Gromov-Witten theory of Deligne-Mumford stacks

Long ago, in math.AG/0112004, we pledged more details on the algebraic version of Chen-Ruan's math.AG/0103156. This is it.Comment: 59 pages, 9 sections, 3 appendices and one figure. Several minor improvement

Effective field theory for acoustic and pseudoacoustic phonons in solids

We present a relativistic effective field theory for the interaction between acoustic and gapped phonons in the limit of a small gap. We show that, while the former are the Goldstone modes associated with the spontaneous breaking of spacetime symmetries, the latter are pseudo-Goldstones associated with some (small) explicit breaking. We hence dub them “pseudoacoustic” phonons. In this first investigation, we build our effective theory for the cases of one and two spatial dimensions, two atomic species, and assuming large distance isotropy. As an illustrative example, we show how the theory can be applied to compute the total lifetime of both acoustic and pseudoacoustic phonons. This construction can find applications that range from the physics of bilayer graphene to sub-GeV dark matter detectors

Choice magnitude and decision time: investigating magnitude sensitivity invalue-based decision making

From an evolutionary perspective, it has been proposed that decision making should be sensitive to the overallmagnitude of the alternatives under consideration in order to resolve costly deadlocks and thus improve long-term rewardintake. We provide initial evidence that the overall magnitude of the alternatives affects decision making, by speeding updecision time in order to maximise a speed-value trade off. Implications for current computational models of decision making,in particular for the Drift Diffusion Model, are discussed

Divergences in insulin resistance between the different phenotypes of the polycystic ovary syndrome

Context/Objective: Current diagnostic criteria for polycystic ovary syndrome (PCOS) have generated distinct PCOS phenotypes, based on the different combinations of diagnostic features found in each patient. Our aim was to assess whether either each single diagnostic feature or their combinations into the PCOS phenotypes may predict insulin resistance in these women. Patients/Design: A total of 137 consecutive Caucasian women with PCOS, diagnosed by the Rotterdam criteria, underwent accurate assessment of diagnostic and metabolic features. Insulin sensitivity was measured by the glucose clamp technique. Results: Among women with PCOS, 84.7% had hyperandrogenism, 84.7% had chronic oligoanovulation, and 89% had polycystic ovaries. According to the individual combinations of these features, 69.4% of women had the classic phenotype, 15.3% had the ovulatory phenotype, and 15.3% had the normoandrogenic phenotype. Most subjects (71.4%) were insulin resistant. However, insulin resistance frequency differed among phenotypes, being 80.4%, 65.0%, and 38.1%, respectively, in the 3 subgroups (P < .001). Although none of the PCOS diagnostic features per se was associated with the impairment in insulin action, after adjustment for covariates, the classic phenotype and, to a lesser extent, the ovulatory phenotype were independently associated with insulin resistance, whereas the normoandrogenic phenotype was not. Metabolic syndrome frequency was also different among phenotypes (P = .030). Conclusions: There is a scale of metabolic risk among women with PCOS. Although no single diagnostic features of PCOS are independently associated with insulin resistance, their combinations, which define PCOS phenotypes, may allow physicians to establish which women should undergo metabolic screening. In metabolic terms, women belonging to the normoandrogenic phenotype behave as a separate group

Linking serial homicide - : towards an ecologically valid application

Purpose Crime linkage analysis (CLA) can be applied in the police investigation-phase to sift through a database to find behaviorally similar cases to the one under investigation and in the trial-phase to try to prove that the perpetrator of two or more offences is the same, by showing similarity and distinctiveness in the offences. Lately, research has moved toward more naturalistic settings, analyzing data sets that are as similar to actual crime databases as possible. One such step has been to include one-off offences in the data sets, but this has not yet been done with homicide. The purpose of this paper is to investigate how linking accuracy of serial homicide is affected as a function of added hard-to-solve one-off offences. Design/methodology/approach A sample (N = 117-1160) of Italian serial homicides (n = 116) and hard-to-solve one-off homicides (n = 1-1044, simulated from 45 cases) was analyzed using a Bayesian approach to identify series membership, and a case by case comparison of similarity using Jaccard's coefficient. Linking accuracy was evaluated using receiver operating characteristics and by examining the sensitivity and specificity of the model. Findings After an initial dip in linking accuracy (as measured by the AUC), the accuracy increased as more one-offs were added to the data. While adding one-offs made it easier to identify correct series (increased sensitivity), there was an increase in false positives (decreased specificity) in the linkage decisions. When rank ordering cases according to similarity, linkage accuracy was affected negatively as a function of added non-serial cases. Practical implications While using a more natural data set, in terms of adding a significant portion of non-serial homicides into the mix, does introduce error into the linkage decision, the authors conclude that taken overall, the findings still support the validity of CLA in practice. Originality/value This is the first crime linkage study on homicide to investigate how linking accuracy is affected as a function of non-serial cases being introduced into the data.Peer reviewe

Prospective blinded evaluation of a novel sensing methodology designed to reduce inappropriate shocks by the subcutaneous implantable cardioverter-defibrillator

Background: Most inappropriate shocks from the subcutaneous implantable cardioverter-defibrillator (S-ICD) are caused by cardiac oversensing. A novel sensing methodology, SMART Pass (SP; Boston Scientific Corporation, Natick, MA), aims to reduce cardiac oversensing. Objective: The purpose of this study was to evaluate the effect of SP on shocks in ambulatory patients with S-ICD. Methods: Patients implanted in 2015–2016 and enrolled in a remote patient monitoring system were included and followed for 1 year. Shocks were adjudicated by 3 independent blinded reviewers as appropriate or inappropriate. Shock incidence was calculated for patients with SP programmed enabled or disabled at implantation, censoring patients when SP programming changed or at the last transmission. The SP setting (enabled vs disabled) was modeled as a time-dependent Cox regression variable. Results: The cohort consisted of 1984 patients, and a total of 880 shocks were adjudicated. At implantation, SP was enabled in 655 patients (33%) and disabled in 1329 patients (67%). SP reduced the risk for the first inappropriate shock by 50% (P <.001) and the risk for all inappropriate shocks by 68% (P <.001) in multivariate analysis adjusted for age and device programming. The incidence of inappropriate shocks was 4.3% in the SP enabled arm vs 9.7% in the SP disabled arm. The incidence of appropriate shocks was similar (5.2

Acute hypoxia impairs posterior cerebral bioenergetics and memory in man

Abstract Hypoxia has the potential to impair cognitive function; however, it is still uncertain which cognitive domains are adversely affected. We examined the effects of acute hypoxia (∼7 h) on central executive (Go/No‐Go) and non‐executive (memory) tasks and the extent to which impairment was potentially related to regional cerebral blood flow and oxygen delivery (CDO2). Twelve male participants performed cognitive tasks following 0, 2, 4 and 6 h of passive exposure to both normoxia and hypoxia (12% O2), in a randomized block cross‐over single‐blinded design. Middle cerebral artery (MCA) and posterior cerebral artery (PCA) blood velocities and corresponding CDO2 were determined using bilateral transcranial Doppler ultrasound. In hypoxia, MCA DO2 was reduced during the Go/No‐Go task (P = 0.010 vs. normoxia, main effect), and PCA DO2 was attenuated during memorization (P = 0.005 vs. normoxia) and recall components (P = 0.002 vs. normoxia) in the memory task. The accuracy of the memory task was also impaired in hypoxia (P = 0.049 vs. normoxia). In contrast, hypoxia failed to alter reaction time (P = 0.19 vs. normoxia) or accuracy (P = 0.20 vs. normoxia) during the Go/No‐Go task, indicating that selective attention and response inhibition were preserved. Hypoxia did not affect cerebral blood flow or corresponding CDO2 responses to cognitive activity (P > 0.05 vs. normoxia). Collectively, these findings highlight the differential sensitivity of cognitive domains, with memory being selectively vulnerable in hypoxia