Putative factors influencing knowledge and behavioural practices of health science undergraduate students towards COVID-19 infection ahead of re-opening universities in Ghana

Background: The coronavirus disease 2019 (COVID-19) virus is a global pandemic affecting daily activities and delaying the reopening of several institutions such as universities. As a result, precautionary and preventive measures are being implemented to curtail the spread of the virus. However, knowledge and compliance measures are essential for adequate preparedness to reopen the universities amidst the pandemic. Methods: This cross-sectional study evaluated knowledge, attitudes, and practices (KAP) along with factors influencing Health Science undergraduate students toward the COVID-19 infection pandemic in Ghana. A total of 606 students provided information regarding KAP of COVID-19 infection using an online questionnaire designed via Google forms. Results: Majority of the students \u27mostly\u27 obtained information on COVID-19 infection from social media (69.4%) followed by Television/radio/newspaper (60.4%). Majority of the students\u27 population had adequate knowledge (92.7%), showed a good attitude (90.9%) and positive cues (90.8%) towards COVID-19 infection. Students that more often obtained information about COVID-19 infection from the news media were 2.86 and 4.01 increased odds of having a positive attitude and good practices towards COVID-19 infection, respectively. Those who obtained information from social media were significantly more likely to have adequate knowledge [OR=2.32 (1.10-7.19] but non-significantly less likely to have good practices [OR=0.57 (0.22-1.51)]. Male students had 0.53 decreased odds of having adequate knowledge of COVID-19 infection compared with female students. When compared with the sixth year students, students in the first year [OR =0.25 (95% CI: 0.10-0.62)] and second year [OR =0.33 (95% CI: 0.14-0.81)] were significantly less knowledgeable about COVID-19 infection. Students from urban settings were significantly associated with higher positive attitude towards COVID-19 infection [OR =2.04 (1.29-3.23)]. Conclusions: Increasing public health education on COVID-19 infection would increase knowledge and awareness, and create an opportunity for compliance with precautionary measures, thereby ensuring continuity of university education amidst the pandemic

Prevalence and risk factors of preterm birth among pregnant women admitted at the labor ward of the Komfo Anokye Teaching Hospital, Ghana

Preterm birth is a global epidemic and a leading cause of neonatal mortality in Sub-Saharan Africa. We evaluated the prevalence and risk factors of preterm birth among women attending the labor ward for delivery at a tertiary hospital in Ghana. This comparative cross-sectional study was conducted among a cohort of 209 pregnant women admitted to the labor ward of the Komfo Anokye Teaching Hospital (KATH). Pregnant women who delivered between 28 and 36 completed weeks of gestation were classified as preterm delivery whereas those who delivered after 37–42 completed weeks were described as term. Sociodemographic, clinical, and obstetric data were collected from patient\u27s folder and hospital archives. Categorical variables were analyzed and expressed as frequencies and proportions. We determined the association between obstetric factors and preterm delivery with multiple logistic regressions. Significance level of the strength of association was determined at p-value \u3c 0.05. of the 209 participants, the prevalence of preterm birth was 37.3% (78/209) whereas 62.7% (131/209) delivered at Term. Intrauterine growth restriction (IUGR) [aOR = 2.15, 95% CI = (1.819.55), p = 0.0390], HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome [aOR = 3.94, 95% CI = (1.64–9.48), p = 0.0020], early gestational obesity [aOR = 2.11, 95% CI = (1.31–11.92), p = 0.0480] and preeclampsia [aOR = 4.56, 95% CI = (1.63–12.76), p = 0.004] were identified as independent risk factors of preterm birth. Prevalence of preterm birth was high among women attending labor admission at the Komfo Anokye Teaching Hospital and this was independently influenced by IUGR, HELLP syndrome, early gestational obesity, and preeclampsia. Identifying early signs of adverse pregnancy outcomes would inform the need for management policy to prevent high prevalence of preterm births

Putative Factors influencing Knowledge, Attitude and Practices of Health Science Undergraduate Students towards COVID-19 ahead of re-opening of Universities in Ghana: An institutional-based cross-sectional study

This dataset provided insights into the KAP towards COVID-19 among College of Health science students in a Ghanaian population. The data was collected based on a survey to understand putative factors influencing knowledge, attitude and practices of health science undergraduate students towards COVID-19, ahead of re-opening of Universities in Ghana from May 1, 2020, to May 30, 2020. The data included 606 Health Science Students (age range: 15-30 years) from the Kwame Nkrumah University of Science and Technology, Ghana. The platform for data collection was a self-reported questionnaire designed using Google Forms and a link shared via class media platforms. In total, 29 questions were answered which took an average time range between 10-15 minutes. The data covers socio-demographic information; awareness, knowledge and sources of knowledge of COVID-19; perceived confidence towards COVID-19 infection and willingness to adhere to preventive protocols; and cues to adherence, preventive practices, and tolerance towards COVID-19 infection

Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia

Background Angiogenic growth mediators (AGMs) and oxidative stress (OS) both play essential roles in normal placental vascular development and as such, placental alterations in these factors contribute to pre-eclampsia (PE). Suboptimal health status (SHS), an intermediate between health and disease, has been associated with imbalanced AGMs and OS biomarkers. Thus, SHS pregnant women may be at increased risk of developing PE and may present abnormal placental alteration and expression of AGMs and OS compared to optimal health status (OHS) pregnant women. We examined the histopathological morphology, immunohistochemical expression of AGMs antibodies and oxidative DNA damage marker in the placentae of SHS and OHS pregnant women who developed early-onset PE (EO-PE) and lateonset (LO-PE) compared to normotensive pregnancy (NTN-P). Methods This nested case-control study recruited 593 singleton normotensive pregnant women at baseline (10-20 weeks gestation) from the Ghanaian Suboptimal Health Status Cohort Study (GHOACS) undertaken at the Komfo Anokye Teaching Hospital, Ghana. Sociodemographic, clinical and obstetrics data were collected, and a validated SHS questionnaire- 25 (SHSQ-25) was used in classifying participants into SHS (n = 297) and OHS (n = 296). Participants were followed until the time of PE diagnosis and delivery (32-42 weeks gestation). Blood samples were collected at the two-time points and were assayed for AGMs; soluble fms-like tyrosine kinase-1 (sFlt - 1), placental growth factor (PIGF), vascular endothelial growth factor-A (VEGF-A), and soluble endoglin (sEng), and OS biomarkers; 8- hydroxydeoxyguanosine (8-OHdG), 8-epiprostaglandinF2-alpha (8- epi-PGF2α) and total antioxidant capacity (TAC) using ELISA. Placental samples were collected for histopathological and immunohistochemical analysis. Results Of the 593 pregnant women, 498 comprising 248 SHS and 250 OHS women returned for delivery and were included in the final analysis. Of the 248 SHS women, 56, 97 and 95 developed EO-PE, LO-PE and NTN-P, respectively, whereas 14, 30 and 206 of the 250 OHS mothers developed EO-PE, LO-PE and NTN-P, respectively. At baseline, SHS_NTN pregnant women had a significant imbalance in AGMs and OS biomarkers compared to OHS_NTN pregnant women (p \u3c 0.0001). At the time of PE diagnosis, SHS_NTN-P women who developed EO-PE, LO-PE, and NTN-P had lower serum levels of P1GF, VEGF-A and TAC and correspondingly higher levels of sEng, sFlt-1, 8-epiPGF2α, and 8-OHdG than OHS-NTN-P women who developed EO-PE and LO-PE, NTN-P (p \u3c 0.0001). A reduced placental size, increased foetal/placental weight ratio, and a significantly higher proportion of fibrinoid necrosis, infarction, villous fibrin, syncytial knots, calcification, chorangiosis, tunica media/vascular wall hypertrophy and chorioamnionitis was associated with the SHS group who developed PE (EO-PE \u3e LO-PE) more than OHS groups who developed PE (EOPE \u3e LO-PE) when all were compared to NTN-P (p \u3c 0.0001). The intensity of antibody expression of PIGF and VEGF-A were significantly reduced, whereas Flt-1, Eng and 8- OHdG were significantly increased in placentae from SHS-pregnant women who developed EO-PE \u3e LO-PE more than OHS- pregnant women who developed EO-PE \u3e LO-PE when all were compared to NTN-P ( p\u3c 0.0001). Conclusion Increased lesions, oxidative DNA damage, and imbalanced expression between pro-and anti-AGMs are associated more with SHS-embodied PE placentae rather than OHSembodied PE subtypes, thus potentially allowing differential evaluation of PE