290 research outputs found
A Rich Cluster of Galaxies Near the Quasar B2 1335+28 at z=1.1: Color Distribution and Star-Formation Properties
We previously reported a significant clustering of red galaxies (R-K=3.5--6)
around the radio-loud quasar B2 1335+28 at z=1.086. In this paper, we establish
the existence of a rich cluster at the quasar redshift, and study the
properties of the cluster galaxies through further detailed analysis of the
photometric data. The color distribution of the galaxies in the cluster is
quite broad and the fraction of blue galaxies (\sim 70%) is much larger than in
intermediate-redshift clusters. Using evolutionary synthesis models, we show
that this color distribution can be explained by galaxies with various amounts
of star-formation activity mixed with the old stellar populations. Notably,
there are about a dozen galaxies which show very red optical-NIR colors but
also show significant UV excess with respect to passive-evolution models. They
can be interpreted as old early-type galaxies with a small amount of star
formation. The fact that the UV-excess red galaxies are more abundant than the
quiescent red ones suggests that a large fraction of old galaxies in this
cluster are still forming stars to some extent. However, a sequence of
quiescent red galaxies is clearly identified on the R-K versus K
color-magnitude (C-M) diagram. The slope and zero point of their C-M relation
appear to be consistent with those expected for the precursors of the C-M
relation of present-day cluster ellipticals when observed at z=1.1. We estimate
the Abell richness class of the cluster to be R \sim 1. New X-ray data
presented here place an upper limit of L_x < 2 10^{44} erg s^{-1} for the
cluster luminosity. Inspections of the wider optical images reveal some lumpy
structure, suggesting that the whole system is still dynamically young.Comment: 54 pages including 13 Postscript figures, 1 jpg figure, and 1 table,
uses aasms4.sty and epsf.sty. Accepted for publication in ApJ: Replaced as
the older verison was missed to include the figure 2c, 2d, and figure
Red Companions to a z=2.15 Radio Loud Quasar
We have conducted observations of the environment around the z=2.15 radio
loud quasar 1550-269 in search of distant galaxies associated either with it or
the z=2.09 CIV absorber along its line of sight. Such objects will be
distinguished by their red colours, R-K>4.5. We find five such objects in a 1.5
arcmin^2 field around the quasar, with typical K magnitudes of ~20.4 and no
detected R band emission. We also find a sixth object with K=19.6+/-0.3, and
undetected at R, just two arcseconds from the quasar. The nature of all these
objects is currently unclear, and will remain so until we have determined their
redshifts. We suggest that it is likely that they are associated with either
the quasar or the CIV absorber, in which case their properties might be similar
to those of the z=2.38 red Ly-alpha emitting galaxies discovered by Francis et
al. (1997). The small separation between the quasar and the brightest of our
objects suggests that it may be the galaxy responsible for the CIV metal line
absorption system. The closeness to the quasar and the red colour might have
precluded similar objects from being uncovered in previous searches for
emission from CIV and eg. damped absorbers.Comment: To appear in "Photometric Redshifts and High Redshift Galaxies", eds.
R. Weymann, L. Storrie-Lombardi, M. Sawicki & R. Brunne
Evidence of Environmental Dependencies of Type Ia Supernovae from the Nearby Supernova Factory indicated by Local H{\alpha}
(Abridged) We study the host galaxy regions in close proximity to Type Ia
supernovae (SNe Ia) to analyze relations between the properties of SN Ia events
and environments most similar to where their progenitors formed. We focus on
local H\alpha\ emission as an indicator of young environments. The Nearby
Supernova Factory has obtained flux-calibrated spectral timeseries for SNe Ia
using integral field spectroscopy, allowing the simultaneous measurement of the
SN and its immediate vicinity. For 89 SNe Ia we measure H\alpha\ emission
tracing ongoing star formation within a 1 kpc radius around each SN. This
constitutes the first direct study of the local environment for a large sample
of SNe Ia also having accurate luminosity, color and stretch measurements. We
find that SNe Ia with local H\alpha\ emission are redder by 0.036+/-0.017 mag,
and that the previously-noted correlation between stretch and host mass is
entirely driven by the SNe Ia coming from passive regions. Most importantly,
the mean standardized brightness for SNe Ia with local H\alpha\ emission is
0.094+/-0.031 mag fainter than for those without. This offset arises from a
bimodal structure in the Hubble residuals, that also explains the
previously-known host-mass bias. We combine this bimodality with the cosmic
star-formation rate to predict changes with redshift in the mean SN Ia
brightness and the host-mass bias. This change is confirmed using high-redshift
SNe Ia from the literature. These environmental dependences point to remaining
systematic errors in SNe Ia standardization. The observed brightness offset is
predicted to cause a significant bias in measurements of the dark energy
equation of state. Recognition of these effects offers new opportunities to
improve SNe Ia as cosmological probes - e.g. SNe Ia having local H\alpha\
emission are more homogeneous, having a brightness dispersion of 0.105+/-0.012
mag.Comment: accepted for publication in Section 3. Cosmology of A&A (The official
date of acceptance is 30/08/2013
Type Ia Supernova Hubble Residuals and Host-Galaxy Properties
Kim et al. (2013) [K13] introduced a new methodology for determining
peak-brightness absolute magnitudes of type Ia supernovae from multi-band light
curves. We examine the relation between their parameterization of light curves
and Hubble residuals, based on photometry synthesized from the Nearby Supernova
Factory spectrophotometric time series, with global host-galaxy properties. The
K13 Hubble residual step with host mass is mag for a supernova
subsample with data coverage corresponding to the K13 training; at , the step is not significant and lower than previous measurements.
Relaxing the data coverage requirement the Hubble residual step with host mass
is mag for the larger sample; a calculation using the modes of
the distributions, less sensitive to outliers, yields a step of 0.019 mag. The
analysis of this article uses K13 inferred luminosities, as distinguished from
previous works that use magnitude corrections as a function of SALT2 color and
stretch parameters: Steps at significance are found in SALT2 Hubble
residuals in samples split by the values of their K13 and
light-curve parameters. affects the light-curve width and color around
peak (similar to the and stretch parameters), and
affects colors, the near-UV light-curve width, and the light-curve decline 20
to 30 days after peak brightness. The novel light-curve analysis, increased
parameter set, and magnitude corrections of K13 may be capturing features of
SN~Ia diversity arising from progenitor stellar evolution.Comment: 17 pages, 6 figures. Accepted by Astrophysical Journa
Measuring cosmic bulk flows with Type Ia Supernovae from the Nearby Supernova Factory
Context. Our Local Group of galaxies appears to be moving relative to the
cosmic microwave background with the source of the peculiar motion still
uncertain. While in the past this has been studied mostly using galaxies as
distance indicators, the weight of type Ia supernovae (SNe Ia) has increased
recently with the continuously improving statistics of available low-redshift
supernovae.
Aims. We measured the bulk flow in the nearby universe ()
using 117 SNe Ia observed by the Nearby Supernova Factory, as well as the
Union2 compilation of SN Ia data already in the literature.
Methods. The bulk flow velocity was determined from SN data binned in
redshift shells by including a coherent motion (dipole) in a cosmological fit.
Additionally, a method of spatially smoothing the Hubble residuals was used to
verify the results of the dipole fit. To constrain the location and mass of a
potential mass concentration (e.g., the Shapley supercluster) responsible for
the peculiar motion, we fit a Hubble law modified by adding an additional mass
concentration.
Results. The analysis shows a bulk flow that is consistent with the direction
of the CMB dipole up to , thereby doubling the volume over which
conventional distance measures are sensitive to a bulk flow. We see no
significant turnover behind the center of the Shapley supercluster. A simple
attractor model in the proximity of the Shapley supercluster is only marginally
consistent with our data, suggesting the need for another, more distant source.
In the redshift shell , we constrain the bulk flow velocity to
(68% confidence level) for the direction of the CMB
dipole, in contradiction to recent claims of the existence of a large-amplitude
dark flow.Comment: 12 pages, 5 figures, added corrigendum
(http://adsabs.harvard.edu/abs/2015A%26A...578C...1F
Interleukin-2 therapy in patients with HIV infection
BACKGROUND
Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known.
METHODS
We conducted two trials: the Subcutaneous Recombinant, Human Interleukin-2 in HIV-Infected Patients with Low CD4+ Counts under Active Antiretroviral Therapy (SILCAAT) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). In each, patients infected with the human immunodeficiency virus (HIV) who had CD4+ cell counts of either 50 to 299 per cubic millimeter (SILCAAT) or 300 or more per cubic millimeter (ESPRIT) were randomly assigned to receive interleukin-2 plus antiretroviral therapy or antiretroviral therapy alone. The interleukin-2 regimen consisted of cycles of 5 consecutive days each, administered at 8-week intervals. The SILCAAT study involved six cycles and a dose of 4.5 million IU of interleukin-2 twice daily; ESPRIT involved three cycles and a dose of 7.5 million IU twice daily. Additional cycles were recommended to maintain the CD4+ cell count above predefined target levels. The primary end point of both studies was opportunistic disease or death from any cause.
RESULTS
In the SILCAAT study, 1695 patients (849 receiving interleukin-2 plus antiretroviral therapy and 846 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 202 cells per cubic millimeter were enrolled; in ESPRIT, 4111 patients (2071 receiving interleukin-2 plus antiretroviral therapy and 2040 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 457 cells per cubic millimeter were enrolled. Over a median follow-up period of 7 to 8 years, the CD4+ cell count was higher in the interleukin-2 group than in the group receiving antiretroviral therapy alone--by 53 and 159 cells per cubic millimeter, on average, in the SILCAAT study and ESPRIT, respectively. Hazard ratios for opportunistic disease or death from any cause with interleukin-2 plus antiretroviral therapy (vs. antiretroviral therapy alone) were 0.91 (95% confidence interval [CI], 0.70 to 1.18; P=0.47) in the SILCAAT study and 0.94 (95% CI, 0.75 to 1.16; P=0.55) in ESPRIT. The hazard ratios for death from any cause and for grade 4 clinical events were 1.06 (P=0.73) and 1.10 (P=0.35), respectively, in the SILCAAT study and 0.90 (P=0.42) and 1.23 (P=0.003), respectively, in ESPRIT.
CONCLUSIONS
Despite a substantial and sustained increase in the CD4+ cell count, as compared with antiretroviral therapy alone, interleukin-2 plus antiretroviral therapy yielded no clinical benefit in either study. (ClinicalTrials.gov numbers, NCT00004978 [ESPRIT] and NCT00013611 [SILCAAT study].
Improving Cosmological Distance Measurements Using Twin Type Ia Supernovae
We introduce a method for identifying "twin" Type Ia supernovae, and using
them to improve distance measurements. This novel approach to Type Ia supernova
standardization is made possible by spectrophotometric time series observations
from the Nearby Supernova Factory (SNfactory). We begin with a well-measured
set of supernovae, find pairs whose spectra match well across the entire
optical window, and then test whether this leads to a smaller dispersion in
their absolute brightnesses. This analysis is completed in a blinded fashion,
ensuring that decisions made in implementing the method do not inadvertently
bias the result. We find that pairs of supernovae with more closely matched
spectra indeed have reduced brightness dispersion. We are able to standardize
this initial set of SNfactory supernovae to 0.083 +/- 0.012 magnitudes,
implying a dispersion of 0.072 +/- 0.010 magnitudes in the absence of peculiar
velocities. We estimate that with larger numbers of comparison SNe, e.g, using
the final SNfactory spectrophotometric dataset as a reference, this method will
be capable of standardizing high-redshift supernovae to within 0.06-0.07
magnitudes. These results imply that at least 3/4 of the variance in Hubble
residuals in current supernova cosmology analyses is due to previously
unaccounted-for astrophysical differences among the supernovaeComment: 37 pages, 9 figures, 5 tables. Accepted for publication in ApJ. Fixed
typo in arXiv abstrac
Dynamics of Highly Supercooled Liquids:Heterogeneity, Rheology, and Diffusion
Highly supercooled liquids with soft-core potentials are studied via
molecular dynamics simulations in two and three dimensions in quiescent and
sheared conditions.We may define bonds between neighboring particle pairs
unambiguously owing to the sharpness of the first peak of the pair correlation
functions. Upon structural rearrangements, they break collectively in the form
of clusters whose sizes grow with lowering the temperature . The bond life
time , which depends on and the shear rate \gdot, is on the order
of the usual structural or relaxation time in weak
shear \gdot \tau_{\alpha} \ll 1, while it decreases as 1/\gdot in strong
shear \gdot\tau_{\alpha} \gg 1 due to shear-induced cage breakage.
Accumulated broken bonds in a time interval () closely
resemble the critical fluctuations of Ising spin systems. For example, their
structure factor is well fitted to the Ornstein-Zernike form, which yields the
correlation length representing the maximum size of the clusters composed
of broken bonds. We also find a dynamical scaling relation, , valid for any and \gdot with in two dimensions and
in three dimensions. The viscosity is of order for any and
\gdot, so marked shear-thinning behavior emerges. The shear stress is close
to a limiting stress in a wide shear region. We also examine motion of tagged
particles in shear in three dimensions. The diffusion constant is found to be
of order with for any and \gdot, so
it is much enhanced in strong shear compared with its value at zero shear. This
indicates breakdown of the Einstein-Stokes relation in accord with experiments.
Some possible experiments are also proposed.Comment: 20pages (including figures
Prevalence of Disorders Recorded in Dogs Attending Primary-Care Veterinary Practices in England
Purebred dog health is thought to be compromised by an increasing occurence of inherited diseases but inadequate prevalence data on common disorders have hampered efforts to prioritise health reforms. Analysis of primary veterinary practice clinical data has been proposed for reliable estimation of disorder prevalence in dogs. Electronic patient record (EPR) data were collected on 148,741 dogs attending 93 clinics across central and south-eastern England. Analysis in detail of a random sample of EPRs relating to 3,884 dogs from 89 clinics identified the most frequently recorded disorders as otitis externa (prevalence 10.2%, 95% CI: 9.1-11.3), periodontal disease (9.3%, 95% CI: 8.3-10.3) and anal sac impaction (7.1%, 95% CI: 6.1-8.1). Using syndromic classification, the most prevalent body location affected was the head-and-neck (32.8%, 95% CI: 30.7-34.9), the most prevalent organ system affected was the integument (36.3%, 95% CI: 33.9-38.6) and the most prevalent pathophysiologic process diagnosed was inflammation (32.1%, 95% CI: 29.8-34.3). Among the twenty most-frequently recorded disorders, purebred dogs had a significantly higher prevalence compared with crossbreds for three: otitis externa (Pâ=â0.001), obesity (Pâ=â0.006) and skin mass lesion (Pâ=â0.033), and popular breeds differed significantly from each other in their prevalence for five: periodontal disease (Pâ=â0.002), overgrown nails (Pâ=â0.004), degenerative joint disease (Pâ=â0.005), obesity (Pâ=â0.001) and lipoma (Pâ=â0.003). These results fill a crucial data gap in disorder prevalence information and assist with disorder prioritisation. The results suggest that, for maximal impact, breeding reforms should target commonly-diagnosed complex disorders that are amenable to genetic improvement and should place special focus on at-risk breeds. Future studies evaluating disorder severity and duration will augment the usefulness of the disorder prevalence information reported herein
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: a case control study
Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR-145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infectionDaniel D. Murray, Kazuo Suzuki, Matthew Law, Jonel Trebicka ... Rogers Gary D, ... David R. Shaw ... et al. (INSIGHT ESPRIT and SMART Study Groups
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