Individual development and adaptation: A life-span longitudinal program suited for person-oriented research

In this article, we give a presentation of the longitudinal research program Individual Development and Adaptation (IDA) that can be helpful as a template for researchers considering to launch their own longitudinal studies, and that opens the door to IDA for researchers looking for suitable data to be analyzed within their own project or in collaboration with IDA. We also introduce the holistic-interactionistic theoretical framework of IDA and the associated person-oriented approach – an approach that is especially suited for analyzing the rich IDA data set with its broad coverage of different areas of adjustment and related factors. The paper provides an overview of the essential features of the IDA database, as well as of ongoing and planned IDA research

Single-cut osteotomy for correction of a complex multiplanar deformity of the radius in a Shetland pony foal

Objective To describe the surgical correction of a multiplanar deformity of the radius in a pony using a single-cut osteotomy. Study design Case report. Animals A 9-week-old male Shetland pony foal with a bodyweight of 47 kg. Methods The foal presented with a complex multiplanar deformity of the right radius. A 3-dimensional model of the bone was created based on computed tomography (CT) imaging. To correct the deformity, the cutting plane for a single-cut osteotomy was calculated following the mathematical approach described by Sangeorzan et al. After osteotomy, the bone was realigned and stabilized with two 4.5 locking compression plates (LCPs). Results Recovery from surgery was uneventful, and the foal remained comfortable. A CT exam 15 weeks after surgery revealed that diaphyseal deformities improved substantially in procurvatum (from 8° to 1°), varus (from 27° to 0°), and rotation (30° to 5°). The operated radius was 2.1 cm shorter than the left. Eighteen-month follow up confirmed a functionally and cosmetically acceptable outcome. Conclusion The single-cut osteotomy resulted in the successful correction of a multiplanar equine long-bone deformity with a favorable outcome in a Shetland pony. Clinical significance Single-cut osteotomy is an alternative surgical technique for the correction of complex diaphyseal long-bone equine deformities. Computed tomography data and the possibility of printing 3D models provides a significant advantage for rehearsing the procedure and for evaluating the correction that was achieved

Homelessness and water insecurity in the Global North: Trapped in the dwelling paradox

In this article, we introduce the “dwelling paradox” to explore how the state actively produces water insecurity for people experiencing homelessness in the Global North. We explain that the dwelling paradox is (1) produced by a modernist ideology of public service delivery that privileges water provision through private infrastructural connections in the home; (2) is reproduced by the welfare-warfare state, which has increasingly weaponized public water facilities and criminalized body functions in public space; and (3) is actively contested by some houseless communities, who challenge hegemonic ideals of the “home”—and its water infrastructure—as a private, atomized space. In advancing a relational and spatial understanding of water insecurity, we use the dwelling paradox to illustrate how unhoused people are caught in a space of institutional entrapment that is forged by state power and amplified by anti-homeless legislation. Such spaces of entrapment make it extremely difficult for unhoused people to achieve a safe, healthy, and thriving life—the basis of the human rights to water and sanitation. This article is categorized under: Human Water \u3e Water Governance

Can the activity matching ability system contribute to employment assessment? An initial discussion of job performance and a survey of work psychologists views

Employment Assessment (EA) is concerned with enabling individuals to predict their performance in job opportunities. Job performance and its analysis are key concerns for organisational psychology, although progress is required to develop their utility for EA client work. The Activity Matching Ability System (AMAS) assesses job activities and individuals' abilities and may contribute to EA. In order to begin to explore this possibility, and whether other significant factors might improve EA, a survey was run in parallel with a sample of Work Psychologist (WP) interviews (n=238). Interviewee characteristics (age, ethnic background, etc.) and WP estimates of impact of disability and probability of obtaining employment indicated a varied group, younger than other samples. WPs found that AMAS would enhance EA for one fifth of the sample. AMAS could contribute by aiding exploration of physical and cognitive factors, by providing a focus for assessment, by reviewing what individuals can do at work and by helping confidence. They considered EA would be improved by developing assessments of interpersonal skills, team working, job specific skills and aptitudes, and work placements. Cross tabulation of the data indicated that WP views were not significantly associated with any of the factors researched

Hematopoietic Cell Types: Prototype for a Revised Cell Ontology

The Cell Ontology (CL) is an OBO Foundry candidate ontology intended for the representation of cell types from all of biology. A recent workshop sponsored by NIAID on hematopoietic cell types in the CL addressed issues of both the content and structure of the CL. The section of the ontology dealing with hematopoietic cells was extensively revised, and plans were made for restructuring these cell type terms as cross-products with logical definitions based on relationships to external ontologies, such as the Protein Ontology and the Gene Ontology. The improvements to the CL in this area represent a paradigm for the future revision of the whole of the CL

Logical Development of the Cell Ontology

<p>Abstract</p> <p>Background</p> <p>The Cell Ontology (CL) is an ontology for the representation of <it>in vivo </it>cell types. As biological ontologies such as the CL grow in complexity, they become increasingly difficult to use and maintain. By making the information in the ontology computable, we can use automated reasoners to detect errors and assist with classification. Here we report on the generation of computable definitions for the hematopoietic cell types in the CL.</p> <p>Results</p> <p>Computable definitions for over 340 CL classes have been created using a genus-differentia approach. These define cell types according to multiple axes of classification such as the protein complexes found on the surface of a cell type, the biological processes participated in by a cell type, or the phenotypic characteristics associated with a cell type. We employed automated reasoners to verify the ontology and to reveal mistakes in manual curation. The implementation of this process exposed areas in the ontology where new cell type classes were needed to accommodate species-specific expression of cellular markers. Our use of reasoners also inferred new relationships within the CL, and between the CL and the contributing ontologies. This restructured ontology can be used to identify immune cells by flow cytometry, supports sophisticated biological queries involving cells, and helps generate new hypotheses about cell function based on similarities to other cell types.</p> <p>Conclusion</p> <p>Use of computable definitions enhances the development of the CL and supports the interoperability of OBO ontologies.</p

Systematic review of Group B Streptococcal capsular types, sequence types and surface proteins as potential vaccine candidates.

BACKGROUND: 21 million pregnant women worldwide (18%) are estimated to carry Group B Streptococcus (GBS), which is a risk for invasive disease in newborns, pregnant women, and stillbirths. Adults ≥ 60 years or with underlying health conditions are also vulnerable to invasive GBS disease. We undertook systematic reviews on GBS organism characteristics including: capsular polysaccharide (serotype), sequence type (multi-locus sequence types (MLST)), and virulence proteins. We synthesised data by at-risk populations, to inform vaccine development. METHODS: We conducted systematic reviews and meta-analyses to estimate proportions of GBS serotypes for at risk populations: maternal colonisation, invasive disease in pregnant women, stillbirths, infants 0-90 days age, and older adults (≥60 years). We considered regional variation and time trends (2001-2018). For these at-risk population groups, we summarised reported MLST and surface proteins. RESULTS: Based on 198 studies (29247isolates), 93-99% of GBS isolates were serotypes Ia, Ib, II, III, IV and V. Regional variation is likely, but data gaps are apparent, even for maternal colonisation which has most data. Serotype III dominates for infant invasive disease (60%) and GBS-associated stillbirths (41%). ST17 accounted for a high proportion of infant invasive disease (41%; 95%CI: 35-47) and was found almost exclusively in serotype III strains, less present in maternal colonisation (9%; 95%CI:6-13),(4%; 95%CI:0-11) infant colonisation, and adult invasive disease (4%, 95%CI:2-6). Percentages of strains with at least one of alp 1, alp2/3, alpha C or Rib surface protein targets were 87% of maternal colonisation, 97% infant colonisation, 93% infant disease and 99% adult invasive disease. At least one of three pilus islands proteins were reported in all strains. DISCUSSION: A hexavalent vaccine (serotypes Ia, Ib, II, III, IV and V) might provide comprehensive cover for all at-risk populations. Surveillance of circulating, disease-causing target proteins is useful to inform vaccines not targeting capsular polysaccharide. Addressing data gaps especially by world region and some at-risk populations (notably stillbirths) is fundamental to evidence-based decision-making during vaccine design

Ethical Considerations for Movement Mapping to Identify Disease Transmission Hotspots.

Traditional public health methods for detecting infectious disease transmission, such as contact tracing and molecular epidemiology, are time-consuming and costly. Information and communication technologies, such as global positioning systems, smartphones, and mobile phones, offer opportunities for novel approaches to identifying transmission hotspots. However, mapping the movements of potentially infected persons comes with ethical challenges. During an interdisciplinary meeting of researchers, ethicists, data security specialists, information and communication technology experts, epidemiologists, microbiologists, and others, we arrived at suggestions to mitigate the ethical concerns of movement mapping. These suggestions include a template Data Protection Impact Assessment that follows European Union General Data Protection Regulations