Pattern of Breast Cancer Presentation

To study the various types of breastcancer presenting in local hospital to ensure betterfacilities, early diagnosis and better treatmentoptionsMethods: In this descriptive study all breast cancerpatients, over a period of two years were included.Triple assessment of patients done for diagnosis andtreatment given all were included in data.Results: Total number of patients who presentedwere 1982. Benign breast disease patients were 1746(88.0%). Breast cancer were 236(11.90%). Fivehundred and two mammographies were done, 197were BIRAD 5. Preferably confirmation was donethrough trucut biopsy (35), FNAC was done in 74and where needed incisional biopsy in fungatingtumors (n=15) and excisional biopsy where in spiteof all modalities diagnosis was not confirmed (n=11). Age varied from 24 to 75 years. Majority (126)were in stage 3. Forty two patients receivedneoadjuvant chemotherapy. Modified radicalmastectomy (n=114), Breast conservation ( n=13) andsimple mastectomy (n=17) were performed .Receptorstatus was dtermined.Conclusion: The most common stage ofpresentation is stage 3. Such patients need downstaging and then surgery. They required propercounseling and support for their treatment. Femalesusually present late due to domestic issues. Earlydiagnosis, treatment and full support is required totreat breast cancer. This study will help to providebetter facilities for early diagnosis and treatment

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Association of Hyperuricemia with Coronary Artery Disease in Gulab Devi Chest Hospital

Abstract Background: Coronary artery disease is the most common and life threatening cardiac emergency presenting to a hospital. Having significant mortality and morbidity are on the rise in Pakistan. The objective of the study is to examine the association of elevated level of serum uric acid with ischemic heart disease among adult population, to guide planning for primary and secondary prevention of this disease in community. Subjects and Methods: This cross-sectional study studied 110 consecutive patients from 20-80 years of age presenting with IHD (Myocardial infarction, unstable angina). All the subjects who were approached to participate in the study, gave their consent. Face-to-face interviews were conducted using a structured questionnaire followed by laboratory tests. Results: Association of serum uric acid were lined up as gender, smoking, hypertension, diabetes mellitus, menopause, dyslipidemia, family history and obesity. In this study, out of 110 patients 35 (32%) were females and 74 (68%) were males. Minimum Age of patients in this study was 30 years and maximum age was 70 years This study revealed that chest pain was the most occurring symptom which was observed in 39 patients which are 35.45% of the total patients and the second most occurring symptom was Dyspnea which was observed in 32 patients which 29.09% of the total patients. The study reveals that the major risk factor observed in CAD patients is ‘HTN’ which was found in 81 patients which are 73.64% of the total patients. However, ‘Smoking’ and ‘DM’ are proximate in occurrence and were found in 59 (53.64%) and 56 (50.91%) patients respectively. The study revealed that hyperuricemia was more in males that was 34(22.67) than in females. Conclusion: This study concluded that there was no significant association between hyperuricemia with ischemic heart disease

Offset Approximation of Rational Trigonometric Bezier Curves

Offset curves are one of the crucial curves, but the presenceof square root function in the representation is main hindrance towardstheir applications in CAD/CAM. The presented technique is based on offsetapproximation using rational trigonometric B´ezier curves. The idea isto construct a new control polygon parallel to original one. The two endpoints of the offset control polygon have been taken as exact offset endpoints, while the middle control points and weights have been computedusing definition of parallel curves. As a result, offsets of rational and nonrationaltrigonometric B´ezier curves have been approximated by rationalcubic trigonometric B´ezier curve. An error between exact and approximatedoffset curves have also been computed to show the efficacy of themethod

A review on the manufacturing techniques for textile based antennas

An antenna is a medium of communication in electronic systems and one of its branches is known as wearable antenna (embedded in clothing or other wearables). Antennas are found in a wide range of applications such as medical, military, sports, safety, fitness, satellite communication etc. Textile based antennas are considered a replacement of conventional communication systems in E-textiles as they are more flexible and comfortable as compared to their metallic counterparts and more efficient than transmission wires. Electronic wiring which is commonly used for data transmission is susceptible to damage because of bending or stretching in wearables and may cause interferences between signals and time delays. One of the most significant advantages of wearable antennas is the reduction of bulk of electronic components as they can act as a sensor and communicator at a time. The cost can also be reduced this way. The current work focuses on the review of different manufacturing techniques for wearable antennas. The scope of this review is to highlight main techniques, their advantages and limitations in comparison with each other as well as to describe the available solutions of associated problems. The findings of this review could be fruitful for researchers to find out the best manufacturing technique for antennas in their perspective. Visual Abstrac

Chemical composition and antioxidant activity of quince fruit pulp collected from different locations

This study was carried out to examine the physicochemical and functional characteristics of quince fruit pulp. The matured quince fruits were collected from different locations of Poonch, AJ&K, Pakistan. Significant differences (P ˂ 0.05) were found among fruits collected from these locations. The quince pulp has the following characteristics: pH (3.43), total soluble solids (14.22°Brix), acidity (1.25%), carbohydrate (13.38 g/100 g), reducing sugar (5.15 g/100 g), non-reducing sugar (4.61 g/100 g), moisture (84.27 g/100 g), ash (0.62 g/100 g), fat (0.24 g/100 g), protein (0.49 g/100 g), fiber (1.65 g/100 g), ascorbic acid (15.46 mg/100 g), and total phenolic (68.13 mg gallic acid equivalent/100 g) and antioxidant activity (50.05%). This exploration is the basic direction, which highlights the nutritional characteristics of quince fruit grown in AJ&K, Pakistan

Design and development of auxetic structures for enhancing ergonomic comfort in women’s intimate apparel (brassiere)

Brassiere straps are commonly perceived as one of the most irritating and uncomfortable components of a brassiere, especially for women with heavier breasts. This study aimed to design and developed auxetic structures to enhance the ergonomics of intimate apparel. The brassiere straps were developed by using textured polyester and nylon yarns with auxetic weave structures in two different widths. Tests were conducted to evaluate Poisson’s ratio, tensile strength, and pressure distribution properties and overall ergonomics of developed straps. Subjective analysis was also performed by conducting wear trials. The development of polyester straps yielded excellent results compared to nylon. In the subjective analysis, the selected polyester sample consistently performed better than others, significantly enhancing ergonomics comfort, fit, and psychological comfort according to respondents’ preferences. Based on the results, Auxetic structure can be a better alternative for brassiere straps in active wear to avoid related health problems and to improve women’s experience

The Allosteric Antagonist of the Sigma-2 Receptors—Elayta (CT1812) as a Therapeutic Candidate for Mild to Moderate Alzheimer’s Disease: A Scoping Systematic Review

Nearly 35 million people worldwide live with Alzheimer’s disease (AD). The prevalence of the disease is expected to rise two-fold by 2050. With only symptomatic treatment options available, it is essential to understand the developments and existing evidence that aims to target brain pathology and dementia outcomes. This scoping systematic review aimed to collate existing evidence of CT1812 for use in patients with AD and summarize the methodologies of ongoing trials. Adhering to PRISMA Statement 2020 guidelines, PubMed/MEDLINE, Embase, Cochrane, and ClinicalTrials.gov were systematically searched through up to 15 November 2022 by applying the following keywords: CT1812, Alzheimer’s disease, dementia, and/or sigma-2 receptor. Three completed clinical trials were included along with three ongoing records of clinical trials. The three completed trials were in Phases I and II of testing. The sample size across all three trials was 135. CT1812 reached endpoints across the trials and obtained a maximum concentration in the cerebrospinal fluid with 97–98% receptor occupancy. The findings of this systematic review must be used with caution as the results, while mostly favorable so far, must be replicated in higher-powered, placebo-controlled Phase II–III trials

Requirement Engineering Challenges in Agile Software Development

Agile software development has large success rate due to its benefits and promising nature but natively where the size of the project is small. Requirement engineering (RE) is crucial as in each software development life cycle, “Requirements” play a vital role. Though agile provides values to customer’s business needs, changing requirement, and interaction, we also have to face impediments in agile, many of which are related to requirement challenges. This article aims to find out the challenges being faced during requirement engineering of agile projects. Many research studies have been conducted on requirement challenges which are somehow biased, no suggestions are given to improve the agile development process, and the research does not highlight large-scale agile development challenges. Hence, this article covers all the challenges discussed above and presents a comprehensive overview of agile models from requirement engineering perspective. The findings and results can be very helpful for software industry to improve development process as well as for researchers who want to work further in this direction