Zayıflama sonrası lomber disk herniasyonunun spontan regresyonu: Olgu sunumu

Diagnosis, treatment, and surgery for lumbar disc herniations have existed for over a century. However, during the last three decades, there have been many new developments in imaging techniques, surgical procedures, physical medicine, and rehabilitation. In light of this, the most effective and appropriate treatment is controversial. Spontaneous regression of sequestrated, extruded, or protruded disc herniation has often been reported in the literature, although it is still a rare phenomenon. After a thorough review of the literature, we did not find any case report about this phenomenon after weight loss. In this report, though, we present a recent case about spontaneous regression of extruded disc herniation following weight loss.Lomber disk hernisi için tanı, tedavi ve cerrahi yaklaşık yüz yıldır bilinmektedir. Bununla birlikte son 30 yıl içinde görüntüleme tekniklerinde, cerrahi tekniklerde ve fizik tedavi rehabilitasyonda birçok yeni gelişmeler olmuştur. Bunun ışığında, en etkili ve uygun tedavi halen tartışmalıdır. Sekestre, ekstrüde veya protrüde disk hernisinin spontan regresyonu literatürde sıkça bildirilmiş olmasına rağmen hâlâ nadir bir fenomendir. Bu fenomen hakkında literatürü taradığımızda, zayıflama sonrası disk hernisinin spontan regrese olduğuna dair bir olgu sunumuna rastlanmadı. Bu olguda zayıflamayı takiben ekstrüde disk hernisinin spontan regrese olduğu gösterildi

Bir erişkinde kronik spinal epidural hematom

Spinal epidural hematoma (SEH) causing neurological deficit is a rare clinical entity. It may have either traumatic origin or it may occur spontaneously. Majority of the reported cases of SEH had nontraumatic causes and most of them were in the acute stage. Early chronic traumatic SEH in an adult is very rare and its prompt diagnosis with magnetic resonance imaging (MRI) is crucial for the accurate management of the patient. Our case was 56 year-old man presented at our neurosurgery clinic with a complaint of progressive burning pain, weakness, paresthesia over the left leg and hypoesthesia over the pelvic region. In this report, we presented a postraumatic lumbar SEH which is a unique presentation of chronic traumatic SEH because of long time interval between the trauma and beginning of the symptoms.Spinal epidural hematomda( SEH) nörolojik defisit nadir görülen bir klinik tablodur. SEH travmatik veya spontan nedenlere bağlı oluşur. Literatürde SEH vakaları akut başlangıçlı ve çoğunda spontan olarak ortaya çıktığı bildirilmiştir.Yetişkin hastalarda SEH nadir görülür. MRG hızlı tanısı konularak uygun tedavi yöntemi seçilmelidir. Bizim sunduğumuz olgu 56 yaşında erkeke hasta idi. Beyin cerrahi polikliniğimize ilerleyici yanma tarzında ağrı, pelvik bölgeden sol bacağa duğru uzanan duyu kaybı, yorgunluk ile başvurdu. Bu yazımızda travma ile semptomların ortaya çıkışı arasında uzun süre olan bir olgu sunulmuştur

Comparison of polyetheretherketone (PEEK) cage and cervical disc prostheses used in anterior cervical microscopic discectomy operations

Objective: The aim of this study was to radiologically and clinically compare the polyetheretherketone (PEEK) cage and cervical disc prostheses used in anterior cervical microdiscectomy operations during the postoperative period. Methods: The study evaluated 25 cervical disc hernia patients. The cervical disc prosthesis group (Group A) comprised 10 patients while the PEEK cage group (Group B) comprised 15 patients. Before and after the operation, the cervical graphics from radiological monitoring and VAS, NDI and Odom scores from clinical monitoring were used. The patients’ preoperative and postoperative cervical graphics disc height, cervical axis and segmental angles were evaluated to determine statistical relationships with neurological situation and quality of life. Results: In the cervical disc prosthesis group (Group A) in the early postoperative period (3rd week), 3rd month and late period (18-36 months), the intervertebral disc height measurements were significantly higher than the cervical PEEK cage group (Group B) (early p0.05). Clinical evaluation of the patients found no statistical difference in the evaluation of VAS, NDI or Odom scores of the two groups before and after the operation. Conclusion: It was shown that in the cervical disc prosthesis group (Group A) in the early and later postoperative period, intervertebral disk heights were preserved by a statistically significant amount compared to the PEEK cage group (Group B). However, this scenario did not create any significant difference in the clinical evaluation results. [Arch Clin Exp Surg 2017; 6(1.000): 1-8

Comparison of anterior cervical discectomy fusion techniques: Bladed and non bladed PEEK cages

WOS: 000379454800014PubMed ID: 27161468AIM: The aim of this study is to compare the different types of fusion materials known as PEEK cages used during anterior cervical discectomy (ACD) surgery. MATERIAL and METHODS: A total of 67 patients were operated and evaluated retrospectively under two groups (group A: 35 PEEK cage patients, group B: 32 bladed PEEK cage patients) between 2009 and 2013. Preoperative and postoperative (postoperative first day, postoperative 1st, 3rd and 12-24th mo) images were obtained. The cervical disc heights, cervical and segmental lordotic angles of the operated levels were calculated. Pain assessment was performed and fusion rates were also compared. Mann-Whitney U test was applied to compare the outcomes. RESULTS: The pain scores (especially for arm pain) were decreased significantly in both groups after surgery regardless of the type of operation technique (P0.05). In addition to these; there was no significant difference between both groups of segmental and cervical lordodic angles in postoperative periods (P>0.05). There was no statistically significant difference between the fusion rates and pain scores of both groups (P>0.05). CONCLUSION: The PEEK cage and bladed PEEK cages can be used safely to obtain fusion after ACD

Genistein exerts neuroprotective effect on focal cerebral ischemia injury in rats

silan, coskun/0000-0002-8352-6571; Guven, Mustafa/0000-0001-8643-9775; Silan, Coskun/0000-0002-8352-6571WOS: 000354086100043PubMed: 25567369Brain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in genistein, previously unstudied, on oxidative damage in cerebral ischemia. Rats were randomly divided into three groups: control group (no medication or surgical procedure), ischemia group, and artery ischemia+genistein group, sacrificed at 24 h after ischemia. the harvested brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after genistein treatment, while increased malondialdehyde levels after ischemia reduced after treatment. Apoptosis-related cysteine peptidase caspase-3 and caspase-9 values increased after ischemia, but reduced after treatment. Our study revealed that genistein treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. We believe that genistein treatment may be an alternative treatment method

The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats

silan, coskun/0000-0002-8352-6571; Guven, Mustafa/0000-0001-8643-9775; Silan, Coskun/0000-0002-8352-6571WOS: 000357666000023PubMed: 25687639Cerebral ischemia is still one of the most important topics in neurosciences. Our study aimed to investigate the neuroprotective and anti-oxidant effects of glycyrrhizic acid on focal cerebral ischemia in rats. Twenty-four rats were divided equally into three groups. A middle cerebral artery occlusion model was performed in this study where sham and glycyrrhizic acid were administered intraperitoneally following middle cerebral artery occlusion. Group I was evaluated as control. Malondialdehyde (MDA), superoxide dismutase (SOD), and nuclear respiratory factor-1 (NRF1) levels were analyzed biochemically on the right cerebral hemisphere, while ischemic histopathological studies were completed to investigate the anti-oxidant status. Biochemical results showed that SOD and NRF1 levels were significantly increased in the glycyrrhizic acid group compared with the sham group while MDA levels were significantly decreased. on histopathological examination, cerebral edema, vacuolization, degeneration, and destruction of neurons were decreased in the glycyrrhizic acid group compared with the sham group. Cerebral ischemia was attenuated by glycyrrhizic acid administration. These observations indicate that glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress

The protective effect of syringic acid on ischemia injury in rat brain

Background/aim: Brain ischemia and treatment are important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most significant causes of damage. Currently there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in syringic acid, previously unstudied, on oxidative damage in cerebral ischemia. Materials and methods: The rats were randomly divided into 4 groups: control group (no medication or surgical procedure), sham group (artery occlusion), artery occlusion + syringic acid group sacrificed at 6 h, and artery occlusion + syringic acid group sacrificed at 24 h. Obtained brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Results: Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after syringic acid treatment, while increased malondialdehyde levels after ischemia were reduced after treatment. Caspase-3 and caspase-9 values increased after ischemia and decreased after treatment; this reduction was more pronounced at 24 h. Conclusion: Our study revealed that syringic acid treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. In the light of the biochemical and histopathologic results of the present study, we think that syringic acid treatment may be an alternative treatment method

The Reasons Of Patients With Headache Chosing The Neurosurgery Outpatient Clinic

OBJECTIVE: We aimed to investigate the preference causes of the patients who were admitted to the neurosurgery clinic with complaints of headache for admission in this clinic. METHODS: The study population has been selected from brain surgery department outpatient clinic. One hundred patients with complaints of headache were enrolled in this study. RESULTS: Questioned the reasons for choosing the neurosurgical and most preferred cause of including word for brain surgery of the brain named (n=54, 54%). Patients were questioned about the information of the neurology and demostrated that there was not any knowledge about neurology (n=66, 66%). CONCLUSION: Headache causes loss of the financial and workforce. Preferences in the wrong departments of the patients, as a result of misdiagnosis and inadequate treatment, increasing the number of hospital admissions. This shows that how important names and introduction of the department

The neuroprotective effect of syringic acid on spinal cordischemia/reperfusion injury in rats

WOS: 000360847200026PubMed ID: 25903968Acute arterial occlusions via different vascular pathologies are the main causes of spinal cord ischemia. We investigated neuroprotective effects of syringic acid on spinal cord ischemia injury in rats. Rats were divided into four groups: (I) sham-operated control rats, (II) spinal cord ischemia group, (III) spinal cord ischemia group performed syringic acid, and (IV) spinal cord ischemia group performed methylprednisolone intraperitoneally. Spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. The spinal cord was removed after the procedure. The biochemical and histopathological changes were observed within the samples. Functional assessment was performed for neurological deficit scores. A significant decrease was seen in malondialdehyde levels in group III as compared to group II (P < 0.05). Besides these, nuclear respiratory factor-1 and superoxide dismutase activity of group III were significantly higher than group II (P < 0.05). In histopathological samples, when group III was compared with group II, there was a significant decrease in numbers of apoptotic neurons (P < 0.05). In immunohistochemical staining, BECN1 and caspase-3-immunopositive neurons were significantly decreased in group III compared with group II (P < 0.05). The neurological deficit scores of group III were significantly higher than group II at twenty-fourth hour of ischemia (P < 0.05). Our study revealed that syringic acid pretreatment in spinal cord ischemia/reperfusion reduced oxidative stress and neuronal degeneration as a neuroprotective agent. Ultrastructural studies are required for syringic acid to be developed as a promising therapeutic agent to be utilized for human spinal cord ischemia in the future