Response to Letter to the Editor

This is a letter responding to a a reply to a literature review about tardive dyskinesia-like syndromes due to drugs that do not block dopamine receptors. The authors are skeptical that many primary dystonias are being misdiagnosed, but certainly think it possible, and agree that dystonia must be considered in the differential diagnosis

Clinical predictors of cognitive impairment and psychiatric complications in Parkinson’s disease

Objective To estimate the clinical and demographics aspects that may contribute to cognitive impairment and psychiatric symptoms in Parkinson’s disease (PD). Method All patients answered a structured standardized clinical questionnaire. Two movement disorders specialists performed the following scale: Unified Parkinson’s disease rating score (UPDRS), the modified Hoehn and Yahr staging, Schwab and England Scale, SCOPA cognition (SCOPA-COG), SCOPA-Psychiatric complications (SCOPA-PC) and Non-Motor Symptoms Scale (NMSS). We built a generalized linear model to assess predictors for the SCOPA-COG and SCOPA-PC scores. Results Almost 37% of our patients were demented as per SCOPA-COG scores. Level of education and the UPDRS-Subscale III were predictors of cognitive impairment. Higher scores in domain 3 of NMSS and male gender were associated with psychiatric complications as assessed per the SCOPA-PC. Conclusion Level of education and disease severity are predictors of dementia in PD. Psychiatric complications are more commonly observed in men

ROI subgroups analysis.

<p>Axial view of significant areas in the comparison of B&O versus controls. Areas described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182735#pone.0182735.t004" target="_blank">Table 4</a>. p-values in red scale colorbar, α = 0.017 (Bonferroni correction).</p

ROI subgroups analysis.

<p>Axial view of significant areas in the comparison of CD versus B&O. Areas described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182735#pone.0182735.t004" target="_blank">Table 4</a>. p-values in red scale colorbar, α = 0.017 (Bonferroni correction).</p

Literature review on previous study findings using voxel-based morphometry analysis in CCD.

<p>Literature review on previous study findings using voxel-based morphometry analysis in CCD.</p

Primary exploratory analysis.

<p>Primary exploratory analysis.</p

Clinical analysis.

<p>Clinical analysis.</p

Subjects demographics.

<p>Subjects demographics.</p