Linear Maps Which are Anti-derivable at Zero

A.M. Peralta was partially supported by the Spanish Ministry of Science, Innovation and Universities (MICINN) and European Regional Development Fund Project No. PGC2018-093332-B-I00, Junta de Andalucia Grant FQM375 and Proyecto de I + D + i del Programa Operativo FEDER Andalucia 2014-2020, ref. A-FQM-242-UGR18. This work was supported by the Deanship of Scientific Research (DSR), King Abdulaziz University. The authors, therefore, gratefully acknowledge DSR technical and financial support. The results in this paper are part of the first author's PhD thesis at King Abdulaziz University. We acknowledge the thorough revision made by the anonymous referee including several sharp comments on Theorem 6.Let T:A→X be a bounded linear operator, where A is a C∗ -algebra, and X denotes an essential Banach A-bimodule. We prove that the following statements are equivalent: (a): T is anti-derivable at zero (i.e., ab=0 in A implies T(b)a+bT(a)=0 ); (b): There exist an anti-derivation d:A→X∗∗ and an element ξ∈X∗∗ satisfying ξa=aξ, ξ[a,b]=0, T(ab)=bT(a)+T(b)a−bξa, and T(a)=d(a)+ξa, for all a,b∈A . We also prove a similar equivalence when X is replaced with A∗∗ . This provides a complete characterization of those bounded linear maps from A into X or into A∗∗ which are anti-derivable at zero. We also present a complete characterization of those continuous linear operators which are ∗-anti-derivable at zero.Spanish Ministry of Science, Innovation and Universities (MICINN)European Regional Development Fund Project PGC2018-093332-B-I00Junta de Andalucia FQM375Proyecto de I + D + i del Programa Operativo FEDER Andalucia 2014-2020 A-FQM-242-UGR18Deanship of Scientific Research (DSR), King Abdulaziz UniversityDS

Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats

Doxorubicin (DOX) is an anticancer drug widely used to treat human and nonhuman tumors but the late and persistent cardio-toxicity reduces the therapeutic utility of the drug. The full mechanism(s) of DOX-induced acute, subchronic and delayed toxicity, which has a preponderant mitochondrial component, remains unclear; therefore, it is clinically relevant to identify early markers to identify patients who are predisposed to DOX-related cardiovascular toxicity. To address this, Wistar rats (16 weeks old) were treated with a single DOX dose (20 mg/kg, i.p.); then, mRNA, protein levels and functional analysis of mitochondrial endpoints were assessed 24 h later in the heart, liver, and kidney. Using an exploratory data analysis, we observed cardiac-specific alterations after DOX treatment for mitochondrial complexes III, IV, and preferentially for complex I. Conversely, the same analysis revealed complex II alterations are associated with DOX response in the liver and kidney. Interestingly, H2O2 production by the mitochondrial respiratory chain as well as loss of calcium-loading capacity, markers of subchronic toxicity, were not reliable indicators of acute DOX cardiotoxicity in this animal model. By using sequential principal component analysis and feature correlation analysis, we demonstrated for the first time alterations in sets of transcripts and proteins, but not functional measurements, that might serve as potential early acute markers of cardiac-specific mitochondrial toxicity, contributing to explain the trajectory of DOX cardiac toxicity and to develop novel interventions to minimize DOX cardiac liabilities

Quaternion-Based Robust Attitude Estimation Using an Adaptive Unscented Kalman Filter

This paper presents the Quaternion-based Robust Adaptive Unscented Kalman Filter (QRAUKF) for attitude estimation. The proposed methodology modifies and extends the standard UKF equations to consistently accommodate the non-Euclidean algebra of unit quaternions and to add robustness to fast and slow variations in the measurement uncertainty. To deal with slow time-varying perturbations in the sensors, an adaptive strategy based on covariance matching that tunes the measurement covariance matrix online is used. Additionally, an outlier detector algorithm is adopted to identify abrupt changes in the UKF innovation, thus rejecting fast perturbations. Adaptation and outlier detection make the proposed algorithm robust to fast and slow perturbations such as external magnetic field interference and linear accelerations. Comparative experimental results that use an industrial manipulator robot as ground truth suggest that our method overcomes a trusted commercial solution and other widely used open source algorithms found in the literature

Tumores do córtex da supra-renal: resultados do tratamento e estudo do escore de Weiss como fator prognóstico

PURPOSE: The differential diagnosis between benign and malignant adrenal cortical tumors circumscribed to the gland is controversial. One hundred and seven patients with adrenal cortex tumors (excluding those with primary hyperaldosteronism) were studied to assess the 5-year survival rate of adults, children, patients stratified by pathological stage, and patients stratified according to Weiss's score of ;3. METHODS: The patients were evaluated both clinically and biochemically. One hundred and five patients underwent surgery and were classified pathologically as stages I, II, III, or IV. The tumors were weighed, measured, and classified according to Weiss's criteria and divided into 2 groups: ;3. RESULTS: After 5 years, the survival rate was 77.5% for the whole group, 74.61% for the adults, 84.3% for the children, 100% for stage I, 83.9% for stage II, 33% for stage III, and 11.7% for stage IV groups. Additionally, after 5 years, 100% of the patients with tumors with Weiss's scoreOBJETIVOS: O diagnóstico diferencial entre tumores benignos e malignos do córtex da supra-renal é controverso. Cento e sete pacientes com tumores do córtex da supra-renal (excluindo aqueles com hiperaldosternismo primário) foram estudados para avaliar a sobrevida em 5 anos de adultos, de crianças e de acordo com o estadio patológico £ 3 ou >;3 segundo o escore de Weiss. MÉTODOS: Os pacientes foram avaliados clínica e laboratorialmente. Cento e cinco pacientes foram operados e foram classificados em estadios patológicos I, II, III ou IV. Os tumores foram pesados, medidos, classificados de acordo com os critérios de Weiss e divididos em 2 grupos: ³ 3 e >;3. RESULTADOS: Após 5 anos a sobrevida foi de 77,5% para o grupo inteiro, 74,61% para os adultos, 84,3% para as crianças, 100% para estadio I, 83,9% para estadio II, 33% para estadio III e 11,7% para estadio IV. Após 5 anos 100% dos pacientes com tumores com escore de Weiss £ 3 estavam vivos contra 61,65% dos que tinham escore de Weiss >;3. Os pesos médios dos tumores com escore de Weiss £ 3 e >;3 foram de 23,38 ± 41,36 g e de 376,2 ± 538,76 g, os quais são estatisticamente diferentes. Os tamanhos médios dos tumores com escore de Weiss £ 3 e >;3 foram de 3,67 ± 2,2 cm e 9,64 ± 5,8 cm que são também estatiscamente diferentes. CONCLUSÃO: O escore de Weiss pode ser um bom fator prognóstico para tumores do córtex da supra-renal. Há também uma diferença estatística significante entre o peso médio e o tamanho médio dos tumores com comportamento benigno (escore de Weiss £ 3) e aqueles com comportamento maligno (escore de Weiss >;3)

Perfil lipídico e uso de anti-TNF-α

AbstractThe use of anti-TNF-α has been associated with several changes in lipid profile, although some study results are conflicting. The knowledge of this fact is of great importance when one observes at the association between rheumatic diseases and accelerated atherogenesis. The aim of this analysis was search for changes in lipid profile in anti TNF-α users in the population of Southern Brazil and its association with duration of use, indications, patient gender and type of anti-TNF. For this purpose, we studied the profiles of total cholesterol (TC), HDL cholesterol (HDLc), LDL cholesterol (LDLc), atherogenic index (ATI) and triglycerides (TGs) of 58 patients (42 with rheumatoid arthritis and 16 with spondyloarthritis) before and after using this drug for a median of 16.0 months. There were no changes in the levels of TC, HDLc, LDLc and ATI (P=NS). However, there was a significant increase in TG levels (P=0.03). The median difference between first and second TG measurements was 16mg/dL and this increase was not associated with gender, time of use, use indication or type of anti TNF-α (P=NS). It was concluded that the use of anti TNF-α is associated with increased values of TG

Mini-quadrotor Attitude Control based on Hybrid Backstepping & Frenet-Serret Theory

This paper is about modeling and control of miniature quadrotors, with a special emphasis on attitude control. Mathematical models for simulation and nonlinear control approaches are introduced and subsequently applied to commercial aircraft: the DraganFlyer quadrotor, which has been hardware-modified in order to perform experimental autonomous flying. Hybrid Backstepping control and the Frenet-Serret theory is used for attitude stabilization, introducing a desired attitude angle acceleration function dependent on aircraft velocity. Finally, improvements on disturbance rejection and attitude tracking at moderate aircraft speeds are validated through various simulation scenarios (indoor navigation based on camera tracking), and flight experiments conducted on the DraganFlyer quadroto

A Study on Binary Asteriod System Deflection

The study of asteroids, its composition and trajectories, has been a persistent interest in the space exploration community. In addition, they are also perceived as a great threat to life on Earth, considering the possibility of an impact with our planet. A considerable portion, around 15%, of the asteroid population are believed to be part of a double or triple asteroid system

Analgesia pós-operatória: Comparação entre Bloqueio Interpleural e Anestesia Peridural

Model: Prospective, randomized, double-blind clinical trialPurpose: The main goal of this research was to compare the efficacy of the interpleural block and theepidural anesthesia, associated to general anesthesia, in the postoperative pain control of upper abdominal surgery.Methods: Eighty patients, allocated in eight groups (G) (n=10), of both genders, with ages varying from 18to 50 years, weight between 50 and 100kg, physical status ASA P1 and P2, submitted to subcostalcholecystectomy under interpleural block (I) or epidural anesthesia (P) associated to general anesthesiawere included in this study. They received levobupivacaine (L) 0,5% (100 mg) with adrenaline (5 µg.mL-1)or ropivacaine (R) 0,75% (150 mg), morphine (M) (3 mg) and clonidine (C) (3 µg.kg-1) or dextroketamine(K) (0,5 mg.kg-1), at the 7th intercostal space, in the mid axillary line, using a Tuohy 17G needle throughinterpleural route. The same medications were administered through epidural route, at the level of T12 - L1,using a Tuohy 17G needle. General anesthesia was induced with etomidate (0,2 mg.kg-1), alfentanil (30µg.kg-1) and rocuronium (0,6 mg.kg-1) and was maintained with oxygen and isoflurane (0,5 vol% at 3,0vol%).The postoperative analgesia was checked at six, twelve, eighteen and twenty-four hours after thesurgical procedure according to the Pain Verbal Analogic Scale. Results: Until six hours after surgery, 14 patients undergoing interpleural block and 7 undergoing epidural anesthesia felt pain. From six to twelve hours, 32 patients undergoing interpleural block and 14undergoing epidural anesthesia presented pain. Between twelve and eighteen hours, 34 patients undergoing interpleural block and 21 undergoing epidural anesthesia felt pain. From eighteen to twenty-fourhours, 36 patients undergoing interpleural block and 25 undergoing epidural anesthesia presentedpain. A statistically significant difference was observed comparing the techniques at the period between6 -12h, 12-18h and 18-24h. Eight patients undergoing interpleural block and three undergoing epiduralanesthesia required opioid.Conclusions: It was observed a decrease in the intensity of the pain and in the use of postoperative painmedication, in both used techniques.Modelo: Pesquisa clínica, aleatorizada, prospectiva e duplo-encoberta. Objetivo: Essa pesquisa objetivoucomparar a eficácia do bloqueio interpleural e da anestesia peridural, associados à anestesia geral, nocontrole da dor pós - operatória de cirurgias de abdome superior. Metodologia: Participaram da pesquisa 80 pacientes alocados em 8 grupos(G) (n=10), de ambos os gêneros, idade variando de 18 a 50anos, peso entre 50 e 100 kg, estado físico ASA P1 e P2, submetidos à colecistectomia por via subcostal,sob bloqueios interpleural(I) ou peridural(P) associados à anestesia geral. Foram administradas:levobupivacaína (L) 0,5% (100 mg) com adrenalina (5 µg.mL-1) ou ropivacaína (R) 0,75% (150 mg),morfina (M) (3 mg) e clonidina (C) (3 µg.kg-1) ou dextrocetamina (K) (0,5 mg.kg-1), por via interpleural, aonível EIC7, na linha axilar média, com agulha de Tuohy 17G; os mesmos fármacos foram injetados, porvia peridural, ao nível T12-L1, com agulha de Tuohy 17G. A indução da anestesia geral foi realizada com aadministração de etomidato (0,2 mg.kg-1), alfentanil (30 µg.kg-1) e rocurônio (0,6 mg.kg-1) e a manuten-ção com oxigênio e isoflurano (0,5vol% a 3,0vol%). A analgesia pós-operatória, analisada pela EscalaVerbal Analógica de Dor, foi observada às 6h, 12h, 18h e 24h após o término do ato operatório.Resultados: Até 6 horas após o término do ato operatório, 14 pacientes sob bloqueio interpleural e 7 sobanestesia peridural apresentaram dor; no período entre 6 e 12 horas, 32 pacientes sob bloqueiointerpleural e 14 sob anestesia peridural apresentaram dor; no período entre 12 e 18 horas, 34 pacientes sob bloqueio interpleural e 21 sob anestesia peridural apresentaram dor; no período entre 18 e 24horas, 36 pacientes sob bloqueio interpleural e 25 sob anestesia peridural apresentaram dor. Observou-se diferença estatística significante entre as técnicas, nos tempos 6-12h, 12-18h e 18-24h. Oitopacientes sob bloqueio interpleural e três sob anestesia peridural necessitaram administração deopióide. Conclusões: Ocorreu diminuição na intensidade da dor e na solicitação de analgésicos nopós-operatório, com as técnicas utilizadas