Assessment of ultrasonic computed tomography in symptomatic breast patients by discriminant analysis

From 95 subjects imaged with both speed of sound and attenuation ultrasonic computed tomography (UCT), quantitative analyses are presented on 40 cases where unequivocal correlating clinical diagnoses are available. Using four attenuation and speed of sound parameters from different regions of interest in the breast, a linear discriminator detects cancer with approximately 90% sensitivity and specificity. Increased confidence in the predictive power of this small study is given by a modern test of predictive power (jackknifing) and by the fact that diagnostic discrimination remains as high as 85% when only two parameters are employed--attenuation and speed of sound in the lesion minus those values in the remaining central mammary tissues. Speed of sound images appear particularly useful in older, fatty breasts where pulse echo ultrasound is particularly lacking. While UCT in the form studied here is not likely to receive wide clinical acceptance in the near future, a combined UCT/pulse echo system might find wide clinical utility if it can be sufficiently convenient and inexpensive.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/28104/1/0000552.pd

Generalisability of vaccine effectiveness estimates: an analysis of cases included in a postlicensure evaluation of 13-valent pneumococcal conjugate vaccine in the USA

External validity, or generalisability, is the measure of how well results from a study pertain to individuals in the target population. We assessed generalisability, with respect to socioeconomic status, of estimates from a matched case–control study of 13-valent pneumococcal conjugate vaccine effectiveness for the prevention of invasive pneumococcal disease in children in the USA

Inelastic Scattering of Dissociable Molecules

138 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1977.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD

Increased Hippocampal Volume in Schizophrenics\u27 Parents with Ancestral History of Schizophrenia

Objective: Decreased hippocampal volume is one of the hypothesized pathological features of schizophrenia, but it is not known if this abnormality is familially transmitted. The aim of this study was to measure the hippocampal volume of the parents of schizophrenic probands. in relationship to the apparent transmission of genetic risk. Method: Eighteen subjects from families consisting of a schizophrenic proband and two clinically unaffected parents were studied. Probands were compared to six control subjects, matched for age, sex, and educational level. The six families were selected so that only one parent had an ancestral family history of schizophrenia. The volumes of both hippocampi were measured by magnetic resonance imaging and adjusted for age and whole brain volume. Research: The total hippocampal volumes of the parents with ancestral family history of schizophrenia were significantly larger than those of their schizophrenic offspring. Conclusions: This study suggests that decreased hippocampal volume in schizophrenia is not a familially transmitted abnormality. Rather. it appears that clinically unaffected parents who transmit apparent genetic risk for schizophrenia may have increased hippocampal volume. which may be a protective factor against the illness

A Prudent dietary pattern is inversely associated with liver fat content among multi‐ethnic youth

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167769/1/ijpo12758.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167769/2/ijpo12758_am.pd