«Минулого не вистачає…»: художня трансформація історичних мотивів у циклі «Суха різьба» Василя Герасим’юка

У статті розглядаються основні складові естетичної еволюції «пізнього» В. Герасим’юка. Об’єктом аналізу слугують нові вірші, що склали основу циклу «Суха різьба». Предметом наукового дискурсу є національно-історіософський план ліричного відтворення світу. Проводиться зіставлення з ранньою лірикою. Визначається художня своєрідність поезії. (The article deals with the main components of the aesthetic evolution of the «late» V.Gerasymyuk. The object of the analysis are the new poems from the series «Dry Thread». The subject of the scientific discourse are demonological, biblical, metaphoric and musical, national and historiosophical plans of the lyric reality representation.The comparison of the early lyrics has been carried out. The artistic peculiarity of the poetry has been defined.

Mechanical properties, biodegradation, and biocompatibility of ultrafine grained magnesium alloy WE43

In this work, the effect of an ultrafine-grained (UFG) structure obtained by multiaxial deformation (MAD) on the mechanical properties, fatigue strength, biodegradation, and biocompatibility in vivo of the magnesium alloy WE43 was studie

Suppressors of RNAi from plant viruses are subject to episodic positive selection

Viral suppressors of RNAi (VSRs) are proteins that actively inhibit the antiviral RNA interference (RNAi) immune response, providing an immune evasion route for viruses. It has been hypothesized that VSRs are engaged in a molecular ‘arms race’ with RNAi pathway genes. Two lines of evidence support this. First, VSRs from plant viruses display high sequence diversity, and are frequently gained and lost over evolutionary time scales. Second, Drosophila antiviral RNAi genes show high rates of adaptive evolution. Here, we investigate whether VSRs diversify faster than other genes and, if so, whether this is a result of positive selection, as might be expected in an arms race. By analysis of 12 plant RNA viruses, we show that the relative rate of protein evolution is higher for VSRs than for other genes, but that this is not attributable to pervasive positive selection. We argue that, because evolutionary time scales are extremely different for viruses and eukaryotes, it is improbable that viral adaptation (as measured by the ratio of non-synonymous to synonymous change) will be dominated by one-to-one coevolution with eukaryotes. Instead, for plant virus VSRs, we find strong evidence of episodic selection—diversifying selection that acts on a subset of lineages—which might be attributable to frequent shifts between different host genotypes or species

CASE-tools for database design: overview and brief description

The article deals with the automation of database design; an overview of existing CASE-tools on the market.Given their brief description and a comparative analysis with emphasis on non-commercial CASE-tools that implement the model method of design automationВ статье рассмотрены средства автоматизации проектирования баз данных; сделан обзор существующих CASE-средств, представленных на рынке. Дана их краткая характеристика и проведен сравнительный анализ с акцентом на некоммерческих CASE-средствах, реализующих модельный метод автоматизации проектировани

Antidiabetogenic Features of Benzimidazoles

Literature data on the insulinogenic effect of 2-aminobenzimidazole prompted us to investigate its novel derivatives, particularly those containing an additional fused cycle in C1,2-α position, including imidazole, dihydroimidazole, or tetrahydropyrimidine ring. Consensus analysis of the hypoglycemic effect of these compounds performed with IT Microcosm and PASS system revealed that activity is mostly characteristic for N9-2,3-dihydroimidazo[1,2-a]benzimidazole derivatives. Substructural analysis of hypoglycemic activity identified substituents that determine the greatest pharmacological effect. According to the in silico assessment of the ADME properties, RU-254 was nominated as a lead compound due to the most optimal calculated and experimental activity and pharmacokinetic parameters. Preclinical studies have shown that identified compound has a pronounced insulinogenic effect and hypoglycemic effect, both in intact animals and in animals with experimental diabetes mellitus. RU-254 also reduces the level of glycated hemoglobin upon chronic administration, slightly decreases the activity of DPP-4, and increases the average number of Langerhans islets in the pancreas. Pharmaceutical drug formulation of RU-254 was developed and investigated for pharmacokinetic, pharmacodynamic, and toxicological properties. The dosage form of the drug under the name limiglidol (compound RU-254, diabenol) was evaluated in the full cycle of clinical studies that confirmed the safety, tolerability, and prominent antidiabetic properties of the drug

Academic stress and its effect on medical students’ mental health status

This review aimed to analyze the data on features of a medical students’ mental status and its dynamics in the course of study. The analysis was applied to the scientific publications (mainly over the past 5 years) on the issue of academic stress and medical students’ mental status in different countries from computer databases: PubMed, Medical-Science, eLibrary, Web of Science, and Scopu

Model of Self-Identification of Youth in the Global Communication Environment

Identity is the result of an identification process. The essence of the identification process is expressed in the acceptance of a certain social role by an individual in the process of entering a social group. The psychological meaning of the phenomenon of “identity” reflects the inner identity and integrity of an individual. This phenomenon can affect both an individual and a group. The novelty of the research is determined by the fact that important factors in the process of identity development are specific events in the past and present, periods of crisis and changes in the history of society. It is shown that the main psychological mechanism for the development of identity is identification associated with the interaction between an individual and a social group. The development of personality identity includes a number of types of identity and continues during ontogenesis, is a dynamic and uneven process. The authors show that the concept of national identity within the framework of various fields of psychological science can relate to a group and a person. The practical significance of the study is determined by the fact that in the study the authors understand national identity as the cognitive and emotional awareness of a person of his own belonging to a particular nation, which has its own characteristics. Student (late adolescence) age is decisive in the formation of a person's identity and sensitive for the development of his national identity. The psychological mechanism for the development of a person's national identity at this age is national identification. An insufficient study of the development of the national identity of student youth has been established

Codification of Terminology: a Case Study of English Legal Terms

The present paper is devoted to the phenomenon of codification and the main inconsistencies between the theoretical requirements for a term and actual terminological units found in terminological dictionaries of law. The paper presents the analysis of terms used in the legal sphere. The objective of the research is to identify and classify the inconsistencies that have a direct impact on codification as the last stage of the creation of a terminological dictionary. Particular attention is paid to the study of the content plane of legal terms listed in English terminological dictionaries as well as their expression plane. The authors conclude that at both levels (those of the content plane and the expression plane) and at the level of functioning the inconsist- encies raise important issues concerning further development of both terminography as a field of science and the dictionary-making process taking place today