance, strength, and physical function will be assessed through standardized tests validated for this population. Statistical analysis will include descriptive statistics, comparisons via chi-square/Fisher’s exact test, and non-parametric tests. RESULTS/ANTICIPATED RESULTS: We expect to recruit a minimum of 12 participants and to administer the program for 12 weeks at a frequency of two visits per week. We anticipate that implementing and supervising the home-based PA protocol will be feasible as determined by recruitment and retention rates, patients’ satisfaction, and compliance with the program. We also expect that this protocol will increase physical activity levels, improve general strength, balance, physical function, and reduce the risk of falls in sedentary older adults with T2DM. DISCUSSION/SIGNIFICANCE: As the third cause of death in PR, T2DM represents a public health challenge. An effective home-based PA program may decrease morbidity and mortality rates in older adults by increasing PA and functional health. This study will provide data for planning a randomized controlled trial to assess its effectiveness in the outcomes of interest

Association of body mass index with anal human papillomavirus infection and histologically confirmed high-grade squamous intraepithelial lesions in people who receive services at the Anal Neoplasia Clinic in Puerto Rico

Objective: This study aimed to assess the association of body mass index (BMI) with anal high-risk human papillomavirus (HR-HPV) and biopsy-confirmed histologic anal high-grade squamous intraepithelial lesions (HSIL) among a clinic-based sample of Hispanics in Puerto Rico. Methods: This cross-sectional study evaluated medical records of adults who received services at the Anal Neoplasia Clinic of the University of Puerto Rico Comprehensive Cancer Center between October 2014 and December 2022. The study included 543 records with complete clinical information regarding anal HR-HPV and anal HSIL status. Chi-square and logistic regression analyses were performed. Results: Mean age of participants was 44.10 ± 13.24 years, 65.2% were men, 71.7% were HIV-infected, 74.4% had anal HR-HPV infection, and 37.9% had biopsy-confirmed HSIL. Regarding BMI, 2.4% were underweight, 31.9% normal weight, and 39.0 % overweight; while 17.3 % had class I, 5.2% class II, and 4.2% class III obesity. No significant association was observed between BMI and anal HR-HPV infection in adjusted analyses. Lower odds of anal HSIL were observed among overweight individuals (OR: 0.63, 95% CI: 0.41 – 0.99) and those with class II/III obesity (OR: 0.48, 95% CI: 0.22 – 1.01) compared to adults with underweight/normal BMI, after adjusting for potential confounders. No significant association was observed for class I obesity. Conclusion: BMI was not associated with anal HR-HPV infection. Overweight and obese individuals had lower odds of having anal HSIL than adults with underweight/normal BMI. This finding could suggest underdiagnosis of HSIL among overweight/obese individuals, or reduced risk in this group

Steps toward determination of the size and structure of the broad-line region in active galactic nuclei. X. Variability of Fairall 9 from optical data

The results of an optical monitoring campaign on the active nucleus in the luminous Seyfert 1 galaxy Fairall 9 are presented. This campaign was undertaken in parallel with ultraviolet spectroscopic monitoring with the IUE satellite which is described in a separate paper. The primary purpose of this program is to measure the response times (or "lags") of the emission lines to continuum variations and thus to extend the range in luminosity of active galactic nuclei (AGNs) for which such measurements have been made. The main conclusions of this work are as follows : 1. Continuum (at 5340 Å ) variations of amplitude ~12% are detected on timescales as short as ~20 days. These variations are much larger than the typical uncertainties in the measurements, which are of order ~2%. Over ~94 days, a factor of 2 change in the nuclear continuum was observed. 2. The optical continuum light curve resembles that of the UV continuum, showing two "events" of low-amplitude variations with a duration of ~70 days and with no measurable lag between the UV and optical continuum light curves. The UV data show a third larger amplitude event that occurred after the optical monitoring had terminated and unfortunately went unobserved in the optical. 3. The Hβ emission-line flux also underwent significant, low-amplitude (≥20%) variations. Crosscorrelation analysis reveals that Hβ lags behind the UV continuum by about 23 days, a value much smaller than what was previously suggested by earlier variability studies. However, this small lag is consistent with the lags for the UV lines during this campaign in the sense that the Hβ lag is approximately 50% larger than that of Lya λ1216, as it has been found for lower luminosity AGNs. 4. The Hβ difference profile produced by subtracting the low-state from the high-state data can be described as a two-component structure with blue and red components of similar width (~2500 km s-ˡ) and that appear to vary in phase

The Stellar spectral features of nearby galaxies in the near infrared : tracers of thermally pulsing asymptotic giant branch stars?

We analyse the stellar absorption features in high signal-to-noise ratio (S/N) near-infrared (NIR) spectra of the nuclear region of 12 nearby galaxies, mostly spirals. The features detected in some or all of the galaxies in this sample are the TiO (0.843 and 0.886 μm), VO (1.048 μm), CN (1.1 and 1.4 μm), H₂O (1.4 and 1.9 μm) and CO (1.6 and 2.3 μm) bands. The C₂ (1.17 and 1.76 μm) bands are generally weak or absent, although C₂ (1.76 μm) may be weakly present in the mean galaxy spectrum. A deep feature near 0.93 μm, likely caused by CN, TiO and/or ZrO, is also detected in all objects. Fitting a combination of stellar spectra to the mean spectrum shows that the absorption features are produced by evolved stars: cool giants and supergiant stars in the early- or thermally pulsing asymptotic giant branch (E-AGB or TP-AGB) phases. The high luminosity of TP-AGB stars, and the appearance of VO and ZrO features in the data, suggest that TP-AGB stars dominate these spectral features. However, a contribution from other evolved stars is also likely. Comparison with evolutionary population synthesis models shows that models based on empirical libraries that predict relatively strong NIR features provide a more accurate description of the data. However, none of the models tested accurately reproduces all of the features observed in the spectra. To do so, the models will need to not only improve the treatment of TP-AGB stars, but also include good quality spectra of red giant and E-AGB stars. The uninterrupted wavelength coverage, high S/N and quantity of features we present here will provide a benchmark for the next generation of models aiming to explain and predict the NIR properties of galaxies.11 page(s